Identification and characterization of human MT5-MMP, a new membrane- bound activator of progelatinase A overexpressed in brain tumors

Cancer Research

Volumn 59, Issue 11, 1999, Pages 2570-2576

  Llano, Elena ^a   Pendás, Alberto M ^a   Freije, José P ^a   Nakano, Atsuhisa ^b   Knäuper, Vera ^c   Murphy, Gillian ^c   López Otin, Carlos ^a  

^a UNIVERSIDAD DE OVIEDO   (Spain)

^b HYOGO COLLEGE OF MEDICINE   (Japan)

^c UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GELATINASE A; HEMOPEXIN; MATRIX METALLOPROTEINASE;

AMINO ACID SEQUENCE; ARTICLE; BASEMENT MEMBRANE; BRAIN TUMOR; DNA LIBRARY; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; GENETIC ORGANIZATION; HUMAN; HUMAN CELL; MEMBRANE BINDING; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; BLOTTING, WESTERN; BRAIN NEOPLASMS; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 20; COS CELLS; DNA PROBES; DNA, COMPLEMENTARY; ENZYME ACTIVATION; ENZYME PRECURSORS; GELATINASES; GENETIC VECTORS; HUMANS; MATRIX METALLOPROTEINASES, MEMBRANE-ASSOCIATED; METALLOENDOPEPTIDASES; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; TRANSFECTION;

EID: 0033152980     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Birkedal-Hansen, H. Proteolytic remodeling of extracellular matrix. Curr. Opin. Cell Biol., 7: 728-735, 1995.
2. Stetler-Stevenson, W. G., Aznavoorian, S., and Liotta, L. A. Tumor cell interactions with the extracellular matrix during invasion and metastasis. Annu. Rev. Cell Biol., 9: 541-573, 1993.
3. Gururajan, R., Grenet, J., Lahti, J. M., and Kidd, V. J. Isolation and characterization of two novel metalloproteinase genes linked to the Cdc2L locus on human chromosome lp36.3. Genomics, 52: 101-106, 1998.
4. Velasco, G., Pendás, A. M., Fueyo, A., Knäuper, V., Murphy, G., and López-Otin, C. Cloning and characterization of human MMP-23, a new matrix metalloproteinase predominantly expressed in reproductive tissues and lacking conserved domains in other family members. J. Biol. Chem., 274: 4570-4576, 1999.
5. Sato, H., Takino, T., Okada, Y., Cao, J., Shinagawa, A., Yamamoto, E., and Seiki, M. A matrix metalloproteinase expressed on the surface of invasive tumor cells. Nature (Lond.), 37: 61-65, 1994.
6. Will, H., and Hinzmann, B. cDNA sequence and mRNA distribution of a novel human matrix metalloproteinase with a potencial transmembrane domain. Eur. J. Biochem., 231: 602-608, 1995.
7. Takino, T., Sato, H., Shinagawa, A., and Seiki, M. Identification of the second membrane-type matrix metalloproteinase (MT-MMP2) gene from a human placenta cDNA library. J. Biol. Chem., 270: 23013-23020, 1995.
8. Puente, X. S., Pendás, A. M., Llano, E., Velasco, G., and López-Otin, C. Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma. Cancer Res., 56: 944-949, 1996.
9. Pei, D., and Weiss, S. J. Transmembrane-deletion mutants of the membrane-type matrix metalloproteinase-1 process progelatinase A and express intrinsic matrix-degrading activity. J. Biol. Chem., 271: 9135-9140, 1996.
10. Cao, J., Rehemtulla, A., Bahou, W., and Zucker, S. Membrane type matrix metalloproteinases 1 activates pro-gelatinase A without furin cleavage of the N-terminal domain. J. Biol. Chem., 271: 30174-30180, 1996.
11. Strongin, A. Y., Collier, I., Bannikov, G., Manner, B. L., Grants, G. A., and Goldberg, G. Mechanism of cell surface activation of 72-kDa type IV collagenase. J. Biol. Chem., 270: 5331-5338, 1995.
12. Yamamoto, M., Mohanam, S., Sawaya, R., Fuller, G. N., Seiki, M., Sato, H., Gokaslan, Z. L., Liotta, L. A., Nicolson, G. L., and Rao, J. S. Differential expression of membrane-type matrix metalloproteinase and its correlation with gelatinase A activation in human malignant brain tumors in vivo and in vitro. Cancer Res., 56: 384-392, 1996.
13. Knäuper, V., Will, H., López-Otin, C., Smith, B., Atkinson, S. J., Stanton, H., Hembry, R. M., and Murphy, G. Cellular mechanisms for human procollagenase-3 (MMP-13) activation: evidence that MTl-MMP (MMP-14) and gelatinase A (MMP-2) are able to generate active enzyme. J. Biol. Chem., 271: 17124-17131, 1996.
14. Cazorla, M., Hernández, L., Nadal, A., Balbin, M., López, J. M., Vizoso, F., Fernández, P. L., Iwata, K., Cardesa, A., López-Otin, C., and Campo, E. Collagenase-3 expression is associated with advanced local invasion in human squamous cell carcinomas of the larynx. J. Pathol., 186: 144-150, 1998.
15. D'Ortho, M-P., Will, H., Atkinson, S., Butler, G., Messent, A., Gavrilovic, J., Smith, B., Timpl, R., Zardi, L., and Murphy, G. Membrane-type matrix metalloproteinase 1 and 2 exhibit broad-spectrum proteolytic capacities comparable to many matrix metalloproteinases. Eur. J. Biochem., 250: 751-757, 1997.
16. Hiraoka, N., Allen, E., Apel, I. J., Gyetko, M. R., and Weiss, S. J. Matrix metalloproteinase regulate neovascularization by acting as pericellular fibrinolysins. Cell, 95: 365-377, 1998.
17. Freije, J. P., Diez-Itza, I., Balbin, M., Sánchez, L. M., Blasco, R., Tolivia, J., and López-Otin, C. Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomas. J. Biol. Chem., 269: 16766-16773, 1994.
18. Pendás, A. M., Knäuper, V., Puente, X. S., Llano, E., Mattei, M. G., Apte, S., Murphy, G., and López-Otin, C. Identification and characterization of a novel human matrix metalloproteinase with unique structural characteristics, chromosomal location, and tissue distribution. J. Biol. Chem., 272: 4281-4286, 1997.
19. Llano, E., Pendás, A. M., Knäuper, V., Sorsa, T., Sato, T., Salido, E., Murphy, G., Simmer, J. P., Bartlett, J. D., and López-Otin, C. Identification and structural and functional characterization of human enamelysin (MMP-20). Biochemistry, 36: 15101-15108, 1997.
20. Linn, R., DuPont, B. R., Knight, C. B., Plaetke, R., and Leach, R. J. Reassignment of the 92-kDa type IV collagenase gene (CLG4B) to human chromosome 20. Cytogenet. Cell Genet., 72: 159-161, 1996.
21. Mattei, M. G., Roeckel, N., Olsen, B. R., and Apte, S. S. Genes of the membrane-type matrix metalloproteinase (MT-MMP) gene family, MMP14, MMP15, and MMP16, localize to human chromosomes 14, 16, and 8, respectively. Genomics, 40: 168-169, 1997.
22. Puente, X. S., Pendás, A. M., Llano, E., and López-Otin, C. Localization of the human membrane type 4-matrix metalloproteinase gene (MMP17) to chromosome 12q24. Genomics, 54: 578-579, 1998.
23. Kinoshita, T., Sato, H., Takino, T., Itoh, M., Akizawa, T., and Seiki, M. Processing of a precursor of 72-kilodalton type IV collagenase/gelatinase A by a recombinant membrane-type matrix metalloprotease. Cancer Res., 56: 2535-2538, 1996.
24. Werb, Z. ECM and cell surface proteolysis: regulating cellular ecology. Cell, 91: 439-442, 1997.
25. Ashley, C. T., and Warren, S. T. Trinucleotide repeat expansion and human disease. Annu. Rev. Genet., 29: 703-728, 1995.
26. Nakamura, H., Ueno, H., Yamashita, K., Yamamoto, E., Noguchi, M., Fujimoto, N., Sato, H., Seiki, M., and Okada, Y. Enhanced production and activation of progelatinase A mediated by membrane-type I matrix metalloproteinase in human papillary thyroid carcinomas. Cancer Res., 59: 467-473, 1999.
27. Rao, P. H., Cigudosa, J. C., Ning, Y., Calasanz, M. J., Iida, S., Tagawa, S., Michaeli, J., Klein, B., Dalla-Favera, R., Jhanwar, S. C., Ried, T., and Chaganti, R. S. Multicolor spectral karyotyping identifies new recurring breakpoints and translocations in multiple myeloma. Blood, 92: 1743-1748, 1998.
28. Tanner, M. M., Tirkkonen, M., Kallioniemi, A., Isola, J., Kuukasjarvi, T., Collins, C., Kowbel, D., Guan, X. Y., Trent, J., Gray, J. W., Meltzer, P., and Kallioniemi, O. P. Independent amplification and frequent coamplification of three nonsyntenic regions on the long arm of chromosome 20 in human breast cancer. Cancer Res., 56: 3441-3445, 1996.
29. Rao, P. H., Houldsworth, J., Palanisamy, N., Murty, V. V., Reuter, V. E., Motzer, R. J., Bosl, G. J., and Chaganti, R. S. Chromosomal amplification is associated with cisplatin resistance of human male germ cell tumors. Cancer Res., 58: 4260-4263, 1998.