Place cell firing correlates with memory deficits and amyloid plaque burden in Tg2576 Alzheimer mouse model

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 22, 2008, Pages 7863-7868

  Cacucci, Francesca ^a   Yi, Ming ^a   Wills, Thomas J ^a   Chapman, Paul ^b   O'Keefe, John ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b GLAXOSMITHKLINE   (Singapore)

Author keywords

Alzheimer's disease; Hippocampus; Spatial memory

Indexed keywords

AMYLOID BETA PROTEIN;

ALZHEIMER DISEASE; AMNESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE MODEL; FORCED CHOICE METHOD; HIPPOCAMPUS; MALE; MAZE TEST; MOUSE; NEOCORTEX; NERVE CELL DEGENERATION; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; SPATIAL MEMORY; TRANSGENIC MOUSE;

AGE FACTORS; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, TRANSGENIC; PLAQUE, AMYLOID; PYRAMIDAL CELLS;

ANIMALIA; MUS MUSCULUS; RODENTIA;

EID: 45549087725     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0802908105     Document Type: Article

References (29)

1. Selkoe D (2002) Alzheimer's disease is a synaptic failure. Science 298:789-791.
2. Hsiao K, et al. (1996) Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice. Science 274:99-102.
3. Chapman PF, et al. (1999) Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nat Neurosci 2:271-276.
4. Barnes P, Hale G, Good M (2004) Intramaze and extramaze cue processing in adult APPSWE Tg2576 transgenic mice. Behav Neurosci 118:1184-1195.
5. Chen G, et al. (2000)Alearning deficit related to age and β-amyloid plaques in a mouse model of Alzheimer's disease. Nature 408:975-979.
6. Gordon MN, et al. (2001) Correlation between cognitive deficits and Aβ deposits in transgenic APP+PS1 mice. Neurobiol Aging 22:377-385.
7. Naslund J, et al. (2000) Correlation between elevated levels of amyloid β-peptide in the brain and cognitive decline. J Am Med Assoc 283:1571-1577.
8. Kotilinek LA, et al. (2002) Reversible memory loss in a mouse transgenic model of Alzheimer's disease. J Neurosci 22:6331-6335.
9. McLean CA, et al. (1999) Soluble pool of Aβ amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease. Ann Neurol 46:860-866.
10. Walsh DM, et al. (2002) Naturally secreted oligomers of amyloid β protein potently inhibit hippocampal long-term potentiation in vivo. Nature 416:535-539.
11. Lesne S, et al. (2006) A specific amyloid-β protein assembly in the brain impairs memory. Nature 440:352-357.
12. Malm T, et al. (2006) β-Amyloid infusion results in delayed and age-dependent learning deficits without role of inflammation or β-amyloid deposits. Proc Natl Acad Sci USA 103:8852-8857.
13. O'Keefe J, Dostrovsky J (1971) The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. Brain Res 34:171-175.
14. Morris RG, Garrud P, Rawlins JN, O'Keefe J (1982) Place navigation impaired in rats with hippocampal lesions. Nature 297:681-683.
15. O'Keefe J, Nadel, L (1978) The Hippocampus as a Cognitive Map (Oxford Univ Press, Oxford).
16. Deacon RM, Bannerman DM, Kirby BP, Croucher A, Rawlins JN (2002) Effects of cytotoxic hippocampal lesions in mice on a cognitive test battery. Behav Brain Res 133:57-68.
17. O'Keefe J, Speakman A (1987) Single unit activity in the rat hippocampus during a spatial memory task. Exp Brain Res 68:1-27.
18. Lenck-Santini PP, Save E, Poucet B (2001) Evidence for a relationship between place-cell spatial firing and spatial memory performance. Hippocampus 11:377-390.
19. Terry RD, et al. (1991) Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment. Ann Neurol 30:572-580.
20. Arriagada PV, Growdon JH, Hedley-Whyte ET, Hyman BT (1992) Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease. Neurology 42:631-639.
21. Braak H, Braak E, Bohl J, Bratzke H (1998) Evolution of Alzheimer's disease related cortical lesions. J Neural Transm Suppl 54:97-106.
22. Dong H, Martin MV, Chambers S, Csernansky JG (2007) Spatial relationship between synapse loss and β-amyloid deposition in Tg2576 mice. J Comp Neurol 500:311-321.
23. Noda-Saita K, et al. (2004) Exclusive association and simultaneous appearance of congophilic plaques and AT8-positive dystrophic neurites in Tg2576 mice suggest a mechanism of senile plaque formation and progression of neuritic dystrophy in Alzheimer's disease. Acta Neuropathol (Berlin) 108:435-442.
24. Tsai J, Grutzendler J, Duff K, Gan WB (2004) Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches. Nat Neurosci 7:1181-1183.
25. Westerman MA, et al. (2002) The relationship between Aβ and memory in the Tg2576 mouse model of Alzheimer's disease. J Neurosci 22:1858-1867.
26. Cacucci F, Wills TJ, Lever C, Giese K, O'Keefe J (2007) Experience-dependent increase in CA1 place cell spatial information, but not spatial reproducibility, is dependent on the autophosphorylation of αCaMKII. J Neurosci 27:7854-7859.
27. Skaggs WE, McNaughton BL, Gothard KM, Markus EJ (1993) An information-theoretic approach to deciphering the hippocampal code. Adv Neural Inf Process Syst 5:1030-1037.
28. Johnson-Wood K, et al. (1997) Amyloid precursor protein processing and A β42 deposition in a transgenic mouse model of Alzheimer disease. Proc Natl Acad Sci USA 94:1550-1555.
29. Best JD, et al. (2005) Quantitative measurement of changes in amyloid-α(40) in the rat brain and cerebrospinal fluid following treatment with the -γ-secretase inhibitor LY-411575 [N2-[(2S)-2-(3,5- difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-ox o-6,7-dihydro-5H- dibenzo[b,d]azepin-7-yl]-L-alaninamide]. J Pharmacol Exp Ther 313:902-908.