RNA exosome depletion reveals transcription upstream of active human promoters

Science

Volumn 322, Issue 5909, 2008, Pages 1851-1854

  Preker, Pascal ^a   Nielsen, Jesper ^a   Kammler, Susanne ^a,b   Lykke Andersen, Søren ^a   Christensen, Marianne S ^a   Mapendano, Christophe K ^a   Schierup, Mikkel H ^a   Jensen, Torben Heick ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b Exiqon AS   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY RNA; MESSENGER RNA; RNA POLYMERASE II; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRANSCRIPTOME;

ENZYME ACTIVITY; GENE EXPRESSION; HOMINID; PROTEIN; RNA;

ACETYLATION; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CHROMATIN STRUCTURE; CORRELATION ANALYSIS; CYTOMEGALOVIRUS; DEMETHYLATION; DNA SEQUENCE; EUKARYOTE; EXOSOME; GENE ACTIVITY; GENE AMPLIFICATION; GENETIC CODE; HUMAN; MICROARRAY ANALYSIS; NONHUMAN; POLYADENYLATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RNA ANALYSIS; RNA DEGRADATION; RNA STABILITY; RNA TRANSCRIPTION; TRANSCRIPTION INITIATION SITE;

DNA METHYLATION; EXOSOMES; HELA CELLS; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROMOTER REGIONS, GENETIC; RNA POLYMERASE II; RNA STABILITY; RNA, ANTISENSE; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION, GENETIC; TRANSFECTION;

EUKARYOTA;

EID: 57849123049     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1164096     Document Type: Article

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15. We thank G. Pruijn for antibodies, D. Libri, A. Sandelin, and D. Schubeler for comments on the manuscript, and D. Riishøj and K. Jürgensen for technical assistance. This work was supported by the Danish National Research Foundation and the Danish Natural Science Research Council. Microarray data have been submitted to gene expression omnibus (GEO) at the National Center for Biotechnology Information (http://www.ncbi.nlm.nih.gov/) under accession number GSE12431.