Intrinsic Tumor Suppression and Epithelial Maintenance by Endocytic Activation of Eiger/TNF Signaling in Drosophila

Developmental Cell

Volumn 16, Issue 3, 2009, Pages 458-465

  Igaki, Tatsushi ^a   Pastor Pareja, Jose Carlos ^a   Aonuma, Hiroka ^b   Miura, Masayuki ^b   Xu, Tian ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

DEVBIO

Indexed keywords

DROSOPHILA PROTEIN; EIGER PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER INHIBITION; CARCINOGENESIS; CELL CLONE; CELL POLARITY; CELL VACUOLE; DROSOPHILA; ENDOCYTOSIS; ENZYME ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TUMOR CELL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; APOPTOSIS; DROSOPHILA; DROSOPHILA PROTEINS; ENDOCYTOSIS; EPITHELIUM; GENES, INSECT; GENES, TUMOR SUPPRESSOR; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MEMBRANE PROTEINS; MUTATION; NEOPLASMS, EXPERIMENTAL; SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 61749087213     PISSN: 15345807     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.devcel.2009.01.002     Document Type: Article

References (34)

1. Adachi-Yamada T., Fujimura-Kamada K., Nishida Y., and Matsumoto K. Distortion of proximodistal information causes JNK-dependent apoptosis in Drosophila wing. Nature 400 (1999) 166-169
2. Adachi-Yamada T., Gotoh T., Sugimura I., Tateno M., Nishida Y., Onuki T., and Date H. De novo synthesis of sphingolipids is required for cell survival by down-regulating c-Jun N-terminal kinase in Drosophila imaginal discs. Mol. Cell. Biol. 19 (1999) 7276-7286
3. Aggarwal B.B. Signalling pathways of the TNF superfamily: a double-edged sword. Nat. Rev. Immunol. 3 (2003) 745-756
4. Agnes F., Suzanne M., and Noselli S. The Drosophila JNK pathway controls the morphogenesis of imaginal discs during metamorphosis. Development 126 (1999) 5453-5462
5. Agrawal N., Kango M., Mishra A., and Sinha P. Neoplastic transformation and aberrant cell-cell interactions in genetic mosaics of lethal(2)giant larvae (lgl), a tumor suppressor gene of Drosophila. Dev. Biol. 172 (1995) 218-229
6. Bilder D. Epithelial polarity and proliferation control: links from the Drosophila neoplastic tumor suppressors. Genes Dev. 18 (2004) 1909-1925
7. Bilder D., and Perrimon N. Localization of apical epithelial determinants by the basolateral PDZ protein Scribble. Nature 403 (2000) 676-680
8. Bissell M.J., and Radisky D. Putting tumours in context. Nat. Rev. Cancer 1 (2001) 46-54
9. Brumby A.M., and Richardson H.E. scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. EMBO J. 22 (2003) 5769-5779
10. Bucci C., Parton R.G., Mather I.H., Stunnenberg H., Simons K., Hoflack B., and Zerial M. The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway. Cell 70 (1992) 715-728
11. Entchev E.V., Schwabedissen A., and Gonzalez-Gaitan M. Gradient formation of the TGF-beta homolog Dpp. Cell 103 (2000) 981-991
12. Fish E.M., and Molitoris B.A. Alterations in epithelial polarity and the pathogenesis of disease states. N. Engl. J. Med. 330 (1994) 1580-1588
13. Floyd S., and De Camilli P. Endocytosis proteins and cancer: a potential link?. Trends Cell Biol. 8 (1998) 299-301
14. Hariharan I.K., and Bilder D. Regulation of imaginal disc growth by tumor-suppressor genes in Drosophila. Annu. Rev. Genet. 40 (2006) 335-361
15. Igaki T., Kanda H., Yamamoto-Goto Y., Kanuka H., Kuranaga E., Aigaki T., and Miura M. Eiger, a TNF superfamily ligand that triggers the Drosophila JNK pathway. EMBO J. 21 (2002) 3009-3018
16. Igaki T., Pagliarini R.A., and Xu T. Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila. Curr. Biol. 16 (2006) 1139-1146
17. Kanda H., Igaki T., Kanuka H., Yagi T., and Miura M. Wengen, a member of the Drosophila tumor necrosis factor receptor superfamily, is required for Eiger signaling. J. Biol. Chem. 277 (2002) 28372-28375
18. Kinzler K.W., and Vogelstein B. Lessons from hereditary colorectal cancer. Cell 87 (1996) 159-170
19. Locksley R.M., Killeen N., and Lenardo M.J. The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104 (2001) 487-501
20. Lowe S.W., Cepero E., and Evan G. Intrinsic tumour suppression. Nature 432 (2004) 307-315
21. Lu H., and Bilder D. Endocytic control of epithelial polarity and proliferation in Drosophila. Nat. Cell Biol. 7 (2005) 1232-1239
22. McDonald P.H., Chow C.W., Miller W.E., Laporte S.A., Field M.E., Lin F.T., Davis R.J., and Lefkowitz R.J. Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. Science 290 (2000) 1574-1577
23. Miaczynska M., Pelkmans L., and Zerial M. Not just a sink: endosomes in control of signal transduction. Curr. Opin. Cell Biol. 16 (2004) 400-406
24. Moberg K.H., Schelble S., Burdick S.K., and Hariharan I.K. Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth. Dev. Cell 9 (2005) 699-710
25. Moreno E., Yan M., and Basler K. Evolution of TNF signaling mechanisms: JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily. Curr. Biol. 12 (2002) 1263-1268
26. Pagliarini R.A., and Xu T. A genetic screen in Drosophila for metastatic behavior. Science 302 (2003) 1227-1231
27. Stowers R.S., and Schwarz T.L. A genetic method for generating Drosophila eyes composed exclusively of mitotic clones of a single genotype. Genetics 152 (1999) 1631-1639
28. Tapon N., Harvey K.F., Bell D.W., Wahrer D.C., Schiripo T.A., Haber D.A., and Hariharan I.K. salvador Promotes both cell cycle exit and apoptosis in Drosophila and is mutated in human cancer cell lines. Cell 110 (2002) 467-478
29. Tepass U., Tanentzapf G., Ward R., and Fehon R. Epithelial cell polarity and cell junctions in Drosophila. Annu. Rev. Genet. 35 (2001) 747-784
30. Thompson B.J., Mathieu J., Sung H.H., Loeser E., Rorth P., and Cohen S.M. Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila. Dev. Cell 9 (2005) 711-720
31. Uhlirova M., Jasper H., and Bohmann D. Non-cell-autonomous induction of tissue overgrowth by JNK/Ras cooperation in a Drosophila tumor model. Proc. Natl. Acad. Sci. USA 102 (2005) 13123-13128
32. Vaccari T., and Bilder D. The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking. Dev. Cell 9 (2005) 687-698
33. Woods D.F., and Bryant P.J. The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions. Cell 66 (1991) 451-464
34. Wucherpfennig T., Wilsch-Brauninger M., and Gonzalez-Gaitan M. Role of Drosophila Rab5 during endosomal trafficking at the synapse and evoked neurotransmitter release. J. Cell Biol. 161 (2003) 609-624