Drosophila cancer models

Developmental Dynamics

Volumn 241, Issue 1, 2012, Pages 107-118

  Rudrapatna, Vivek A ^a   Cagan, Ross L ^a   Das, Tirtha K ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Cancer; Drosophila; animal models; Drug discovery; Metastasis; Oncogene; Therapeutics; Tumor suppressor

Indexed keywords

ACTIVATED PROTEIN C; BETA CATENIN; EPIDERMAL GROWTH FACTOR RECEPTOR; JANUS KINASE; MYC PROTEIN; NEUROFIBROMIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN TYROSINE KINASE; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR E2F; VANDETANIB;

ANTINEOPLASTIC ACTIVITY; CANCER GROWTH; CANCER INHIBITION; CANCER INVASION; CANCER MODEL; CARCINOGENESIS; CELL POLARITY; CHROMATIN ASSEMBLY AND DISASSEMBLY; COLON CANCER; DROSOPHILA; GENE MUTATION; GENETIC MODEL; GLIOBLASTOMA; HUMAN; MAMMAL; METASTASIS; MULTIPLE ENDOCRINE NEOPLASIA; NEUROFIBROMATOSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; THYROID MEDULLARY CARCINOMA; TUBEROUS SCLEROSIS; TUMOR MICROENVIRONMENT; TUMOR VOLUME;

ANIMALS; CELL POLARITY; CHROMATIN; DISEASE PROGRESSION; DROSOPHILA MELANOGASTER; DRUG DISCOVERY; HUMANS; MAMMALS; MODELS, ANIMAL; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASMS; TUMOR MICROENVIRONMENT;

ANIMALIA; VERTEBRATA;

EID: 83655184795     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.22771     Document Type: Review

References (132)

1. Bagchi A, Mills AA. 2008. The quest for the 1p36 tumor suppressor. Cancer Res 68: 2551-2556.
2. Bagchi A, Papazoglu C, Wu Y, Capurso D, Brodt M, Francis D, Bredel M, Vogel H, Mills AA. 2007. CHD5 is a tumor suppressor at human 1p36. Cell 128: 459-475.
3. Barkan B, Starinsky S, Friedman E, Stein R, Kloog Y. 2006. The Ras inhibitor farnesylthiosalicylic acid as a potential therapy for neurofibromatosis type 1. Clin Cancer Res 12: 5533-5542.
4. Bergmann A, Agapite J, McCall K, Steller H. 1998. The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling. Cell 95: 331-341.
5. Bobinski M, Greco CM, Schrot RJ. 2009. Giant intracranial medullary thyroid carcinoma metastasis presenting as apoplexy. Skull Base 19: 359-362.
6. Bondar T, Medzhitov R. 2010. p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell 6: 309-322.
7. Brumby AM, Richardson HE. 2003. scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. EMBO J 22: 5769-5779.
8. Brumby AM, Goulding KR, Schlosser T, Loi S, Galea R, Khoo P, Bolden JE, Aigaki T, Humbert PO, Richardson HE. 2011. Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis. Genetics 188: 105-125.
9. Bryant PJ, Schubiger G. 1971. Giant and duplicated imaginal discs in a new lethal mutant of Drosophila melanogaster. Dev Biol 24: 233-263.
10. Cakir M, Grossman AB. 2009. Medullary thyroid cancer: molecular biology and novel molecular therapies. Neuroendocrinology 90: 323-348.
11. Campbell PJ, Yachida S, Mudie LJ, Stephens PJ, Pleasance ED, Stebbings LA, Morsberger LA, Latimer C, McLaren S, Lin ML, McBride DJ, Varela I, Nik-Zainal SA, Leroy C, Jia M, Menzies A, Butler AP, Teague JW, Griffin CA, Burton J, Swerdlow H, Quail MA, Stratton MR, Iacobuzio-Donahue C, Futreal PA. 2010. The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature 467: 1109-1113.
12. Carlomagno F, Vitagliano D, Guida T, Ciardiello F, Tortora G, Vecchio G, Ryan AJ, Fontanini G, Fusco A, Santoro M. 2002. ZD6474, an orally available inhibitor of KDR tyrosine kinase activity, efficiently blocks oncogenic RET kinases. Cancer Res 62: 7284-7290.
13. Carlson KM, Dou S, Chi D, Scavarda N, Toshima K, Jackson CE, Wells SA Jr, Goodfellow PJ, Donis-Keller H. 1994. Single missense mutation in the tyrosine kinase catalytic domain of the RET protooncogene is associated with multiple endocrine neoplasia type 2B. Proc Natl Acad Sci U S A 91: 1579-1583.
14. Chang S, Bray SM, Li Z, Zarnescu DC, He C, Jin P, Warren ST. 2008. Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila. Nat Chem Biol 4: 256-263.
15. Classen AK, Bunker BD, Harvey KF, Vaccari T, Bilder D. 2009. A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling. Nat Genet 41: 1150-1155.
16. Clevers H. 2006. Wnt/beta-catenin signaling in development and disease. Cell 127: 469-480.
17. Cordero JB, Macagno JP, Stefanatos RK, Strathdee KE, Cagan RL, Vidal M. 2010. Oncogenic Ras diverts a host TNF tumor suppressor activity into tumor promoter. Dev Cell 18: 999-1011.
18. Cranston AN, Ponder BA. 2003. Modulation of medullary thyroid carcinoma penetrance suggests the presence of modifier genes in a RET transgenic mouse model. Cancer Res 63: 4777-4780.
19. Curran SP, Wu X, Riedel CG, Ruvkun G. 2009. A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants. Nature 459: 1079-1084.
20. Dancey JE, Chen HX. 2006. Strategies for optimizing combinations of molecularly targeted anticancer agents. Nat Rev Drug Discov 5: 649-659.
21. Das T, Cagan R. 2010. Drosophila as a novel therapeutic discovery tool for thyroid cancer. Thyroid 20: 689-695.
22. de la Cova C, Abril M, Bellosta P, Gallant P, Johnston LA. 2004. Drosophila myc regulates organ size by inducing cell competition. Cell 117: 107-116.
23. de Lau W, Barker N, Clevers H. 2007. WNT signaling in the normal intestine and colorectal cancer. Front Biosci 12: 471-491.
24. Deshpande H, Roman S, Thumar J, Sosa JA. 2010. Vandetanib (ZD6474) in the Treatment of Medullary Thyroid Cancer. Clin Med Insights Oncol 5: 213-221.
25. Dong J, Feldmann G, Huang J, Wu S, Zhang N, Comerford SA, Gayyed MF, Anders RA, Maitra A, Pan D. 2007. Elucidation of a universal size-control mechanism in Drosophila and mammals. Cell 130: 1120-1133.
26. Donis-Keller H, Dou S, Chi D, Carlson KM, Toshima K, Lairmore TC, Howe JR, Moley JF, Goodfellow P, Wells SA Jr. 1993. Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC. Hum Mol Genet 2: 851-856.
27. Dow LE, Elsum IA, King CL, Kinross KM, Richardson HE, Humbert PO. 2008. Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling. Oncogene 27: 5988-6001.
28. Eng C, Clayton D, Schuffenecker I, Lenoir G, Cote G, Gagel RF, van Amstel HK, Lips CJ, Nishisho I, Takai SI, Marsh DJ, Robinson BG, Frank-Raue K, Raue F, Xue F, Noll WW, Romei C, Pacini F, Fink M, Niederle B, Zedenius J, Nordenskjold M, Komminoth P, Hendy GN, Mulligan LM, et al. 1996. The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis. JAMA 276: 1575-1579.
29. Fearon ER, Vogelstein B. 1990. A genetic model for colorectal tumorigenesis. Cell 61: 759-767.
30. Fernandez-Medarde A, Santos E. 2011. Ras in cancer and developmental diseases. Genes Cancer 2: 344-358.
31. Ferner RE. 2007. Neurofibromatosis 1 and neurofibromatosis 2: a twenty first century perspective. Lancet Neurol 6: 340-351.
32. Froldi F, Ziosi M, Garoia F, Pession A, Grzeschik NA, Bellosta P, Strand D, Richardson HE, Grifoni D. 2010. The lethal giant larvae tumour suppressor mutation requires dMyc oncoprotein to promote clonal malignancy. BMC Biol 8: 33.
33. Fujita T, Igarashi J, Okawa ER, Gotoh T, Manne J, Kolla V, Kim J, Zhao H, Pawel BR, London WB, Maris JM, White PS, Brodeur GM. 2008. CHD5, a tumor suppressor gene deleted from 1p36.31 in neuroblastomas. J Natl Cancer Inst 100: 940-949.
34. Furnari FB, Fenton T, Bachoo RM, Mukasa A, Stommel JM, Stegh A, Hahn WC, Ligon KL, Louis DN, Brennan C, Chin L, DePinho RA, Cavenee WK. 2007. Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev 21: 2683-2710.
35. Gallant P. 2005. Myc, cell competition, and compensatory proliferation. Cancer Res 65: 6485-6487.
36. Gardiol D, Zacchi A, Petrera F, Stanta G, Banks L. 2006. Human discs large and scrib are localized at the same regions in colon mucosa and changes in their expression patterns are correlated with loss of tissue architecture during malignant progression. Int J Cancer 119: 1285-1290.
37. Gateff E. 1978. Malignant neoplasms of genetic origin in Drosophila melanogaster. Science 200: 1448-1459.
38. Grifoni D, Garoia F, Schimanski CC, Schmitz G, Laurenti E, Galle PR, Pession A, Cavicchi S, Strand D. 2004. The human protein Hugl-1 substitutes for Drosophila lethal giant larvae tumour suppressor function in vivo. Oncogene 23: 8688-8694.
39. Grifoni D, Garoia F, Bellosta P, Parisi F, De Biase D, Collina G, Strand D, Cavicchi S, Pession A. 2007. aPKCzeta cortical loading is associated with Lgl cytoplasmic release and tumor growth in Drosophila and human epithelia. Oncogene 26: 5960-5965.
40. Grose R, Martin P. 1999. Parallels between wound repair and morphogenesis in the embryo. Semin Cell Dev Biol 10: 395-404.
41. Grzeschik NA, Amin N, Secombe J, Brumby AM, Richardson HE. 2007. Abnormalities in cell proliferation and apico-basal cell polarity are separable in Drosophila lgl mutant clones in the developing eye. Dev Biol 311: 106-123.
42. Grzeschik NA, Parsons LM, Allott ML, Harvey KF, Richardson HE. 2010. Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms. Curr Biol 20: 573-581.
43. Halder G, Johnson RL. 2011. Hippo signaling: growth control and beyond. Development 138: 9-22.
44. Hanahan D, Weinberg RA. 2000. The hallmarks of cancer. Cell 100: 57-70.
45. Hanahan D, Weinberg RA. 2011. Hallmarks of cancer: the next generation. Cell 144: 646-674.
46. Hazard JB, Hawk WA, Crile G Jr. 1959. Medullary (solid) carcinoma of the thyroid; a clinicopathologic entity. J Clin Endocrinol Metab 19: 152-161.
47. Hogan C, Dupre-Crochet S, Norman M, Kajita M, Zimmermann C, Pelling AE, Piddini E, Baena-Lopez LA, Vincent JP, Itoh Y, Hosoya H, Pichaud F, Fujita Y. 2009. Characterization of the interface between normal and transformed epithelial cells. Nat Cell Biol 11: 460-467.
48. Homsy JG, Jasper H, Peralta XG, Wu H, Kiehart DP, Bohmann D. 2006. JNK signaling coordinates integrin and actin functions during Drosophila embryogenesis. Dev Dyn 235: 427-434.
49. Hough CD, Woods DF, Park S, Bryant PJ. 1997. Organizing a functional junctional complex requires specific domains of the Drosophila MAGUK Discs large. Genes Dev 11:3242-3253.
50. Huang J, Wu S, Barrera J, Matthews K, Pan D. 2005. The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP. Cell 122: 421-434.
51. Huang Q, Li F, Liu X, Li W, Shi W, Liu FF, O'sullivan B, He Z, Peng Y, Tan AC, Zhou L, Shen J, Han G, Wang XJ, Thorburn J, Thorburn A, Jimeno A, Raben D, Bedford JS, Li CY. 2011. Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy. Nat Med 17: 860-866.
52. Huh JR, Guo M, Hay BA. 2004. Compensatory proliferation induced by cell death in the Drosophila wing disc requires activity of the apical cell death caspase Dronc in a nonapoptotic role. Curr Biol 14: 1262-1266.
53. Humbert PO, Grzeschik NA, Brumby AM, Galea R, Elsum I, Richardson HE. 2008. Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module. Oncogene 27: 6888-6907.
54. Igaki T, Pagliarini RA, Xu T. 2006. Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila. Curr Biol 16: 1139-1146.
55. Igaki T, Pastor-Pareja JC, Aonuma H, Miura M, Xu T. 2009. Intrinsic tumor suppression and epithelial maintenance by endocytic activation of Eiger/TNF signaling in Drosophila. Dev Cell 16: 458-465.
56. Jacinto A, Wood W, Balayo T, Turmaine M, Martinez-Arias A, Martin P. 2000. Dynamic actin-based epithelial adhesion and cell matching during Drosophila dorsal closure. Curr Biol 10: 1420-1426.
57. Janic A, Mendizabal L, Llamazares S, Rossell D, Gonzalez C. 2010. Ectopic expression of germline genes drives malignant brain tumor growth in Drosophila. Science 330: 1824-1827.
58. Jasper H, Benes V, Schwager C, Sauer S, Clauder-Munster S, Ansorge W, Bohmann D. 2001. The genomic response of the Drosophila embryo to JNK signaling. Dev Cell 1: 579-586.
59. Jiang Z, Li X, Hu J, Zhou W, Jiang Y, Li G, Lu D. 2006. Promoter hypermethylation-mediated down-regulation of LATS1 and LATS2 in human astrocytoma. Neurosci Res 56: 450-458.
60. Jimenez C, Hu MI, Gagel RF. 2008. Management of medullary thyroid carcinoma. Endocrinol Metab Clin North Am 37: 481-496, x-xi.
61. Justice RW, Zilian O, Woods DF, Noll M, Bryant PJ. 1995. The Drosophila tumor suppressor gene warts encodes a homolog of human myotonic dystrophy kinase and is required for the control of cell shape and proliferation. Genes Dev 9: 534-546.
62. Kajita M, Hogan C, Harris AR, Dupre-Crochet S, Itasaki N, Kawakami K, Charras G, Tada M, Fujita Y. 2010. Interaction with surrounding normal epithelial cells influences signalling pathways and behaviour of Src-transformed cells. J Cell Sci 123: 171-180.
63. Kalluri R, Zeisberg M. 2006. Fibroblasts in cancer. Nat Rev Cancer 6: 392-401.
64. Kapoor A, Goldberg MS, Cumberland LK, Ratnakumar K, Segura MF, Emanuel PO, Menendez S, Vardabasso C, Leroy G, Vidal CI, Polsky D, Osman I, Garcia BA, Hernando E, Bernstein E. 2010. The histone variant macroH2A suppresses melanoma progression through regulation of CDK8. Nature 468: 1105-1109.
65. Karaman MW, Herrgard S, Treiber DK, Gallant P, Atteridge CE, Campbell BT, Chan KW, Ciceri P, Davis MI, Edeen PT, Faraoni R, Floyd M, Hunt JP, Lockhart DJ, Milanov ZV, Morrison MJ, Pallares G, Patel HK, Pritchard S, Wodicka LM, Zarrinkar PP. 2008. A quantitative analysis of kinase inhibitor selectivity. Nat Biotechnol 26: 127-132.
66. Kinzler KW, Vogelstein B. 1996. Lessons from hereditary colorectal cancer. Cell 87: 159-170.
67. Kleihues P, Aguzzi A, Ohgaki H. 1995. Genetic and environmental factors in the etiology of human brain tumors. Toxicol Lett 82-83: 601-605.
68. Knudson AG Jr. 1971. Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci U S A 68: 820-823.
69. Kockel L, Homsy JG, Bohmann D. 2001. Drosophila AP-1: lessons from an invertebrate. Oncogene 20: 2347-2364.
70. Korshunov A, Sycheva R, Golanov A. 2006. Genetically distinct and clinically relevant subtypes of glioblastoma defined by array-based comparative genomic hybridization (array-CGH). Acta Neuropathol 111: 465-474.
71. Kurada P, White K. 1998. Ras promotes cell survival in Drosophila by downregulating hid expression. Cell 95: 319-329.
72. Lassmann S, Weis R, Makowiec F, Roth J, Danciu M, Hopt U, Werner M. 2007. Array CGH identifies distinct DNA copy number profiles of oncogenes and tumor suppressor genes in chromosomal- and microsatellite-unstable sporadic colorectal carcinomas. J Mol Med (Berl) 85: 293-304.
73. Lee KP, Lee JH, Kim TS, Kim TH, Park HD, Byun JS, Kim MC, Jeong WI, Calvisi DF, Kim JM, Lim DS. 2010. The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis. Proc Natl Acad Sci U S A 107: 8248-8253.
74. Lu L, Li Y, Kim SM, Bossuyt W, Liu P, Qiu Q, Wang Y, Halder G, Finegold MJ, Lee JS, Johnson RL. 2010. Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A 107: 1437-1442.
75. Maher EA, Furnari FB, Bachoo RM, Rowitch DH, Louis DN, Cavenee WK, DePinho RA. 2001. Malignant glioma: genetics and biology of a grave matter. Genes Dev 15: 1311-1333.
76. Martinez AM, Schuettengruber B, Sakr S, Janic A, Gonzalez C, Cavalli G. 2009. Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling. Nat Genet 41: 1076-1082.
77. Matsumine A, Ogai A, Senda T, Okumura N, Satoh K, Baeg GH, Kawahara T, Kobayashi S, Okada M, Toyoshima K, Akiyama T. 1996. Binding of APC to the human homolog of the Drosophila discs large tumor suppressor protein. Science 272: 1020-1023.
78. Min KT, Benzer S. 1999. Preventing neurodegeneration in the Drosophila mutant bubblegum. Science 284: 1985-1988.
79. Minoo P, Zlobec I, Baker K, Tornillo L, Terracciano L, Jass JR, Lugli A. 2007. Prognostic significance of mammalian sterile20-like kinase 1 in colorectal cancer. Mod Pathol 20: 331-338.
80. Mocellin S, Nitti D. 2008. TNF and cancer: the two sides of the coin. Front Biosci 13: 2774-2783.
81. Moreno E, Basler K. 2004. dMyc transforms cells into super-competitors. Cell 117: 117-129.
82. Morris EJ, Ji JY, Yang F, Di Stefano L, Herr A, Moon NS, Kwon EJ, Haigis KM, Naar AM, Dyson NJ. 2008. E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8. Nature 455: 552-556.
83. Mulero-Navarro S, Esteller M. 2008. Chromatin remodeling factor CHD5 is silenced by promoter CpG island hypermethylation in human cancer. Epigenetics 3: 210-215.
84. Navarro C, Nola S, Audebert S, Santoni MJ, Arsanto JP, Ginestier C, Marchetto S, Jacquemier J, Isnardon D, Le Bivic A, Birnbaum D, Borg JP. 2005. Junctional recruitment of mammalian Scribble relies on E-cadherin engagement. Oncogene 24: 4330-4339.
85. Nevins JR. 2001. The Rb/E2F pathway and cancer. Hum Mol Genet 10: 699-703.
86. Nowell PC. 1976. The clonal evolution of tumor cell populations. Science 194: 23-28.
87. Ostman A, Augsten M. 2009. Cancer-associated fibroblasts and tumor growth--bystanders turning into key players. Curr Opin Genet Dev 19: 67-73.
88. Pagliarini RA, Xu T. 2003. A genetic screen in Drosophila for metastatic behavior. Science 302: 1227-1231.
89. Pan D. 2010. The hippo signaling pathway in development and cancer. Dev Cell 19: 491-505.
90. Pan D, Dong J, Zhang Y, Gao X. 2004. Tuberous sclerosis complex: from Drosophila to human disease. Trends Cell Biol 14: 78-85.
91. Perez-Garijo A, Martin FA, Morata G. 2004. Caspase inhibition during apoptosis causes abnormal signalling and developmental aberrations in Drosophila. Development 131: 5591-5598.
92. Petrelli A, Giordano S. 2008. From single- to multi-target drugs in cancer therapy: when aspecificity becomes an advantage. Curr Med Chem 15: 422-432.
93. Pietras K, Ostman A. 2010. Hallmarks of cancer: interactions with the tumor stroma. Exp Cell Res 316: 1324-1331.
94. Potter CJ, Huang H, Xu T. 2001. Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size. Cell 105: 357-368.
95. Read RD, Goodfellow PJ, Mardis ER, Novak N, Armstrong JR, Cagan RL. 2005. A Drosophila model of multiple endocrine neoplasia type 2. Genetics 171: 1057-1081.
96. Read RD, Cavenee WK, Furnari FB, Thomas JB. 2009. A drosophila model for EGFR-Ras and PI3K-dependent human glioma. PLoS Genet 5: e1000374.
97. Rouleau GA, Merel P, Lutchman M, Sanson M, Zucman J, Marineau C, Hoang-Xuan K, Demczuk S, Desmaze C, Plougastel B, et al. 1993. Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2. Nature 363: 515-521.
98. Ryoo HD, Gorenc T, Steller H. 2004. Apoptotic cells can induce compensatory cell proliferation through the JNK and the Wingless signaling pathways. Dev Cell 7: 491-501.
99. Schuettengruber B, Chourrout D, Vervoort M, Leblanc B, Cavalli G. 2007. Genome regulation by polycomb and trithorax proteins. Cell 128: 735-745.
100. Seidel C, Schagdarsurengin U, Blumke K, Wurl P, Pfeifer GP, Hauptmann S, Taubert H, Dammann R. 2007. Frequent hypermethylation of MST1 and MST2 in soft tissue sarcoma. Mol Carcinog 46: 865-871.
101. Simpson AJ, Caballero OL, Jungbluth A, Chen YT, Old LJ. 2005. Cancer/testis antigens, gametogenesis and cancer. Nat Rev Cancer 5: 615-625.
102. Smith-Hicks CL, Sizer KC, Powers JF, Tischler AS, Costantini F. 2000. C-cell hyperplasia, pheochromocytoma and sympathoadrenal malformation in a mouse model of multiple endocrine neoplasia type 2B. EMBO J 19: 612-622.
103. Sparagana SP, Roach ES. 2000. Tuberous sclerosis complex. Curr Opin Neurol 13: 115-119.
104. Sparmann A, van Lohuizen M. 2006. Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer 6: 846-856.
105. Stebbins MJ, Yin JC. 2001. Adaptable doxycycline-regulated gene expression systems for Drosophila. Gene 270: 103-111.
106. Stebbins MJ, Urlinger S, Byrne G, Bello B, Hillen W, Yin JC. 2001. Tetracycline-inducible systems for Drosophila. Proc Natl Acad Sci U S A 98: 10775-10780.
107. Strome S, Lehmann R. 2007. Germ versus soma decisions: lessons from flies and worms. Science 316: 392-393.
108. Stronach BE, Perrimon N. 1999. Stress signaling in Drosophila. Oncogene 18: 6172-6182.
109. Sun G, Irvine KD. 2011. Regulation of Hippo signaling by Jun kinase signaling during compensatory cell proliferation and regeneration, and in neoplastic tumors. Dev Biol 350: 139-151.
110. Takahashi Y, Miyoshi Y, Takahata C, Irahara N, Taguchi T, Tamaki Y, Noguchi S. 2005. Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers. Clin Cancer Res 11: 1380-1385.
111. Tapon N, Ito N, Dickson BJ, Treisman JE, Hariharan IK. 2001. The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell 105: 345-355.
112. Tapon N, Harvey KF, Bell DW, Wahrer DC, Schiripo TA, Haber DA, Hariharan IK. 2002. salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell 110: 467-478.
113. Trofatter JA, MacCollin MM, Rutter JL, Murrell JR, Duyao MP, Parry DM, Eldridge R, Kley N, Menon AG, Pulaski K, et al. 1993. A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor. Cell 72: 791-800.
114. Udan RS, Kango-Singh M, Nolo R, Tao C, Halder G. 2003. Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nat Cell Biol 5: 914-920.
115. Uhlirova M, Bohmann D. 2006. JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila. EMBO J 25: 5294-5304.
116. Uhlirova M, Jasper H, Bohmann D. 2005. Non-cell-autonomous induction of tissue overgrowth by JNK/Ras cooperation in a Drosophila tumor model. Proc Natl Acad Sci U S A 102: 13123-13128.
117. Vidal M, Wells S, Ryan A, Cagan R. 2005. ZD6474 suppresses oncogenic RET isoforms in a Drosophila model for type 2 multiple endocrine neoplasia syndromes and papillary thyroid carcinoma. Cancer Res 65: 3538-3541.
118. Vidal M, Larson DE, Cagan RL. 2006. Csk-deficient boundary cells are eliminated from normal Drosophila epithelia by exclusion, migration, and apoptosis. Dev Cell 10: 33-44.
119. Vidal M, Warner S, Read R, Cagan RL. 2007. Differing Src signaling levels have distinct outcomes in Drosophila. Cancer Res 67: 10278-10285.
120. Wagner EF, Nebreda AR. 2009. Signal integration by JNK and p38 MAPK pathways in cancer development. Nat Rev Cancer 9: 537-549.
121. Wang D, Kennedy S, Conte D Jr, Kim JK, Gabel HW, Kamath RS, Mello CC, Ruvkun G. 2005. Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants. Nature 436: 593-597.
122. Wang X, Lau KK, So LK, Lam YW. 2009. CHD5 is down-regulated through promoter hypermethylation in gastric cancer. J Biomed Sci 16: 95.
123. Wedge SR, Ogilvie DJ, Dukes M, Kendrew J, Chester R, Jackson JA, Boffey SJ, Valentine PJ, Curwen JO, Musgrove HL, Graham GA, Hughes GD, Thomas AP, Stokes ES, Curry B, Richmond GH, Wadsworth PF, Bigley AL, Hennequin LF. 2002. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res 62: 4645-4655.
124. Williams JA, Su HS, Bernards A, Field J, Sehgal A. 2001. A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras/MAPK. Science 293: 2251-2256.
125. Woodhouse E, Hersperger E, Stetler-Stevenson WG, Liotta LA, Shearn A. 1994. Increased type IV collagenase in lgl-induced invasive tumors of Drosophila. Cell Growth Differ 5: 151-159.
126. Woodhouse E, Hersperger E, Shearn A. 1998. Growth, metastasis, and invasiveness of Drosophila tumors caused by mutations in specific tumor suppressor genes. Dev Genes Evol 207: 542-550.
127. Woods DF, Hough C, Peel D, Callaini G, Bryant PJ. 1996. Dlg protein is required for junction structure, cell polarity, and proliferation control in Drosophila epithelia. J Cell Biol 134: 1469-1482.
128. Wu M, Pastor-Pareja JC, Xu T. 2010. Interaction between Ras(V12) and scribbled clones induces tumour growth and invasion. Nature 463: 545-548.
129. Yachida S, Jones S, Bozic I, Antal T, Leary R, Fu B, Kamiyama M, Hruban RH, Eshleman JR, Nowak MA, Velculescu VE, Kinzler KW, Vogelstein B, Iacobuzio-Donahue CA. 2010. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 467: 1114-1117.
130. Zeitler J, Hsu CP, Dionne H, Bilder D. 2004. Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor Scribble. J Cell Biol 167:1137-1146.
131. Zhan L, Rosenberg A, Bergami KC, Yu M, Xuan Z, Jaffe AB, Allred C, Muthuswamy SK. 2008. Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma. Cell 135: 865-878.
132. Zhang X, Smith DL, Meriin AB, Engemann S, Russel DE, Roark M, Washington SL, Maxwell MM, Marsh JL, Thompson LM, Wanker EE, Young AB, Housman DE, Bates GP, Sherman MY, Kazantsev AG. 2005. A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo. Proc Natl Acad Sci U S A 102: 892-897.