Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 294, Issue 5, 2008, Pages

  Sipe, Walter E B ^a   Brierley, Stuart M ^c,e   Martin, Christopher M ^c   Phillis, Benjamin D ^c   Cruz, Francisco Bautista ^f   Grady, Eileen F ^a   Liedtke, Wolfgang ^g   Cohen, David M ^h   Vanner, Stephen ^f   Blackshaw, L Ashley ^c,d,e   Bunnett, Nigel W ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ROYAL ADELAIDE HOSPITAL   (Australia)

^d UNIVERSITY OF ADELAIDE   (Australia)

^e UNIVERSITY OF ADELAIDE   (Australia)

^f QUEEN S UNIVERSITY   (Canada)

^g DUKE UNIVERSITY MEDICAL CENTER   (United States)

^h PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

Protease activated receptors; Proteases; Transient receptor potential channels; Visceral pain

Indexed keywords

PROTEINASE ACTIVATED RECEPTOR 2; VANILLOID RECEPTOR 4; 5,6 EPOXY 8,11,14 ICOSATRIENOIC ACID; 5,6-EPOXY-8,11,14-EICOSATRIENOIC ACID; CALCITONIN GENE RELATED PEPTIDE; DIHOMO GAMMA LINOLENIC ACID; DRUG DERIVATIVE; PHORBOL DIDECANOATE; PHORBOL ESTER; PHORBOL-12,13-DIDECANOATE; RUTHENIUM RED; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRPC4 ION CHANNEL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; COLON; COLON DILATATION; CONTROLLED STUDY; FEMALE; HYPERALGESIA; MALE; MECHANOTRANSDUCTION; MOUSE; NERVE CELL EXCITABILITY; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RECEPTOR SENSITIVITY; SENSORY NERVE; SPINAL GANGLION; VISCERAL PAIN; ACTION POTENTIAL; ANIMAL; C57BL MOUSE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; ELECTROMYOGRAPHY; INNERVATION; MOUSE MUTANT; MOUSE STRAIN; NOCICEPTIVE RECEPTOR; PATHOPHYSIOLOGY; PHYSIOLOGY; RAT; SENSORY NERVE CELL; SEROSA; SPRAGUE DAWLEY RAT; VISCERA;

8,11,14-EICOSATRIENOIC ACID; ACTION POTENTIALS; ANIMALS; CALCITONIN GENE-RELATED PEPTIDE; COLON; ELECTROMYOGRAPHY; FEMALE; GANGLIA, SPINAL; HYPERALGESIA; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, KNOCKOUT; NEURONS, AFFERENT; NOCICEPTORS; PHORBOL ESTERS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, PAR-2; RUTHENIUM RED; SEROUS MEMBRANE; TRPC CATION CHANNELS; VISCERA;

EID: 45849149616     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00002.2008     Document Type: Article

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