Systemic challenge with the TLR3 agonist poly I: C induces amplified IFNα/β and IL-1β responses in the diseased brain and exacerbates chronic neurodegeneration

Brain, Behavior, and Immunity

Volumn 24, Issue 6, 2010, Pages 996-1007

  Field, Robert ^a   Campion, Suzanne ^b   Warren, Colleen ^a   Murray, Carol ^a   Cunningham, Colm ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Alzheimer's disease; Cytokine; Delirium; Dementia; Infection; Inflammation; Microglia; Priming; Prion; Type I interferon

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CASPASE 3; CYCLOOXYGENASE 2; FAS ANTIGEN; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GELATINASE B; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; POLYINOSINIC POLYCYTIDYLIC ACID; PROTEIN KINASE R; TOLL LIKE RECEPTOR 3; ANTIVIRUS AGENT; CYTOKINE; INTERFERON INDUCING AGENT; RNA; TLR3 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIVIRAL ACTIVITY; APOPTOSIS; ARTICLE; CHRONIC DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE EXACERBATION; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; HIPPOCAMPUS; HYPOTHALAMUS; HYPOTHERMIA; ILLNESS BEHAVIOR; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MICROGLIA; MOTOR COORDINATION; MOUSE; MUSCLE STRENGTH; NERVE DEGENERATION; NICK END LABELING; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; AGONISTS; ANIMAL; ANIMAL BEHAVIOR; BIOSYNTHESIS; BODY TEMPERATURE; BRAIN LEVEL; C57BL MOUSE; CHEMICALLY INDUCED; DISEASE COURSE; DRUG EFFECTS; GENETICS; PATHOLOGY; PHYSIOLOGY; PSYCHOLOGY; PSYCHOMOTOR PERFORMANCE; STEREOTACTIC PROCEDURE; VIROLOGY;

ANIMALS; ANTIVIRAL AGENTS; APOPTOSIS; BEHAVIOR, ANIMAL; BODY TEMPERATURE; BRAIN CHEMISTRY; CYTOKINES; DISEASE PROGRESSION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; INFLAMMATION; INTERFERON INDUCERS; INTERFERON-ALPHA; INTERFERON-BETA; INTERLEUKIN-1BETA; MICE; MICE, INBRED C57BL; NERVE DEGENERATION; POLY I-C; PRION DISEASES; PSYCHOMOTOR PERFORMANCE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; STEREOTAXIC TECHNIQUES; TOLL-LIKE RECEPTOR 3;

EID: 77954218298     PISSN: 08891591     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbi.2010.04.004     Document Type: Article

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