Agonists of the Mas-related gene (Mrgs) orphan receptors as novel mediators of mast cell-sensory nerve interactions

Journal of Immunology

Volumn 180, Issue 4, 2008, Pages 2251-2255

  Lee, Min Goo ^a,b   Dong, Xinzhong ^a   Liu, Qin ^a   Patel, Kush N ^a   Choi, Oksoon Hong ^a   Vonakis, Becky ^a   Undem, Bradley J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Korea University College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; FURA 2; IMMUNOGLOBULIN E; NEUROPEPTIDE; NEUROPEPTIDE FF; RF AMIDE NEUROPEPTIDE; UNCLASSIFIED DRUG; G PROTEIN COUPLED RECEPTOR; MRGC11 PROTEIN, MOUSE; NEUROPEPTIDE FF RECEPTOR; NEUROPEPTIDE RECEPTOR; ONCOPROTEIN; PROTEIN PRECURSOR; PROTO ONCOGENE PROTEINS C MAS 1; PROTO-ONCOGENE PROTEINS C-MAS-1;

ANIMAL CELL; ARTICLE; BONE MARROW; CELL INTERACTION; CELL ISOLATION; CELL STRAIN HEK293; GENE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MAS RELATED GENE; MAST CELL LEUKEMIA; MEDIATOR RELEASE; MOUSE; NEWBORN; NONHUMAN; PRECURSOR; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSORY NERVE CELL; SKIN CELL; WILD TYPE; ANIMAL; BIOSYNTHESIS; BONE MARROW CELL; CELL COMMUNICATION; CELL LINE; DRUG POTENTIATION; GENETICS; HUMAN; MAST CELL; METABOLISM; PHYSIOLOGY; RAT; TUMOR CELL LINE;

ANIMALS; ANIMALS, NEWBORN; BONE MARROW CELLS; CELL COMMUNICATION; CELL LINE; CELL LINE, TUMOR; HUMANS; MAST CELLS; MICE; NEURONS, AFFERENT; PROTEIN PRECURSORS; PROTO-ONCOGENE PROTEINS; RATS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE;

EID: 42149141793     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.4.2251     Document Type: Article

References (32)

1. Olsson, Y. 1968. Mast cells in the nervous system. Int. Rev. Cytol. 24: 27-70.
2. Bienenstock, J., M. Tomioka, R. Stead, P. Ernst, M. Jordana, J. Gauldie, J. Dolovich, and J. Denburg. 1987. Mast cell involvement in various inflammatory processes. Am. Rev. Respir. Dis. 135: S5-S8.
3. Greene, R., J. Fowler, D. MacGlashan, and D. Weinreich. 1988. IgE-challenged human lung mast cells excite vagal sensory neurons in vitro. J. Appl. Physiol. 64: 2249-2253.
4. Undem, B. J., W. Hubbard, and D. Weinreich. 1993. Immunologically induced neuromodulation of guinea pig nodose ganglion neurons. J. Auton. Nerv. Syst. 44: 35-44.
5. Riccio, M. M., D. Proud, and B. J. Undem. 1995. Enhancement of afferent nerve excitability in the airways by allergic inflammation. Pulm. Pharmacol. 8: 181-185.
6. Myers, A. C., R. Kajekar, and B. J. Undem. 2002. Allergic inflammation-induced neuropeptide production in rapidly adapting afferent nerves in guinea pig airways. Am. J. Physiol. 282: L775-L781.
7. van Houwelingen, A. H., M. Kool, S. C. de Jager, F. A. Redegeld, D. van Heuven-Nolsen, A. D. Kraneveld, and F. P. Nijkamp. 2002. Mast cell-derived TNF-α primes sensory nerve endings in a pulmonary hypersensitivity reaction. J. Immunol. 168: 5297-5302.
8. Kakurai, M., R. Monteforte, H. Suto, M. Tsai, S. Nakae, and S. J. Galli. 2006. Mast cell-derived tumor necrosis factor can promote nerve fiber elongation in the skin during contact hypersensitivity in mice. Am. J. Pathol. 169: 1713-1721.
9. Chuaychoo, B., D. D. Hunter, A. C. Myers, M. Kollarik, and B. J. Undem. 2005. Allergen-induced substance P synthesis in large-diameter sensory neurons innervating the lungs. J. Allergy Clin. Immunol. 116: 325-331.
10. Barbara, G., B. Wang, V. Stanghellini, R. de Giorgio, C. Cremon, G. Di Nardo, M. Trevisani, B. Campi, P. Geppetti, M. Tonini, et al. 2007. Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome. Gastroenterology 132: 26-37.
11. Ellis, J. L., and B. J. Undem. 1992. Antigen-induced enhancement of noncholinergic contractile responses to vagus nerve and electrical field stimulation in guinea pig isolated trachea. J. Pharmacol. Exp. Ther. 262: 646-653.
12. Yosipovitch, G., and A. Fleischer. 2003. Itch associated with skin disease: advances in pathophysiology and emerging therapies. Am. J. Clin. Dermatol. 4: 617-622.
13. Dong, X., S. Han, M. J. Zylka, M. I. Simon, and D. J. Anderson. 2001. A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons. Cell 106: 619-632.
14. Lembo, P. M., E. Grazzini, T. Groblewski, D. O'Donnell, M. O. Roy, J. Zhang, C. Hoffert, J. Cao, R. Schmidt, M. Pelletier, et al. 2002. Proenkephalin A gene products activate a new family of sensory neuron-specific GPCRs. Nat. Neurosci. 5: 201-209.
15. Choi, S. S., and B. T. Lahn. 2003. Adaptive evolution of MRG, a neuron-specific gene family implicated in nociception. Genome Res. 13: 2252-2259.
16. Zhang, L., N. Taylor, Y. Xie, R. Ford, J. Johnson, J. E. Paulsen, and B. Bates. 2005. Cloning and expression of MRG receptors in macaque, mouse, and human. Brain Res. Mol. Brain Res. 133: 187-197.
17. Han, S. K., X. Dong, J. I. Hwang, M. J. Zylka, D. J. Anderson, and M. I. Simon. 2002. Orphan G protein-coupled receptors MrgA1 and MrgC11 are distinctively activated by RF-amide-related peptides through the Gα q/11 pathway. Proc. Natl. Acad. Sci. USA 99: 14740-14745.
18. Robas, N., E. Mead, and M. Fidock. 2003. MrgX2 is a high potency cortistatin receptor expressed in dorsal root ganglion. J. Biol. Chem. 278: 44400-44404.
19. Cesare, P., L. V. Dekker, A. Sardini, P. J. Parker, and P. A. McNaughton. 1999. Specific involvement of PKC-epsilon in sensitization of the neuronal response to painful heat. Neuron 23: 617-624.
20. Neves, S. R., P. T. Ram, and R. Iyengar. 2002. G protein pathways. Science 296: 1636-1639.
21. Crozier, R. A., S. K. Ajit, E. J. Kaftan, and M. H. Pausch. 2007. MrgD activation inhibits KCNQ/M-currents and contributes to enhanced neuronal excitability. J. Neurosci. 27: 4492-4496.
22. Undem, B. J., T. J. Torphy, D. Goldman, and F. H. Chilton. 1990. Inhibition by adenosine 3′:5′-monophosphate of eicosanoid and platelet-activating factor biosynthesis in the mouse PT-18 mast cell. J. Biol. Chem. 265: 6750-6758.
23. + mobilization in RBL-2H3 cells: role of I(1,4,5)P3 and S1P and necessity of I(1,4,5)P3 production. Cell Calcium 38: 581-592.
24. Botchkarev, V. A., R. Paus, B. M. Czarnetzki, V. S. Kupriyanov, D. S. Gordon, and O. Johansson. 1995. Hair cycle-dependent changes in mast cell histochemistry in murine skin. Arch. Dermatol. Res. 287: 683-686.
25. Williams, R. M., H. R. Berthoud, and R. H. Stead. 1997. Vagal afferent nerve fibres contact mast cells in rat small intestinal mucosa. Neuroimmunomodulation 4: 266-270.
26. Greenberg, M. J., and D. A. Price. 1992. Relationships among the FMRFamide-like peptides. Prog. Brain Res. 92: 25-37.
27. Artuc, M., M. Bohm, A. Grutzkau, A. Smorodchenko, T. Zuberbier, T. Luger, and B. M. Henz. 2006. Human mast cells in the neurohormonal network: expression of POMC, detection of precursor proteases, and evidence for IgE-dependent secretion of α-MSH. J. Invest. Dermatol. 126: 1976-1981.
28. Yudin, Y. K., Z. A. Tamarova, O. I. Ostrovskaya, L. L. Moroz, and O. A. Krishtal. 2004. RFa-related peptides are algogenic: evidence in vitro and in vivo. Eur. J. Neurosci. 20: 1419-1423.
29. Grazzini, E., C. Puma, M. O. Roy, X. H. Yu, D. O'Donnell, R. Schmidt, S. Dautrey, J. Ducharme, M. Perkins, R. Panetta, et al. 2004. Sensory neuron-specific receptor activation elicits central and peripheral nociceptive effects in rats. Proc. Natl. Acad. Sci. USA 101: 7175-7180.
30. +-gated currents in cultured dorsal root ganglion neurons. J. Neurophysiol. 89: 2459-2465.
31. Bonini, J. A., K. A. Jones, N. Adham, C. Forray, R. Artymyshyn, M. M. Durkin, K. E. Smith, J. A. Tamm, L. W. Boteju, P. P. Lakhlani, et al. 2000. Identification and characterization of two G protein-coupled receptors for neuropeptide FF. J. Biol. Chem. 275: 39324-39331.
32. Tatemoto, K., Y. Nozaki, R. Tsuda, S. Konno, K. Tomura, M. Furuno, H. Ogasawara, K. Edamura, H. Takagi, H. Iwamura, et al. 2006. Immunoglobulin E-independent activation of mast cell is mediated by Mrg receptors. Biochem. Biophys. Res. Commun. 349: 1322-1328.