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Volumn 67, Issue 21, 2007, Pages 10278-10285

Differing Src signaling levels have distinct outcomes in Drosophila

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXY TERMINAL SRC KINASE; ISOENZYME; PROTEIN TYROSINE KINASE; RAS PROTEIN; UNCLASSIFIED DRUG;

EID: 35948935013     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-1376     Document Type: Article
Times cited : (52)

References (50)
  • 1
  • 3
    • 0028520779 scopus 로고
    • Activity of pp60c-src in 60 different cell lines derived from human tumors
    • Budde RJ, Ke S, Levin VA. Activity of pp60c-src in 60 different cell lines derived from human tumors. Cancer Biochem Biophys 1994;14:171-5.
    • (1994) Cancer Biochem Biophys , vol.14 , pp. 171-175
    • Budde, R.J.1    Ke, S.2    Levin, V.A.3
  • 4
    • 0020645860 scopus 로고
    • Expression of pp60c-src protein kinase in adult and fetal human tissue: High activities in some sarcomas and mammary carcinomas
    • Jacobs C, Rubsamen H. Expression of pp60c-src protein kinase in adult and fetal human tissue: high activities in some sarcomas and mammary carcinomas. Cancer Res 1983;43:1696-702.
    • (1983) Cancer Res , vol.43 , pp. 1696-1702
    • Jacobs, C.1    Rubsamen, H.2
  • 5
    • 6844259884 scopus 로고    scopus 로고
    • Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential
    • Mao W, Irby R, Coppola D, et al. Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential. Oncogene 1997;15: 3083-90.
    • (1997) Oncogene , vol.15 , pp. 3083-3090
    • Mao, W.1    Irby, R.2    Coppola, D.3
  • 6
    • 0022930029 scopus 로고
    • Analysis of pp60c-src protein kinase activity in human tumor cell lines and tissues
    • Rosen N, Bolen JB, Schwartz AM, Cohen P, DeSeau V, Israel MA. Analysis of pp60c-src protein kinase activity in human tumor cell lines and tissues. J Biol Chem 1986; 261:13754-9.
    • (1986) J Biol Chem , vol.261 , pp. 13754-13759
    • Rosen, N.1    Bolen, J.B.2    Schwartz, A.M.3    Cohen, P.4    DeSeau, V.5    Israel, M.A.6
  • 7
    • 0029896163 scopus 로고    scopus 로고
    • Regulation, substrates and functions of src
    • Brown MT, Cooper JA. Regulation, substrates and functions of src. Biochim Biophys Acta 1996;1287:121-49.
    • (1996) Biochim Biophys Acta , vol.1287 , pp. 121-149
    • Brown, M.T.1    Cooper, J.A.2
  • 8
    • 0032933797 scopus 로고    scopus 로고
    • c-Src, receptor tyrosine kinases, and human cancer
    • Biscardi JS, Tice DA, Parsons SJ. c-Src, receptor tyrosine kinases, and human cancer. Adv Cancer Res 1999;76:61-119.
    • (1999) Adv Cancer Res , vol.76 , pp. 61-119
    • Biscardi, J.S.1    Tice, D.A.2    Parsons, S.J.3
  • 9
    • 0034693877 scopus 로고    scopus 로고
    • Role of Src expression and activation in human cancer
    • Irby RB, Yeatman TJ. Role of Src expression and activation in human cancer. Oncogene 2000;19:5636-42.
    • (2000) Oncogene , vol.19 , pp. 5636-5642
    • Irby, R.B.1    Yeatman, T.J.2
  • 10
    • 0026023289 scopus 로고
    • Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice
    • Soriano P, Montgomery C, Geske R, Bradley A. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 1991;64:693-702.
    • (1991) Cell , vol.64 , pp. 693-702
    • Soriano, P.1    Montgomery, C.2    Geske, R.3    Bradley, A.4
  • 11
    • 0033522510 scopus 로고    scopus 로고
    • Src family kinases are required for integrin but not PDGFR signal transduction
    • Klinghoffer RA, Sachsenmaier C, Cooper JA, Soriano P. Src family kinases are required for integrin but not PDGFR signal transduction. EMBO J 1999;18:2459-71.
    • (1999) EMBO J , vol.18 , pp. 2459-2471
    • Klinghoffer, R.A.1    Sachsenmaier, C.2    Cooper, J.A.3    Soriano, P.4
  • 13
    • 0034632698 scopus 로고    scopus 로고
    • The Src/Csk regulatory circuit arose early in metazoan evolution
    • Miller MA, Malik IA, Shenk MA, Steele RE. The Src/Csk regulatory circuit arose early in metazoan evolution. Oncogene 2000;19:3925-30.
    • (2000) Oncogene , vol.19 , pp. 3925-3930
    • Miller, M.A.1    Malik, I.A.2    Shenk, M.A.3    Steele, R.E.4
  • 14
    • 0027289232 scopus 로고
    • Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice
    • Imamoto A, Soriano P. Disruption of the csk gene, encoding a negative regulator of Src family tyrosine kinases, leads to neural tube defects and embryonic lethality in mice. Cell 1993;73:1117-24.
    • (1993) Cell , vol.73 , pp. 1117-1124
    • Imamoto, A.1    Soriano, P.2
  • 15
    • 0035823484 scopus 로고    scopus 로고
    • Functional analysis of Csk and CHK kinases in breast cancer cells
    • Bougeret C, Jiang S, Keydar I, Avraham H. Functional analysis of Csk and CHK kinases in breast cancer cells. J Biol Chem 2001;276:33711-20.
    • (2001) J Biol Chem , vol.276 , pp. 33711-33720
    • Bougeret, C.1    Jiang, S.2    Keydar, I.3    Avraham, H.4
  • 16
    • 0142092607 scopus 로고    scopus 로고
    • A genetic screen for modifiers of the lats tumor suppressor gene identifies C-terminal Src kinase as a regulator of cell proliferation in Drosophila
    • Stewart RA, Li DM, Huang H, Xu T. A genetic screen for modifiers of the lats tumor suppressor gene identifies C-terminal Src kinase as a regulator of cell proliferation in Drosophila. Oncogene 2003;22:6436-44.
    • (2003) Oncogene , vol.22 , pp. 6436-6444
    • Stewart, R.A.1    Li, D.M.2    Huang, H.3    Xu, T.4
  • 17
    • 3242700398 scopus 로고    scopus 로고
    • Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways
    • Read RD, Bach EA, Cagan RL. Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways. Mol Cell Biol 2004;24:6676-89.
    • (2004) Mol Cell Biol , vol.24 , pp. 6676-6689
    • Read, R.D.1    Bach, E.A.2    Cagan, R.L.3
  • 18
    • 0027170845 scopus 로고
    • Ras1-dependent signaling by ectopically-expressed Drosophila src gene product in the embryo and developing eye
    • Kussick SJ, Basler K, Cooper JA. Ras1-dependent signaling by ectopically-expressed Drosophila src gene product in the embryo and developing eye. Oncogene 1993;8:2791-803.
    • (1993) Oncogene , vol.8 , pp. 2791-2803
    • Kussick, S.J.1    Basler, K.2    Cooper, J.A.3
  • 19
    • 0029736912 scopus 로고    scopus 로고
    • Regulation of cell-cell contacts in developing Drosophila eyes by Dsrc41, a new, close relative of vertebrate c-src
    • Takahashi F, Endo S, Kojima T, Saigo K. Regulation of cell-cell contacts in developing Drosophila eyes by Dsrc41, a new, close relative of vertebrate c-src. Genes Dev 1996;10:1645-56.
    • (1996) Genes Dev , vol.10 , pp. 1645-1656
    • Takahashi, F.1    Endo, S.2    Kojima, T.3    Saigo, K.4
  • 20
    • 2942722677 scopus 로고    scopus 로고
    • Drosophila Src-family kinases function with Csk to regulate cell proliferation and apoptosis
    • Pedraza LG, Stewart RA, Li DM, Xu T. Drosophila Src-family kinases function with Csk to regulate cell proliferation and apoptosis. Oncogene 2004;23:4754-62.
    • (2004) Oncogene , vol.23 , pp. 4754-4762
    • Pedraza, L.G.1    Stewart, R.A.2    Li, D.M.3    Xu, T.4
  • 22
    • 0034461259 scopus 로고    scopus 로고
    • v-Src generates a p53-independent apoptotic signal
    • Webb BL, Jimenez E, Martin GS. v-Src generates a p53-independent apoptotic signal. Mol Cell Biol 2000;20: 9271-80.
    • (2000) Mol Cell Biol , vol.20 , pp. 9271-9280
    • Webb, B.L.1    Jimenez, E.2    Martin, G.S.3
  • 23
    • 0027469402 scopus 로고
    • Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer
    • Talamonti MS, Roh MS, Curley SA, Gallick GE. Increase in activity and level of pp60c-src in progressive stages of human colorectal cancer. J Clin Invest 1993;91: 53-60.
    • (1993) J Clin Invest , vol.91 , pp. 53-60
    • Talamonti, M.S.1    Roh, M.S.2    Curley, S.A.3    Gallick, G.E.4
  • 24
    • 0345192349 scopus 로고    scopus 로고
    • A genetic method for generating Drosophila eyes composed exclusively of mitotic clones of a single genotype
    • Stowers RS, Schwarz TL. A genetic method for generating Drosophila eyes composed exclusively of mitotic clones of a single genotype. Genetics 1999;152: 1631-9.
    • (1999) Genetics , vol.152 , pp. 1631-1639
    • Stowers, R.S.1    Schwarz, T.L.2
  • 25
    • 0034193520 scopus 로고    scopus 로고
    • The Drosophila Bcl-2 family member dBorg-1 functions in the apoptotic response to UV-irradiation
    • Brachmann CB, Jassim OW, Wachsmuth BD, Cagan RL. The Drosophila Bcl-2 family member dBorg-1 functions in the apoptotic response to UV-irradiation. Curr Biol 2000;10:547-50.
    • (2000) Curr Biol , vol.10 , pp. 547-550
    • Brachmann, C.B.1    Jassim, O.W.2    Wachsmuth, B.D.3    Cagan, R.L.4
  • 26
    • 33746854581 scopus 로고    scopus 로고
    • Csk differentially regulates Src64 during distinct morphological events in Drosophila germ cells
    • O'Reilly AM, Ballew AC, Miyazawa B, Stocker H, Hafen E, Simon MA. Csk differentially regulates Src64 during distinct morphological events in Drosophila germ cells. Development 2006;133:2627-38.
    • (2006) Development , vol.133 , pp. 2627-2638
    • O'Reilly, A.M.1    Ballew, A.C.2    Miyazawa, B.3    Stocker, H.4    Hafen, E.5    Simon, M.A.6
  • 27
    • 0024432466 scopus 로고
    • Drosophila laminin: Sequence of B2 subunit and expression of all three subunits during embryogenesis
    • Montell DJ, Goodman CS. Drosophila laminin: sequence of B2 subunit and expression of all three subunits during embryogenesis. J Cell Biol 1989;109: 2441-53.
    • (1989) J Cell Biol , vol.109 , pp. 2441-2453
    • Montell, D.J.1    Goodman, C.S.2
  • 28
    • 0036083580 scopus 로고    scopus 로고
    • Csk, a critical link of g protein signals to actin cytoskeletal reorganization
    • Lowry WE, Huang J, Ma YC, et al. Csk, a critical link of g protein signals to actin cytoskeletal reorganization. Dev Cell 2002;2:733-44.
    • (2002) Dev Cell , vol.2 , pp. 733-744
    • Lowry, W.E.1    Huang, J.2    Ma, Y.C.3
  • 29
    • 0028929414 scopus 로고
    • Identifying tumor suppressors in genetic mosaics: The Drosophila lats gene encodes a putative protein kinase
    • Xu T, Wang W, Zhang S, Stewart RA, Yu W. Identifying tumor suppressors in genetic mosaics: the Drosophila lats gene encodes a putative protein kinase. Development 1995;121:1053-63.
    • (1995) Development , vol.121 , pp. 1053-1063
    • Xu, T.1    Wang, W.2    Zhang, S.3    Stewart, R.A.4    Yu, W.5
  • 30
    • 0033710512 scopus 로고    scopus 로고
    • Programmed cell death and patterning in Drosophila
    • Rusconi JC, Hays R, Cagan RL. Programmed cell death and patterning in Drosophila. Cell Death Differ 2000;7:1063-70.
    • (2000) Cell Death Differ , vol.7 , pp. 1063-1070
    • Rusconi, J.C.1    Hays, R.2    Cagan, R.L.3
  • 31
    • 30644469503 scopus 로고    scopus 로고
    • Drosophila models for cancer research
    • Vidal M, Cagan RL. Drosophila models for cancer research. Curr Opin Genet Dev 2006;16:10-6.
    • (2006) Curr Opin Genet Dev , vol.16 , pp. 10-16
    • Vidal, M.1    Cagan, R.L.2
  • 32
    • 29744462234 scopus 로고    scopus 로고
    • Csk-deficient boundary cells are eliminated from normal Drosophila epithelia by exclusion, migration, and apoptosis
    • Vidal M, Larson DE, Cagan RL. Csk-deficient boundary cells are eliminated from normal Drosophila epithelia by exclusion, migration, and apoptosis. Dev Cell 2006;10:33-44.
    • (2006) Dev Cell , vol.10 , pp. 33-44
    • Vidal, M.1    Larson, D.E.2    Cagan, R.L.3
  • 33
    • 0029904262 scopus 로고    scopus 로고
    • Requirement for c-Src catalytic activity and the SH3 domain in platelet-derived growth factor BB and epidermal growth factor mitogenic signaling
    • Broome MA, Hunter T. Requirement for c-Src catalytic activity and the SH3 domain in platelet-derived growth factor BB and epidermal growth factor mitogenic signaling. J Biol Chem 1996;271:16798-806.
    • (1996) J Biol Chem , vol.271 , pp. 16798-16806
    • Broome, M.A.1    Hunter, T.2
  • 35
    • 2942618768 scopus 로고    scopus 로고
    • A renaissance for SRC
    • Yeatman TJ. A renaissance for SRC. Nat Rev Cancer 2004;4:470-80.
    • (2004) Nat Rev Cancer , vol.4 , pp. 470-480
    • Yeatman, T.J.1
  • 36
    • 0037844867 scopus 로고    scopus 로고
    • Tyrosine phosphatase-epsilon activates Src and supports the transformed phenotype of Neu-induced mammary tumor cells
    • Gil-Henn H, Elson A. Tyrosine phosphatase-epsilon activates Src and supports the transformed phenotype of Neu-induced mammary tumor cells. J Biol Chem 2003;278:15579-86.
    • (2003) J Biol Chem , vol.278 , pp. 15579-15586
    • Gil-Henn, H.1    Elson, A.2
  • 37
    • 0028047315 scopus 로고
    • Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity
    • Muthuswamy SK, Siegel PM, Dankort DL, Webster MA, Muller WJ. Mammary tumors expressing the neu proto-oncogene possess elevated c-Src tyrosine kinase activity. Mol Cell Biol 1994;14:735-43.
    • (1994) Mol Cell Biol , vol.14 , pp. 735-743
    • Muthuswamy, S.K.1    Siegel, P.M.2    Dankort, D.L.3    Webster, M.A.4    Muller, W.J.5
  • 38
    • 21244459197 scopus 로고    scopus 로고
    • Requirements of genetic interactions between Src42A, armadillo and shotgun, a gene encoding E-cadherin, for normal development in Drosophila
    • Takahashi M, Takahashi F, Ui-Tei K, Kojima T, Saigo K. Requirements of genetic interactions between Src42A, armadillo and shotgun, a gene encoding E-cadherin, for normal development in Drosophila. Development 2005;132:2547-59.
    • (2005) Development , vol.132 , pp. 2547-2559
    • Takahashi, M.1    Takahashi, F.2    Ui-Tei, K.3    Kojima, T.4    Saigo, K.5
  • 39
    • 0023663443 scopus 로고
    • Molecular characterization and expression of sevenless, a gene involved in neuronal pattern formation in the Drosophila eye
    • Banerjee U, Renfranz PJ, Pollock JA, Benzer S. Molecular characterization and expression of sevenless, a gene involved in neuronal pattern formation in the Drosophila eye. Cell 1987;49:281-91.
    • (1987) Cell , vol.49 , pp. 281-291
    • Banerjee, U.1    Renfranz, P.J.2    Pollock, J.A.3    Benzer, S.4
  • 40
    • 0141544141 scopus 로고
    • Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation
    • Cooper JA, MacAuley A. Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation. Proc Natl Acad Sci U S A 1988;85: 4232-6.
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 4232-4236
    • Cooper, J.A.1    MacAuley, A.2
  • 41
    • 0242666126 scopus 로고    scopus 로고
    • A genetic screen in Drosophila for metastatic behavior
    • Pagliarini RA, Xu T. A genetic screen in Drosophila for metastatic behavior. Science 2003;302:1227-31.
    • (2003) Science , vol.302 , pp. 1227-1231
    • Pagliarini, R.A.1    Xu, T.2
  • 42
    • 0242641565 scopus 로고    scopus 로고
    • scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila
    • Brumby AM, Richardson HE. scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. EMBO J 2003;22:5769-79.
    • (2003) EMBO J , vol.22 , pp. 5769-5779
    • Brumby, A.M.1    Richardson, H.E.2
  • 43
    • 33744525123 scopus 로고    scopus 로고
    • Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila
    • Igaki T, Pagliarini RA, Xu T. Loss of cell polarity drives tumor growth and invasion through JNK activation in Drosophila. Curr Biol 2006;16:1139-46.
    • (2006) Curr Biol , vol.16 , pp. 1139-1146
    • Igaki, T.1    Pagliarini, R.A.2    Xu, T.3
  • 44
    • 33751111927 scopus 로고    scopus 로고
    • JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila
    • Uhlirova M, Bohmann D. JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila. EMBO J 2006;25:5294-304.
    • (2006) EMBO J , vol.25 , pp. 5294-5304
    • Uhlirova, M.1    Bohmann, D.2
  • 45
    • 0033103536 scopus 로고    scopus 로고
    • Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis
    • Lee T, Luo L. Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis. Neuron 1999;22:451-61.
    • (1999) Neuron , vol.22 , pp. 451-461
    • Lee, T.1    Luo, L.2
  • 46
    • 0033582219 scopus 로고    scopus 로고
    • Functional analysis of an eye specific enhancer of the eyeless gene in Drosophila
    • Hauck B, Gehring WJ, Walldorf U. Functional analysis of an eye specific enhancer of the eyeless gene in Drosophila. Proc Natl Acad Sci U S A 1999;96:564-9.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 564-569
    • Hauck, B.1    Gehring, W.J.2    Walldorf, U.3
  • 48
    • 0033805783 scopus 로고    scopus 로고
    • Molecular prognostic markers in pancreatic cancer
    • Coppola D. Molecular prognostic markers in pancreatic cancer. Cancer Control 2000;7:421-7.
    • (2000) Cancer Control , vol.7 , pp. 421-427
    • Coppola, D.1
  • 49
    • 9744242077 scopus 로고    scopus 로고
    • Inhibition of SRC tyrosine kinase as treatment for human pancreatic cancer growing orthotopically in nude mice
    • Yezhelyev MV, Koehl G, Guba M, et al. Inhibition of SRC tyrosine kinase as treatment for human pancreatic cancer growing orthotopically in nude mice. Clin Cancer Res 2004;10:8028-36.
    • (2004) Clin Cancer Res , vol.10 , pp. 8028-8036
    • Yezhelyev, M.V.1    Koehl, G.2    Guba, M.3
  • 50
    • 29244490072 scopus 로고    scopus 로고
    • The G691S RET polymorphism increases glial cell line-derived neurotrophic factor-induced pancreatic cancer cell invasion by amplifying mitogen-activated protein kinase signaling
    • Sawai H, Okada Y, Kazanjian K, et al. The G691S RET polymorphism increases glial cell line-derived neurotrophic factor-induced pancreatic cancer cell invasion by amplifying mitogen-activated protein kinase signaling. Cancer Res 2005;65:11536-44.
    • (2005) Cancer Res , vol.65 , pp. 11536-11544
    • Sawai, H.1    Okada, Y.2    Kazanjian, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.