Essential role for TRPV1 in stress-induced (mast cell-dependent) colonic hypersensitivity in maternally separated rats

Neurogastroenterology and Motility

Volumn 21, Issue 10, 2009, Pages

  Van Den Wijngaard, R M ^a   Klooker, T K ^a   Welting, O ^a   Stanisor, O I ^a   Wouters, M M ^b   Van Der Coelen, D ^a   Bulmer, D C ^c   Peeters, P J ^d   Aerssens, J ^d   De Hoogt, R ^d   Lee, K ^c   De Jonge, W J ^a   Boeckxstaens, G E ^a,b  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^c GLAXOSMITHKLINE   (United Kingdom)

^d JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Mast cells; Maternal separation; Stress; Transient receptor ion channel 1; Visceral hypersensitivity

Indexed keywords

1 (2 BROMOPHENYL) 3 [1 (5 TRIFLUOROMETHYL 2 PYRIDINYL) 3 PYRROLIDINYL]UREA; CAPSAZEPINE; DOXANTRAZOLE; GROWTH FACTOR; VANILLOID RECEPTOR 1;

ACUTE STRESS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASCENDING COLON; COLON DILATATION; COLON MUCOSA; CONTROLLED STUDY; DESCENDING COLON; EXPERIMENTAL MODEL; GENETIC TRANSCRIPTION; HYPERSENSITIVITY; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LYMPHOCYTE; MACROPHAGE; MALE; MAST CELL; MAST CELL DEGRANULATION; MATERNAL DEPRIVATION; MICRODISSECTION; MOTOR PERFORMANCE; NERVE CELL GROWTH; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENSORY NERVE; SPINAL GANGLION; T LYMPHOCYTE; VISCERAL HYPERSENSITIVITY;

ANIMALS; BALLOON DILATATION; BLOTTING, WESTERN; CAPSAICIN; COLON; DRINKING BEHAVIOR; FEMALE; IMMUNOHISTOCHEMISTRY; MACROPHAGES; MAST CELLS; MATERNAL DEPRIVATION; NERVE GROWTH FACTOR; PREGNANCY; PYRROLIDINES; RATS; RATS, LONG-EVANS; STRESS, PSYCHOLOGICAL; T-LYMPHOCYTES; TRANSCRIPTION, GENETIC; TRPV CATION CHANNELS; UREA;

EID: 70049108197     PISSN: 13501925     EISSN: 13652982     Source Type: Journal    
DOI: 10.1111/j.1365-2982.2009.01339.x     Document Type: Article

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