Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice

Journal of Physiology

Volumn 578, Issue 3, 2007, Pages 715-733

  Grant, Andrew D ^a   Cottrell, Graeme S ^a   Amadesi, Silvia ^a   Trevisani, Marcello ^b   Nicoletti, Paola ^b   Materazzi, Serena ^b   Altier, Christophe ^c   Cenac, Nicolas ^c   Zamponi, Gerald W ^c   Bautista Cruz, Francisco ^d,e   Lopez, Carlos Barajas ^d,e   Joseph, Elizabeth K ^f   Levine, Jon D ^f   Liedtke, Wolfgang ^g   Vanner, Stephen ^e   Vergnolle, Nathalie ^c   Geppetti, Pierangelo ^b   Bunnett, Nigel W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF FLORENCE   (Italy)

^c UNIVERSITY OF CALGARY   (Canada)

^d INSTITUTO POTOSINO DE INVESTIGACIÓN CIENTÍFICA Y TECNOLÓGICA   (Mexico)

^e QUEEN S UNIVERSITY   (Canada)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4ALPHA PHORBOL DIDECANOATE; CALCITONIN GENE RELATED PEPTIDE; CAPSAICIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; HYPOTONIC SOLUTION; ION TRANSPORT AFFECTING AGENT; PHOSPHOLIPASE C BETA1; PROTEIN KINASE C; PROTEIN KINASE D; PROTEINASE ACTIVATED RECEPTOR 2; UNCLASSIFIED DRUG; VANILLOID RECEPTOR; VANILLOID RECEPTOR 4; SUBSTANCE P;

ANALGESIA; ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CALCIUM SIGNALING; CHANNEL GATING; HYPERALGESIA; MALE; MECHANICAL STIMULATION; MOUSE; NERVE CELL MEMBRANE POTENTIAL; NOCICEPTION; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; SECOND MESSENGER; SPINAL CORD; SPINAL CORD DORSAL HORN; ANALYSIS OF VARIANCE; ANIMAL TISSUE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; EPITHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOREACTIVITY; MECHANICAL HYPERALGESIA; MOLECULAR CLONING; NEUROTRANSMISSION; OSMOREGULATION; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL GANGLION;

ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; CALCIUM SIGNALING; CELL LINE; CELLS, CULTURED; EPITHELIAL CELLS; GANGLIA, SPINAL; HUMANS; HYPERALGESIA; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NOCICEPTORS; PAIN; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, PAR-2; SUBSTANCE P; TRPV CATION CHANNELS;

EID: 33846502156     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2006.121111     Document Type: Article

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