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Volumn 302, Issue 5648, 2003, Pages 1227-1231

A Genetic Screen in Drosophila for Metastatic Behavior

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; GENES; MUTAGENESIS; ONCOLOGY; TISSUE; TUMORS;

EID: 0242666126     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1088474     Document Type: Article
Times cited : (486)

References (39)
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    • 0242645678 scopus 로고    scopus 로고
    • note
    • See supporting material on Science Online.
  • 7
    • 0242393835 scopus 로고    scopus 로고
    • note
    • ey also expresses in the CNS, ocelli, and Bolwig's organ. In larvae, however, eyFLP did not produce visible clones outside of the noted locations.
  • 12
    • 0242561031 scopus 로고    scopus 로고
    • note
    • V12-expressing cells in mosaic flies were also made homozygous for additional second-site mutations (862 mutant lines): reduced tumor growth (76 lines), enhanced tumor growth (9 lines), and tumors with metastatic behavior (2 lines).
  • 17
    • 0242393838 scopus 로고    scopus 로고
    • note
    • When using the GFP-labeled collagen IV protein trap, mutant cells were marked with UAS-lacZ instead of UAS-GFP.
  • 19
  • 20
  • 39
    • 0242645680 scopus 로고    scopus 로고
    • note
    • We thank D. DiMaio, A. Horwich, R. Lifton, D. Stem, and K. White for critical review; R. Li, T. Ni, and H. Lee for participating in the screen; X. Fei for transgene injections; E. Hersperger and A. Sheam for teaching transplantation techniques; and D. Bilder, M. Bimbaum, H. Chang, L. Cooley, R. Fehon, P. Gallant, I. Hariharan, B. Hay, X. Morin, H. Oda, J. P. Vincent, and T. Uemura for strains and reagents. Supported by NIH grant CA69408 (T.X.) and the Linda Tallen and David Paul Kane Educational and Research Foundation. T.X. is a HHMI Investigator, R.A.P. is a predoctoral fellow in the Department of Genetics.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.