메뉴 건너뛰기




Volumn 7, Issue 1, 2012, Pages 60-73

Non-steroidal anti-inflammatory drugs and cognitive function: Are prostaglandins at the heart of cognitive impairment in dementia and delirium?

Author keywords

Alzheimer's disease; Cyclooxygenase; Delirium; Dementia; Learning; Memory; Microglia; Prostaglandin

Indexed keywords

5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; ACETYLSALICYLIC ACID; AMYLOID BETA PROTEIN; CELECOXIB; DICLOFENAC; IBUPROFEN; INDOMETACIN; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE; PROSTANOID RECEPTOR; SULINDAC SULFIDE; TRIFLUSAL;

EID: 81755181762     PISSN: 15571890     EISSN: 15571904     Source Type: Journal    
DOI: 10.1007/s11481-011-9312-5     Document Type: Review
Times cited : (46)

References (151)
  • 1
    • 29544440041 scopus 로고    scopus 로고
    • Prostaglandin EP1 receptor contributes to excitotoxicity and focal ischemic brain damage
    • DOI 10.1093/toxsci/kfj022
    • Ahmad AS, Saleem S, Ahmad M, Dore S (2006a) Prostaglandin EP1 receptor contributes to excitotoxicity and focal ischemic brain damage. Toxicol Sci 89:265-270 (Pubitemid 43013774)
    • (2006) Toxicological Sciences , vol.89 , Issue.1 , pp. 265-270
    • Ahmad, A.S.1    Saleem, S.2    Ahmad, M.3    Dore, S.4
  • 2
    • 33845922141 scopus 로고    scopus 로고
    • Stimulation of prostaglandin EP2 receptors prevents NMDA-induced excitotoxicity
    • DOI 10.1089/neu.2006.23.1895
    • Ahmad AS, Zhuang H, Echeverria V, Dore S (2006b) Stimulation of prostaglandin EP2 receptors prevents NMDA-induced excitotoxicity. J Neurotrauma 23:1895-1903 (Pubitemid 46034458)
    • (2006) Journal of Neurotrauma , vol.23 , Issue.12 , pp. 1895-1903
    • Ahmad, A.S.1    Zhuang, H.2    Echeverria, V.3    Dore, S.4
  • 3
    • 0037046179 scopus 로고    scopus 로고
    • Randomized pilot study of nimesulide treatment in alzheimer's disease
    • Aisen PS, Schmeidler J, Pasinetti GM (2002) Randomized pilot study of nimesulide treatment in Alzheimer's disease. Neurology 58:1050-1054 (Pubitemid 34298544)
    • (2002) Neurology , vol.58 , Issue.7 , pp. 1050-1054
    • Aisen, P.S.1    Schmeidler, J.2    Pasinetti, G.M.3
  • 6
    • 77949540912 scopus 로고    scopus 로고
    • Emerging roles of PGE2 receptors in models of neurological disease
    • Andreasson K (2010) Emerging roles of PGE2 receptors in models of neurological disease. Prostag Other Lipid Mediat 91:104-112
    • (2010) Prostag Other Lipid Mediat , vol.91 , pp. 104-112
    • Andreasson, K.1
  • 9
    • 77953675879 scopus 로고    scopus 로고
    • Probing the biology of Alzheimer's disease in mice
    • Ashe KH, Zahs KR (2010) Probing the biology of Alzheimer's disease in mice. Neuron 66:631-645
    • (2010) Neuron , vol.66 , pp. 631-645
    • Ashe, K.H.1    Zahs, K.R.2
  • 10
    • 0342905422 scopus 로고    scopus 로고
    • Double dissociation of function within the hippocampus: A comparison of dorsal, ventral, and complete hippocampal cytotoxic lesions
    • Bannerman DM, Yee BK, Good MA, Heupel MJ, Iversen SD, Rawlins JN (1999) Double dissociation of function within the hippocampus: a comparison of dorsal, ventral, and complete hippocampal cytotoxic lesions. Behav Neurosci 113:1170-1188 (Pubitemid 30013825)
    • (1999) Behavioral Neuroscience , vol.113 , Issue.6 , pp. 1170-1188
    • Bannerman, D.M.1    Good, M.A.2    Yee, B.K.3    Heupel, M.J.4    Iversen, S.D.5    Rawlins, J.N.P.6
  • 12
    • 9644294394 scopus 로고    scopus 로고
    • SWE Tg2576 transgenic mice
    • DOI 10.1037/0735-7044.118.6.1184
    • Barnes P, Hale G, Good M (2004) Intramaze and extramaze cue processing in adult APPSWE Tg2576 transgenic mice. Behav Neurosci 118:1184-1195 (Pubitemid 39578466)
    • (2004) Behavioral Neuroscience , vol.118 , Issue.6 , pp. 1184-1195
    • Barnes, P.1    Hale, G.2    Good, M.3
  • 15
    • 29144524943 scopus 로고    scopus 로고
    • Cyclooxygenase 2 (COX-2) inhibition increases the inflammatory response in the brain during systemic immune stimuli
    • DOI 10.1111/j.1471-4159.2005.03480.x
    • Blais V, Turrin NP, Rivest S (2005) Cyclooxygenase 2 (COX-2) inhibition increases the inflammatory response in the brain during systemic immune stimuli. J Neurochem 95:1563-1574 (Pubitemid 41804054)
    • (2005) Journal of Neurochemistry , vol.95 , Issue.6 , pp. 1563-1574
    • Blais, V.1    Turrin, N.P.2    Rivest, S.3
  • 16
    • 34250624816 scopus 로고    scopus 로고
    • Arachidonic acid metabolism in brain physiology and pathology: Lessons from genetically altered mouse models
    • DOI 10.1111/j.1471-4159.2007.04558.x
    • Bosetti F (2007) Arachidonic acid metabolism in brain physiology and pathology: lessons from genetically altered mouse models. J Neurochem 102:577-586 (Pubitemid 47057279)
    • (2007) Journal of Neurochemistry , vol.102 , Issue.3 , pp. 577-586
    • Bosetti, F.1
  • 18
    • 0034603520 scopus 로고    scopus 로고
    • Vascular risk factors for Alzheimer's disease: An epidemiologic perspective
    • DOI 10.1016/S0197-4580(99)00110-4, PII S0197458099001104
    • Breteler MM (2000) Vascular risk factors for Alzheimer's disease: an epidemiologic perspective. Neurobiol Aging 21:153-160 (Pubitemid 30387074)
    • (2000) Neurobiology of Aging , vol.21 , Issue.2 , pp. 153-160
    • Breteler, M.M.B.1
  • 21
    • 34250818767 scopus 로고    scopus 로고
    • Lithium reduces tau phosphorylation but not Aβ or working memory deficits in a transgenic model with both plaques and tangles
    • DOI 10.2353/ajpath.2007.061178
    • Caccamo A, Oddo S, Tran LX, Laferla FM (2007) Lithium reduces tau phosphorylation but not A beta or working memory deficits in a transgenic model with both plaques and tangles. Am J Pathol 170:1669-1675 (Pubitemid 47339311)
    • (2007) American Journal of Pathology , vol.170 , Issue.5 , pp. 1669-1675
    • Caccamo, A.1    Oddo, S.2    Tran, L.X.3    LaFerla, F.M.4
  • 24
    • 12544250740 scopus 로고    scopus 로고
    • Endogenous PGE2 regulates membrane excitability and synaptic transmission in hippocampal CA1 pyramidal neurons
    • Chen C, Bazan NG (2005) Endogenous PGE2 regulates membrane excitability and synaptic transmission in hippocampal CA1 pyramidal neurons. J Neurophysiol 93:929-941
    • (2005) J Neurophysiol , vol.93 , pp. 929-941
    • Chen, C.1    Bazan, N.G.2
  • 25
    • 38649119160 scopus 로고    scopus 로고
    • Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system
    • DOI 10.1016/j.bbi.2007.08.014, PII S0889159107002176
    • Chen J, Buchanan JB, Sparkman NL, Godbout JP, Freund GG, Johnson RW (2008) Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system. Brain Behav Immun 22:301-311 (Pubitemid 351172703)
    • (2008) Brain, Behavior, and Immunity , vol.22 , Issue.3 , pp. 301-311
    • Chen, J.1    Buchanan, J.B.2    Sparkman, N.L.3    Godbout, J.P.4    Freund, G.G.5    Johnson, R.W.6
  • 26
    • 77953953898 scopus 로고    scopus 로고
    • Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid
    • Choi SH, Bosetti F (2009) Cyclooxygenase-1 null mice show reduced neuroinflammation in response to beta-amyloid. Aging 1:234-244
    • (2009) Aging , vol.1 , pp. 234-244
    • Choi, S.H.1    Bosetti, F.2
  • 27
    • 43249109884 scopus 로고    scopus 로고
    • Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury
    • DOI 10.1096/fj.07-9411com
    • Choi SH, Langenbach R, Bosetti F (2008) Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide- induced inflammatory response and brain injury. FASEB J 22:1491-1501 (Pubitemid 351656789)
    • (2008) FASEB Journal , vol.22 , Issue.5 , pp. 1491-1501
    • Choi, S.-H.1    Langenbach, R.2    Bosetti, F.3
  • 28
    • 62949176283 scopus 로고    scopus 로고
    • The distinct roles of cyclooxygenase-1 and -2 in neuroinflammation: Implications for translational research
    • Choi SH, Aid S, Bosetti F (2009) The distinct roles of cyclooxygenase-1 and -2 in neuroinflammation: implications for translational research. Trends Pharmacol Sci 30:174-181
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 174-181
    • Choi, S.H.1    Aid, S.2    Bosetti, F.3
  • 32
    • 0034651101 scopus 로고    scopus 로고
    • Inflammatory mechanisms in Alzheimer's disease: Inhibition of β- amyloid-stimulated proinflammatory responses and neurotoxicity by PPARγ agonists
    • Combs CK, Johnson DE, Karlo JC, Cannady SB, Landreth GE (2000) Inflammatory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma agonists. J Neurosci 20:558-567 (Pubitemid 30225558)
    • (2000) Journal of Neuroscience , vol.20 , Issue.2 , pp. 558-567
    • Combs, C.K.1    Johnson, D.E.2    Karlo, J.C.3    Cannady, S.B.4    Landreth, G.E.5
  • 33
    • 0036743625 scopus 로고    scopus 로고
    • Overexpression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's disease
    • Corcoran KA, Lu Y, Turner RS, Maren S (2002) Overexpression of hAPPswe impairs rewarded alternation and contextual fear conditioning in a transgenic mouse model of Alzheimer's disease. Learn Mem 9:243-252
    • (2002) Learn Mem , vol.9 , pp. 243-252
    • Corcoran, K.A.1    Lu, Y.2    Turner, R.S.3    Maren, S.4
  • 34
    • 45149104720 scopus 로고    scopus 로고
    • COX-2, but not COX-1, activity is necessary for the induction of perforant path long-term potentiation and spatial learning in vivo
    • DOI 10.1111/j.1460-9568.2008.06251.x
    • Cowley TR, Fahey B, O'mara SM (2008) COX-2, but not COX-1, activity is necessary for the induction of perforant path long-term potentiation and spatial learning in vivo. Eur J Neurosci 27:2999-3008 (Pubitemid 351832213)
    • (2008) European Journal of Neuroscience , vol.27 , Issue.11 , pp. 2999-3008
    • Cowley, T.R.1    Fahey, B.2    O'Mara, S.M.3
  • 35
    • 79960866841 scopus 로고    scopus 로고
    • Systemic inflammation and delirium: Important co-factors in the progression of dementia
    • Cunningham C (2011) Systemic inflammation and delirium: important co-factors in the progression of dementia. Biochem Soc Trans 39 (4):945-953
    • (2011) Biochem Soc Trans , vol.39 , Issue.4 , pp. 945-953
    • Cunningham, C.1
  • 36
    • 52949117520 scopus 로고    scopus 로고
    • Malaise in the water maze: Untangling the effects of LPS and IL-1beta on learning and memory
    • Cunningham C, Sanderson DJ (2008) Malaise in the water maze: untangling the effects of LPS and IL-1beta on learning and memory. Brain Behav Immun 22:1117-1127
    • (2008) Brain Behav Immun , vol.22 , pp. 1117-1127
    • Cunningham, C.1    Sanderson, D.J.2
  • 38
    • 27144470284 scopus 로고    scopus 로고
    • Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration
    • DOI 10.1523/JNEUROSCI.2614-05.2005
    • Cunningham C, Wilcockson DC, Campion S, Lunnon K, Perry VH (2005) Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration. J Neurosci 25:9275-9284 (Pubitemid 41500836)
    • (2005) Journal of Neuroscience , vol.25 , Issue.40 , pp. 9275-9284
    • Cunningham, C.1    Wilcockson, D.C.2    Campion, S.3    Lunnon, K.4    Perry, V.H.5
  • 40
    • 0011162190 scopus 로고
    • Selective loss of central cholinergic neurons in Alzheimer's disease
    • Davies P, Maloney AJ (1976) Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 2:1403 (Pubitemid 8004505)
    • (1976) Lancet , vol.2 , Issue.8000 , pp. 1403
    • Davies, P.1    Maloney, A.J.F.2
  • 41
    • 1242331823 scopus 로고    scopus 로고
    • Is Alzheimer's disease a neurodegenerative or a vascular disorder? Data, dogma, and dialectics
    • DOI 10.1016/S1474-4422(04)00683-0
    • De La Torre JC (2004) Is Alzheimer's disease a neurodegenerative or a vascular disorder? data, dogma, and dialectics. Lancet Neurol 3:184-190 (Pubitemid 38232669)
    • (2004) Lancet Neurology , vol.3 , Issue.3 , pp. 184-190
    • De La Torre, J.C.1
  • 45
    • 0038375640 scopus 로고    scopus 로고
    • Effect of non-steroidal antiinflammatory drugs on risk of Alzheimer's disease: Systematic review and meta-analysis of observational studies
    • Etminan M, Gill S, Samii A (2003) Effect of non-steroidal antiinflammatory drugs on risk of Alzheimer's disease: systematic review and meta-analysis of observational studies. BMJ 327:128
    • (2003) BMJ , vol.327 , pp. 128
    • Etminan, M.1    Gill, S.2    Samii, A.3
  • 47
    • 77954218298 scopus 로고    scopus 로고
    • Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNalpha/beta and IL-1beta responses in the diseased brain and exacerbates chronic neurodegeneration
    • Field R, Campion S, Warren C, Murray C, Cunningham C (2010) Systemic challenge with the TLR3 agonist poly I:C induces amplified IFNalpha/beta and IL-1beta responses in the diseased brain and exacerbates chronic neurodegeneration. Brain Behav Immun 24:996-1007
    • (2010) Brain Behav Immun , vol.24 , pp. 996-1007
    • Field, R.1    Campion, S.2    Warren, C.3    Murray, C.4    Cunningham, C.5
  • 48
    • 69449089051 scopus 로고    scopus 로고
    • Age-related cognitive decline and nesting behavior in an APPswe/PS1 bigenic model of Alzheimer's disease
    • Filali M, Lalonde R (2009) Age-related cognitive decline and nesting behavior in an APPswe/PS1 bigenic model of Alzheimer's disease. Brain Res 1292:93-99
    • (2009) Brain Res , vol.1292 , pp. 93-99
    • Filali, M.1    Lalonde, R.2
  • 51
    • 36049030643 scopus 로고    scopus 로고
    • Effects of progesterone administration and APPswe+PSEN1Δe9 mutation for cognitive performance of mid-aged mice
    • DOI 10.1016/j.nlm.2007.09.008, PII S107474270700161X
    • Frye CA, Walf AA (2008) Effects of progesterone administration and APPswe+PSEN1Deltae9 mutation for cognitive performance of mid-aged mice. Neurobiol Learn Mem 89:17-26 (Pubitemid 350102253)
    • (2008) Neurobiology of Learning and Memory , vol.89 , Issue.1 , pp. 17-26
    • Frye, C.A.1    Walf, A.A.2
  • 52
    • 70350435147 scopus 로고    scopus 로고
    • Cerebrovascular cyclooxygenase-1 expression, regulation, and role in hypothalamicpituitary- adrenal axis activation by inflammatory stimuli
    • Garcia-Bueno B, Serrats J, Sawchenko PE (2009) Cerebrovascular cyclooxygenase-1 expression, regulation, and role in hypothalamicpituitary- adrenal axis activation by inflammatory stimuli. J Neurosci 29:12970-12981
    • (2009) J Neurosci , vol.29 , pp. 12970-12981
    • Garcia-Bueno, B.1    Serrats, J.2    Sawchenko, P.E.3
  • 54
    • 23444443814 scopus 로고    scopus 로고
    • Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system
    • DOI 10.1096/fj.05-3776fje
    • Godbout JP, Chen J, Abraham J, Richwine AF, Berg BM, Kelley KW, Johnson RW (2005) Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system. FASEB J 19:1329-1331 (Pubitemid 41113739)
    • (2005) FASEB Journal , vol.19 , Issue.10 , pp. 1329-1331
    • Godbout, J.P.1    Chen, J.2    Abraham, J.3    Richwine, A.F.4    Berg, B.M.5    Kelley, K.W.6    Johnson, R.W.7
  • 56
    • 38149078876 scopus 로고    scopus 로고
    • The "swedish" mutation of the amyloid precursor protein (APPswe) dissociates components of objectlocation memory in aged Tg2576 mice
    • Good MA, Hale G (2007) The "Swedish" mutation of the amyloid precursor protein (APPswe) dissociates components of objectlocation memory in aged Tg2576 mice. Behav Neurosci 121:1180-1191
    • (2007) Behav Neurosci , vol.121 , pp. 1180-1191
    • Good, M.A.1    Hale, G.2
  • 57
    • 0028261146 scopus 로고
    • Elevated central nervous systemprostaglandins in human immunodeficiency virus-associated dementia
    • Griffin DE,Wesselingh SL,Mcarthur JC (1994) Elevated central nervous systemprostaglandins in human immunodeficiency virus-associated dementia. Ann Neurol 35:592-597
    • (1994) Ann Neurol , vol.35 , pp. 592-597
    • Griffin, D.E.1    Wesselingh, S.L.2    McArthur, J.C.3
  • 58
    • 0034883360 scopus 로고    scopus 로고
    • Early behavioural changes in scrapie-affected mice and the influence of dapsone
    • DOI 10.1046/j.0953-816X.2001.01645.x
    • Guenther K, Deacon RM, Perry VH, Rawlins JN (2001) Early behavioural changes in scrapie-affected mice and the influence of dapsone. Eur J Neurosci 14:401-409 (Pubitemid 32777645)
    • (2001) European Journal of Neuroscience , vol.14 , Issue.2 , pp. 401-409
    • Guenther, K.1    Deacon, R.M.J.2    Perry, V.H.3    Rawlins, J.N.P.4
  • 59
    • 0032509740 scopus 로고    scopus 로고
    • Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease
    • DOI 10.1016/S0006-8993(97)01215-8, PII S0006899397012158
    • Hauss-Wegrzyniak B, Dobrzanski P, Stoehr JD, Wenk GL (1998) Chronic neuroinflammation in rats reproduces components of the neurobiology of Alzheimer's disease. Brain Res 780:294-303 (Pubitemid 28082916)
    • (1998) Brain Research , vol.780 , Issue.2 , pp. 294-303
    • Hauss-Wegrzyniak, B.1    Dobrzanski, P.2    Stoehr, J.D.3    Wenk, G.L.4
  • 60
    • 69849092027 scopus 로고    scopus 로고
    • Neuroinflammation and memory: The role of prostaglandins
    • Hein AM, O'banion MK (2009) Neuroinflammation and memory: the role of prostaglandins. Mol Neurobiol 40:15-32
    • (2009) Mol Neurobiol , vol.40 , pp. 15-32
    • Hein, A.M.1    O'Banion, M.K.2
  • 61
    • 36849052929 scopus 로고    scopus 로고
    • Prostaglandins are necessary and sufficient to induce contextual fear learning impairments after interleukin-1 beta injections into the dorsal hippocampus
    • DOI 10.1016/j.neuroscience.2007.10.003, PII S0306452207012791
    • Hein AM, Stutzman DL, Bland ST, Barrientos RM, Watkins LR, Rudy JW, Maier SF (2007) Prostaglandins are necessary and sufficient to induce contextual fear learning impairments after interleukin-1 beta injections into the dorsal hippocampus. Neuroscience 150:754-763 (Pubitemid 350235798)
    • (2007) Neuroscience , vol.150 , Issue.4 , pp. 754-763
    • Hein, A.M.1    Stutzman, D.L.2    Bland, S.T.3    Barrientos, R.M.4    Watkins, L.R.5    Rudy, J.W.6    Maier, S.F.7
  • 62
    • 20444499367 scopus 로고    scopus 로고
    • Acute treatment with the PPARγ agonist pioglitazone and ibuprofen reduces glial inflammation and Aβ1-42 levels in APPV717I transgenic mice
    • DOI 10.1093/brain/awh452
    • Heneka MT, Sastre M, Dumitrescu-Ozimek L, Hanke A, Dewachter I, Kuiperi C, O'banion K, Klockgether T, Van Leuven F, Landreth GE (2005) Acute treatment with the PPARgamma agonist pioglitazone and ibuprofen reduces glial inflammation and Abeta1-42 levels in APPV717I transgenic mice. Brain 128:1442-1453 (Pubitemid 40826196)
    • (2005) Brain , vol.128 , Issue.6 , pp. 1442-1453
    • Heneka, M.T.1    Sastre, M.2    Dumitrescu-Ozimek, L.3    Hanke, A.4    Dewachter, I.5    Kuiperi, C.6    O'Banion, K.7    Klockgether, T.8    Van Leuven, F.9    Landreth, G.E.10
  • 67
    • 0021145680 scopus 로고
    • Alzheimer's disease: Cell-specific pathology isolates the hippocampal formation
    • Hyman BT, Van Hoesen GW, Damasio AR, Barnes CL (1984) Alzheimer's disease: cell-specific pathology isolates the hippocampal formation. Science 225:1168-1170 (Pubitemid 14029099)
    • (1984) Science , vol.225 , Issue.4667 , pp. 1168-1170
    • Hyman, B.T.1    Van Hoesen, G.W.2    Damasio, A.R.3    Barnes, C.L.4
  • 71
    • 71249148133 scopus 로고    scopus 로고
    • The role of the hippocampus in mnemonic integration and retrieval: Complementary evidence from lesion and inactivation studies
    • Iordanova MD, Burnett DJ, Aggleton JP, Good M, Honey RC (2009) The role of the hippocampus in mnemonic integration and retrieval: complementary evidence from lesion and inactivation studies. Eur J Neurosci 30:2177-2189
    • (2009) Eur J Neurosci , vol.30 , pp. 2177-2189
    • Iordanova, M.D.1    Burnett, D.J.2    Aggleton, J.P.3    Good, M.4    Honey, R.C.5
  • 73
    • 0037088956 scopus 로고    scopus 로고
    • Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19 months
    • DOI 10.1016/S0031-9384(02)00639-X, PII S003193840200639X
    • King DL, Arendash GW (2002) Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19 months. Physiol Behav 75:627-642 (Pubitemid 34521825)
    • (2002) Physiology and Behavior , vol.75 , Issue.5 , pp. 627-642
    • King, D.L.1    Arendash, G.W.2
  • 75
    • 25644456097 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease
    • DOI 10.1523/JNEUROSCI.2868-05.2005
    • Kitazawa M, Oddo S, Yamasaki TR, Green KN, Laferla FM (2005) Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. J Neurosci 25:8843-8853 (Pubitemid 41384452)
    • (2005) Journal of Neuroscience , vol.25 , Issue.39 , pp. 8843-8853
    • Kitazawa, M.1    Oddo, S.2    Yamasaki, T.R.3    Green, K.N.4    LaFerla, F.M.5
  • 80
    • 0035693506 scopus 로고    scopus 로고
    • Anti-inflammatory actions of peroxisome proliferator-activated receptor gamma agonists in Alzheimer's disease
    • DOI 10.1016/S0197-4580(01)00296-2, PII S0197458001002962
    • Landreth GE, Heneka MT (2001) Anti-inflammatory actions of peroxisome proliferator-activated receptor gamma agonists in Alzheimer's disease. Neurobiol Aging 22:937-944 (Pubitemid 34066562)
    • (2001) Neurobiology of Aging , vol.22 , Issue.6 , pp. 937-944
    • Landreth, G.E.1    Heneka, M.T.2
  • 81
    • 46749115113 scopus 로고    scopus 로고
    • PPARγ Agonists as Therapeutics for the Treatment of Alzheimer's Disease
    • DOI 10.1016/j.nurt.2008.05.003, PII S1933721308000925
    • Landreth G, Jiang Q, Mandrekar S, Heneka M (2008) PPARgamma agonists as therapeutics for the treatment of Alzheimer's disease. Neurotherapeutics 5:481-489 (Pubitemid 351952487)
    • (2008) Neurotherapeutics , vol.5 , Issue.3 , pp. 481-489
    • Landreth, G.1    Jiang, Q.2    Mandrekar, S.3    Heneka, M.4
  • 82
    • 34548317001 scopus 로고    scopus 로고
    • EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses
    • DOI 10.1038/nn1949, PII NN1949
    • Lazarus M, Yoshida K, Coppari R, Bass CE, Mochizuki T, Lowell BB, Saper CB (2007) EP3 prostaglandin receptors in the median preoptic nucleus are critical for fever responses. Nat Neurosci 10:1131-1133 (Pubitemid 47339949)
    • (2007) Nature Neuroscience , vol.10 , Issue.9 , pp. 1131-1133
    • Lazarus, M.1    Yoshida, K.2    Coppari, R.3    Bass, C.E.4    Mochizuki, T.5    Lowell, B.B.6    Saper, C.B.7
  • 84
    • 0031013395 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs
    • Lehmann JM, Lenhard JM, Oliver BB, Ringold GM, Kliewer SA (1997) Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J Biol Chem 272:3406-3410
    • (1997) J Biol Chem , vol.272 , pp. 3406-3410
    • Lehmann, J.M.1    Lenhard, J.M.2    Oliver, B.B.3    Ringold, G.M.4    Kliewer, S.A.5
  • 85
    • 80053383308 scopus 로고    scopus 로고
    • Effects of non-steroidal anti-inflammatory drug treatments on cognitive decline vary by phase of pre-clinical Alzheimer disease: Findings from the randomized controlled Alzheimer's disease anti-inflammatory prevention trial
    • For the ADAPT Research Team, doi:10.1002/gps.2723
    • Leoutsakos JM, Muthen BO, Breitner JC, Lyketsos CG, For the ADAPT Research Team (2011) Effects of non-steroidal anti-inflammatory drug treatments on cognitive decline vary by phase of pre-clinical Alzheimer disease: findings from the randomized controlled Alzheimer's disease anti-inflammatory prevention trial. Int J Geriatr Psychiatr. doi:10.1002/gps.2723
    • (2011) Int J Geriatr Psychiatr.
    • Leoutsakos, J.M.1    Muthen, B.O.2    Breitner, J.C.3    Lyketsos, C.G.4
  • 86
    • 27744462871 scopus 로고    scopus 로고
    • 2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease
    • DOI 10.1523/JNEUROSCI.3591-05.2005
    • Liang X,Wang Q,Hand T,Wu L, Breyer RM, Montine TJ, AndreassonK (2005) Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer's disease. J Neurosci 25:10180-10187 (Pubitemid 41636214)
    • (2005) Journal of Neuroscience , vol.25 , Issue.44 , pp. 10180-10187
    • Liang, X.1    Wang, Q.2    Hand, T.3    Wu, L.4    Breyer, R.M.5    Montine, T.J.6    Andreasson, K.7
  • 89
    • 18244380066 scopus 로고    scopus 로고
    • 2 EP2 receptor in permanent focal cerebral ischemia
    • DOI 10.1002/ana.20461
    • Liu D, Wu L, Breyer R, Mattson MP, Andreasson K (2005) Neuroprotection by the PGE2 EP2 receptor in permanent focal cerebral ischemia. Ann Neurol 57:758-761 (Pubitemid 40628868)
    • (2005) Annals of Neurology , vol.57 , Issue.5 , pp. 758-761
    • Liu, D.1    Wu, L.2    Breyer, R.3    Mattson, M.P.4    Andreasson, K.5
  • 90
    • 34249058674 scopus 로고    scopus 로고
    • Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial
    • DOI 10.1212/01.wnl.0000260269.93245.d2
    • Lyketsos CG, Breitner JC, Green RC, Martin BK, Meinert C, Piantadosi S, SabbaghM(2007) Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial. Neurology 68:1800-1808 (Pubitemid 46791392)
    • (2007) Neurology , vol.68 , Issue.21 , pp. 1800-1808
    • Lyketsos, C.G.1    Breitner, J.C.S.2    Green, R.C.3    Martin, B.K.4    Meinert, C.5    Piantadosi, S.6    Sabbagh, M.7
  • 91
    • 49149119577 scopus 로고    scopus 로고
    • Unravelling the pathophysiology of delirium: A focus on the role of aberrant stress responses
    • Maclullich AM, Ferguson KJ, Miller T, De Rooij SE, Cunningham C (2008) Unravelling the pathophysiology of delirium: a focus on the role of aberrant stress responses. J Psychosom Res 65:229-238
    • (2008) J Psychosom Res , vol.65 , pp. 229-238
    • MacLullich, A.M.1    Ferguson, K.J.2    Miller, T.3    De Rooij, S.E.4    Cunningham, C.5
  • 93
    • 47549107705 scopus 로고    scopus 로고
    • Cognitive function over time in the Alzheimer's disease anti-inflammatory prevention trial (ADAPT): Results of a randomized, controlled trial of naproxen and celecoxib
    • DOI 10.1001/archneur.2008.65.7.nct70006
    • Martin BK, Szekely C, Brandt J, Piantadosi S, Breitner JC, Craft S, Evans D, Green R, Mullan M (2008) Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT): results of a randomized, controlled trial of naproxen and celecoxib. Arch Neurol 65:896-905 (Pubitemid 352008472)
    • (2008) Archives of Neurology , vol.65 , Issue.7 , pp. 896-905
    • Martin, B.K.1    Szekely, C.2    Brandt, J.3    Piantadosi, S.4    Breitner, J.C.S.5    Craft, S.6    Evans, D.7    Green, R.8    Mullan, M.9
  • 94
    • 77953304874 scopus 로고    scopus 로고
    • Cyclooxygenase-1 mediates prostaglandin E(2) elevation and contextual memory impairment in a model of sustained hippocampal interleukin-1beta expression
    • Matousek SB, Hein AM, Shaftel SS, Olschowka JA, Kyrkanides S, O'banion MK (2010) Cyclooxygenase-1 mediates prostaglandin E(2) elevation and contextual memory impairment in a model of sustained hippocampal interleukin-1beta expression. J Neurochem 114:247-258
    • (2010) J Neurochem , vol.114 , pp. 247-258
    • Matousek, S.B.1    Hein, A.M.2    Shaftel, S.S.3    Olschowka, J.A.4    Kyrkanides, S.5    O'Banion, M.K.6
  • 95
    • 1942500987 scopus 로고    scopus 로고
    • Involvement of arachidonic acid cascade in working memory impairment induced by interleukin-1 beta
    • DOI 10.1016/j.neuropharm.2004.02.012, PII S0028390804000504
    • Matsumoto Y, Yamaguchi T, Watanabe S, Yamamoto T (2004) Involvement of arachidonic acid cascade in working memory impairment induced by interleukin-1 beta. Neuropharmacology 46:1195-1200 (Pubitemid 38529943)
    • (2004) Neuropharmacology , vol.46 , Issue.8 , pp. 1195-1200
    • Matsumoto, Y.1    Yamaguchi, T.2    Watanabe, S.3    Yamamoto, T.4
  • 100
    • 0029811901 scopus 로고    scopus 로고
    • Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease: A review of 17 epidemiologic studies
    • Mcgeer PL, Schulzer M, Mcgeer EG (1996) Arthritis and antiinflammatory agents as possible protective factors for Alzheimer's disease: a review of 17 epidemiologic studies. Neurology 47:425-432 (Pubitemid 26324038)
    • (1996) Neurology , vol.47 , Issue.2 , pp. 425-432
    • McGeer, P.L.1    Schulzer, M.2    McGeer, E.G.3
  • 102
    • 60749096558 scopus 로고    scopus 로고
    • More attention, less confusion: Time to lessen the burden of delirium
    • Meagher D (2009) More attention, less confusion: time to lessen the burden of delirium. Int Rev Psychiatr 21:1-3
    • (2009) Int Rev Psychiatr , vol.21 , pp. 1-3
    • Meagher, D.1
  • 103
    • 33746433950 scopus 로고    scopus 로고
    • Cycloxygenase-2 activity promotes cognitive deficits but not increased amyloid burden in a model of Alzheimer's disease in a sex-dimorphic pattern
    • DOI 10.1016/j.neuroscience.2006.05.001, PII S030645220600621X
    • Melnikova T, Savonenko A, Wang Q, Liang X, Hand T, Wu L, Kaufmann WE, Vehmas A, Andreasson KI (2006) Cycloxygenase-2 activity promotes cognitive deficits but not increased amyloid burden in a model of Alzheimer's disease in a sex-dimorphic pattern. Neuroscience 141(3):1149-1162 (Pubitemid 44128685)
    • (2006) Neuroscience , vol.141 , Issue.3 , pp. 1149-1162
    • Melnikova, T.1    Savonenko, A.2    Wang, Q.3    Liang, X.4    Hand, T.5    Wu, L.6    Kaufmann, W.E.7    Vehmas, A.8    Andreasson, K.I.9
  • 106
    • 19344361883 scopus 로고    scopus 로고
    • 1-antichymotrypsin to ameliorate β-amyloid (aβ) pathology in Alzheimer's models
    • DOI 10.1038/sj.npp.1300668
    • Morihara T, Teter B, Yang F, Lim GP, Boudinot S, Boudinot FD, Frautschy SA, Cole GM (2005) Ibuprofen suppresses interleukin- 1beta induction of pro-amyloidogenic alpha1-antichymotrypsin to ameliorate beta-amyloid (abeta) pathology in Alzheimer's models. Neuropsychopharmacology 30:1111-1120 (Pubitemid 40720969)
    • (2005) Neuropsychopharmacology , vol.30 , Issue.6 , pp. 1111-1120
    • Morihara, T.1    Teter, B.2    Yang, F.3    Lim, G.P.4    Boudinot, S.5    Boudinot, F.D.6    Frautschy, S.A.7    Cole, G.M.8
  • 107
    • 0019957779 scopus 로고
    • Place navigation impaired in rats with hippocampal lesions
    • DOI 10.1038/297681a0
    • Morris RGM, Garrud P, Rawlins JNP, O'keefe J (1982) Place navigation impaired in rats with hippocampal lesions. Nature 297:681-683 (Pubitemid 12096189)
    • (1982) Nature , vol.297 , Issue.5868 , pp. 681-683
    • Morris, R.G.M.1    Garrud, P.2    Rawlins, J.N.P.3    O'Keefe, J.4
  • 108
    • 77951957277 scopus 로고    scopus 로고
    • Systemic inflammation induces acute working memory deficits in the primed brain: Relevance for delirium
    • doi:10.1016/j.neurobiolaging. 2010.04.002
    • Murray C, Sanderson DJ, Barkus C, Deacon RM, Rawlins JN, Bannerman DM, Cunningham C (2010) Systemic inflammation induces acute working memory deficits in the primed brain: relevance for delirium. Neurobiol Aging. doi:10.1016/j.neurobiolaging. 2010.04.002
    • (2010) Neurobiol Aging.
    • Murray, C.1    Sanderson, D.J.2    Barkus, C.3    Deacon, R.M.4    Rawlins, J.N.5    Bannerman, D.M.6    Cunningham, C.7
  • 110
    • 1242336763 scopus 로고    scopus 로고
    • Exacerbation of Motor Neuron Disease by Chronic Stimulation of Innate Immunity in a Mouse Model of Amyotrophic Lateral Sclerosis
    • DOI 10.1523/JNEUROSCI.4786-03.2004
    • Nguyen MD, D'aigle T, Gowing G, Julien JP, Rivest S (2004) Exacerbation of motor neuron disease by chronic stimulation of innate immunity in a mouse model of amyotrophic lateral sclerosis. J Neurosci 24:1340-1349 (Pubitemid 38222984)
    • (2004) Journal of Neuroscience , vol.24 , Issue.6 , pp. 1340-1349
    • Nguyen, M.D.1    D'Aigle, T.2    Gowing, G.3    Julien, J.-P.4    Rivest, S.5
  • 111
    • 0030909616 scopus 로고    scopus 로고
    • Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage
    • Nogawa S, Zhang F, Ross ME, Iadecola C (1997) Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage. J Neurosci 17:2746-2755 (Pubitemid 27155008)
    • (1997) Journal of Neuroscience , vol.17 , Issue.8 , pp. 2746-2755
    • Nogawa, S.1    Zhang, F.2    Elizabeth Ross, M.3    Iadecola, C.4
  • 112
    • 77956230017 scopus 로고    scopus 로고
    • Contribution of systemic inflammation to chronic neurodegeneration
    • Perry VH (2010) Contribution of systemic inflammation to chronic neurodegeneration. Acta Neuropathol 120:277-286
    • (2010) Acta Neuropathol , vol.120 , pp. 277-286
    • Perry, V.H.1
  • 113
    • 46849088998 scopus 로고    scopus 로고
    • Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease
    • DOI 10.1093/brain/awn101
    • Pott Godoy MC, Tarelli R, Ferrari CC, Sarchi MI, Pitossi FJ (2008) Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease. Brain 131:1880-1894 (Pubitemid 351957456)
    • (2008) Brain , vol.131 , Issue.7 , pp. 1880-1894
    • Godoy, M.C.P.1    Tarelli, R.2    Ferrari, C.C.3    Sarchi, M.I.4    Pitossi, F.J.5
  • 114
    • 0037376760 scopus 로고    scopus 로고
    • Inflammation and cerebral amyloidosis are disconnected in an animal model of Alzheimer's disease
    • DOI 10.1016/S0165-5728(03)00037-7
    • Quinn J, Montine T, Morrow J, Woodward WR, Kulhanek D, Eckenstein F (2003) Inflammation and cerebral amyloidosis are disconnected in an animal model of Alzheimer's disease. J Neuroimmunol 137:32-41 (Pubitemid 36351563)
    • (2003) Journal of Neuroimmunology , vol.137 , Issue.1-2 , pp. 32-41
    • Quinn, J.1    Montine, T.2    Morrow, J.3    Woodward, W.R.4    Kulhanek, D.5    Eckenstein, F.6
  • 115
    • 0033807096 scopus 로고    scopus 로고
    • Delirium episode as a sign of undetected dementia among community dwelling elderly subjects: A 2 year follow up study
    • Rahkonen T, Luukkainen-Markkula R, Paanila S, Sivenius J, Sulkava R (2000) Delirium episode as a sign of undetected dementia among community dwelling elderly subjects: a 2 year follow up study. J Neurol Neurosurg Psychiatr 69:519-521
    • (2000) J Neurol Neurosurg Psychiatr , vol.69 , pp. 519-521
    • Rahkonen, T.1    Luukkainen-Markkula, R.2    Paanila, S.3    Sivenius, J.4    Sulkava, R.5
  • 116
    • 77952883191 scopus 로고    scopus 로고
    • Effect size of reference memory deficits in the Morris water maze in Tg2576 mice
    • Reed MN, Liu P, Kotilinek LA, Ashe KH (2010) Effect size of reference memory deficits in the Morris water maze in Tg2576 mice. Behav Brain Res 212:115-120
    • (2010) Behav Brain Res , vol.212 , pp. 115-120
    • Reed, M.N.1    Liu, P.2    Kotilinek, L.A.3    Ashe, K.H.4
  • 119
    • 27344433516 scopus 로고    scopus 로고
    • Postsynaptically synthesized prostaglandin E2 (PGE2) modulates hippocampal synaptic transmission via a presynaptic PGE2 EP2 receptor
    • DOI 10.1523/JNEUROSCI.2392-05.2005
    • Sang N, Zhang J, Marcheselli V, Bazan NG, Chen C (2005) Postsynaptically synthesized prostaglandin E2 (PGE2) modulates hippocampal synaptic transmission via a presynaptic PGE2 EP2 receptor. J Neurosci 25:9858-9870 (Pubitemid 41528023)
    • (2005) Journal of Neuroscience , vol.25 , Issue.43 , pp. 9858-9870
    • Sang, N.1    Zhang, J.2    Marcheselli, V.3    Bazan, N.G.4    Chen, C.5
  • 120
    • 72849142054 scopus 로고    scopus 로고
    • Alzheimer's disease: Synaptic dysfunction and abeta
    • Shankar GM, Walsh DM (2009) Alzheimer's disease: synaptic dysfunction and abeta. Mol Neurodegener 4:48
    • (2009) Mol Neurodegener , vol.4 , pp. 48
    • Shankar, G.M.1    Walsh, D.M.2
  • 121
    • 0042835437 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid β peptide in APPswe transgenic mice
    • DOI 10.1016/S0969-9961(03)00069-X
    • Sheng JG, Bora SH, Xu G, Borchelt DR, Price DL, Koliatsos VE (2003) Lipopolysaccharide-induced-neuroinflammation increases intracellular accumulation of amyloid precursor protein and amyloid beta peptide in APPswe transgenic mice. Neurobiol Dis 14:133-145 (Pubitemid 37103187)
    • (2003) Neurobiology of Disease , vol.14 , Issue.1 , pp. 133-145
    • Sheng, J.G.1    Bora, S.H.2    Xu, G.3    Borchelt, D.R.4    Price, D.L.5    Koliatsos, V.E.6
  • 122
    • 77953638394 scopus 로고    scopus 로고
    • The prostaglandin E2 E-prostanoid 4 receptor exerts anti-inflammatory effects in brain innate immunity
    • Shi J, Johansson J, Woodling NS, Wang Q, Montine TJ, Andreasson K (2010) The prostaglandin E2 E-prostanoid 4 receptor exerts anti-inflammatory effects in brain innate immunity. J Immunol 184:7207-7218
    • (2010) J Immunol , vol.184 , pp. 7207-7218
    • Shi, J.1    Johansson, J.2    Woodling, N.S.3    Wang, Q.4    Montine, T.J.5    Andreasson, K.6
  • 123
    • 17144380506 scopus 로고    scopus 로고
    • Microglia lacking E prostanoid receptor subtype 2 have enhanced Aβ phagocytosis yet lack Aβ-activated neurotoxicity
    • Shie FS, Breyer RM, Montine TJ (2005) Microglia lacking E prostanoid receptor subtype 2 have enhanced abeta phagocytosis yet lack abeta-activated neurotoxicity. Am J Pathol 166:1163-1172 (Pubitemid 40524440)
    • (2005) American Journal of Pathology , vol.166 , Issue.4 , pp. 1163-1172
    • Shie, F.-S.1    Breyer, R.M.2    Montine, T.J.3
  • 125
    • 0035704245 scopus 로고    scopus 로고
    • Endogenous brain cytokine mRNA and inflammatory responses to lipopolysaccharide are elevated in the Tg2576 transgenic mouse model of Alzheimer's disease
    • DOI 10.1016/S0361-9230(01)00730-4, PII S0361923001007304
    • Sly LM, Krzesicki RF, Brashler JR, Buhl AE, Mckinley DD, Carter DB, Chin JE (2001) Endogenous brain cytokine mRNA and inflammatory responses to lipopolysaccharide are elevated in the Tg2576 transgenic mouse model of Alzheimer's disease. Brain Res Bull 56:581-588 (Pubitemid 34098810)
    • (2001) Brain Research Bulletin , vol.56 , Issue.6 , pp. 581-588
    • Sly, L.M.1    Krzesicki, R.F.2    Brashler, J.R.3    Buhl, A.E.4    McKinley, D.D.5    Carter, D.B.6    Chin, J.E.7
  • 127
    • 80052335857 scopus 로고    scopus 로고
    • Which memory task for my mouse? a systematic review of spatial memory performance in the Tg2576 Alzheimer's mouse model
    • Stewart S, Cacucci F, Lever C (2011) Which memory task for my mouse? a systematic review of spatial memory performance in the Tg2576 Alzheimer's mouse model. J Alzheimers Dis
    • (2011) J Alzheimers Dis
    • Stewart, S.1    Cacucci, F.2    Lever, C.3
  • 129
    • 9644275598 scopus 로고    scopus 로고
    • Modulation of nuclear factor-κB activity by indomethacin influences Aβ levels but not Aβ precursor protein metabolism in a model of Alzheimer's disease
    • Sung S, Yang H, Uryu K, Lee EB, Zhao L, Shineman D, Trojanowski JQ, Lee VM-Y, Pratico D (2004) Modulation of nuclear factor-{kappa} B activity by indomethacin influences A{beta} levels but not A {beta} precursor protein metabolism in a model of Alzheimer's disease. Am J Pathol 165:2197-2206 (Pubitemid 39578396)
    • (2004) American Journal of Pathology , vol.165 , Issue.6 , pp. 2197-2206
    • Sung, S.1    Yang, H.2    Uryu, K.3    Lee, E.B.4    Zhao, L.5    Shineman, D.6    Trojanowski, J.Q.7    Lee, V.M.-Y.8    Pratico, D.9
  • 130
    • 0036209131 scopus 로고    scopus 로고
    • Post-training cyclooxygenase-2 (COX-2) inhibition impairs memory consolidation
    • DOI 10.1101/lm.43602
    • Teather LA, Packard MG, Bazan NG (2002) Post-training cyclooxygenase-2 (COX-2) inhibition impairs memory consolidation. Learn Mem 9:41-47 (Pubitemid 34273350)
    • (2002) Learning and Memory , vol.9 , Issue.1 , pp. 41-47
    • Teather, L.A.1    Packard, M.G.2    Bazan, N.G.3
  • 131
    • 77951620638 scopus 로고    scopus 로고
    • The effect of non-steroidal anti-inflammatory agents on behavioural changes and cytokine production following systemic inflammation: Implications for a role of COX-1
    • Teeling JL, Cunningham C, Newman TA, Perry VH (2010) The effect of non-steroidal anti-inflammatory agents on behavioural changes and cytokine production following systemic inflammation: implications for a role of COX-1. Brain Behav Immun 24:409-419
    • (2010) Brain Behav Immun , vol.24 , pp. 409-419
    • Teeling, J.L.1    Cunningham, C.2    Newman, T.A.3    Perry, V.H.4
  • 133
    • 0025987048 scopus 로고
    • Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
    • Terry RD, Masliah E, Salmon DP, Butters N, Deteresa R, Hill R, Hansen LA, Katzman R (1991) Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 30:572-580
    • (1991) Ann Neurol , vol.30 , pp. 572-580
    • Terry, R.D.1    Masliah, E.2    Salmon, D.P.3    Butters, N.4    Deteresa, R.5    Hill, R.6    Hansen, L.A.7    Katzman, R.8
  • 134
    • 0019353236 scopus 로고
    • Cell loss in the locus coeruleus in senile dementia of Alzheimer type
    • DOI 10.1016/0022-510X(81)90031-9
    • Tomlinson BE, Irving D, Blessed G (1981) Cell loss in the locus coeruleus in senile dementia of Alzheimer type. J Neurol Sci 49:419-428 (Pubitemid 11184187)
    • (1981) Journal of the Neurological Sciences , vol.49 , Issue.3 , pp. 419-428
    • Tomlinson, B.E.1    Irving, D.2    Blessed, G.3
  • 135
    • 11144353535 scopus 로고    scopus 로고
    • Activation of vascular endothelial cells and perivascular cells by systemic inflammation - An immunohistochemical study of postmortem human brain tissues
    • DOI 10.1007/s00401-003-0815-x
    • Uchikado H, Akiyama H, Kondo H, Ikeda K, Tsuchiya K, Kato M, Oda T, Togo T, Iseki E, Kosaka K (2004) Activation of vascular endothelial cells and perivascular cells by systemic inflammation-an immunohistochemical study of postmortem human brain tissues. Acta Neuropathol 107:341-351 (Pubitemid 38477361)
    • (2004) Acta Neuropathologica , vol.107 , Issue.4 , pp. 341-351
    • Uchikado, H.1    Akiyama, H.2    Kondo, H.3    Ikeda, K.4    Tsuchiya, K.5    Kato, M.6    Oda, T.7    Togo, T.8    Iseki, E.9    Kosaka, K.10
  • 141
    • 43149102747 scopus 로고    scopus 로고
    • Protective effects of NSAIDs on the development of Alzheimer disease
    • DOI 10.1212/01.wnl.0000311269.57716.63, PII 0000611420080506000006
    • Vlad SC, Miller DR, Kowall NW, Felson DT (2008) Protective effects of NSAIDs on the development of Alzheimer disease. Neurology 70:1672-1677 (Pubitemid 351644133)
    • (2008) Neurology , vol.70 , Issue.19 PART 1 , pp. 1672-1677
    • Vlad, S.C.1    Miller, D.R.2    Kowall, N.W.3    Felson, D.T.4
  • 142
    • 0037041426 scopus 로고    scopus 로고
    • Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo
    • DOI 10.1038/416535a
    • Walsh DM, Klyubin I, Fadeeva JV, Cullen WK, Anwyl R, Wolfe MS, Rowan MJ, Selkoe DJ (2002) Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416:535-539 (Pubitemid 34288854)
    • (2002) Nature , vol.416 , Issue.6880 , pp. 535-539
    • Walsh, D.M.1    Klyubin, I.2    Fadeeva, J.V.3    Cullen, W.K.4    Anwyl, R.5    Wolfe, M.S.6    Rowan, M.J.7    Selkoe, D.J.8
  • 144
    • 34748896047 scopus 로고    scopus 로고
    • NSAIDs: Small molecules for prevention of Alzheimer's disease or precursors for future drug development?
    • DOI 10.1016/j.tips.2007.09.004, PII S016561470700212X
    • Weggen S, Rogers M, Eriksen J (2007) NSAIDs: small molecules for prevention of Alzheimer's disease or precursors for future drug development? Trends Pharmacol Sci 28:536-543 (Pubitemid 47488508)
    • (2007) Trends in Pharmacological Sciences , vol.28 , Issue.10 , pp. 536-543
    • Weggen, S.1    Rogers, M.2    Eriksen, J.3
  • 145
    • 0019410162 scopus 로고
    • Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis
    • DOI 10.1002/ana.410100203
    • Whitehouse PJ, Price DL, Clark AW, Coyle JT, Delong MR (1981) Alzheimer disease: evidence for selective loss of cholinergic neurons in the nucleus basalis. Ann Neurol 10:122-126 (Pubitemid 11053099)
    • (1981) Annals of Neurology , vol.10 , Issue.2 , pp. 122-126
    • Whitehouse, P.J.1    Price, D.L.2    Clark, A.W.3
  • 146
    • 0020072221 scopus 로고
    • Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain
    • Whitehouse PJ, Price DL, Struble RG, Clark AW, Coyle JT, Delon MR (1982) Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science 215:1237-1239 (Pubitemid 12106486)
    • (1982) Science , vol.215 , Issue.4537 , pp. 1237-1239
    • Whitehouse, P.J.1    Price, D.L.2    Struble, R.G.3
  • 148
    • 77956815064 scopus 로고    scopus 로고
    • Neuron loss in transgenic mouse models of Alzheimer's disease
    • doi:10.4061/2010/723782
    • Wirths O, Bayer TA (2010) Neuron loss in transgenic mouse models of Alzheimer's disease. Int J Alzheimers Dis. doi:10.4061/2010/ 723782
    • (2010) Int J Alzheimers Dis.
    • Wirths, O.1    Bayer, T.A.2
  • 149
    • 0041921071 scopus 로고    scopus 로고
    • Anti-inflammatory drug therapy alters β-amyloid processing and deposition in an animal model of Alzheimer's disease
    • Yan Q, Zhang J, Liu H, Babu-Khan S, Vassar R, Biere AL, Citron M, Landreth G (2003) Anti-inflammatory drug therapy alters betaamyloid processing and deposition in an animal model of Alzheimer's disease. J Neurosci 23:7504-7509 (Pubitemid 37034066)
    • (2003) Journal of Neuroscience , vol.23 , Issue.20 , pp. 7504-7509
    • Yan, Q.1    Zhang, J.2    Liu, H.3    Babu-Khan, S.4    Vassar, R.5    Biere, A.L.6    Citron, M.7    Landreth, G.8
  • 150
    • 0033526660 scopus 로고    scopus 로고
    • Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs
    • DOI 10.1016/S0006-8993(99)01389-X, PII S000689939901389X
    • Yasojima K, Schwab C, Mcgeer EG, Mcgeer PL (1999) Distribution of cyclooxygenase-1 and cyclooxygenase-2 mRNAs and proteins in human brain and peripheral organs. Brain Res 830:226-236 (Pubitemid 29297950)
    • (1999) Brain Research , vol.830 , Issue.2 , pp. 226-236
    • Yasojima, K.1    Schwab, C.2    McGeer, E.G.3    McGeer, P.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.