Relevance of mast cell-nerve interactions in intestinal nociception

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1822, Issue 1, 2012, Pages 74-84

  van Diest, Sophie A ^a   Stanisor, Oana I ^a   Boeckxstaens, Guy E ^a,b   de Jonge, Wouter J ^a   van den Wijngaard, René M ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

Gut; Mast cell; Neuropeptide; Nociception; Sensory afferent; TRP channel

Indexed keywords

NEUROPEPTIDE; TRANSIENT RECEPTOR POTENTIAL CHANNEL;

CELL ACTIVATION; CELL INTERACTION; HUMAN; INFLAMMATION; MAST CELL; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN SECRETION; REVIEW; SENSITIZATION; SENSORY NERVE CELL;

ANIMALS; CELL COMMUNICATION; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; INFLAMMATORY BOWEL DISEASES; INTESTINES; MAST CELLS; NEUROIMMUNOMODULATION; NEURONS, AFFERENT; NOCICEPTION; NOCICEPTIVE PAIN; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL;

EID: 82955227457     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2011.03.019     Document Type: Review

References (221)

1. Ahern G.P., Brooks I.M., Miyares R.L., Wang X.B. Extracellular cations sensitize and gate capsaicin receptor TRPV1 modulating pain signaling. J. Neurosci. 2005, 25:5109.
2. Akbar A., Yiangou Y., Facer P., Brydon W.G., Walters J.R., Anand P., Ghosh S. Expression of the TRPV1 receptor differs in quiescent inflammatory bowel disease with or without abdominal pain. Gut 2010, 59:767.
3. Akbar A., Yiangou Y., Facer P., Walters J.R., Anand P., Ghosh S. Increased capsaicin receptor TRPV1-expressing sensory fibres in irritable bowel syndrome and their correlation with abdominal pain. Gut 2008, 57:923.
4. Amadesi S., Cottrell G.S., Divino L., Chapman K., Grady E.F., Bautista F., Karanjia R., Barajas-Lopez C., Vanner S., Vergnolle N., Bunnett N.W. Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice. J. Physiol. 2006, 575:555.
5. Amadesi S., Nie J., Vergnolle N., Cottrell G.S., Grady E.F., Trevisani M., Manni C., Geppetti P., McRoberts J.A., Ennes H., Davis J.B., Mayer E.A., Bunnett N.W. Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia. J. Neurosci. 2004, 24:4300.
6. Amaya F., Shimosato G., Nagano M., Ueda M., Hashimoto S., Tanaka Y., Suzuki H., Tanaka M. NGF and GDNF differentially regulate TRPV1 expression that contributes to development of inflammatory thermal hyperalgesia. Eur. J. Neurosci. 2004, 20:2303.
7. Andres K.H., von D.M., Veh R.W. Subnuclear organization of the rat habenular complexes. J. Comp. Neurol. 1999, 407:130.
8. Ansel J.C., Brown J.R., Payan D.G., Brown M.A. Substance P selectively activates TNF-alpha gene expression in murine mast cells. J. Immunol. 1993, 150:4478.
9. Ansel J.C., Kaynard A.H., Armstrong C.A., Olerud J., Bunnett N., Payan D. Skin-nervous system interactions. J. Invest. Dermatol. 1996, 106:198.
10. Arizono N., Matsuda S., Hattori T., Kojima Y., Maeda T., Galli S.J. Anatomical variation in mast cell nerve associations in the rat small intestine, heart, lung, and skin. Similarities of distances between neural processes and mast cells, eosinophils, or plasma cells in the jejunal lamina propria. Lab. Invest. 1990, 62:626.
11. Bandell M., Story G.M., Hwang S.W., Viswanath V., Eid S.R., Petrus M.J., Earley T.J., Patapoutian A. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 2004, 41:849.
12. Bar-Or A., Nuttall R.K., Duddy M., Alter A., Kim H.J., Ifergan I., Pennington C.J., Bourgoin P., Edwards D.R., Yong V.W. Analyses of all matrix metalloproteinase members in leukocytes emphasize monocytes as major inflammatory mediators in multiple sclerosis. Brain 2003, 126:2738.
13. Barbara G., Stanghellini V., De G.R., Cremon C., Cottrell G.S., Santini D., Pasquinelli G., Morselli-Labate A.M., Grady E.F., Bunnett N.W., Collins S.M., Corinaldesi R. Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology 2004, 126:693.
14. Bautista D.M., Jordt S.E., Nikai T., Tsuruda P.R., Read A.J., Poblete J., Yamoah E.N., Basbaum A.I., Julius D. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell 2006, 124:1269.
15. Bautista D.M., Movahed P., Hinman A., Axelsson H.E., Sterner O., Hogestatt E.D., Julius D., Jordt S.E., Zygmunt P.M. Pungent products from garlic activate the sensory ion channel TRPA1. Proc. Natl Acad. Sci. U. S. A. 2005, 102:12248.
16. Bhat Y.M., Bielefeldt K. Capsaicin receptor (TRPV1) and non-erosive reflux disease. Eur. J. Gastroenterol. Hepatol. 2006, 18:263.
17. Biederer T., Sara Y., Mozhayeva M., Atasoy D., Liu X., Kavalali E.T., Sudhof T.C. SynCAM, a synaptic adhesion molecule that drives synapse assembly. Science 2002, 297:1525.
18. Bielefeldt K., Davis B.M. Differential effects of ASIC3 and TRPV1 deletion on gastroesophageal sensation in mice. Am. J. Physiol. Gastrointest. Liver Physiol. 2008, 294:G130-G138.
19. Bienenstock J., Befus A.D., Pearce F., Denburg J., Goodacre R. Mast cell heterogeneity: derivation and function, with emphasis on the intestine. J. Allergy Clin. Immunol. 1982, 70:407.
20. Biro T., Maurer M., Modarres S., Lewin N.E., Brodie C., Acs G., Acs P., Paus R., Blumberg P.M. Characterization of functional vanilloid receptors expressed by mast cells. Blood 1998, 91:1332.
21. Bischoff S.C., Schwengberg S., Lorentz A., Manns M.P., Bektas H., Sann H., Levi-Schaffer F., Shanahan F., Schemann M. Substance P and other neuropeptides do not induce mediator release in isolated human intestinal mast cells. Neurogastroenterol. Motil. 2004, 16:185.
22. Blackshaw L.A., Brierley S.M., Hughes P.A. TRP channels: new targets for visceral pain. Gut 2010, 59:126.
23. Blennerhassett M.G., Tomioka M., Bienenstock J. Formation of contacts between mast cells and sympathetic neurons in vitro. Cell Tissue Res. 1991, 265:121.
24. Bolcskei K., Helyes Z., Szabo A., Sandor K., Elekes K., Nemeth J., Almasi R., Pinter E., Petho G., Szolcsanyi J. Investigation of the role of TRPV1 receptors in acute and chronic nociceptive processes using gene-deficient mice. Pain 2005, 117:368.
25. Bonnington J.K., McNaughton P.A. Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor. J. Physiol. 2003, 551:433.
26. Borovikova L.V., Ivanova S., Nardi D., Zhang M., Yang H., Ombrellino M., Tracey K.J. Role of vagus nerve signaling in CNI-1493-mediated suppression of acute inflammation. Auton. Neurosci. 2000, 85:141.
27. Borovikova L.V., Ivanova S., Zhang M., Yang H., Botchkina G.I., Watkins L.R., Wang H., Abumrad N., Eaton J.W., Tracey K.J. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature 2000, 405:458.
28. Brierley S.M., Carter R., Jones W., Xu L., Robinson D.R., Hicks G.A., Gebhart G.F., Blackshaw L.A. Differential chemosensory function and receptor expression of splanchnic and pelvic colonic afferents in mice. J. Physiol. 2005, 567:267.
29. Brierley S.M., Jones R.C., Xu L., Gebhart G.F., Blackshaw L.A. Activation of splanchnic and pelvic colonic afferents by bradykinin in mice. Neurogastroenterol. Motil. 2005, 17:854.
30. Brierley S.M., Page A.J., Hughes P.A., Adam B., Liebregts T., Cooper N.J., Holtmann G., Liedtke W., Blackshaw L.A. Selective role for TRPV4 ion channels in visceral sensory pathways. Gastroenterology 2008, 134:2059.
31. Brightling C., Berry M., Amrani Y. Targeting TNF-alpha: a novel therapeutic approach for asthma. J. Allergy Clin. Immunol. 2008, 121:5.
32. Brogden K.A., Guthmiller J.M., Salzet M., Zasloff M. The nervous system and innate immunity: the neuropeptide connection. Nat. Immunol. 2005, 6:558.
33. Bulut K., Felderbauer P., Deters S., Hoeck K., Schmidt-Choudhury A., Schmidt W.E., Hoffmann P. Sensory neuropeptides and epithelial cell restitution: the relevance of SP- and CGRP-stimulated mast cells. Int. J. Colorectal Dis. 2008, 23:535.
34. Cannon K.E., Chazot P.L., Hann V., Shenton F., Hough L.B., Rice F.L. Immunohistochemical localization of histamine H3 receptors in rodent skin, dorsal root ganglia, superior cervical ganglia, and spinal cord: potential antinociceptive targets. Pain 2007, 129:76.
35. Cao J., Papadopoulou N., Kempuraj D., Boucher W.S., Sugimoto K., Cetrulo C.L., Theoharides T.C. Human mast cells express corticotropin-releasing hormone (CRH) receptors and CRH leads to selective secretion of vascular endothelial growth factor. J. Immunol. 2005, 174:7665.
36. Caterina M.J., Leffler A., Malmberg A.B., Martin W.J., Trafton J., Petersen-Zeitz K.R., Koltzenburg M., Basbaum A.I., Julius D. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 2000, 288:306.
37. Caughey G.H., Leidig F., Viro N.F., Nadel J.A. Substance P and vasoactive intestinal peptide degradation by mast cell tryptase and chymase. J. Pharmacol. Exp. Ther. 1988, 244:133.
38. Cavanaugh D.J., Lee H., Lo L., Shields S.D., Zylka M.J., Basbaum A.I., Anderson D.J. Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli. Proc. Natl Acad. Sci. U. S. A. 2009, 106:9075.
39. Cavanaugh E.J., Simkin D., Kim D. Activation of transient receptor potential A1 channels by mustard oil, tetrahydrocannabinol and Ca2+ reveals different functional channel states. Neuroscience 2008, 154:1467.
40. Cenac N., Altier C., Chapman K., Liedtke W., Zamponi G., Vergnolle N. Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms. Gastroenterology 2008, 135:937-946.
41. Cenac N., Altier C., Motta J.P., d'Aldebert E., Galeano S., Zamponi G.W., Vergnolle N. Potentiation of TRPV4 signalling by histamine and serotonin: an important mechanism for visceral hypersensitivity. Gut 2010, 59:481.
42. Cenac N., Garcia-Villar R., Ferrier L., Larauche M., Vergnolle N., Bunnett N.W., Coelho A.M., Fioramonti J., Bueno L. Proteinase-activated receptor-2-induced colonic inflammation in mice: possible involvement of afferent neurons, nitric oxide, and paracellular permeability. J. Immunol. 2003, 170:4296.
43. Chan C.L., Facer P., Davis J.B., Smith G.D., Egerton J., Bountra C., Williams N.S., Anand P. Sensory fibres expressing capsaicin receptor TRPV1 in patients with rectal hypersensitivity and faecal urgency. Lancet 2003, 361:385.
44. Christoph T., Grunweller A., Mika J., Schafer M.K., Wade E.J., Weihe E., Erdmann V.A., Frank R., Gillen C., Kurreck J. Silencing of vanilloid receptor TRPV1 by RNAi reduces neuropathic and visceral pain in vivo. Biochem. Biophys. Res. Commun. 2006, 350:238.
45. Chrousos G.P. The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N. Engl. J. Med. 1995, 332:1351.
46. Chuang H.H., Prescott E.D., Kong H., Shields S., Jordt S.E., Basbaum A.I., Chao M.V., Julius D. Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. Nature 2001, 411:957.
47. Constantin C.E., Mair N., Sailer C.A., Andratsch M., Xu Z.Z., Blumer M.J., Scherbakov N., Davis J.B., Bluethmann H., Ji R.R., Kress M. Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model. J. Neurosci. 2008, 28:5072.
48. Corey D.P., Garcia-Anoveros J., Holt J.R., Kwan K.Y., Lin S.Y., Vollrath M.A., Amalfitano A., Cheung E.L., Derfler B.H., Duggan A., Geleoc G.S., Gray P.A., Hoffman M.P., Rehm H.L., Tamasauskas D., Zhang D.S. TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells. Nature 2004, 432:723.
49. Coruzzi G., Adami M., Guaita E., de Esch I.J., Leurs R. Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation. Eur. J. Pharmacol. 2007, 563:240.
50. Corvera C.U., Dery O., McConalogue K., Bohm S.K., Khitin L.M., Caughey G.H., Payan D.G., Bunnett N.W. Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2. J. Clin. Invest. 1997, 100:1383.
51. Cox P.J., Pitcher T., Trim S.A., Bell C.H., Qin W., Kinloch R.A. The effect of deletion of the orphan G-protein coupled receptor (GPCR) gene MrgE on pain-like behaviours in mice. Mol. Pain 2008, 4:2.
52. Dai Y., Moriyama T., Higashi T., Togashi K., Kobayashi K., Yamanaka H., Tominaga M., Noguchi K. Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain. J. Neurosci. 2004, 24:4293.
53. Dai Y., Wang S., Tominaga M., Yamamoto S., Fukuoka T., Higashi T., Kobayashi K., Obata K., Yamanaka H., Noguchi K. Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain. J. Clin. Invest. 2007, 117:1979.
54. Davis J.B., Gray J., Gunthorpe M.J., Hatcher J.P., Davey P.T., Overend P., Harries M.H., Latcham J., Clapham C., Atkinson K., Hughes S.A., Rance K., Grau E., Harper A.J., Pugh P.L., Rogers D.C., Bingham S., Randall A., Sheardown S.A. Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature 2000, 405:183.
55. de Haan J.J., Thuijls G., Lubbers T., Hadfoune M., Reisinger K., Heineman E., Greve J.W., Buurman W.A. Protection against early intestinal compromise by lipid-rich enteral nutrition through cholecystokinin receptors. Crit. Care Med. 2010, 38:1592.
56. de Jonge W.J., The F.O., van der Zanden E.P., van den Wijngaard R.M., Boeckxstaens G.E. Inflammation and gut motility; neural control of intestinal immune cell activation. J. Pediatr. Gastroenterol. Nutr. 2005, 41(Suppl. 1):S10-S11.
57. de Jonge W.J., The F.O., van der C.D., Bennink R.J., Reitsma P.H., van Deventer S.J., van den Wijngaard R.M., Boeckxstaens G.E. Mast cell degranulation during abdominal surgery initiates postoperative ileus in mice. Gastroenterology 2004, 127:535.
58. de Jonge W.J., van der Zanden E.P., The F.O., Bijlsma M.F., van Westerloo D.J., Bennink R.J., Berthoud H.R., Uematsu S., Akira S., van den Wijngaard R.M., Boeckxstaens G.E. Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway. Nat. Immunol. 2005, 6:844.
59. De Schepper H.U., De Winter B.Y., Van N.L., Timmermans J.P., Herman A.G., Pelckmans P.A., De Man J.G. TRPV1 receptors on unmyelinated C-fibres mediate colitis-induced sensitization of pelvic afferent nerve fibres in rats. J. Physiol. 2008, 586:5247.
60. DeLeo J.A., Colburn R.W., Rickman A.J. Cytokine and growth factor immunohistochemical spinal profiles in two animal models of mononeuropathy. Brain Res. 1997, 759:50.
61. Dery O., Corvera C.U., Steinhoff M., Bunnett N.W. Proteinase-activated receptors: novel mechanisms of signaling by serine proteases. Am. J. Physiol. 1998, 274:C1429-C1452.
62. Diogenes A., Akopian A.N., Hargreaves K.M. NGF up-regulates TRPA1: implications for orofacial pain. J. Dent. Res. 2007, 86:550.
63. Doerner J.F., Gisselmann G., Hatt H., Wetzel C.H. Transient receptor potential channel A1 is directly gated by calcium ions. J. Biol. Chem. 2007, 282:13180.
64. Dong X., Han S., Zylka M.J., Simon M.I., Anderson D.J. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell 2001, 106:619.
65. Dvorak A.M., Kissell S. Granule changes of human skin mast cells characteristic of piecemeal degranulation and associated with recovery during wound healing in situ. J. Leukoc. Biol. 1991, 49:197.
66. Dvorak A.M., McLeod R.S., Onderdonk A., Monahan-Earley R.A., Cullen J.B., Antonioli D.A., Morgan E., Blair J.E., Estrella P., Cisneros R.L., et al. Ultrastructural evidence for piecemeal and anaphylactic degranulation of human gut mucosal mast cells in vivo. Int. Arch. Allergy Immunol. 1992, 99:74.
67. Engelhardt B., Ransohoff R.M. The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanisms. Trends Immunol. 2005, 26:485.
68. Eskandari F., Sternberg E.M. Neural-immune interactions in health and disease. Ann. N. Y. Acad. Sci. 2002, 966:20.
69. Eskandari F., Webster J.I., Sternberg E.M. Neural immune pathways and their connection to inflammatory diseases. Arthritis Res. Ther. 2003, 5:251.
70. Alessandri-Haber N., Joseph E., Dina O.A., Liedtke W., Levine J.D. TRPV4 mediates pain-related behavior induced by mild hypertonic stimuli in the presence of inflammatory mediator. Pain 2005, 118:70.
71. essandri-Haber N., Yeh J.J., Boyd A.E., Parada C.A., Chen X., Reichling D.B., Levine J.D. Hypotonicity induces TRPV4-mediated nociception in rat. Neuron 2003, 39:497.
72. Fevrier B., Raposo G. Exosomes: endosomal-derived vesicles shipping extracellular messages. Curr. Opin. Cell Biol. 2004, 16:415.
73. Folgueras A.R., Valdes-Sanchez T., Llano E., Menendez L., Baamonde A., Denlinger B.L., Belmonte C., Juarez L., Lastra A., Garcia-Suarez O., Astudillo A., Kirstein M., Pendas A.M., Farinas I., Lopez-Otin C. Metalloproteinase MT5-MMP is an essential modulator of neuro-immune interactions in thermal pain stimulation. Proc. Natl Acad. Sci. U. S. A. 2009, 106:16451.
74. Furuno T., Ito A., Koma Y., Watabe K., Yokozaki H., Bienenstock J., Nakanishi M., Kitamura Y. The spermatogenic Ig superfamily/synaptic cell adhesion molecule mast-cell adhesion molecule promotes interaction with nerves. J. Immunol. 2005, 174:6934.
75. Geppetti P., Trevisani M. Activation and sensitisation of the vanilloid receptor: role in gastrointestinal inflammation and function. Br. J. Pharmacol. 2004, 141:1313.
76. Gershon M.D. Review article: roles played by 5-hydroxytryptamine in the physiology of the bowel. Aliment. Pharmacol. Ther. 1999, 13(Suppl 2):15.
77. Gibbs B.F., Wierecky J., Welker P., Henz B.M., Wolff H.H., Grabbe J. Human skin mast cells rapidly release preformed and newly generated TNF-alpha and IL-8 following stimulation with anti-IgE and other secretagogues. Exp. Dermatol. 2001, 10:312.
78. Goetzl E.J., Sreedharan S.P., Turck C.W. Structurally distinctive vasoactive intestinal peptides from rat basophilic leukemia cells. J. Biol. Chem. 1988, 263:9083.
79. Gosset P., Tsicopoulos A., Wallaert B., Joseph M., Capron A., Tonnel A.B. Tumor necrosis factor alpha and interleukin-6 production by human mononuclear phagocytes from allergic asthmatics after IgE-dependent stimulation. Am. Rev. Respir. Dis. 1992, 146:768.
80. Gottwald T., Lhotak S., Stead R.H. Effect of truncal vagotomy and capsaicin on mast cells and IgA-positive plasma cells in rat jejunal mucosa. Neurogastroenterol. Motil. 1997, 9:25.
81. Grant A.D., Cottrell G.S., Amadesi S., Trevisani M., Nicoletti P., Materazzi S., Altier C., Cenac N., Zamponi G.W., Bautista-Cruz F., Lopez C.B., Joseph E.K., Levine J.D., Liedtke W., Vanner S., Vergnolle N., Geppetti P., Bunnett N.W. Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice. J. Physiol. 2007, 578:715.
82. Grazzini E., Puma C., Roy M.O., Yu X.H., O'Donnell D., Schmidt R., Dautrey S., Ducharme J., Perkins M., Panetta R., Laird J.M., Ahmad S., Lembo P.M. Sensory neuron-specific receptor activation elicits central and peripheral nociceptive effects in rats. Proc. Natl Acad. Sci. U. S. A. 2004, 101:7175.
83. Greenberg G., Burnstock G. A novel cell-to-cell interaction between mast cells and other cell types. Exp. Cell Res. 1983, 147:1.
84. Hagenacker T., Czeschik J.C., Schafers M., Busselberg D. Sensitization of voltage activated calcium channel currents for capsaicin in nociceptive neurons by tumor-necrosis-factor-alpha. Brain Res. Bull. 2010, 81:157.
85. Hager U.A., Hein A., Lennerz J.K., Zimmermann K., Neuhuber W.L., Reeh P.W. Morphological characterization of rat Mas-related G-protein-coupled receptor C and functional analysis of agonists. Neuroscience 2008, 151:242.
86. Hakanson R., Vallgren S., Ekelund M., Rehfeld J.F., Sundler F. The vagus exerts trophic control of the stomach in the rat. Gastroenterology 1984, 86:28.
87. Han S.K., Dong X., Hwang J.I., Zylka M.J., Anderson D.J., Simon M.I. Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Galpha q/11 pathway. Proc. Natl Acad. Sci. U. S. A. 2002, 99:14740.
88. Hayashita-Kinoh H., Kinoh H., Okada A., Komori K., Itoh Y., Chiba T., Kajita M., Yana I., Seiki M. Membrane-type 5 matrix metalloproteinase is expressed in differentiated neurons and regulates axonal growth. Cell Growth Differ. 2001, 12:573.
89. Hensellek S., Brell P., Schaible H.G., Brauer R., Segond von B.G. The cytokine TNFalpha increases the proportion of DRG neurones expressing the TRPV1 receptor via the TNFR1 receptor and ERK activation. Mol. Cell. Neurosci. 2007, 36:381.
90. Higashijima T., Burnier J., Ross E.M. Regulation of Gi and Go by mastoparan, related amphiphilic peptides, and hydrophobic amines. Mechanism and structural determinants of activity. J. Biol. Chem. 1990, 265:14176.
91. Holzer P. Efferent-like roles of afferent neurons in the gut: blood flow regulation and tissue protection. Auton. Neurosci. 2006, 125:70.
92. Hu Y., Gu Q., Lin R.L., Kryscio R., Lee L.Y. Calcium transient evoked by TRPV1 activators is enhanced by tumor necrosis factor-{alpha} in rat pulmonary sensory neurons. Am. J. Physiol. Lung Cell. Mol. Physiol. 2010, 299:L483-L492.
93. Hughes P.A., Brierley S.M., Martin C.M., Brookes S.J., Linden D.R., Blackshaw L.A. Post-inflammatory colonic afferent sensitisation: different subtypes, different pathways and different time courses. Gut 2009, 58:1333.
94. Hukkanen J., Jacob P., Benowitz N.L. Metabolism and disposition kinetics of nicotine. Pharmacol. Rev. 2005, 57:79.
95. Hunt S.P., Mantyh P.W. The molecular dynamics of pain control. Nat. Rev. Neurosci. 2001, 2:83.
96. Inoue R., Jensen L.J., Shi J., Morita H., Nishida M., Honda A., Ito Y. Transient receptor potential channels in cardiovascular function and disease. Circ. Res. 2006, 99:119.
97. Ishihara H., Connolly A.J., Zeng D., Kahn M.L., Zheng Y.W., Timmons C., Tram T., Coughlin S.R. Protease-activated receptor 3 is a second thrombin receptor in humans. Nature 1997, 386:502.
98. Ito A., Hagiyama M., Oonuma J. Nerve-mast cell and smooth muscle-mast cell interaction mediated by cell adhesion molecule-1, CADM1. J. Smooth Muscle Res. 2008, 44:83.
99. Ito A., Jippo T., Wakayama T., Morii E., Koma Y., Onda H., Nojima H., Iseki S., Kitamura Y. SgIGSF: a new mast-cell adhesion molecule used for attachment to fibroblasts and transcriptionally regulated by MITF. Blood 2003, 101:2601.
100. Ito A., Oonuma J. Direct interaction between nerves and mast cells mediated by the SgIGSF/SynCAM adhesion molecule. J. Pharmacol. Sci. 2006, 102:1.
101. Jones R.C., Xu L., Gebhart G.F. The mechanosensitivity of mouse colon afferent fibers and their sensitization by inflammatory mediators require transient receptor potential vanilloid 1 and acid-sensing ion channel 3. J. Neurosci. 2005, 25:10981.
102. Jordt S.E., Bautista D.M., Chuang H.H., McKemy D.D., Zygmunt P.M., Hogestatt E.D., Meng I.D., Julius D. Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 2004, 427:260.
103. Kageyama-Yahara N., Suehiro Y., Yamamoto T., Kadowaki M. IgE-induced degranulation of mucosal mast cells is negatively regulated via nicotinic acetylcholine receptors. Biochem. Biophys. Res. Commun. 2008, 377:321.
104. Kahn M.L., Zheng Y.W., Huang W., Bigornia V., Zeng D., Moff S., Farese R.V., Tam C., Coughlin S.R. A dual thrombin receptor system for platelet activation. Nature 1998, 394:690.
105. Kajihara Y., Murakami M., Imagawa T., Otsuguro K., Ito S., Ohta T. Histamine potentiates acid-induced responses mediating transient receptor potential V1 in mouse primary sensory neurons. Neuroscience 2010, 166:292.
106. Kamohara M., Matsuo A., Takasaki J., Kohda M., Matsumoto M., Matsumoto S., Soga T., Hiyama H., Kobori M., Katou M. Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides. Biochem. Biophys. Res. Commun. 2005, 330:1146.
107. Kim B.M., Lee S.H., Shim W.S., Oh U. Histamine-induced Ca(2+) influx via the PLA(2)/lipoxygenase/TRPV1 pathway in rat sensory neurons. Neurosci. Lett. 2004, 361:159.
108. Kjorsvik B.A., Warsame A.A., Gustafsson H., Tjolsen A., Hole K., Stiller C.O. Stimulation of spinal 5-HT(2A/2C) receptors potentiates the capsaicin-induced in vivo release of substance P-like immunoreactivity in the rat dorsal horn. Brain Res. 2003, 987:10.
109. Kochukov M.Y., McNearney T.A., Yin H., Zhang L., Ma F., Ponomareva L., Abshire S., Westlund K.N. Tumor necrosis factor-alpha (TNF-alpha) enhances functional thermal and chemical responses of TRP cation channels in human synoviocytes. Mol. Pain 2009, 5:49.
110. Kowalski M.L., Kaliner M.A. Neurogenic inflammation, vascular permeability, and mast cells. J. Immunol. 1988, 140:3905.
111. Kulka M., Sheen C.H., Tancowny B.P., Grammer L.C., Schleimer R.P. Neuropeptides activate human mast cell degranulation and chemokine production. Immunology 2008, 123:398.
112. Kwan K.Y., Allchorne A.J., Vollrath M.A., Christensen A.P., Zhang D.S., Woolf C.J., Corey D.P. TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron 2006, 50:277.
113. Lee M.G., Dong X., Liu Q., Patel K.N., Choi O.H., Vonakis B., Undem B.J. Agonists of the MAS-related gene (Mrgs) orphan receptors as novel mediators of mast cell-sensory nerve interactions. J. Immunol. 2008, 180:2251.
114. Lembo P.M., Grazzini E., Groblewski T., O'Donnell D., Roy M.O., Zhang J., Hoffert C., Cao J., Schmidt R., Pelletier M., Labarre M., Gosselin M., Fortin Y., Banville D., Shen S.H., Strom P., Payza K., Dray A., Walker P., Ahmad S. Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. Nat. Neurosci. 2002, 5:201.
115. Llano E., Pendas A.M., Freije J.P., Nakano A., Knauper V., Murphy G., Lopez-Otin C. Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase a overexpressed in brain tumors. Cancer Res. 1999, 59:2570.
116. Lorenz D., Wiesner B., Zipper J., Winkler A., Krause E., Beyermann M., Lindau M., Bienert M. Mechanism of peptide-induced mast cell degranulation. Translocation and patch-clamp studies. J. Gen. Physiol. 1998, 112:577.
117. Lubbers T., Luyer M.D., de Haan J.J., Hadfoune M., Buurman W.A., Greve J.W. Lipid-rich enteral nutrition reduces postoperative ileus in rats via activation of cholecystokinin-receptors. Ann. Surg. 2009, 249:481.
118. Luyer M.D., Greve J.W., Hadfoune M., Jacobs J.A., Dejong C.H., Buurman W.A. Nutritional stimulation of cholecystokinin receptors inhibits inflammation via the vagus nerve. J. Exp. Med. 2005, 202:1023.
119. MacDonald A.J., Pick J., Bissonnette E.Y., Befus A.D. Rat mucosal mast cells: the cultured bone marrow-derived mast cell is biochemically and functionally analogous to its counterpart in vivo. Immunology 1998, 93:533.
120. Macpherson L.J., Dubin A.E., Evans M.J., Marr F., Schultz P.G., Cravatt B.F., Patapoutian A. Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature 2007, 445:541.
121. MacQueen G., Marshall J., Perdue M., Siegel S., Bienenstock J. Pavlovian conditioning of rat mucosal mast cells to secrete rat mast cell protease II. Science 1989, 243:83.
122. Marchand F., Perretti M., McMahon S.B. Role of the immune system in chronic pain. Nat. Rev. Neurosci. 2005, 6:521.
123. McCary C., Tancowny B.P., Catalli A., Grammer L.C., Harris K.E., Schleimer R.P., Kulka M. Substance P downregulates expression of the high affinity IgE receptor (FcepsilonRI) by human mast cells. J. Neuroimmunol. 2010, 220:17.
124. McKay D.M., Bienenstock J. The interaction between mast cells and nerves in the gastrointestinal tract. Immunol. Today 1994, 15:533.
125. McNamara C.R., Mandel-Brehm J., Bautista D.M., Siemens J., Deranian K.L., Zhao M., Hayward N.J., Chong J.A., Julius D., Moran M.M., Fanger C.M. TRPA1 mediates formalin-induced pain. Proc. Natl Acad. Sci. U. S. A. 2007, 104:13525.
126. Medhurst S.J., Collins S.D., Billinton A., Bingham S., Dalziel R.G., Brass A., Roberts J.C., Medhurst A.D., Chessell I.P. Novel histamine H3 receptor antagonists GSK189254 and GSK334429 are efficacious in surgically-induced and virally-induced rat models of neuropathic pain. Pain 2008, 138:61.
127. Metcalfe D.D., Baram D., Mekori Y.A. Mast cells. Physiol. Rev. 1997, 77:1033.
128. Miller H.R., Wright S.H., Knight P.A., Thornton E.M. A novel function for transforming growth factor-beta1: upregulation of the expression and the IgE-independent extracellular release of a mucosal mast cell granule-specific beta-chymase, mouse mast cell protease-1. Blood 1999, 93:3473.
129. Molino M., Barnathan E.S., Numerof R., Clark J., Dreyer M., Cumashi A., Hoxie J.A., Schechter N., Woolkalis M., Brass L.F. Interactions of mast cell tryptase with thrombin receptors and PAR-2. J. Biol. Chem. 1997, 272:4043.
130. Monea S., Jordan B.A., Srivastava S., DeSouza S., Ziff E.B. Membrane localization of membrane type 5 matrix metalloproteinase by AMPA receptor binding protein and cleavage of cadherins. J. Neurosci. 2006, 26:2300.
131. Mousli M., Bueb J.L., Bronner C., Rouot B., Landry Y. G protein activation: a receptor-independent mode of action for cationic amphiphilic neuropeptides and venom peptides. Trends Pharmacol. Sci. 1990, 11:358.
132. Mousli M., Hugli T.E., Landry Y., Bronner C. Peptidergic pathway in human skin and rat peritoneal mast cell activation. Immunopharmacology 1994, 27:1.
133. Nakajima K., Obata H., Ito N., Goto F., Saito S. The nociceptive mechanism of 5-hydroxytryptamine released into the peripheral tissue in acute inflammatory pain in rats. Eur. J. Pain 2009, 13:441.
134. Nakanishi M., Furuno T. Molecular basis of neuroimmune interaction in an in vitro coculture approach. Cell. Mol. Immunol. 2008, 5:249.
135. Nguyen C., Coelho A.M., Grady E., Compton S.J., Wallace J.L., Hollenberg M.D., Cenac N., Garcia-Villar R., Bueno L., Steinhoff M., Bunnett N.W., Vergnolle N. Colitis induced by proteinase-activated receptor-2 agonists is mediated by a neurogenic mechanism. Can. J. Physiol. Pharmacol. 2003, 81:920.
136. Ninkovic M., Hunt S.P. Opiate and histamine H1 receptors are present on some substance P-containing dorsal root ganglion cells. Neurosci. Lett. 1985, 53:133.
137. Nystedt S., Emilsson K., Wahlestedt C., Sundelin J. Molecular cloning of a potential proteinase activated receptor. Proc. Natl Acad. Sci. U. S. A. 1994, 91:9208.
138. Obata K., Katsura H., Mizushima T., Yamanaka H., Kobayashi K., Dai Y., Fukuoka T., Tokunaga A., Tominaga M., Noguchi K. TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury. J. Clin. Invest. 2005, 115:2393.
139. Oehlke J., Lorenz D., Wiesner B., Bienert M. Studies on the cellular uptake of substance P and lysine-rich, KLA-derived model peptides. J. Mol. Recognit. 2005, 18:50.
140. Ohta T., Ikemi Y., Murakami M., Imagawa T., Otsuguro K., Ito S. Potentiation of transient receptor potential V1 functions by the activation of metabotropic 5-HT receptors in rat primary sensory neurons. J. Physiol. 2006, 576:809.
141. Ottaway C.A. Neuroimmunomodulation in the intestinal mucosa. Gastroenterol. Clin. North Am. 1991, 20:511.
142. Parada C.A., Tambeli C.H., Cunha F.Q., Ferreira S.H. The major role of peripheral release of histamine and 5-hydroxytryptamine in formalin-induced nociception. Neuroscience 2001, 102:937.
143. Patil M.J., Jeske N.A., Akopian A.N. Transient receptor potential V1 regulates activation and modulation of transient receptor potential A1 by Ca(2+). Neuroscience 2010, 171:1109.
144. Pavlov V.A., Ochani M., Yang L.H., Gallowitsch-Puerta M., Ochani K., Lin X., Levi J., Parrish W.R., Rosas-Ballina M., Czura C.J., Larosa G.J., Miller E.J., Tracey K.J., Al-Abed Y. Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis. Crit. Care Med. 2007, 35:1139.
145. Pedotti R., De Voss J.J., Steinman L., Galli S.J. Involvement of both 'allergic' and 'autoimmune' mechanisms in EAE, MS and other autoimmune diseases. Trends Immunol. 2003, 24:479.
146. Pei D. Identification and characterization of the fifth membrane-type matrix metalloproteinase MT5-MMP. J. Biol. Chem. 1999, 274:8925.
147. Petrus M., Peier A.M., Bandell M., Hwang S.W., Huynh T., Olney N., Jegla T., Patapoutian A. A role of TRPA1 in mechanical hyperalgesia is revealed by pharmacological inhibition. Mol. Pain 2007, 3:40.
148. Pollock J., McFarlane S.M., Connell M.C., Zehavi U., Vandenabeele P., MacEwan D.J., Scott R.H. TNF-alpha receptors simultaneously activate Ca2+ mobilisation and stress kinases in cultured sensory neurones. Neuropharmacology 2002, 42:93.
149. Poyner D.R., Sexton P.M., Marshall I., Smith D.M., Quirion R., Born W., Muff R., Fischer J.A., Foord S.M. International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors. Pharmacol. Rev. 2002, 54:233.
150. Qin H.Y., Luo J.L., Qi S.D., Xu H.X., Sung J.J., Bian Z.X. Visceral hypersensitivity induced by activation of transient receptor potential vanilloid type 1 is mediated through the serotonin pathway in rat colon. Eur. J. Pharmacol. 2010, 647:75.
151. Reed D.E., Barajas-Lopez C., Cottrell G., Velazquez-Rocha S., Dery O., Grady E.F., Bunnett N.W., Vanner S.J. Mast cell tryptase and proteinase-activated receptor 2 induce hyperexcitability of guinea-pig submucosal neurons. J. Physiol. 2003, 547:531.
152. Robas N., Mead E., Fidock M. MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion. J. Biol. Chem. 2003, 278:44400.
153. Rong W., Hillsley K., Davis J.B., Hicks G., Winchester W.J., Grundy D. Jejunal afferent nerve sensitivity in wild-type and TRPV1 knockout mice. J. Physiol. 2004, 560:867.
154. Said S.I. Vasoactive intestinal peptide and nitric oxide: divergent roles in relation to tissue injury. Ann. N. Y. Acad. Sci. 1996, 805:379.
155. Said S.I., Rosenberg R.N. Vasoactive intestinal polypeptide: abundant immunoreactivity in neural cell lines and normal nervous tissue. Science 1976, 192:907.
156. Sander L.E., Lorentz A., Sellge G., Coeffier M., Neipp M., Veres T., Frieling T., Meier P.N., Manns M.P., Bischoff S.C. Selective expression of histamine receptors H1R, H2R, and H4R, but not H3R, in the human intestinal tract. Gut 2006, 55:498.
157. Santos J., Yang P.C., Soderholm J.D., Benjamin M., Perdue M.H. Role of mast cells in chronic stress induced colonic epithelial barrier dysfunction in the rat. Gut 2001, 48:630.
158. Shanahan F., Denburg J.A., Fox J., Bienenstock J., Befus D. Mast cell heterogeneity: effects of neuroenteric peptides on histamine release. J. Immunol. 1985, 135:1331.
159. Shim W.S., Tak M.H., Lee M.H., Kim M., Kim M., Koo J.Y., Lee C.H., Kim M., Oh U. TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase. J. Neurosci. 2007, 27:2331.
160. Shu X., Mendell L.M. Nerve growth factor acutely sensitizes the response of adult rat sensory neurons to capsaicin. Neurosci. Lett. 1999, 274:159.
161. Shu X., Mendell L.M. Acute sensitization by NGF of the response of small-diameter sensory neurons to capsaicin. J. Neurophysiol. 2001, 86:2931.
162. Shubayev V.I., Myers R.R. Axonal transport of TNF-alpha in painful neuropathy: distribution of ligand tracer and TNF receptors. J. Neuroimmunol. 2001, 114:48.
163. Sipe W.E., Brierley S.M., Martin C.M., Phillis B.D., Cruz F.B., Grady E.F., Liedtke W., Cohen D.M., Vanner S., Blackshaw L.A., Bunnett N.W. Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia. Am. J. Physiol. Gastrointest. Liver Physiol. 2008, 294:G1288-G1298.
164. Skofitsch G., Hamill G.S., Jacobowitz D.M. Capsaicin depletes corticotropin-releasing factor-like immunoreactive neurons in the rat spinal cord and medulla oblongata. Neuroendocrinology 1984, 38:514.
165. Skokos D., Botros H.G., Demeure C., Morin J., Peronet R., Birkenmeier G., Boudaly S., Mecheri S. Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo. J. Immunol. 2003, 170:3037.
166. Skokos D., Le P.S., Villa I., Rousselle J.C., Peronet R., David B., Namane A., Mecheri S. Mast cell-dependent B and T lymphocyte activation is mediated by the secretion of immunologically active exosomes. J. Immunol. 2001, 166:868.
167. Smalheiser N.R. Exosomal transfer of proteins and RNAs at synapses in the nervous system. Biol. Direct 2007, 2:35.
168. Spicarova D., Palecek J. Tumor necrosis factor alpha sensitizes spinal cord TRPV1 receptors to the endogenous agonist N-oleoyldopamine. J. Neuroinflammation 2010, 7:49.
169. Stander S., Moormann C., Schumacher M., Buddenkotte J., Artuc M., Shpacovitch V., Brzoska T., Lippert U., Henz B.M., Luger T.A., Metze D., Steinhoff M. Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures. Exp. Dermatol. 2004, 13:129.
170. Stanisor O.I., van Diest S.A., Welting O., Cailotto C., van der Vliet J., de Jonge W., Boeckxstaens G.E., van den Wijngaard R.M. 7 the peripheral histamine 1-receptor antagonist fexofenadine effectively reverses stress-induced visceral hypersensitivity in a rat model of maternal separation. Gastroenterology 2010, 138:S-1.
171. Stead R.H., Colley E.C., Wang B., Partosoedarso E., Lin J., Stanisz A., Hillsley K. Vagal influences over mast cells. Auton. Neurosci. 2006, 125:53.
172. Stead R.H., Dixon M.F., Bramwell N.H., Riddell R.H., Bienenstock J. Mast cells are closely apposed to nerves in the human gastrointestinal mucosa. Gastroenterology 1989, 97:575.
173. Stead R.H., Tomioka M., Quinonez G., Simon G.T., Felten S.Y., Bienenstock J. Intestinal mucosal mast cells in normal and nematode-infected rat intestines are in intimate contact with peptidergic nerves. Proc. Natl Acad. Sci. U. S. A. 1987, 84:2975.
174. Stein A.T., Ufret-Vincenty C.A., Hua L., Santana L.F., Gordon S.E. Phosphoinositide 3-kinase binds to TRPV1 and mediates NGF-stimulated TRPV1 trafficking to the plasma membrane. J. Gen. Physiol. 2006, 128:509.
175. Steinhoff M., Vergnolle N., Young S.H., Tognetto M., Amadesi S., Ennes H.S., Trevisani M., Hollenberg M.D., Wallace J.L., Caughey G.H., Mitchell S.E., Williams L.M., Geppetti P., Mayer E.A., Bunnett N.W. Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism. Nat. Med. 2000, 6:151.
176. Story G.M., Peier A.M., Reeve A.J., Eid S.R., Mosbacher J., Hricik T.R., Earley T.J., Hergarden A.C., Andersson D.A., Hwang S.W., McIntyre P., Jegla T., Bevan S., Patapoutian A. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 2003, 112:819.
177. Story G.M., Peier A.M., Reeve A.J., Eid S.R., Mosbacher J., Hricik T.R., Earley T.J., Hergarden A.C., Andersson D.A., Hwang S.W., McIntyre P., Jegla T., Bevan S., Patapoutian A. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 2003, 112:819.
178. Strakhova M.I., Nikkel A.L., Manelli A.M., Hsieh G.C., Esbenshade T.A., Brioni J.D., Bitner R.S. Localization of histamine H4 receptors in the central nervous system of human and rat. Brain Res. 2009, 1250:41.
179. Straub R.H. Complexity of the bi-directional neuroimmune junction in the spleen. Trends Pharmacol. Sci. 2004, 25:640.
180. Straub R.H., Westermann J., Scholmerich J., Falk W. Dialogue between the CNS and the immune system in lymphoid organs. Immunol. Today 1998, 19:409.
181. Sugiuar T., Bielefeldt K., Gebhart G.F. TRPV1 function in mouse colon sensory neurons is enhanced by metabotropic 5-hydroxytryptamine receptor activation. J. Neurosci. 2004, 24:9521.
182. Suzuki A., Suzuki R., Furuno T., Teshima R., Nakanishi M. N-cadherin plays a role in the synapse-like structures between mast cells and neurites. Biol. Pharm. Bull. 2004, 27:1891.
183. Suzuki M., Mizuno A., Kodaira K., Imai M. Impaired pressure sensation in mice lacking TRPV4. J. Biol. Chem. 2003, 278:22664.
184. Szallasi A., Blumberg P.M. Vanilloid (Capsaicin) receptors and mechanisms. Pharmacol. Rev. 1999, 51:159.
185. Tancowny B.P., Karpov V., Schleimer R.P., Kulka M. Substance P primes lipoteichoic acid- and Pam3CysSerLys4-mediated activation of human mast cells by up-regulating Toll-like receptor 2. Immunology 2010, 131:220.
186. Tatemoto K., Nozaki Y., Tsuda R., Konno S., Tomura K., Furuno M., Ogasawara H., Edamura K., Takagi H., Iwamura H., Noguchi M., Naito T. Immunoglobulin E-independent activation of mast cell is mediated by Mrg receptors. Biochem. Biophys. Res. Commun. 2006, 349:1322.
187. The F.O., Bennink R.J., Ankum W.M., Buist M.R., Busch O.R., Gouma D.J., van der H.S., van den Wijngaard R.M., de Jonge W.J., Boeckxstaens G.E. Intestinal handling-induced mast cell activation and inflammation in human postoperative ileus. Gut 2008, 57:33.
188. The F.O., Boeckxstaens G.E., Snoek S.A., Cash J.L., Bennink R., Larosa G.J., van den Wijngaard R.M., Greaves D.R., de Jonge W.J. Activation of the cholinergic anti-inflammatory pathway ameliorates postoperative ileus in mice. Gastroenterology 2007, 133:1219.
189. Theoharides T.C., Bondy P.K., Tsakalos N.D., Askenase P.W. Differential release of serotonin and histamine from mast cells. Nature 1982, 297:229.
190. Theoharides T.C., Conti P. Mast cells: the Jekyll and Hyde of tumor growth. Trends Immunol. 2004, 25:235.
191. Theoharides T.C., Kempuraj D., Tagen M., Conti P., Kalogeromitros D. Differential release of mast cell mediators and the pathogenesis of inflammation. Immunol. Rev. 2007, 217:65.
192. Thibault K., Van S.J., Brisorgueil M.J., Fischer J., Hamon M., Calvino B., Conrath M. Serotonin 5-HT2A receptor involvement and Fos expression at the spinal level in vincristine-induced neuropathy in the rat. Pain 2008, 140:305.
193. Thomas P.S. Tumour necrosis factor-alpha: the role of this multifunctional cytokine in asthma. Immunol. Cell Biol. 2001, 79:132.
194. Thompson-Cree M.E., Stevenson M.R., Shields M.D., Ennis M. The effect of nicotine on basophil histamine release. Inflamm. Res. 2004, 53:211.
195. Tore F., Tuncel N. Mast cells: target and source of neuropeptides. Curr. Pharm. Des. 2009, 15:3433.
196. Tuncel N., Sener E., Cerit C., Karasu U., Gurer F., Sahinturk V., Baycu C., Ak D., Filiz Z. Brain mast cells and therapeutic potential of vasoactive intestinal peptide in a Parkinson's disease model in rats: brain microdialysis, behavior, and microscopy. Peptides 2005, 26:827.
197. Valadi H., Ekstrom K., Bossios A., Sjostrand M., Lee J.J., Lotvall J.O. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat. Cell Biol. 2007, 9:654.
198. van den Wijngaard R.M., Klooker T.K., de Jonge W.J., Boeckxstaens G.E. Peripheral relays in stress-induced activation of visceral afferents in the gut. Auton. Neurosci. 2010, 153:99.
199. van den Wijngaard R.M., Klooker T.K., Welting O., Stanisor O.I., Wouters M.M., van der C.D., Bulmer D.C., Peeters P.J., Aerssens J., de H.R., Lee K., de Jonge W.J., Boeckxstaens G.E. Essential role for TRPV1 in stress-induced (mast cell-dependent) colonic hypersensitivity in maternally separated rats. Neurogastroenterol. Motil. 2009, 21:1107.
200. van der Stelt M., Trevisani M., Vellani V., De Petrocellis P.L., Schiano M.A., Campi B., McNaughton P., Geppetti P., Di Marzo V. Anandamide acts as an intracellular messenger amplifying Ca2+ influx via TRPV1 channels. EMBO J. 2005, 24:3026.
201. van Houwelingen A.H., Kool M., de Jager S.C., Redegeld F.A., van Heuven-Nolsen D., Kraneveld A.D., Nijkamp F.P. Mast cell-derived TNF-alpha primes sensory nerve endings in a pulmonary hypersensitivity reaction. J. Immunol. 2002, 168:5297.
202. Van Nassauw L., Adriaensen D., Timmermans J.P. The bidirectional communication between neurons and mast cells within the gastrointestinal tract. Auton. Neurosci. 2007, 133:91.
203. van Niel G., Porto-Carreiro I., Simoes S., Raposo G. Exosomes: a common pathway for a specialized function. J. Biochem. 2006, 140:13.
204. Van Steenwinckel J., Noghero A., Thibault K., Brisorgueil M.J., Fischer J., Conrath M. The 5-HT2A receptor is mainly expressed in nociceptive sensory neurons in rat lumbar dorsal root ganglia. Neuroscience 2009, 161:838.
205. Vellani V., Kinsey A.M., Prandini M., Hechtfischer S.C., Reeh P., Magherini P.C., Giacomoni C., McNaughton P.A. Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones. Mol. Pain 2010, 6:61.
206. Vergnolle N., Bunnett N.W., Sharkey K.A., Brussee V., Compton S.J., Grady E.F., Cirino G., Gerard N., Basbaum A.I., Andrade-Gordon P., Hollenberg M.D., Wallace J.L. Proteinase-activated receptor-2 and hyperalgesia: a novel pain pathway. Nat. Med. 2001, 7:821.
207. Vu T.K., Hung D.T., Wheaton V.I., Coughlin S.R. Molecular cloning of a functional thrombin receptor reveals a novel proteolytic mechanism of receptor activation. Cell 1991, 64:1057.
208. Wang H., Liao H., Ochani M., Justiniani M., Lin X., Yang L., Al-Abed Y., Wang H., Metz C., Miller E.J., Tracey K.J., Ulloa L. Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. Nat. Med. 2004, 10:1216.
209. Ward S.M., Bayguinov J., Won K.J., Grundy D., Berthoud H.R. Distribution of the vanilloid receptor (VR1) in the gastrointestinal tract. J. Comp. Neurol. 2003, 465:121.
210. Wershil B.K., Turck C.W., Sreedharan S.P., Yang J., An S., Galli S.J., Goetzl E.J. Variants of vasoactive intestinal peptide in mouse mast cells and rat basophilic leukemia cells. Cell. Immunol. 1993, 151:369.
211. Wilhelm M., Silver R., Silverman A.J. Central nervous system neurons acquire mast cell products via transgranulation. Eur. J. Neurosci. 2005, 22:2238.
212. Williams R.M., Bienenstock J., Stead R.H. Mast cells: the neuroimmune connection. Chem. Immunol. 1995, 61:208.
213. Winston J., Shenoy M., Medley D., Naniwadekar A., Pasricha P.J. The vanilloid receptor initiates and maintains colonic hypersensitivity induced by neonatal colon irritation in rats. Gastroenterology 2007, 132:615.
214. Winston J., Toma H., Shenoy M., Pasricha P.J. Nerve growth factor regulates VR-1 mRNA levels in cultures of adult dorsal root ganglion neurons. Pain 2001, 89:181.
215. Xu H., Delling M., Jun J.C., Clapham D.E. Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat. Neurosci. 2006, 9:628.
216. Ye B., Jan Y.N. The cadherin superfamily and dendrite development. Trends Cell Biol. 2005, 15:64.
217. Yu S., Gao G., Peterson B.Z., Ouyang A. TRPA1 in mast cell activation-induced long-lasting mechanical hypersensitivity of vagal afferent C-fibers in guinea pig esophagus. Am. J. Physiol. Gastrointest. Liver Physiol. 2009, 297:G34-G42.
218. Zagorodnyuk V.P., Brookes S.J. Transduction sites of vagal mechanoreceptors in the guinea pig esophagus. J. Neurosci. 2000, 20:6249.
219. Zhuang Z.Y., Xu H., Clapham D.E., Ji R.R. Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. J. Neurosci. 2004, 24:8300.
220. Zurborg S., Yurgionas B., Jira J.A., Caspani O., Heppenstall P.A. Direct activation of the ion channel TRPA1 by Ca2+. Nat. Neurosci. 2007, 10:277.
221. Zylka M.J., Dong X., Southwell A.L., Anderson D.J. Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family. Proc. Natl Acad. Sci. U. S. A. 2003, 100:10043.