Early behavioural changes in scrapie-affected mice and the influence of dapsone

European Journal of Neuroscience

Volumn 14, Issue 2, 2001, Pages 401-409

  Guenther, Katja ^a   Deacon, Robert M J ^a   Perry, V Hugh ^b   Rawlins, J Nicholas P ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Burrowing; Encephalopathy; Inflammation; Neurodegeneration; Prions

Indexed keywords

DAPSONE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BRAIN DISEASE; CHRONOPHARMACOLOGY; CONTROLLED STUDY; CREUTZFELDT JAKOB DISEASE; DRUG EFFECT; FEMALE; FOOD INTAKE; HISTOPATHOLOGY; INFLAMMATION; MOTOR ACTIVITY; MOUSE; NERVE DEGENERATION; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; SCRAPIE; TASK PERFORMANCE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AVOIDANCE LEARNING; BEHAVIOR, ANIMAL; BODY WEIGHT; BRAIN; CELL EXTRACTS; DAPSONE; DISEASE MODELS, ANIMAL; EATING; ENCEPHALITIS; FEMALE; GLIOSIS; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MICROGLIA; MOTOR ACTIVITY; NERVE DEGENERATION; PRPSC PROTEINS; SCRAPIE; TIME FACTORS;

EID: 0034883360     PISSN: 0953816X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0953-816X.2001.01645.x     Document Type: Article

References (35)

1. Prion diseases and the immune system
2. Double dissociation of function within the hippocampus: A comparison of dorsal, ventral, and complete hippocampal cytotoxic lesions
3. Behavioural consequences of prion disease targeted to the hippocampus in a mouse model of scrapie
4. Evidence for an early inflammatory response in the central nervous system of mice with scrapie
5. The hippocampus, objects and their contexts
6. Protein misfolding and prion diseases
7. Urodynamic parameters in scrapie-affected ewes and their modification in the course of the disease
8. Identification of microglial signal transduction pathways mediating a neurotoxic response to amyloidogenic fragments of beta-amyloid and prion proteins
9. Burrowing into prion disease
10. Alzheimer's disease and Creutzfeldt-Jakob disease: Overlap of pathogenic mechanisms
11. Apoptosis-mediated neurotoxicity induced by beta-amyloid and PRP fragments
12. Scrapie in mice: Agent-strain differences in the distribution and intensity of grey matter vacuolation
13. Comparison between the behavioural effects of septal and hippocampal lesions: A review
14. Behaviour in emergence and open-field tests of normal and scrapie mice
15. Species-barrier-independent prion replication in apparently resistant species
16. Learning ability of mice infected with different strains of scrapie
17. Synapse loss associated with abnormal PrP precedes neuronal degeneration in the scrapie-infected murine hippocampus
18. Alzheimer's beta amyloid, human islet amylin, and prion protein fragment evoke intracellular free calcium elevations by a common mechanism in a hypothalamic GnRH neuronal cell line
19. Microglia: A sensor for pathological events in the CNS
20. The effects of excitotoxic lesion of the medial prefrontal cortex on latent inhibition, prepulse inhibition, food hoarding, elevated plus maze, active avoidance and locomotor activity in the rat
21. Spatial reversal learning in preclinical scrapie-inoculated mice
22. 3-aminopropyl-triethoxysilane (APES): A new advance in section adhesion
23. Dapsone to delay symptoms in Creutzfeldt-Jakob disease
24. Volume -evoked micturition reflex is mediated by the ventrolateral periaqueductal gray in anesthetized rats
25. Early behavioural abnormalities in mice due to scrapie virus encephalopathy
26. The importance of inflammatory mechanisms in Alzheimer disease
27. Spatial learning impairment parallels the magnitude of dorsal hippocampal lesions but is hardly present following ventral lesions
28. Changes in drinking and feeding habits of mice with experimental scrapie
29. Reduced susceptibility to scrapie in mice after steroid administration
30. The blood-brain barrier and the inflammatory response
31. Prions
32. Macrosialin, a macrophage-restricted membrane sialoprotein differentially glycosylated in response to inflammatory stimuli
33. Activation of microglial cells by PrP and beta-amyloid fragments raises intracellular calcium through L-type voltage sensitive calcium channels
34. Motor activity changes in scrapie-affected mice
35. Bovine spongiform encephalopathy: Epidemiological studies