-
2
-
-
0014733991
-
Impaired immunologic reactivity and recurrence following cancer surgery
-
Eilber FR, Morton DL. Impaired immunologic reactivity and recurrence following cancer surgery. Cancer 25(2), 362-367 (1970).
-
(1970)
Cancer
, vol.25
, Issue.2
, pp. 362-367
-
-
Eilber, F.R.1
Morton, D.L.2
-
3
-
-
0033056609
-
Posttransplant malignancies
-
DOI 10.1016/S0041-1345(98)01987-3, PII S0041134598019873
-
Penn I. Posttransplant malignancies. Transplant. Proc. 31(1-2), 1260-1262 (1999). (Pubitemid 29127895)
-
(1999)
Transplantation Proceedings
, vol.31
, Issue.1-2
, pp. 1260-1262
-
-
Penn, I.1
-
4
-
-
0036561909
-
AIDS-related malignancies
-
Boshoff C, Weiss R. AIDS-related malignancies. Nat. Rev. Cancer 2(5), 373-382 (2002). (Pubitemid 37328950)
-
(2002)
Nature Reviews Cancer
, vol.2
, Issue.5
, pp. 373-382
-
-
Boshoff, C.1
Weiss, R.2
-
5
-
-
0036644685
-
Is human immunosenescence clinically relevant looking for'immunological risk phenotypes
-
DOI 10.1016/S1471-4906(02)02255-X, PII S147149060202255X
-
Pawelec G, Ouyang Q, Colonna Romano G, Candore G, Lio D, Caruso C. Is human immunosenescence clinically relevant? Looking for 'immunological risk phenotypes'. Trends Immunol. 23(7), 330-332 (2002). (Pubitemid 34717900)
-
(2002)
Trends in Immunology
, vol.23
, Issue.7
, pp. 330-332
-
-
Pawelec, G.1
Ouyang, Q.2
Colonna-Romano, G.3
Candore, G.4
Lio, D.5
Caruso, C.6
-
6
-
-
53549087527
-
How tumours escape mass destruction
-
Stewart TJ, Abrams SI. How tumours escape mass destruction. Oncogene 27(45), 5894-5903 (2008).
-
(2008)
Oncogene
, vol.27
, Issue.45
, pp. 5894-5903
-
-
Stewart, T.J.1
Abrams, S.I.2
-
7
-
-
0001415346
-
Ueber den jetzigen stand der karcinomforschung
-
Ehrlich H. Ueber den jetzigen Stand der Karcinomforschung. Ned. Tijdschr. Geneeskd 5(1), 273-290 (1909).
-
(1909)
Ned. Tijdschr. Geneeskd
, vol.5
, Issue.1
, pp. 273-290
-
-
Ehrlich, H.1
-
9
-
-
0014887939
-
The concept of immunological surveillance
-
Burnet FM. The concept of immunological surveillance. Prog. Exp. Tumor Res. 13, 1-27 (1970).
-
(1970)
Prog. Exp. Tumor Res.
, vol.13
, pp. 1-27
-
-
Burnet, F.M.1
-
10
-
-
84965157146
-
Antigenic properties of methylcholanthrene-induced tumors in mice of the strain of origin
-
Foley EJ. Antigenic properties of methylcholanthrene-induced tumors in mice of the strain of origin. Cancer Res. 13(12), 835-837 (1953).
-
(1953)
Cancer Res.
, vol.13
, Issue.12
, pp. 835-837
-
-
Foley, E.J.1
-
11
-
-
70449193189
-
Immunity to methylcholanthrene-induced sarcomas
-
Prehn RT, Main JM. Immunity to methylcholanthrene-induced sarcomas. J. Natl Cancer Inst. 18(6), 769-778 (1957).
-
(1957)
J. Natl Cancer Inst.
, vol.18
, Issue.6
, pp. 769-778
-
-
Prehn, R.T.1
Main, J.M.2
-
12
-
-
0013909693
-
Specific antigens of tumors and leukemias of experimental animals
-
Old LJ, Boyse EA. Specific antigens of tumors and leukemias of experimental animals. Med. Clin. North Am. 50(3), 901-912 (1966).
-
(1966)
Med. Clin. North Am.
, vol.50
, Issue.3
, pp. 901-912
-
-
Old, L.J.1
Boyse, E.A.2
-
13
-
-
34548223215
-
Challenges and prospects of immunotherapy as cancer treatment
-
DOI 10.1016/j.bbcan.2007.07.003, PII S0304419X07000236
-
Rescigno M, Avogadri F, Curigliano G. Challenges and prospects of immunotherapy as cancer treatment. Biochim. Biophys. Acta 1776(1), 108-123 (2007). (Pubitemid 47332077)
-
(2007)
Biochimica et Biophysica Acta - Reviews on Cancer
, vol.1776
, Issue.1
, pp. 108-123
-
-
Rescigno, M.1
Avogadri, F.2
Curigliano, G.3
-
14
-
-
0036852241
-
Cancer immunoediting: From immunosurveillance to tumor escape
-
DOI 10.1038/ni1102-991
-
Dunn GP, Bruce AT, Ikeda H, Old LJ, Schreiber RD. Cancer immunoediting: from immunosurveillance to tumor escape. Nat. Immunol. 3(11), 991-998 (2002). (Pubitemid 35363648)
-
(2002)
Nature Immunology
, vol.3
, Issue.11
, pp. 991-998
-
-
Dunn, G.P.1
Bruce, A.T.2
Ikeda, H.3
Old, L.J.4
Schreiber, R.D.5
-
16
-
-
0032529466
-
+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer
-
+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer. Cancer Res. 58(16), 3491-3494 (1998). (Pubitemid 28376536)
-
(1998)
Cancer Research
, vol.58
, Issue.16
, pp. 3491-3494
-
-
Naito, Y.1
Saito, K.2
Shiiba, K.3
Ohuchi, A.4
Saigenji, K.5
Nagura, H.6
Ohtani, H.7
-
17
-
-
33749319703
-
Type, density, and location of immune cells within human colorectal tumors predict clinical outcome
-
DOI 10.1126/science.1129139
-
Galon J, Costes A, Sanchez Cabo F et al. Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313(5795), 1960-1964 (2006). (Pubitemid 44498003)
-
(2006)
Science
, vol.313
, Issue.5795
, pp. 1960-1964
-
-
Galon, J.1
Costes, A.2
Sanchez-Cabo, F.3
Kirilovsky, A.4
Mlecnik, B.5
Lagorce-Pages, C.6
Tosolini, M.7
Camus, M.8
Berger, A.9
Wind, P.10
Zinzindohoue, F.11
Bruneval, P.12
Cugnenc, P.-H.13
Trajanoski, Z.14
Fridman, W.-H.15
Pages, F.16
-
18
-
-
0024814687
-
Model predicting survival in stage I melanoma based on tumor progression
-
Clark WH Jr, Elder DE, Guerry DT et al. Model predicting survival in stage I melanoma based on tumor progression. J. Natl Cancer Inst. 81(24), 1893-1904 (1989). (Pubitemid 20026075)
-
(1989)
Journal of the National Cancer Institute
, vol.81
, Issue.24
, pp. 1893-1904
-
-
Clark Jr., W.H.1
Elder, D.E.2
Guerry IV, D.3
Braitman, L.E.4
Trock, B.J.5
Schultz, D.6
Synnestvedt, M.7
Halpern, A.C.8
-
19
-
-
0029925375
-
Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma
-
DOI 10.1002/(SICI)1097-0142(19960401)77:7<1303::AID-CNCR12>3.0. CO;2-5
-
Clemente CG, Mihm MC JR, Bufalino R, Zurrida S, Collini P, Cascinelli N. Prognostic value of tumor infiltrating lymphocytes in the vertical growth phase of primary cutaneous melanoma. Cancer 77(7), 1303-1310 (1996). (Pubitemid 26102328)
-
(1996)
Cancer
, vol.77
, Issue.7
, pp. 1303-1310
-
-
Clemente, C.G.1
Mihm Jr., M.C.2
Bufalino, R.3
Zurrida, S.4
Collini, P.5
Cascinelli, N.6
-
20
-
-
18744371278
-
Immunity to cancer: Attack and escape in T lymphocyte-tumor cell interaction
-
DOI 10.1034/j.1600-065X.2002.18809.x
-
Rivoltini L, Carrabba M, Huber V et al. Immunity to cancer: attack and escape in T lymphocyte-tumor cell interaction. Immunol. Rev. 188, 97-113 (2002). (Pubitemid 35398868)
-
(2002)
Immunological Reviews
, vol.188
, pp. 97-113
-
-
Rivoltini, L.1
Carrabba, M.2
Huber, V.3
Castelli, C.4
Novellino, L.5
Dalerba, P.6
Mortarini, R.7
Arancia, G.8
Anichini, A.9
Fais, S.10
Parmiani, G.11
-
21
-
-
4644324025
-
Cancer immunotherapy: Moving beyond current vaccines
-
DOI 10.1038/nm1100
-
Rosenberg SA, Yang JC, Restifo NP. Cancer immunotherapy: moving beyond current vaccines. Nat. Med. 10(9), 909-915 (2004). (Pubitemid 39273730)
-
(2004)
Nature Medicine
, vol.10
, Issue.9
, pp. 909-915
-
-
Rosenberg, S.A.1
Yang, J.C.2
Restifo, N.P.3
-
22
-
-
0013869541
-
Tumor antigens
-
Klein G. Tumor antigens. Annu. Rev. Microbiol. 20, 223-252 (1966).
-
(1966)
Annu. Rev. Microbiol.
, vol.20
, pp. 223-252
-
-
Klein, G.1
-
23
-
-
0014433598
-
Cellular and humoral immunity to different types of human neoplasms
-
Hellstrom I, Hellstrom KE, Pierce GE, Yang JP. Cellular and humoral immunity to different types of human neoplasms. Nature 220(5174), 1352-1354 (1968).
-
(1968)
Nature
, vol.220
, Issue.5174
, pp. 1352-1354
-
-
Hellstrom, I.1
Hellstrom, K.E.2
Pierce, G.E.3
Yang, J.P.4
-
24
-
-
33745632047
-
+ T cells in a patient with malignant melanoma ascites
-
DOI 10.1007/s00262-005-0118-2
-
Harlin H, Kuna TV, Peterson AC, Meng Y, Gajewski TF. Tumor progression despite massive influx of activated CD8(+) T cells in a patient with malignant melanoma ascites. Cancer Immunol. Immunother. 55(10), 1185-1197 (2006). (Pubitemid 43992045)
-
(2006)
Cancer Immunology, Immunotherapy
, vol.55
, Issue.10
, pp. 1185-1197
-
-
Harlin, H.1
Kuna, T.V.2
Peterson, A.C.3
Meng, Y.4
Gajewski, T.F.5
-
25
-
-
27144500671
-
+ T cells in patients with melanoma
-
+ T cells in patients with melanoma. J. Immunol. 175(9), 6169-6176 (2005). (Pubitemid 41508105)
-
(2005)
Journal of Immunology
, vol.175
, Issue.9
, pp. 6169-6176
-
-
Rosenberg, S.A.1
Sherry, R.M.2
Morton, K.E.3
Scharfman, W.J.4
Yang, J.C.5
Topalian, S.L.6
Royal, R.E.7
Kammula, U.8
Restifo, N.P.9
Hughes, M.S.10
Schwartzentruber, D.11
Berman, D.M.12
Schwarz, S.L.13
Ngo, L.T.14
Mavroukakis, S.A.15
White, D.E.16
Steinberg, S.M.17
-
26
-
-
4043079706
-
The paradox of T cell-mediated antitumor immunity in spite of poor clinical outcome in human melanoma
-
DOI 10.1007/s00262-004-0526-8
-
Anichini A, Vegetti C, Mortarini R. The paradox of T cell-mediated antitumor immunity in spite of poor clinical outcome in human melanoma. Cancer Immunol. Immunother. 53(10), 855-864 (2004). (Pubitemid 39312653)
-
(2004)
Cancer Immunology, Immunotherapy
, vol.53
, Issue.10
, pp. 855-864
-
-
Anichini, A.1
Vegetti, C.2
Mortarini, R.3
-
27
-
-
33746092947
-
Immune suppression in the tumor microenvironment
-
DOI 10.1097/01.cji.0000199193.29048.56, PII 0000237120060500000001
-
Gajewski TF, Meng Y, Harlin H. Immune suppression in the tumor microenvironment. J. Immunother 29(3), 233-240 (2006). (Pubitemid 44297291)
-
(2006)
Journal of Immunotherapy
, vol.29
, Issue.3
, pp. 233-240
-
-
Gajewski, T.F.1
Meng, Y.2
Harlin, H.3
-
28
-
-
0347123433
-
Tumour-educated macrophages promote tumour progression and metastasis
-
Pollard JW. Tumour-educated macrophages promote tumour progression and metastasis. Nat. Rev. Cancer 4(1), 71-78 (2004). (Pubitemid 38082155)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.1
, pp. 71-78
-
-
Pollard, J.W.1
-
29
-
-
18844428327
-
Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
-
DOI 10.1016/j.cell.2005.02.034, PII S0092867405002370
-
Orimo A, Gupta PB, Sgroi DC et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF 1/CXCL12 secretion. Cell 121(3), 335-348 (2005). (Pubitemid 40692295)
-
(2005)
Cell
, vol.121
, Issue.3
, pp. 335-348
-
-
Orimo, A.1
Gupta, P.B.2
Sgroi, D.C.3
Arenzana-Seisdedos, F.4
Delaunay, T.5
Naeem, R.6
Carey, V.J.7
Richardson, A.L.8
Weinberg, R.A.9
-
30
-
-
60949112215
-
CXCL14 is an autocrine growth factor for fibroblasts and acts as a multi-modal stimulator of prostate tumor growth
-
Augsten M, Hagglof C, Olsson E et al. CXCL14 is an autocrine growth factor for fibroblasts and acts as a multi-modal stimulator of prostate tumor growth. Proc. Natl Acad. Sci. USA 106(9), 3414-3419 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, Issue.9
, pp. 3414-3419
-
-
Augsten, M.1
Hagglof, C.2
Olsson, E.3
-
31
-
-
58749093606
-
CCL3-CCR5 axis regulates intratumoral accumulation of leukocytes and fibroblasts and promotes angiogenesis in murine lung metastasis process
-
Wu Y, Li YY, Matsushima K, Baba T, Mukaida N. CCL3-CCR5 axis regulates intratumoral accumulation of leukocytes and fibroblasts and promotes angiogenesis in murine lung metastasis process. J. Immunol. 181(9), 6384-6393 (2008).
-
(2008)
J. Immunol.
, vol.181
, Issue.9
, pp. 6384-6393
-
-
Wu, Y.1
Li, Y.Y.2
Matsushima, K.3
Baba, T.4
Mukaida, N.5
-
33
-
-
36849021712
-
T cell-encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection
-
DOI 10.1038/nm1676, PII NM1676
-
Stephan MT, Ponomarev V, Brentjens RJ et al. T cell-encoded CD80 and 4 1BBL induce auto- and transcostimulation, resulting in potent tumor rejection. Nat. Med. 13(12), 1440-1449 (2007). (Pubitemid 350224246)
-
(2007)
Nature Medicine
, vol.13
, Issue.12
, pp. 1440-1449
-
-
Stephan, M.T.1
Ponomarev, V.2
Brentjens, R.J.3
Chang, A.H.4
Dobrenkov, K.V.5
Heller, G.6
Sadelain, M.7
-
34
-
-
43249121177
-
Stromal gene expression predicts clinical outcome in breast cancer
-
DOI 10.1038/nm1764, PII NM1764
-
Finak G, Bertos N, Pepin F et al. Stromal gene expression predicts clinical outcome in breast cancer. Nat. Med. 14(5), 518-527 (2008). (Pubitemid 351655218)
-
(2008)
Nature Medicine
, vol.14
, Issue.5
, pp. 518-527
-
-
Finak, G.1
Bertos, N.2
Pepin, F.3
Sadekova, S.4
Souleimanova, M.5
Zhao, H.6
Chen, H.7
Omeroglu, G.8
Meterissian, S.9
Omeroglu, A.10
Hallett, M.11
Park, M.12
-
35
-
-
58149334773
-
A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer
-
Farmer P, Bonnefoi H, Anderle P et al. A stroma-related gene signature predicts resistance to neoadjuvant chemotherapy in breast cancer. Nat. Med. 15(1), 68-74 (2009).
-
(2009)
Nat. Med.
, vol.15
, Issue.1
, pp. 68-74
-
-
Farmer, P.1
Bonnefoi, H.2
Anderle, P.3
-
36
-
-
0036790060
-
Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy
-
Pietras K, Rubin K, Sjoblom T et al. Inhibition of PDGF receptor signaling in tumor stroma enhances antitumor effect of chemotherapy. Cancer Res. 62(19), 5476-5484 (2002).
-
(2002)
Cancer Res.
, vol.62
, Issue.19
, pp. 5476-5484
-
-
Pietras, K.1
Rubin, K.2
Sjoblom, T.3
-
37
-
-
60949101225
-
Cancer-associated fibroblasts and tumor growth - bystanders turning into key players
-
Ostman A, Augsten M. Cancer-associated fibroblasts and tumor growth - bystanders turning into key players. Curr. Opin Genet. Dev. 19(1), 67-73 (2009).
-
(2009)
Curr. Opin Genet. Dev.
, vol.19
, Issue.1
, pp. 67-73
-
-
Ostman, A.1
Augsten, M.2
-
38
-
-
38849202330
-
Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting
-
Pietras K, Pahler J, Bergers G, Hanahan D. Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting. PLoS Med. 5(1), e19 (2008).
-
(2008)
PLoS Med.
, vol.5
, Issue.1
-
-
Pietras, K.1
Pahler, J.2
Bergers, G.3
Hanahan, D.4
-
39
-
-
0028286026
-
Molecular cloning of fibroblast activation protein α, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers
-
DOI 10.1073/pnas.91.12.5657
-
Scanlan MJ, Raj B, Calvo B et al. Molecular cloning of fibroblast activation protein a, a member of the serine protease family selectively expressed in stromal fibroblasts of epithelial cancers. Proc. Natl Acad. Sci. USA 91(12), 5657-5661 (1994). (Pubitemid 24174387)
-
(1994)
Proceedings of the National Academy of Sciences of the United States of America
, vol.91
, Issue.12
, pp. 5657-5661
-
-
Scanlan, M.J.1
Raj, B.K.M.2
Calvo, B.3
Garin-Chesa, P.4
Sanz-Moncasi, M.P.5
Healey, J.H.6
Old, L.J.7
Rettig, W.J.8
-
40
-
-
0037102412
-
Promotion of tumor growth by murine fibroblast activation protein a serine protease in an animal model
-
Cheng JD, Dunbrack RL Jr, Valianou M, Rogatko A, Alpaugh RK, Weiner LM. Promotion of tumor growth by murine fibroblast activation protein, a serine protease, in an animal model. Cancer Res. 62(16), 4767-4772 (2002).
-
(2002)
Cancer Res.
, vol.62
, Issue.16
, pp. 4767-4772
-
-
Cheng, J.D.1
Dunbrack, Jr.R.L.2
Valianou, M.3
Rogatko, A.4
Alpaugh, R.K.5
Weiner, L.M.6
-
41
-
-
72849125358
-
Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice
-
Santos AM, Jung J, Aziz N, Kissil JL, Pure E. Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice. J. Clin. Invest. 119(12), 3613-3625 (2009).
-
(2009)
J. Clin. Invest.
, vol.119
, Issue.12
, pp. 3613-3625
-
-
Santos, A.M.1
Jung, J.2
Aziz, N.3
Kissil, J.L.4
Pure, E.5
-
42
-
-
33745837774
-
Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake
-
DOI 10.1172/JCI26532
-
Loeffler M, Kruger JA, Niethammer AG, Reisfeld RA. Targeting tumor-associated fibroblasts improves cancer chemotherapy by increasing intratumoral drug uptake. J. Clin. Invest. 116(7), 1955-1962 (2006). (Pubitemid 44033319)
-
(2006)
Journal of Clinical Investigation
, vol.116
, Issue.7
, pp. 1955-1962
-
-
Loeffler, M.1
Kruger, J.A.2
Niethammer, A.G.3
Reisfeld, R.A.4
-
43
-
-
51649087512
-
Effective immunoconjugate therapy in cancer models targeting a serine protease of tumor fibroblasts
-
Ostermann E, Garin-Chesa P, Heider KH et al. Effective immunoconjugate therapy in cancer models targeting a serine protease of tumor fibroblasts. Clin. Cancer Res. 14(14), 4584-4592 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, Issue.14
, pp. 4584-4592
-
-
Ostermann, E.1
Garin-Chesa, P.2
Heider, K.H.3
-
44
-
-
75849116069
-
Molecular biology of cancer-associated fibroblasts: Can these cells be targeted in anti-cancer therapy
-
Gonda TA, Varro A, Wang TC, Tycko B. Molecular biology of cancer-associated fibroblasts: can these cells be targeted in anti-cancer therapy? Semin. Cell Dev. Biol. 21(1), 2-10 (2010).
-
(2010)
Semin. Cell Dev. Biol.
, vol.21
, Issue.1
, pp. 2-10
-
-
Gonda, T.A.1
Varro, A.2
Wang, T.C.3
Tycko, B.4
-
45
-
-
67149143399
-
Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer
-
Olive KP, Jacobetz MA, Davidson CJ et al. Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer. Science 324(5933), 1457-1461 (2009).
-
(2009)
Science
, vol.324
, Issue.5933
, pp. 1457-1461
-
-
Olive, K.P.1
Jacobetz, M.A.2
Davidson, C.J.3
-
46
-
-
0037989982
-
A phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer
-
Scott AM, Wiseman G, Welt S et al. A Phase I dose-escalation study of sibrotuzumab in patients with advanced or metastatic fibroblast activation protein-positive cancer. Clin. Cancer Res. 9(5), 1639-1647 (2003). (Pubitemid 36554586)
-
(2003)
Clinical Cancer Research
, vol.9
, Issue.5
, pp. 1639-1647
-
-
Scott, A.M.1
Wiseman, G.2
Welt, S.3
Adjei, A.4
Lee, F.-T.5
Hopkins, W.6
Divgi, C.R.7
Hanson, L.H.8
Mitchell, P.9
Gansen, D.N.10
Larson, S.M.11
Ingle, J.N.12
Hoffman, E.W.13
Tanswell, P.14
Ritter, G.15
Cohen, L.S.16
Bette, P.17
Arvay, L.18
Amelsberg, A.19
Vlock, D.20
Rettig, W.J.21
Old, L.J.22
more..
-
47
-
-
0038476608
-
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
-
Bergers G, Song S, Meyer-Morse N, Bergsland E, Hanahan D. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J. Clin. Invest. 111(9), 1287-1295 (2003).
-
(2003)
J. Clin. Invest.
, vol.111
, Issue.9
, pp. 1287-1295
-
-
Bergers, G.1
Song, S.2
Meyer-Morse, N.3
Bergsland, E.4
Hanahan, D.5
-
48
-
-
1442290142
-
Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms
-
Erber R, Thurnher A, Katsen AD et al. Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms. FASEB J. 18(2), 338-340 (2004).
-
(2004)
FASEB J.
, vol.18
, Issue.2
, pp. 338-340
-
-
Erber, R.1
Thurnher, A.2
Katsen, A.D.3
-
49
-
-
1442271244
-
Halofuginone to treat fibrosis in chronic graft-versus-host disease and scleroderma
-
DOI 10.1016/S1083-8791(03)00151-4, PII S1083879103001514
-
Pines M, Snyder D, Yarkoni S, Nagler A. Halofuginone to treat fibrosis in chronic graft-versus-host disease and scleroderma. Biol. Blood Marrow Transplant 9(7), 417-425 (2003). (Pubitemid 38351799)
-
(2003)
Biology of Blood and Marrow Transplantation
, vol.9
, Issue.7
, pp. 417-425
-
-
Pines, M.1
Snyder, D.2
Yarkoni, S.3
Nagler, A.4
-
50
-
-
0027469572
-
Halofuginone: An inhibitor of collagen type I synthesis
-
DOI 10.1016/0304-4165(93)90123-P
-
Granot I, Halevy O, Hurwitz S, Pines M. Halofuginone. an inhibitor of collagen type I synthesis. Biochim. Biophys. Acta 1156(2), 107-112 (1993). (Pubitemid 23049941)
-
(1993)
Biochimica et Biophysica Acta - General Subjects
, vol.1156
, Issue.2
, pp. 107-112
-
-
Granot, I.1
Halevy, O.2
Hurwitz, S.3
Pines, M.4
-
51
-
-
0035995041
-
Effect of halofuginone on the development of tight skin TSK syndrome
-
Mcgaha T, Kodera T, Phelps R, Spiera H, Pines M, Bona C. Effect of halofuginone on the development of tight skin (TSK) syndrome. Autoimmunity 35(4), 277-282 (2002).
-
(2002)
Autoimmunity
, vol.35
, Issue.4
, pp. 277-282
-
-
Mcgaha, T.1
Kodera, T.2
Phelps, R.3
Spiera, H.4
Pines, M.5
Bona, C.6
-
52
-
-
33947143078
-
Gene expression during chemically induced liver fibrosis: Effect of halofuginone on TGF-β signaling
-
DOI 10.1007/s00441-006-0330-1
-
Gnainsky Y, Kushnirsky Z, Bilu G et al. Gene expression during chemically induced liver fibrosis: effect of halofuginone on TGF β signaling. Cell Tissue Res. 328(1), 153-166 (2007). (Pubitemid 46411910)
-
(2007)
Cell and Tissue Research
, vol.328
, Issue.1
, pp. 153-166
-
-
Gnainsky, Y.1
Kushnirsky, Z.2
Bilu, G.3
Hagai, Y.4
Genina, O.5
Volpin, H.6
Bruck, R.7
Spira, G.8
Nagler, A.9
Kawada, N.10
Yoshizato, K.11
Reinhardt, D.P.12
Libermann, T.A.13
Pines, M.14
-
53
-
-
66749107425
-
Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response
-
Sundrud MS, Koralov SB, Feuerer M et al. Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Science 324(5932), 1334-1338 (2009).
-
(2009)
Science
, vol.324
, Issue.5932
, pp. 1334-1338
-
-
Sundrud, M.S.1
Koralov, S.B.2
Feuerer, M.3
-
54
-
-
33748853355
-
Halofuginone inhibits NF-κB and p38 MAPK in activated T cells
-
DOI 10.1189/jlb.0705409
-
Leiba M, Cahalon L, Shimoni A et al. Halofuginone inhibits NF k B and p38 MAPK in activated T cells. J. Leukoc. Biol. 80(2), 399-406 (2006). (Pubitemid 44835513)
-
(2006)
Journal of Leukocyte Biology
, vol.80
, Issue.2
, pp. 399-406
-
-
Leiba, M.1
Cahalon, L.2
Shimoni, A.3
Lider, O.4
Zanin-Zhorov, A.5
Hecht, I.6
Sela, U.7
Vlodavsky, I.8
Nagler, A.9
-
55
-
-
0033566986
-
Inhibition of bladder carcinoma angiogenesis, stromal support, and tumor growth by halofuginone
-
Elkin M, Ariel I, Miao HQ et al. Inhibition of bladder carcinoma angiogenesis, stromal support, and tumor growth by halofuginone. Cancer Res. 59(16), 4111-4118 (1999). (Pubitemid 29393586)
-
(1999)
Cancer Research
, vol.59
, Issue.16
, pp. 4111-4118
-
-
Elkin, M.1
Ariel, I.2
Miao, H.-Q.3
Nagler, A.4
Pines, M.5
De-Groot, N.6
Hochberg, A.7
Vlodavsky, I.8
-
56
-
-
0036571304
-
Growth inhibition of prostate cancer xenografts by halofuginone
-
Gavish Z, Pinthus JH, Barak V et al. Growth inhibition of prostate cancer xenografts by halofuginone. Prostate 51(2), 73-83 (2002).
-
(2002)
Prostate
, vol.51
, Issue.2
, pp. 73-83
-
-
Gavish, Z.1
Pinthus, J.H.2
Barak, V.3
-
57
-
-
2942522641
-
Suppression of hepatocellular carcinoma growth in mice by the alkaloid coccidiostat halofuginone
-
DOI 10.1016/j.ejca.2003.11.036, PII S0959804904002011
-
Nagler A, Ohana M, Shibolet O et al. Suppression of hepatocellular carcinoma growth in mice by the alkaloid coccidiostat halofuginone. Eur. J. Cancer 40(9), 1397-1403 (2004). (Pubitemid 38737026)
-
(2004)
European Journal of Cancer
, vol.40
, Issue.9
, pp. 1397-1403
-
-
Nagler, A.1
Ohana, M.2
Shibolet, O.3
Shapira, M.Y.4
Alper, R.5
Vlodavsky, I.6
Pines, M.7
Ilan, Y.8
-
58
-
-
77954668887
-
Angiogenesis inhibitors: Current strategies and future prospects
-
Cook KM, Figg WD. Angiogenesis inhibitors: current strategies and future prospects. CA. Cancer J. Clin. 60(4), 222-243 (2010).
-
(2010)
CA. Cancer J. Clin.
, vol.60
, Issue.4
, pp. 222-243
-
-
Cook, K.M.1
Figg, W.D.2
-
59
-
-
72949119124
-
Integrins in cancer: Biological implications and therapeutic opportunities
-
Desgrosellier JS, Cheresh DA. Integrins in cancer: biological implications and therapeutic opportunities. Nat. Rev. Cancer 10(1), 9-22 (2010).
-
(2010)
Nat. Rev. Cancer
, vol.10
, Issue.1
, pp. 9-22
-
-
Desgrosellier, J.S.1
Cheresh, D.A.2
-
61
-
-
0028972105
-
Antiintegrin a v b 3 blocks human breast cancer growth and angiogenesis in human skin
-
Brooks PC, Stromblad S, Klemke R, Visscher D, Sarkar FH, Cheresh DA. Antiintegrin a v b 3 blocks human breast cancer growth and angiogenesis in human skin. J. Clin. Invest. 96(4), 1815-1822 (1995).
-
(1995)
J. Clin. Invest.
, vol.96
, Issue.4
, pp. 1815-1822
-
-
Brooks, P.C.1
Stromblad, S.2
Klemke, R.3
Visscher, D.4
Sarkar, F.H.5
Cheresh, D.A.6
-
62
-
-
34247504971
-
v integrin monoclonal antibody (CNTO 95) in patients with advanced solid tumors
-
DOI 10.1158/1078-0432.CCR-06-2779
-
Mullamitha SA, Ton NC, Parker GJ et al. Phase I evaluation of a fully human anti-av integrin monoclonal antibody (CNTO 95) in patients with advanced solid tumors. Clin. Cancer Res. 13(7), 2128-2135 (2007). (Pubitemid 46649882)
-
(2007)
Clinical Cancer Research
, vol.13
, Issue.7
, pp. 2128-2135
-
-
Mullamitha, S.A.1
Ton, N.C.2
Parker, G.J.M.3
Jackson, A.4
Julyan, P.J.5
Roberts, C.6
Buonaccorsi, G.A.7
Watson, Y.8
Davies, K.9
Cheung, S.10
Hope, L.11
Valle, J.W.12
Radford, J.A.13
Lawrance, J.14
Saunders, M.P.15
Munteanu, M.C.16
Nakada, M.T.17
Nemeth, J.A.18
Davis, H.M.19
Jiao, Q.20
Prabhakar, U.21
Lang, Z.22
Corringham, R.E.23
Beckman, R.A.24
Jayson, G.C.25
more..
-
63
-
-
77950594400
-
Extracellular matrix: A gatekeeper in the transition from dormancy to metastatic growth
-
Barkan D, Green JE, Chambers AF. Extracellular matrix: a gatekeeper in the transition from dormancy to metastatic growth. Eur. J. Cancer 46(7), 1181-1188 (2010).
-
(2010)
Eur. J. Cancer
, vol.46
, Issue.7
, pp. 1181-1188
-
-
Barkan, D.1
Green, J.E.2
Chambers, A.F.3
-
64
-
-
77950931419
-
Matrix metalloproteinases: Regulators of the tumor microenvironment
-
Kessenbrock K, Plaks V, Werb Z. Matrix metalloproteinases: regulators of the tumor microenvironment. Cell 141(1), 52-67 (2010).
-
(2010)
Cell
, vol.141
, Issue.1
, pp. 52-67
-
-
Kessenbrock, K.1
Plaks, V.2
Werb, Z.3
-
65
-
-
0035813126
-
Membrane type 1-matrix metalloproteinase is activated during migration of human endothelial cells and modulates endothelial motility and matrix remodeling
-
Galvez BG, Matias-Roman S, Albar JP, Sanchez-Madrid F, Arroyo AG. Membrane type 1-matrix metalloproteinase is activated during migration of human endothelial cells and modulates endothelial motility and matrix remodeling. J. Biol. Chem. 276(40), 37491-37500 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, Issue.40
, pp. 37491-37500
-
-
Galvez, B.G.1
Matias-Roman, S.2
Albar, J.P.3
Sanchez-Madrid, F.4
Arroyo, A.G.5
-
66
-
-
77949445888
-
Genetic polymorphisms of matrix metalloproteinases and their inhibitors in potentially malignant and malignant lesions of the head and neck
-
Chaudhary AK, Sing B, Bharti AC et al. Genetic polymorphisms of matrix metalloproteinases and their inhibitors in potentially malignant and malignant lesions of the head and neck. J. Biomed Sci .17, 10 (2010).
-
(2010)
J. Biomed. Sci.
, vol.17
, pp. 10
-
-
Chaudhary, A.K.1
Sing, B.2
Bharti, A.C.3
-
67
-
-
77954861244
-
Matrix metalloproteinase-induced epithelial-mesenchymal transition in breast cancer
-
Radisky ES, Radisky DC. Matrix metalloproteinase-induced epithelial-mesenchymal transition in breast cancer. J. Mammary Gland Biol. Neoplasia 15(2), 201-212 (2010).
-
(2010)
J. Mammary Gland Biol. Neoplasia.
, vol.15
, Issue.2
, pp. 201-212
-
-
Radisky, E.S.1
Radisky, D.C.2
-
68
-
-
78650424066
-
Roles of MMPs in cancer progression and their pharmacological targeting
-
Gialleli C, Theocharis AD, Karamanos NK. Roles of MMPs in cancer progression and their pharmacological targeting. FEBS J. 278(1), 16-27 (2011).
-
(2011)
FEBS J.
, vol.278
, Issue.1
, pp. 16-27
-
-
Gialleli, C.1
Theocharis, A.D.2
Karamanos, N.K.3
-
69
-
-
0030609810
-
1.8-Å crystal structure of the catalytic domain of human neutrophil collagenase matrix metalloproteinase-8 complexed with a peptidomimetic hydroxamate primed-side inhibitor with a distinct selectivity profile
-
Betz M, Huxley P, Davies SJ et al. 1.8 A crystal structure of the catalytic domain of human neutrophil collagenase (matrix metalloproteinase 8 complexed with a peptidomimetic hydroxamate primedside inhibitor with a distinct selectivity profile. Eur. J. Biochem. 247(1), 356-363 (1997). (Pubitemid 27319524)
-
(1997)
European Journal of Biochemistry
, vol.247
, Issue.1
, pp. 356-363
-
-
Betz, M.1
Huxley, P.2
Davies, S.J.3
Mushtaq, Y.4
Pieper, M.5
Tschesche, H.6
Bode, W.7
Gomis-Ruth, E.X.8
-
70
-
-
31344476048
-
Tetracyclines: Nonantibiotic properties and their clinical implications
-
Sapadin AM, Fleichmajer R. Tetracyclines: nonantibiotic properties and their clinical implications. J. Am. Acad. Dermatol. 54(2), 258-265 (2006).
-
(2006)
J. Am. Acad. Dermatol.
, vol.54
, Issue.2
, pp. 258-265
-
-
Sapadin, A.M.1
Fleichmajer, R.2
-
71
-
-
33646383590
-
Recent advances in understanding the mechanism of action of bisphosphonates
-
DOI 10.1016/j.coph.2006.03.005, PII S1471489206000610, Respiratory/Musculoskeletal
-
Coxon FP, Thompson K, Rogers MJ. Recent advances in understanding the mechanism of action of biphosphonates. Curr. Opin Pharmacol. 6(3), 307-312 (2006). (Pubitemid 43670914)
-
(2006)
Current Opinion in Pharmacology
, vol.6
, Issue.3
, pp. 307-312
-
-
Coxon, F.P.1
Thompson, K.2
Rogers, M.J.3
-
72
-
-
0035207897
-
Neovastat, a naturally occurring multifunctional antiangiogenic drug, in phase III clinical trials
-
Falardeau P, Champagne P, Poyet P et al. Neovastat, a naturally occurring multifunctional antiangiogenic drug, in Phase III clinical trials. Semin. Oncol. 28(6), 620-625 (2001). (Pubitemid 33134422)
-
(2001)
Seminars in Oncology
, vol.28
, Issue.6
, pp. 620-625
-
-
Falardeau, P.1
Champagne, P.2
Poyet, P.3
Hariton, C.4
Dupont, E.5
-
73
-
-
22844432461
-
Genistein suppresses the invasive potential of human breast cancer cells through transcriptional regulation of metalloproteinases and their tissue inhibitors
-
Kousidou OC, Mitropoulou TN, Rousidis AE et al. Genistein suppresses the invasive potential of human breast cancer cells through transcriptional regulation of metalloproteinases and their tissue inhibitors. Int. J. Oncol. 26(4), 1101-1109 (2005).
-
(2005)
Int. J. Oncol.
, vol.26
, Issue.4
, pp. 1101-1109
-
-
Kousidou, O.C.1
Mitropoulou, T.N.2
Rousidis, A.E.3
-
74
-
-
0345935809
-
Collagenolytic activity in amphibian tissue: A tissue culture assay
-
USA
-
Gross J, Lapiere CM. Collagenolytic activity in amphibian tissue: a tissue culture assay. Proc. Natl Acad. Sci. USA 48, 1014-1022 (1962).
-
(1962)
Proc. Natl Acad. Sci.
, vol.48
, pp. 1014-1022
-
-
Gross, J.1
Lapiere, C.M.2
-
75
-
-
70450181696
-
Selective matrix metalloproteinase inhibitors for cancer
-
Lia NG, Shib ZH, Tang YP, Duan JA. Selective matrix metalloproteinase inhibitors for cancer. Curr. Med. Chem. 16(29), 3805-3827 (2009).
-
(2009)
Curr. Med. Chem.
, vol.16
, Issue.29
, pp. 3805-3827
-
-
Lia, N.G.1
Shib, Z.H.2
Tang, Y.P.3
Duan, J.A.4
-
76
-
-
77952647070
-
Matrix metalloproteinase inhibitor: A critical appraisal of design princilles and proposed therapeutic utility
-
Dorman G, Cseh S, Haidu I et al. Matrix metalloproteinase inhibitor: a critical appraisal of design princilles and proposed therapeutic utility. Drugs 70(8), 949-964 (2010).
-
(2010)
Drugs
, vol.70
, Issue.8
, pp. 949-964
-
-
Dorman, G.1
Cseh, S.2
Haidu, I.3
-
77
-
-
33644874747
-
Potential prognostic and therapeutic roles for cytokines in breast cancer review
-
Rao VS, Dyer CE, Jameel JK, Drew PJ, Greenman J. Potential prognostic and therapeutic roles for cytokines in breast cancer (review).Oncol. Rep. 15(1), 179-185 (2006).
-
(2006)
Oncol. Rep.
, vol.15
, Issue.1
, pp. 179-185
-
-
Rao, V.S.1
Dyer, C.E.2
Jameel, J.K.3
Drew, P.J.4
Greenman, J.5
-
78
-
-
2442589013
-
Cancer immunotherapy using cells modified with cytokine genes
-
Kowalczyk DW, Wysocki PJ, Mackiewicz A. Cancer immunotherapy using cells modified with cytokine genes. Acta Biochim. Pol. 50(3), 613-624 (2003). (Pubitemid 38623796)
-
(2003)
Acta Biochimica Polonica
, vol.50
, Issue.3
, pp. 613-624
-
-
Kowalczyk, D.W.1
Wysocki, P.J.2
Mackiewicz, A.3
-
79
-
-
22144457398
-
Targeting the local tumor microenvironment with vaccinia virus expressing B7.1 for the treatment of melanoma
-
DOI 10.1172/JCI24624
-
Kaufman HL, Deraffele G, Mitcham J et al. Targeting the local tumor microenvironment with vaccinia virus expressing B7.1 for the treatment of melanoma. J. Clin. Invest. 115(7), 1903-1912 (2005). (Pubitemid 40979730)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.7
, pp. 1903-1912
-
-
Kaufman, H.L.1
DeRaffele, G.2
Mitcham, J.3
Moroziewicz, D.4
Cohen, S.M.5
Hurst-Wicker, K.S.6
Cheung, K.7
Lee, D.S.8
Divito, J.9
Voulo, M.10
Donovan, J.11
Dolan, K.12
Manson, K.13
Panicali, D.14
Wang, E.15
Horig, H.16
Marincola, F.M.17
-
80
-
-
0036813199
-
GM CSF-based cancer vaccines
-
Dranoff G. GM CSF-based cancer vaccines. Immunol. Rev. 188, 147-154 (2002).
-
(2002)
Immunol. Rev.
, vol.188
, pp. 147-154
-
-
Dranoff, G.1
-
81
-
-
0027538181
-
Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity
-
Dranoff G, Jaffee E, Lazenby A et al. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc. Natl Acad. Sci. USA 90(8), 3539-3543 (1993). (Pubitemid 23111402)
-
(1993)
Proceedings of the National Academy of Sciences of the United States of America
, vol.90
, Issue.8
, pp. 3539-3543
-
-
Dranoff, G.1
Jaffee, E.2
Lazenby, A.3
Golumbek, P.4
Levitsky, H.5
Brose, K.6
Jackson, V.7
Hamada, H.8
Pardoll, D.9
Mulligan, R.C.10
-
82
-
-
0032573225
-
Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma
-
USA
-
Soiffer R, Lynch T, Mihm M et al. Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma. Proc. Natl Acad. Sci. USA 95(22), 13141-13146 (1998).
-
(1998)
Proc. Natl Acad. Sci.
, vol.95
, Issue.22
, pp. 13141-13146
-
-
Soiffer, R.1
Lynch, T.2
Mihm, M.3
-
83
-
-
2342473348
-
Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: Results from two phase III, randomized, vehicle-controlled studies
-
DOI 10.1016/j.jaad.2003.11.066
-
Geisse J, Caro I, Lindholm J, Golitz L, Stampone P, Owens M. Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: results from two Phase III, randomized, vehicle-controlled studies. J. Am. Acad. Dermatol. 50(5), 722-733 (2004). (Pubitemid 38580549)
-
(2004)
Journal of the American Academy of Dermatology
, vol.50
, Issue.5
, pp. 722-733
-
-
Geisse, J.1
Caro, I.2
Lindholm, J.3
Golitz, L.4
Stampone, P.5
Owens, M.6
-
84
-
-
33745555459
-
Imiquimod for actinic keratosis: Systematic review and meta-analysis
-
DOI 10.1038/sj.jid.5700264, PII 5700264
-
Hadley G, Derry S, Moore RA. Imiquimod for actinic keratosis: systematic review and meta-analysis. J. Invest. Dermatol. 126(6), 1251-1255 (2006). (Pubitemid 43997904)
-
(2006)
Journal of Investigative Dermatology
, vol.126
, Issue.6
, pp. 1251-1255
-
-
Hadley, G.1
Derry, S.2
Moore, R.A.3
-
85
-
-
50649093779
-
The use of TLR7 and TLR8 ligands for the enhancement of cancer immunotherapy
-
Smits EL, Ponsaerts P, Berneman ZN, Van Tendeloo VF. The use of TLR7 and TLR8 ligands for the enhancement of cancer immunotherapy. Oncologist 13(8), 859-875 (2008).
-
(2008)
Oncologist
, vol.13
, Issue.8
, pp. 859-875
-
-
Smits, E.L.1
Ponsaerts, P.2
Berneman, Z.N.3
Van Tendeloo, V.F.4
-
86
-
-
77958528420
-
Mechanisms regulating dendritic cell specification and development
-
Watowich SS, Liu YJ. Mechanisms regulating dendritic cell specification and development. Immunol. Rev. 238(1) 76-92 (2010).
-
(2010)
Immunol. Rev.
, vol.238
, Issue.1
, pp. 76-92
-
-
Watowich, S.S.1
Liu, Y.J.2
-
87
-
-
77957989419
-
Dendritic cells: Are they critically relevant
-
Palucka K, Ueno H, Roberts L, Fay J, Banchereau J. Dendritic cells: are they critically relevant? Cancer J. 16(4) 318-324 (2010).
-
(2010)
Cancer J.
, vol.16
, Issue.4
, pp. 318-324
-
-
Palucka, K.1
Ueno, H.2
Roberts, L.3
Fay, J.4
Banchereau, J.5
-
88
-
-
78650199162
-
Dendritic cells and immunity against cancer
-
Palucka K, Ueno H, Fay J, Banchereau J. Dendritic cells and immunity against cancer. J. Intern. Med. 269(1) 64-73 (2010).
-
(2010)
J. Intern. Med.
, vol.269
, Issue.1
, pp. 64-73
-
-
Palucka, K.1
Ueno, H.2
Fay, J.3
Banchereau, J.4
-
89
-
-
65249173447
-
Adoptive cell therapy for the treatment of patients with metastatic melanoma
-
Rosenberg SA, Dudley ME. Adoptive cell therapy for the treatment of patients with metastatic melanoma. Curr. Opin Immunol. 21(2), 233-240 (2009).
-
(2009)
Curr. Opin Immunol.
, vol.21
, Issue.2
, pp. 233-240
-
-
Rosenberg, S.A.1
Dudley, M.E.2
-
90
-
-
77951714425
-
Clinical responses in a Phase II study using adoptive transfer of short-term cultured tumor infiltration lymphocytes in metastatic melanoma patients
-
Besser MJ, Shapira-Frommer R, Treves AJ et al. Clinical responses in a Phase II study using adoptive transfer of short-term cultured tumor infiltration lymphocytes in metastatic melanoma patients. Clin. Cancer Res. 16(9), 2646-2655 (2010).
-
(2010)
Clin. Cancer Res.
, vol.16
, Issue.9
, pp. 2646-2655
-
-
Besser, M.J.1
Shapira-Frommer, R.2
Treves, A.J.3
-
91
-
-
77957606517
-
Successful treatment of melanoma brain metastases with adoptive cell therapy
-
Hong JJ, Rosenberg SA, Dudley ME et al. Successful treatment of melanoma brain metastases with adoptive cell therapy. Clin. Cancer Res. 16(19), 4892-4898 (2010).
-
(2010)
Clin. Cancer Res.
, vol.16
, Issue.19
, pp. 4892-4898
-
-
Hong, J.J.1
Rosenberg, S.A.2
Dudley, M.E.3
-
92
-
-
33749624177
-
Cancer regression in patients after transfer of genetically engineered lymphocytes
-
DOI 10.1126/science.1129003
-
Morgan RA, Dudley ME, Wunderlich JR et al. Cancer regression in patients after transfer of genetically engineered lymphocytes. Science 314(5796), 126-129 (2006). (Pubitemid 44547756)
-
(2006)
Science
, vol.314
, Issue.5796
, pp. 126-129
-
-
Morgan, R.A.1
Dudley, M.E.2
Wunderlich, J.R.3
Hughes, M.S.4
Yang, J.C.5
Sherry, R.M.6
Royal, R.E.7
Topalian, S.L.8
Kammula, U.S.9
Restifo, N.P.10
Zheng, Z.11
Nahvi, A.12
De Vries, C.R.13
Rogers-Freezer, L.J.14
Mavroukakis, S.A.15
Rosenberg, S.A.16
-
93
-
-
3442901908
-
Colony-stimulating factor-1 blockade by antisense oligonucleotides and small interfering RNAs suppresses growth of human mammary tumor xenografts in mice
-
DOI 10.1158/0008-5472.CAN-04-0961
-
Aharinejad S, Paulus P, Sioud M et al. Colony-stimulating factor 1 blockade by antisense oligonucleotides and small interfering RNAs suppresses growth of human mammary tumor xenografts in mice. Cancer Res. 64(15), 5378-5384 (2004). (Pubitemid 39006559)
-
(2004)
Cancer Research
, vol.64
, Issue.15
, pp. 5378-5384
-
-
Aharinejad, S.1
Paulus, P.2
Sioud, M.3
Hofmann, M.4
Zins, K.5
Schafer, R.6
Stanley, E.R.7
Abraham, D.8
-
94
-
-
33746926292
-
Clodronate-liposome-mediated depletion of tumour-associated macrophages: A new and highly effective antiangiogenic therapy approach
-
DOI 10.1038/sj.bjc.6603240, PII 6603240
-
Zeisberger SM, Odermatt B, Marty C, Zehnder Fjallman AH, Ballmer Hofer K, Schwendener RA. Clodronate-liposome-mediated depletion of tumour-associated macrophages: a new and highly effective antiangiogenic therapy approach. Br. J. Cancer 95(3), 272-281 (2006). (Pubitemid 44187587)
-
(2006)
British Journal of Cancer
, vol.95
, Issue.3
, pp. 272-281
-
-
Zeisberger, S.M.1
Odermatt, B.2
Marty, C.3
Zehnder-Fjallman, A.H.M.4
Ballmer-Hofer, K.5
Schwendener, R.A.6
-
95
-
-
42249115328
-
Targeting tumor-associated macrophages in an orthotopic murine model of diffuse malignant mesothelioma
-
DOI 10.1158/1535-7163.MCT-07-0579
-
Miselis NR, Wu ZJ, Van Rooijen N, Kane AB. Targeting tumor-associated macrophages in an orthotopic murine model of diffuse malignant mesothelioma. Mol. Cancer Ther. 7(4), 788-799 (2008). (Pubitemid 351551032)
-
(2008)
Molecular Cancer Therapeutics
, vol.7
, Issue.4
, pp. 788-799
-
-
Miselis, N.R.1
Wu, Z.J.2
Van Rooijen, N.3
Kane, A.B.4
-
96
-
-
49749146393
-
Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages
-
Hiraoka K, Zenmyo M, Watari K et al. Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages. Cancer Sci. 99(8), 1595-1602 (2008).
-
(2008)
Cancer Sci.
, vol.99
, Issue.8
, pp. 1595-1602
-
-
Hiraoka, K.1
Zenmyo, M.2
Watari, K.3
-
97
-
-
63049104211
-
Microenvironmental regulation of metastasis
-
Joyce JA, Pollard JW. Microenvironmental regulation of metastasis. Nat. Rev. Cancer 9(4), 239-252 (2009).
-
(2009)
Nat. Rev. Cancer
, vol.9
, Issue.4
, pp. 239-252
-
-
Joyce, J.A.1
Pollard, J.W.2
-
98
-
-
45149134605
-
Re-educating tumor-associated macrophages by targeting NF k B
-
Hagemann T, Lawrence T, McNeish I et al. "Re-educating" tumor-associated macrophages by targeting NF k B. J. Exp Med. 205(6),1261-1268 (2008).
-
(2008)
J. Exp Med.
, vol.205
, Issue.6
, pp. 1261-1268
-
-
Hagemann, T.1
Lawrence, T.2
McNeish, I.3
-
99
-
-
73649093148
-
Folate receptor b is expressed by tumor-associated macrophages and constitutes a marker for M2 anti-inflammatory/regulatory macrophages
-
Puig-Kroger A, Sierra-Filardi E, Dominguez-Soto A et al. Folate receptor b is expressed by tumor-associated macrophages and constitutes a marker for M2 anti-inflammatory/regulatory macrophages. Cancer Res. 69(24), 9395-9403 (2009).
-
(2009)
Cancer Res.
, vol.69
, Issue.24
, pp. 9395-9403
-
-
Puig-Kroger, A.1
Sierra-Filardi, E.2
Dominguez-Soto, A.3
-
100
-
-
68549104285
-
Targeting tumor-associated macrophages in an experimental glioma model with a recombinant immunotoxin to folate receptor b
-
Nagai T, Tanaka M, Tsuneyoshi Y et al. Targeting tumor-associated macrophages in an experimental glioma model with a recombinant immunotoxin to folate receptor b. Cancer Immunol. Immunother. 58(10), 1577-1586 (2009).
-
(2009)
Cancer Immunol. Immunother.
, vol.58
, Issue.10
, pp. 1577-1586
-
-
Nagai, T.1
Tanaka, M.2
Tsuneyoshi, Y.3
-
101
-
-
77955344402
-
Lipid accumulation and dendritic cell dysfunction in cancer
-
Herber DL Cao W, Nefedova Y et al. Lipid accumulation and dendritic cell dysfunction in cancer. Nat. Med. 16(8), 880-886 (2010).
-
(2010)
Nat. Med.
, vol.16
, Issue.8
, pp. 880-886
-
-
Herber, D.L.1
Cao, W.2
Nefedova, Y.3
-
102
-
-
38049181485
-
Reversion of immune tolerance in advanced malignancy: Modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function
-
Pan PY, Wang GX, Yin B et al. Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function. Blood 111(1), 219-228 (2008).
-
(2008)
Blood
, vol.111
, Issue.1
, pp. 219-228
-
-
Pan, P.Y.1
Wang, G.X.2
Yin, B.3
-
103
-
-
78649674576
-
Targeting immune suppressing myeloid-derived suppressor cells in oncology
-
Kao J, Ko EC, Eisenstein S, Sikora AG, Fu S, Chen SH. Targeting immune suppressing myeloid-derived suppressor cells in oncology. Crit. Rev. Oncol. Hematol. 77(1), 12-19 (2010).
-
(2010)
Crit. Rev. Oncol. Hematol.
, vol.77
, Issue.1
, pp. 12-19
-
-
Kao, J.1
Ko, E.C.2
Eisenstein, S.3
Sikora, A.G.4
Fu, S.5
Chen, S.H.6
-
104
-
-
65549141834
-
The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies
-
Ozao-Choy J, Ma G, Kao J et al. The novel role of tyrosine kinase inhibitor in the reversal of immune suppression and modulation of tumor microenvironment for immune-based cancer therapies. Cancer Res. 69(6), 2514-2522 (2009).
-
(2009)
Cancer Res.
, vol.69
, Issue.6
, pp. 2514-2522
-
-
Ozao-Choy, J.1
Ma, G.2
Kao, J.3
-
106
-
-
67349133537
-
Gemcitabine directly inhibits myeloid derived suppressor cells in BALB/c mice bearing 4T1 mammary carcinoma and augments expansion of T cells from tumor-bearing mice
-
Le HK, Graham L, Cha E, Morales JK, Manjili MH, Bear HD. Gemcitabine directly inhibits myeloid derived suppressor cells in BALB/c mice bearing 4T1 mammary carcinoma and augments expansion of T cells from tumor-bearing mice. Int. Immunopharmacol. 9(7-8), 900-909 (2009).
-
(2009)
Int. Immunopharmacol.
, vol.9
, Issue.7-8
, pp. 900-909
-
-
Le, H.K.1
Graham, L.2
Cha, E.3
Morales, J.K.4
Manjili, M.H.5
Bear, H.D.6
-
107
-
-
24944587964
-
Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors
-
DOI 10.1016/j.ccr.2005.08.002, PII S1535610805002606
-
De Palma M, Venneri Ma, Galli R et al. Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors. Cancer Cell 8(3), 211-226 (2005). (Pubitemid 41317592)
-
(2005)
Cancer Cell
, vol.8
, Issue.3
, pp. 211-226
-
-
De Palma, M.1
Venneri, M.A.2
Galli, R.3
Sergi, L.S.4
Politi, L.S.5
Sampaolesi, M.6
Naldini, L.7
-
108
-
-
21144454780
-
+ T cells to the antitumor immune response
-
DOI 10.1084/jem.20042167
-
Ercolini AM, Ladle BH, Manning EA et al. Recruitment of latent pools of high-avidity CD8(+) T cells to the antitumor immune response. J. Exp. Med. 201(10), 1591-1602 (2005). (Pubitemid 40723662)
-
(2005)
Journal of Experimental Medicine
, vol.201
, Issue.10
, pp. 1591-1602
-
-
Ercolini, A.M.1
Ladle, B.H.2
Manning, E.A.3
Pfannenstiel, L.W.4
Armstrong, T.D.5
Machiels, J.-P.H.6
Bieler, J.G.7
Emens, L.A.8
Reilly, R.T.9
Jaffee, E.M.10
-
109
-
-
36148939150
-
IL-2 immunotoxin denileukin diftitox reduces regulatory T cells and enhances vaccine-mediated T-cell immunity
-
DOI 10.1182/blood-2007-06-094615
-
Litzinger MT, Fernando R, Curiel TJ, Grosenbach DW, Schlom J, Palena C. IL 2 immunotoxin denileukin diftitox reduces regulatory T cells and enhances vaccine-mediated T cell immunity. Blood 110(9), 3192-3201 (2007). (Pubitemid 350106311)
-
(2007)
Blood
, vol.110
, Issue.9
, pp. 3192-3201
-
-
Litzinger, M.T.1
Fernando, R.2
Curiel, T.J.3
Grosenbach, D.W.4
Schlom, J.5
Palena, C.6
-
110
-
-
75149141334
-
CCL2 blockade augments cancer immunotherapy
-
Fridlender ZG, Buchlis G, Kapoor V et al. CCL2 blockade augments cancer immunotherapy. Cancer Res. 70(1), 109-118 (2010).
-
(2010)
Cancer Res.
, vol.70
, Issue.1
, pp. 109-118
-
-
Fridlender, Z.G.1
Buchlis, G.2
Kapoor, V.3
-
111
-
-
0033168037
-
Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor α) monoclonal antibody
-
Onizuka S, Tawara I, Shimizu J, Sakaguchi S, Fujita T, Nakayama E. Tumor rejection by in vivo administration of anti-CD25 (interleukin 2 receptor a) monoclonal antibody. Cancer Res. 59(13), 3128-3133 (1999). (Pubitemid 29316012)
-
(1999)
Cancer Research
, vol.59
, Issue.13
, pp. 3128-3133
-
-
Onizuka, S.1
Tawara, I.2
Shimizu, J.3
Sakaguchi, S.4
Fujita, T.5
Nakayama, E.6
-
112
-
-
25844517914
-
+ regulatory T cells
-
DOI 10.1084/jem.20050940
-
+ regulatory T cells. J. Exp. Med. 202(7), 885-891 (2005). (Pubitemid 41396888)
-
(2005)
Journal of Experimental Medicine
, vol.202
, Issue.7
, pp. 885-891
-
-
Ko, K.1
Yamazaki, S.2
Nakamura, K.3
Nishioka, T.4
Hirota, K.5
Yamaguchi, T.6
Shimizu, J.7
Nomura, T.8
Chiba, T.9
Sakaguchi, S.10
-
113
-
-
0029947568
-
Enhancement of antitumor immunity by CTLA-4 blockade
-
Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA 4 blockade. Science 271(5256), 1734-1736 (1996). (Pubitemid 26102823)
-
(1996)
Science
, vol.271
, Issue.5256
, pp. 1734-1736
-
-
Leach, D.R.1
Krummel, M.F.2
Allison, J.P.3
-
114
-
-
0344341626
-
Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients
-
DOI 10.1073/pnas.0830997100
-
Hodi FS, Mihm MC, Soiffer RJ et al. Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients. Proc. Natl Acad. Sci. USA 100(8), 4712-4717 (2003). (Pubitemid 36457795)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.8
, pp. 4712-4717
-
-
Hodi, F.S.1
Mihm, M.C.2
Soiffer, R.J.3
Haluska, F.G.4
Butler, M.5
Seiden, M.V.6
Davis, T.7
Henry-Spires, R.8
MacRae, S.9
Willman, A.10
Padera, R.11
Jaklitsch, M.T.12
Shankar, S.13
Chen, T.C.14
Korman, A.15
Allison, J.P.16
Dranoff, G.17
-
115
-
-
77953807455
-
T regulatory cells the evolution of targeted immunotherapy
-
Nizar S, Meyer B, Galustian C, Kumar D, Dalgleish A. T regulatory cells, the evolution of targeted immunotherapy. Biochim. Biophys. Acta 1806(1), 7-17 (2010).
-
(2010)
Biochim. Biophys. Acta
, vol.1806
, Issue.1
, pp. 7-17
-
-
Nizar, S.1
Meyer, B.2
Galustian, C.3
Kumar, D.4
Dalgleish, A.5
-
116
-
-
0038153907
-
Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
-
DOI 10.1073/pnas.1533209100
-
Phan GQ, Yang JC, Sherry RM et al. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc. Natl Acad. Sci. USA 100(14), 8372-8377 (2003). (Pubitemid 36842552)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.14
, pp. 8372-8377
-
-
Phan, G.Q.1
Yang, J.C.2
Sherry, R.M.3
Hwu, P.4
Topalian, S.L.5
Schwartzentruber, D.J.6
Restifo, N.P.7
Haworth, L.R.8
Seipp, C.A.9
Freezer, L.J.10
Morton, K.E.11
Mavroukakis, S.A.12
Duray, P.H.13
Steinberg, S.M.14
Allison, J.P.15
Davis, T.A.16
Rosenberg, S.A.17
-
117
-
-
33645286546
-
Regulatory T cells tumour immunity and immunotherapy
-
Zou W. Regulatory T cells, tumour immunity and immunotherapy. Nat. Rev. Immunol. 6(4), 295-307 (2006).
-
(2006)
Nat. Rev. Immunol.
, vol.6
, Issue.4
, pp. 295-307
-
-
Zou, W.1
-
118
-
-
0023930413
-
+ suppressor-inducer T-cells
-
Berd D, Mastrangelo MJ. Effect of low dose cyclophosphamide on the immune system of cancer patients: depletion of CD4+, 2H4+ suppressor-inducer T cells. Cancer Res. 48(6), 1671-1675 (1988). (Pubitemid 18091225)
-
(1988)
Cancer Research
, vol.48
, Issue.6
, pp. 1671-1675
-
-
Berd, D.1
Mastrangelo, M.J.2
-
119
-
-
27544457676
-
Addressing the fas counterattack controversy: Blocking fas ligand expression suppresses tumor immune evasion of colon cancer in vivo
-
DOI 10.1158/0008-5472.CAN-05-1462
-
Ryan AE, Shanahan F, O'Connell J, Houston AM. Addressing the "Fas counterattack" controversy: blocking fas ligand expression suppresses tumor immune evasion of colon cancer in vivo. Cancer Res. 65(21), 9817-9823 (2005). (Pubitemid 41541459)
-
(2005)
Cancer Research
, vol.65
, Issue.21
, pp. 9817-9823
-
-
Ryan, A.E.1
Shanahan, F.2
O'Connell, J.3
Houston, A.M.4
-
121
-
-
13444270323
-
Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity
-
Hirano F, Kaneko K, Tamura H et al. Blockade of B7 H1 and PD 1 by monoclonal antibodies potentiates cancer therapeutic immunity. Cancer Res. 65(3), 1089-1096 (2005). (Pubitemid 40216472)
-
(2005)
Cancer Research
, vol.65
, Issue.3
, pp. 1089-1096
-
-
Hirano, F.1
Kaneko, K.2
Tamura, H.3
Dong, H.4
Wang, S.5
Ichikawa, M.6
Rietz, C.7
Flies, D.B.8
Lau, J.S.9
Zhu, G.10
Tamada, K.11
Chen, L.12
-
122
-
-
49649114804
-
Phase I safety and pharmacokinetic study of CT-011 a humanized antibody interacting with PD 1 in patients with advanced hematologic malignancies
-
Berger R, Rotem-Yehudar R, Slama G et al. Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD 1, in patients with advanced hematologic malignancies. Clin. Cancer Res. 14(10), 3044-3051 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, Issue.10
, pp. 3044-3051
-
-
Berger, R.1
Rotem-Yehudar, R.2
Slama, G.3
-
123
-
-
18544380239
-
Tumor-associated B7 H1 promotes T cell apoptosis: A potential mechanism of immune evasion
-
Dong H, Strome SE, Salomao DR et al. Tumor-associated B7 H1 promotes T cell apoptosis: a potential mechanism of immune evasion. Nat. Med. 8(8), 793-800 (2002).
-
(2002)
Nat. Med.
, vol.8
, Issue.8
, pp. 793-800
-
-
Dong, H.1
Strome, S.E.2
Salomao, D.R.3
-
124
-
-
50649093779
-
The use of TLR7 and TLR8 ligands for the enhancement of cancer immunotherapy
-
Smits EL, Ponsaerts P, Bernerman ZM, Van Tendeloo VF. The use of TLR7 and TLR8 ligands for the enhancement of cancer immunotherapy. Oncologist 13(8), 859-875 (2008).
-
(2008)
Oncologist
, vol.13
, Issue.8
, pp. 859-875
-
-
Smits, E.L.1
Ponsaerts, P.2
Bernerman, Z.M.3
Van Tendeloo, V.F.4
-
125
-
-
0038783532
-
The imidazoquinolines and their place in the therapy of cutaneous disease
-
DOI 10.1517/eoph.4.7.1105.21069
-
Smith KJ, Hamza S, Skelton H. The imidazoquinolines and their place in the therapy of cutaneous disease. Exp. Opin Pharmacother. 4(7), 1105-1119 (2003). (Pubitemid 36857192)
-
(2003)
Expert Opinion on Pharmacotherapy
, vol.4
, Issue.7
, pp. 1105-1119
-
-
Smith, K.J.1
Hamza, S.2
Skelton, H.3
-
126
-
-
77953212611
-
Structure-activity relationship in human toll-like receptor 7-active imideazoquinoline analogues
-
Shukla NM, Malladi SS, Mutz CA et al. Structure-activity relationship in human toll-like receptor 7-active imideazoquinoline analogues. J. Med. Chem. 53(11), 4450-4465 (2010).
-
(2010)
J. Med. Chem.
, vol.53
, Issue.11
, pp. 4450-4465
-
-
Shukla, N.M.1
Malladi, S.S.2
Mutz, C.A.3
-
127
-
-
78449243490
-
Anti-CTLA 4 therapy: Immune monitoring during clinical development of a novel immunotherapy
-
Callahan MK, Wolchok JD, Allison JP. Anti-CTLA 4 therapy: immune monitoring during clinical development of a novel immunotherapy. Semin. Oncol. 37(5), 473-484 (2010).
-
(2010)
Semin. Oncol.
, vol.37
, Issue.5
, pp. 473-484
-
-
Callahan, M.K.1
Wolchok, J.D.2
Allison, J.P.3
-
128
-
-
77953464932
-
Targeting cytotoxic T lymphocyte antigen 4 in immunotherapies for melanoma and other cancers
-
Page DB, Yuan J, Wolchok JD. Targeting cytotoxic T lymphocyte antigen 4 in immunotherapies for melanoma and other cancers. Immunotherapy 2(3), 367-379 (2010).
-
(2010)
Immunotherapy
, vol.2
, Issue.3
, pp. 367-379
-
-
Page, D.B.1
Yuan, J.2
Wolchok, J.D.3
-
129
-
-
80755141842
-
Effect of ipilimumab treatment on 18 month survival: Update of patients pts with advanced melanoma treated with 10 mg/kg ipilimumab in three Phase II clinical trials
-
Orlando, FL, USA, 29 May-2 June 2009.
-
O'Day S, Weber J, Lebbe C et al. Effect of ipilimumab treatment on 18 month survival: update of patients (pts) with advanced melanoma treated with 10 mg/kg ipilimumab in three Phase II clinical trials. Presented at: 2009 ASCO Annual Meeting. Orlando, FL, USA, 29 May-2 June 2009.
-
Presented at:1 2009 ASCO Annual Meeting
-
-
O'Day, S.1
Weber, J.2
Lebbe, C.3
-
130
-
-
33751249635
-
The chemokine network: A target in cancer biology?
-
DOI 10.1016/j.addr.2006.03.012, PII S0169409X06001414
-
Slettenaar VI, Wilson JL. The chemokine network: a target in cancer biology? Adv. Drug Deliv. Rev. 58(8), 962-974 (2006). (Pubitemid 44780906)
-
(2006)
Advanced Drug Delivery Reviews
, vol.58
, Issue.8
, pp. 962-974
-
-
Slettenaar, V.I.F.1
Wilson, J.L.2
-
131
-
-
2342591450
-
The significance of cancer cell expression of the chemokine receptor CXCR4
-
DOI 10.1016/j.semcancer.2003.10.003, PII S1044579X03000981
-
Balkwill F. The significance of cancer cell expression of the chemokine receptor CXCR4. Semin. Cancer Biol. 14(3), 171-179 (2004). (Pubitemid 38586742)
-
(2004)
Seminars in Cancer Biology
, vol.14
, Issue.3
, pp. 171-179
-
-
Balkwill, F.1
-
132
-
-
33845348208
-
P53 attenuates cancer cell migration and invasion through repression of SDF-1/CXCL12 expression in stromal fibroblasts
-
DOI 10.1158/0008-5472.CAN-06-2323
-
Moskovits N, Kalinkovich A, Bar J, Lapidot T, Oren M. p53 Attenuates cancer cell migration and invasion through repression of SDF-1/CXCL12 expression in stromal fibroblasts. Cancer Res. 66(22), 10671-10676 (2006). (Pubitemid 44876961)
-
(2006)
Cancer Research
, vol.66
, Issue.22
, pp. 10671-10676
-
-
Moskovits, N.1
Kalinkovich, A.2
Bar, J.3
Lapidot, T.4
Oren, M.5
-
133
-
-
35148852659
-
Targeting CCL2 with systemic delivery of neutralizing antibodies induces prostate cancer tumor regression in vivo
-
DOI 10.1158/0008-5472.CAN-07-1286
-
Loberg RD, Ying C, Craig M et al. Targeting CCL2 with systemic delivery of neutralizing antibodies induces prostate cancer tumor regression in vivo. Cancer Res. 67(19), 9417-9424 (2007). (Pubitemid 47535932)
-
(2007)
Cancer Research
, vol.67
, Issue.19
, pp. 9417-9424
-
-
Loberg, R.D.1
Ying, C.2
Craig, M.3
Day, L.L.4
Sargent, E.5
Neeley, C.6
Wojno, K.7
Snyder, L.A.8
Yan, L.9
Pienta, K.J.10
-
134
-
-
54049101977
-
A central role for tumor-derived monocyte chemoattractant protein-1 in malignant pleural effusion
-
Stathopoulos GT, Psallidas I, Moustaki A et al. A central role for tumor-derived monocyte chemoattractant protein-1 in malignant pleural effusion. J. Natl Cancer Inst. 100(20), 1464-1476 (2008).
-
(2008)
J. Natl Cancer Inst.
, vol.100
, Issue.20
, pp. 1464-1476
-
-
Stathopoulos, G.T.1
Psallidas, I.2
Moustaki, A.3
-
135
-
-
77949329326
-
Chemokines and chemokine receptors: New insights into cancer-related inflammation
-
Lazennec G, Richmond A. Chemokines and chemokine receptors: new insights into cancer-related inflammation. Trends Mol. Med. 16(3), 133-144 (2010).
-
(2010)
Trends Mol. Med.
, vol.16
, Issue.3
, pp. 133-144
-
-
Lazennec, G.1
Richmond, A.2
-
136
-
-
50049089470
-
Tumor immunotherapy in melanoma: Strategies for overcoming mechanisms of resistance and escape
-
Zigler M, Villares GJ, Lev DC, Melnikova VO, Bar-Eli M. Tumor immunotherapy in melanoma: strategies for overcoming mechanisms of resistance and escape. Am. J. Clin. Dermatol. 9(5), 307-311 (2008).
-
(2008)
Am. J. Clin. Dermatol.
, vol.9
, Issue.5
, pp. 307-311
-
-
Zigler, M.1
Villares, G.J.2
Lev, D.C.3
Melnikova, V.O.4
Bar-Eli, M.5
-
137
-
-
0034770605
-
Immune-mediated eradication of tumors through the blockade of transforming growth factor-β signaling in T cells
-
DOI 10.1038/nm1001-1118
-
Gorelik L, Flavell RA. Immune-mediated eradication of tumors through the blockade of transforming growth factor b signaling in T cells. Nat. Med. 7(10), 1118-1122 (2001). (Pubitemid 33010019)
-
(2001)
Nature Medicine
, vol.7
, Issue.10
, pp. 1118-1122
-
-
Gorelink, L.1
Flavell, R.A.2
-
138
-
-
0034880059
-
+ T-regulatory cells and systemic collapse of antitumour immunity
-
DOI 10.1046/j.1365-2567.2001.01279.x
-
Seo N, Hayakawa S, Takigawa M, Tokura Y. Interleukin 10 expressed at early tumour sites induces subsequent generation of CD4(+) T regulatory cells and systemic collapse of antitumour immunity. Immunology 103(4), 449-457 (2001). (Pubitemid 32744391)
-
(2001)
Immunology
, vol.103
, Issue.4
, pp. 449-457
-
-
Seo, N.1
Hayakawa, S.2
Takigawa, M.3
Tokura, Y.4
-
139
-
-
55149094739
-
Interleukin 10: New perspectives on an old cytokine
-
Mosser DM, Zhang X. Interleukin 10: new perspectives on an old cytokine. Immunol. Rev. 226, 205-218 (2008).
-
(2008)
Immunol. Rev.
, vol.226
, pp. 205-218
-
-
Mosser, D.M.1
Zhang, X.2
-
140
-
-
45549085803
-
An anti-transforming growth factor b antibody suppresses metastasis via cooperative effects on multiple cell compartments
-
Nam JS, Terabe M, Mamura M et al. An anti-transforming growth factor b antibody suppresses metastasis via cooperative effects on multiple cell compartments. Cancer Res. 68(10), 3835-3843 (2008).
-
(2008)
Cancer Res.
, vol.68
, Issue.10
, pp. 3835-3843
-
-
Nam, J.S.1
Terabe, M.2
Mamura, M.3
-
141
-
-
33845684545
-
TGF-β2 inhibition augments the effect of tumor vaccine and improves the survival of animals with pre-established brain tumors
-
DOI 10.1007/s11060-006-9222-1
-
Liu Y, Wang Q, Kleinschmidt Demasters BK, Franzusoff A, Ng KY, Lillehei KO. TGF β inhibition augments the effect of tumor vaccine and improves the survival of animals with pre-established brain tumors. J. Neurooncol. 81(2), 149-162 (2007). (Pubitemid 44963973)
-
(2007)
Journal of Neuro-Oncology
, vol.81
, Issue.2
, pp. 149-162
-
-
Liu, Y.1
Wang, Q.2
Kleinschmidt-DeMasters, B.K.3
Franzusoff, A.4
Ng, K.-Y.5
Lillehei, K.O.6
-
142
-
-
67650077101
-
Modulation of TGF β activity by latent TGF β-binding protein 1 in human malignant glioma cells
-
Tritschler I, Gramatzki D, Capper D et al. Modulation of TGF β activity by latent TGF β-binding protein 1 in human malignant glioma cells. Int. J. Cancer 125(3), 530-540 (2009).
-
(2009)
Int. J. Cancer
, vol.125
, Issue.3
, pp. 530-540
-
-
Tritschler, I.1
Gramatzki, D.2
Capper, D.3
-
144
-
-
68549123632
-
Cytokine gene polymorphisms are associated with risk of urinary bladder cancer and recurrence after BCG immunotherapy
-
Ahirwar DK, Agrahari A, Mandhani A, Mittal RD. Cytokine gene polymorphisms are associated with risk of urinary bladder cancer and recurrence after BCG immunotherapy. Biomarkers 14(4), 213-218 (2009).
-
(2009)
Biomarkers
, vol.14
, Issue.4
, pp. 213-218
-
-
Ahirwar, D.K.1
Agrahari, A.2
Mandhani, A.3
Mittal, R.D.4
-
145
-
-
33749239193
-
Cytokine gene polymorphisms can alter the effect of Bacillus Calmette-Guérin (BCG) immunotherapy
-
DOI 10.1016/j.cyto.2006.06.009, PII S1043466606001931
-
Basturk B, Yavascaoglu I, Oral B, Goral G, Oktay B. Cytokine gene polymorphisms can alter the effect of Bacillus Calmette-Guerin (BCG) immunotherapy. Cytokine 35(1-2), 1-5 (2006). (Pubitemid 44485528)
-
(2006)
Cytokine
, vol.35
, Issue.1-2
, pp. 1-5
-
-
Basturk, B.1
Yavascaoglu, I.2
Oral, B.3
Goral, G.4
Oktay, B.5
-
146
-
-
47549090432
-
TGF β in cancer
-
Massague J. TGF β in cancer. Cell 134(2), 215-230 (2008).
-
(2008)
Cell
, vol.134
, Issue.2
, pp. 215-230
-
-
Massague, J.1
-
147
-
-
7444226411
-
SD-208, a novel transforming growth factor β receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo
-
DOI 10.1158/0008-5472.CAN-04-1013
-
Uhl M, Aulwurm S, Wischhusen J et al. SD 208, a novel transforming growth factor b receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo. Cancer Res. 64(21), 7954-7961 (2004). (Pubitemid 39446929)
-
(2004)
Cancer Research
, vol.64
, Issue.21
, pp. 7954-7961
-
-
Uhl, M.1
Aulwurm, S.2
Wischhusen, J.3
Weiler, M.4
Ma, J.Y.5
Almirez, R.6
Mangadu, R.7
Liu, Y.-W.8
Platten, M.9
Herrlinger, U.10
Murphy, A.11
Wong, D.H.12
Wick, W.13
Higgins, L.S.14
Weller, M.15
-
148
-
-
5644248080
-
RNA interference targeting transforming growth factor-β enhances NKG2D-mediated antiglioma immune response, inhibits glioma cell migration and invasiveness, and abrogates tumorigenicity in vivo
-
DOI 10.1158/0008-5472.CAN-04-1627
-
Friese MA, Wischhusen J, Wick W et al. RNA interference targeting transforming growth factor b enhances NKG2D-mediated antiglioma immune response, inhibits glioma cell migration and invasiveness, and abrogates tumorigenicity in vivo. Cancer Res. 64(20), 7596-7603 (2004). (Pubitemid 39372105)
-
(2004)
Cancer Research
, vol.64
, Issue.20
, pp. 7596-7603
-
-
Friese, M.A.1
Wischhusen, J.2
Wick, W.3
Weiler, M.4
Eisele, G.5
Steinle, A.6
Weller, M.7
-
149
-
-
77954129034
-
+ T cells infiltrating prostatic tumors are induced to become suppressor cells
-
+ T cells infiltrating prostatic tumors are induced to become suppressor cells. J. Immunol 183(8), 4848-4852 (2009).
-
(2009)
J. Immunol.
, vol.183
, Issue.8
, pp. 4848-4852
-
-
Shafer-Weaver, K.A.1
Anderson, M.J.2
Stagliano, K.3
Malyguine, A.4
Greenberg, N.M.5
Hurwitz, A.A.6
-
150
-
-
0037446966
-
Transforming growth factor β inhibits the antigen-presenting functions and antitumor activity of dendritic cell vaccines
-
Kobie JJ, Wu RS, Kurt RA et al. Transforming growth factor b inhibits the antigen-presenting functions and antitumor activity of dendritic cell vaccines. Cancer Res. 63(8), 1860-1864 (2003). (Pubitemid 36460849)
-
(2003)
Cancer Research
, vol.63
, Issue.8
, pp. 1860-1864
-
-
Kobie, J.J.1
Wu, R.S.2
Kurt, R.A.3
Lou, S.4
Adelman, M.K.5
Whitesell, L.J.6
Ramanathapuram, L.V.7
Arteaga, C.L.8
Akporiaye, E.T.9
-
152
-
-
68849083767
-
TGF β can leave you breathless
-
Qian Bf, Wahl SM. TGF β can leave you breathless. Curr. Opin Pharmacol. 9(4), 454-461 (2009).
-
(2009)
Curr. Opin Pharmacol.
, vol.9
, Issue.4
, pp. 454-461
-
-
Qian, B.F.1
Wahl, S.M.2
-
153
-
-
64849111865
-
Targeting STAT3 in cancer: How successful are we
-
Yue P, Turkson J. Targeting STAT3 in cancer: how successful are we? Exp. Opin Investig. Drugs 18(1), 45-56 (2009).
-
(2009)
Exp. Opin Investig. Drugs
, vol.18
, Issue.1
, pp. 45-56
-
-
Yue, P.1
Turkson, J.2
-
154
-
-
5444237088
-
STAT proteins as novel targets for cancer drug discovery
-
DOI 10.1517/14728222.8.5.409
-
Turkson J. STAT proteins as novel targets for cancer drug discovery. Exp. Opin Ther. Targets 8, 409-422 (2004). (Pubitemid 39359648)
-
(2004)
Expert Opinion on Therapeutic Targets
, vol.8
, Issue.5
, pp. 409-422
-
-
Turkson, J.1
-
155
-
-
1042302005
-
The stats of cancer - New molecular targets come of age
-
Yu H, Jove R. The STATs of cancer: new molecular targets come of age. Nat. Rev. Cancer 4, 97-105 (2004). (Pubitemid 38198738)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.2
, pp. 97-105
-
-
Yu, H.1
Jove, R.2
-
156
-
-
20944441928
-
Validating STAT3 in cancer therapy
-
Darnell JE. Validating STAT3 in cancer therapy. Nat. Med. 11, 595-596 (2005).
-
(2005)
Nat. Med.
, vol.11
, pp. 595-596
-
-
Darnell, J.E.1
-
157
-
-
33845865825
-
Crosstalk between cancer and immune cells: Role of STAT3 in the tumour microenvironment
-
DOI 10.1038/nri1995, PII NRI1995
-
Yu H, Kortylewski M, Pardoll D. Crosstalk between cancer and immune cells: role of STAT3 in the tumour microenvironment. Nat. Rev. Immunol. 7(1), 41-51 (2007). (Pubitemid 46020826)
-
(2007)
Nature Reviews Immunology
, vol.7
, Issue.1
, pp. 41-51
-
-
Yu, H.1
Kortylewski, M.2
Pardoll, D.3
-
158
-
-
1442285917
-
Inactivation of Stat3 in tumor cells: Releasing a brake on immune responses against cancer?
-
DOI 10.1016/S1535-6108(04)00028-5, PII S1535610804000285
-
Gamero AM, Young HA, Wiltrout RH. Inactivation of Stat3 in tumor cells: releasing a brake on immune responses against cancer? Cancer Cell 5(2), 111-112 (2004). (Pubitemid 38283795)
-
(2004)
Cancer Cell
, vol.5
, Issue.2
, pp. 111-112
-
-
Gamero, A.M.1
Young, H.A.2
Wiltrout, R.H.3
-
159
-
-
0032984589
-
Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
-
DOI 10.1016/S1074-7613(00)80011-4
-
Catlett-Falcone R, Landowski TH, Oshiro MM et al. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells. Immunity 10(1), 105-115 (1999). (Pubitemid 29077388)
-
(1999)
Immunity
, vol.10
, Issue.1
, pp. 105-115
-
-
Catlett-Falcone, R.1
Landowski, T.H.2
Oshiro, M.M.3
Turkson, J.4
Levitzki, A.5
Savino, R.6
Ciliberto, G.7
Moscinski, L.8
Fernandez-Luna, J.L.9
Nunez, G.10
Dalton, W.S.11
Jove, R.12
-
160
-
-
21544473172
-
Targeting STAT3 affects melanoma on multiple fronts
-
DOI 10.1007/s10555-005-1580-1
-
Kortylewski M, Jove R, Yu H. Targeting STAT3 affects melanoma on multiple fronts. Cancer Metastasis Rev. 24(2), 315-327 (2005). (Pubitemid 40922802)
-
(2005)
Cancer and Metastasis Reviews
, vol.24
, Issue.2
, pp. 315-327
-
-
Kortylewski, M.1
Jove, R.2
Yu, H.3
-
161
-
-
24644457736
-
Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways
-
DOI 10.1038/sj.onc.1208719, PII 1208719
-
Xu Q, Briggs J, Park S et al. Targeting Stat3 blocks both HIF 1 and VEGF expression induced by multiple oncogenic growth signaling pathways. Oncogene 24(36), 5552-5560 (2005). (Pubitemid 43119350)
-
(2005)
Oncogene
, vol.24
, Issue.36
, pp. 5552-5560
-
-
Xu, Q.1
Briggs, J.2
Park, S.3
Niu, G.4
Kortylewski, M.5
Zhang, S.6
Gritsko, T.7
Turkson, J.8
Kay, H.9
Semenza, G.L.10
Cheng, J.Q.11
Jove, R.12
Yu, H.13
-
162
-
-
42149111675
-
Inhibition of STAT3 promotes the efficacy of adoptive transfer therapy using type-1 CTLs by modulation of the immunological microenvironment in a murine intracranial glioma
-
Fujita M, Zhu X, Sasaki K et al. Inhibition of STAT3 promotes the efficacy of adoptive transfer therapy using type-1 CTLs by modulation of the immunological microenvironment in a murine intracranial glioma. J. Immunol. 180(4), 2089-2098 (2008).
-
(2008)
J. Immunol.
, vol.180
, Issue.4
, pp. 2089-2098
-
-
Fujita, M.1
Zhu, X.2
Sasaki, K.3
-
163
-
-
3543055012
-
Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity
-
Turkson J, Kim JS, Zhang S et al. Novel peptidomimetic inhibitors of signal transducer and activator of transcription 3 dimerization and biological activity. Mol. Cancer Ther. 3(3), 261-269 (2004). (Pubitemid 39193701)
-
(2004)
Molecular Cancer Therapeutics
, vol.3
, Issue.3
, pp. 261-269
-
-
Turkson, J.1
Kim, J.S.2
Zhang, S.3
Yuan, J.4
Huang, M.5
Glenn, M.6
Haura, E.7
Sebti, S.8
Hamilton, A.D.9
Jove, R.10
-
164
-
-
38649129118
-
An oxazole-based small-molecule stat3 inhibitor modulates stat3 stability and processing and induces antitumor cell effects
-
DOI 10.1021/cb7001973
-
Siddiquee KA, Gunning PT, Glenn M et al. An oxazole-based small molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects. ACS Chem. Biol. 2, 787-798 (2007). (Pubitemid 351166054)
-
(2007)
ACS Chemical Biology
, vol.2
, Issue.12
, pp. 787-798
-
-
Siddiquee, K.A.Z.1
Gunning, P.T.2
Glen, M.3
Katt, W.P.4
Zhang, S.5
Schroeck, C.6
Sebti, S.M.7
Jove, R.8
Hamilton, A.D.9
Turkson, J.10
-
165
-
-
3543070089
-
The interaction of specific peptide aptamers with the DNA binding domain and the dimerization domain of the transcription factor Stat3 inhibits transactivation and induces apoptosis in tumor cells
-
Nagel-Wolfrum K, Buerger C, Wittig I, Butz K, Hoppe-Sevler F, Groner B. The interaction of specific peptide aptamers with the DNA binding domain of the transcription factor Stat3 inhibits transactivation and induces apoptosis in tumor cells. Mol. Cancer Res. 2(3), 170-182 (2004). (Pubitemid 39030307)
-
(2004)
Molecular Cancer Research
, vol.2
, Issue.3
, pp. 170-182
-
-
Nagel-Wolfrum, K.1
Buerger, C.2
Wittig, I.3
Butz, K.4
Hoppe-Seyler, F.5
Groner, B.6
-
166
-
-
16344380754
-
A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells
-
DOI 10.1073/pnas.0409894102
-
Song H, Wang R, Wang S, Lin J. A low molecular weight compound discovered through virtual data base screening inhibits Stat3 function in breast cancer cells. Proc. Natl Acad. Sci. USA 102(13), 4700-4705 (2005). (Pubitemid 40471517)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.13
, pp. 4700-4705
-
-
Song, H.1
Wang, R.2
Wang, S.3
Lin, J.4
-
167
-
-
25444513779
-
A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells
-
DOI 10.1074/jbc.M502694200
-
Turkson J, Zhang S Mora LB, Burns A, Sebti S, Jove R. A novel platinum compound inhibits constitutive Stat3 signaling and induces cell cycle arrest and apoptosis of malignant cells. J. Biol. Chem. 280(38), 32979-32988 (2005). (Pubitemid 41368347)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.38
, pp. 32979-32988
-
-
Turkson, J.1
Zhang, S.2
Mora, L.B.3
Burns, A.4
Sebti, S.5
Jove, R.6
-
168
-
-
12344328541
-
Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity
-
Turkson J, Zhang S, Palmer J et al. Inhibition of constitutive signal transducer and activator of transcription 3 activation by novel platinum complexes with potent antitumor activity. Mol. Cancer Ther. 3(12), 1533-1542 (2004). (Pubitemid 40136708)
-
(2004)
Molecular Cancer Therapeutics
, vol.3
, Issue.12
, pp. 1533-1542
-
-
Turkson, J.1
Zhang, S.2
Palmer, J.3
Kay, H.4
Stanko, J.5
Mora, L.B.6
Sebti, S.7
Yu, H.8
Jove, R.9
-
169
-
-
24344455107
-
Down-regulation of signal transducer and activator of transcription 3 expression using vector-based small interfering RNAs suppresses growth of human prostate tumor in vivo
-
DOI 10.1158/1078-0432.CCR-05-0148
-
Gao L, Zhang L, Hu J et al. Down-regulation of signal transducer and activator of transcription 3 expression using vector-based small interfering RNA suppresses growth of human prostate tumor in vivo. Clin. Cancer Res. 11(17), 6333-6341 (2005). (Pubitemid 41262965)
-
(2005)
Clinical Cancer Research
, vol.11
, Issue.17
, pp. 6333-6341
-
-
Gao, L.1
Zhang, L.2
Hu, J.3
Li, F.4
Shao, Y.5
Zhao, D.6
Kalvakolanu, D.V.7
Kopecko, D.J.8
Zhao, X.9
Xu, D.-Q.10
-
170
-
-
34748831139
-
Therapeutic effects of STAT3 decoy oligodeoxynucleotide on human lung cancer in xenograft mice
-
Zhang X, Zhang J, Wang L et al. Therapeutic effects of STAT3 decoy oligodeoxynucleotide on human lung cancer in xenograft mice. BMC Cancer 7, 149-159 (2007).
-
(2007)
BMC Cancer
, vol.7
, pp. 149-159
-
-
Zhang, X.1
Zhang, J.2
Wang, L.3
-
171
-
-
0037444373
-
Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice
-
Blaskovich MA, Sun J, Cantor A Turkson J, Jove R, Sebti SM. Discovery of JSI 124 (cucurbitacin 1), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. Cancer Res. 63(6), 1270-1279 (2003). (Pubitemid 36348705)
-
(2003)
Cancer Research
, vol.63
, Issue.6
, pp. 1270-1279
-
-
Blaskovich, M.A.1
Sun, J.2
Cantor, A.3
Turkson, J.4
Jove, R.5
Sebti, S.M.6
-
172
-
-
33645464650
-
Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein
-
Kotha A, Sekharam M, Cilenti L et al. Resveratrol inhibits Src and Stat3 signaling and induces the apoptosis of malignant cells containing activated Stat3 protein. Mol. Cancer Ther. 5(3), 621-629 (2006).
-
(2006)
Mol. Cancer Ther.
, vol.5
, Issue.3
, pp. 621-629
-
-
Kotha, A.1
Sekharam, M.2
Cilenti, L.3
-
173
-
-
0141955061
-
Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells
-
Bharti AC, Donato N, Aggarwal BB. Curcumin (diferuloylmethane) inhibits constitutive and IL 6-inducible STAT3 phosphorylation in human multiple myeloma cells. J. Immunol. 171(7), 3863-3871 (2003). (Pubitemid 37254592)
-
(2003)
Journal of Immunology
, vol.171
, Issue.7
, pp. 3863-3871
-
-
Bharti, A.C.1
Donato, N.2
Aggarwal, B.B.3
-
174
-
-
78650356983
-
Effects of siltuximab on the IL 6-induced signaling pathway in ovarian cancer
-
Guo Y, Nemeth J, O'Brien C et al. Effects of siltuximab on the IL 6-induced signaling pathway in ovarian cancer. Clin. Cancer Res. 16(23), 5759-5769 (2010).
-
(2010)
Clin. Cancer Res.
, vol.16
, Issue.23
, pp. 5759-5769
-
-
Guo, Y.1
Nemeth, J.2
O'Brien, C.3
-
175
-
-
77956627676
-
Structure-based design and conformationally constraned cell-permeable STAT3 inhibitors
-
Chen J, Bai L, Bernard D et al. Structure-based design and conformationally constraned cell-permeable STAT3 inhibitors. ACS Med. Chem. Lett. 1(2) 85-89 (2010).
-
(2010)
ACS Med. Chem. Lett.
, vol.1
, Issue.2
, pp. 85-89
-
-
Chen, J.1
Bai, L.2
Bernard, D.3
-
176
-
-
77649178678
-
A novel small molecule disrupts STAT3 SH2 domain-phosphotyrosine interaction and STAT-dependent tumor processes
-
Zhang X, Yue P, Fletcher S, Zhao N, Gunning PT, Turkson J. A novel small molecule disrupts STAT3 SH2 domain-phosphotyrosine interaction and STAT-dependent tumor processes. Biochem. Pharmacol. 79(10), 1398-1409 (2010).
-
(2010)
Biochem. Pharmacol.
, vol.79
, Issue.10
, pp. 1398-1409
-
-
Zhang, X.1
Yue, P.2
Fletcher, S.3
Zhao, N.4
Gunning, P.T.5
Turkson, J.6
-
177
-
-
77956238512
-
Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL 6 in human liver cancer cells
-
Liu Y, Li PK, Lin J. Inhibition of STAT3 signaling blocks the anti-apoptotic activity of IL 6 in human liver cancer cells. J. Biol. Chem. 285(35), 27249-27439 (2010).
-
(2010)
J. Biol. Chem.
, vol.285
, Issue.35
, pp. 27249-27439
-
-
Liu, Y.1
Li, P.K.2
Lin, J.3
-
178
-
-
77950595599
-
Targeting the transforming growth factor b signalling pathway in metastatic cancer
-
Korpal M, Kang Y. Targeting the transforming growth factor b signalling pathway in metastatic cancer. Eur. J. Cancer 46(7), 1232-1240 (2010).
-
(2010)
Eur. J. Cancer
, vol.46
, Issue.7
, pp. 1232-1240
-
-
Korpal, M.1
Kang, Y.2
-
179
-
-
34247552726
-
Stat3 as a potential target for cancer immunotherapy
-
DOI 10.1097/01.cji.0000211327.76266.65, PII 0000237120070200000001
-
Kortylewski M, Yu H. Stat3 as a potential target for cancer immunotherapy. J. Immunother. 30(2), 131-139 (2007). (Pubitemid 46667794)
-
(2007)
Journal of Immunotherapy
, vol.30
, Issue.2
, pp. 131-139
-
-
Kortylewski, M.1
Yu, H.2
-
180
-
-
0032555614
-
Prevention of allogeneic fetal rejection by tryptophan catabolism
-
Munn DH, Zhou M, Attwood JT et al. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 281(5380), 1191-1193 (1998). (Pubitemid 28406294)
-
(1998)
Science
, vol.281
, Issue.5380
, pp. 1191-1193
-
-
Munn, D.H.1
Zhou, M.2
Attwood, J.T.3
Bondarev, I.4
Conway, S.J.5
Marshall, B.6
Brown, C.7
Mellor, A.L.8
-
181
-
-
71049176625
-
Role of IDO in organ transplantation: Promises and difficulties
-
Lob S, Konigsrainer A. Role of IDO in organ transplantation: promises and difficulties. Int. Rev. Immunol. 28(3-4), 185-206 (2009).
-
(2009)
Int. Rev. Immunol.
, vol.28
, Issue.3-4
, pp. 185-206
-
-
Lob, S.1
Konigsrainer, A.2
-
182
-
-
67649432744
-
Inhibitors of indoleamine 2 3 dioxygenase for cancer therapy: Can we see the wood for the trees
-
Lob S, Konigsrainer A, Rammensee HG, Opelz G, Terness P. Inhibitors of indoleamine 2,3 dioxygenase for cancer therapy: can we see the wood for the trees? Nat. Rev. Cancer 9(6), 445-452 (2009).
-
(2009)
Nat. Rev. Cancer
, vol.9
, Issue.6
, pp. 445-452
-
-
Lob, S.1
Konigsrainer, A.2
Rammensee, H.G.3
Opelz, G.4
Terness, P.5
-
183
-
-
70249098095
-
The immune system strikes back: Cellular immune responses against indoleamine 2 3 dioxygenase
-
Sorensen RB, Berge-Hansen L, Junker N et al. The immune system strikes back: cellular immune responses against indoleamine 2,3 dioxygenase. PLoS ONE 4(9), E6910 (2009).
-
(2009)
PLoS ONE
, vol.4
, Issue.9
-
-
Sorensen, R.B.1
Berge-Hansen, L.2
Junker, N.3
-
184
-
-
0033954723
-
Chronic hypoxia enhances adenosine release in rat PC12 cells by altering adenosine metabolism and membrane transport
-
DOI 10.1046/j.1471-4159.2000.740621.x
-
Kobayashi S, Zimmermann H, Millhorn DE. Chronic hypoxia enhances adenosine release in rat PC12 cells by altering adenosine metabolism and membrane transport. J. Neurochem. 74(2), 621-632 (2000). (Pubitemid 30053734)
-
(2000)
Journal of Neurochemistry
, vol.74
, Issue.2
, pp. 621-632
-
-
Kobayashi, S.1
Zimmermann, H.2
Millhorn, D.E.3
-
185
-
-
0030785819
-
The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine
-
Blay J, White TD, Hoskin DW. The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine. Cancer Res. 57(13), 2602-2605 (1997). (Pubitemid 27283766)
-
(1997)
Cancer Research
, vol.57
, Issue.13
, pp. 2602-2605
-
-
Blay, J.1
White, T.D.2
Hoskin, D.W.3
-
186
-
-
58149147369
-
Hypoxia-adenosinergic immunosuppression: Tumor protection by T regulatory cells and cancerous tissue hypoxia
-
Sitkovsky MV, Kjaergaard J, Lukashev D, Ohta A. Hypoxia-adenosinergic immunosuppression: tumor protection by T regulatory cells and cancerous tissue hypoxia. Clin. Cancer Res. 14(19), 5947-5952 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, Issue.19
, pp. 5947-5952
-
-
Sitkovsky, M.V.1
Kjaergaard, J.2
Lukashev, D.3
Ohta, A.4
-
187
-
-
33947633432
-
From hellstrom paradox to anti-adenosinergic cancer immunotherapy
-
Lukashev D, Sitkovsky M, Ohta A. From "Hellstrom paradox" to anti-adenosinergic cancer immunotherapy. Purinergic Signal 3(1-2), 129-134 (2007).
-
(2007)
Purinergic Signal
, vol.3
, Issue.1-2
, pp. 129-134
-
-
Lukashev, D.1
Sitkovsky, M.2
Ohta, A.3
-
188
-
-
77949452240
-
Mirna 17 92 expression in differentiated T cells - Implications for cancer immunotherapy
-
Sasaki K, Kohanbash G, Hoji A et al. miRNA 17 92 expression in differentiated T cells - implications for cancer immunotherapy. J. Transl. Med. 8, 17 (2010).
-
(2010)
J. Transl. Med.
, vol.8
, pp. 17
-
-
Sasaki, K.1
Kohanbash, G.2
Hoji, A.3
-
189
-
-
33751209215
-
Combined chemoimmunotherapy of solid tumours: Improving vaccines?
-
DOI 10.1016/j.addr.2006.04.002, PII S0169409X06001426
-
Nowak AK Lake RA, Robinson BW. Combined chemoimmunotherapy of solid tumours: improving vaccines? Adv. Drug Deliv. Rev. 58(8), 975-990 (2006). (Pubitemid 44780907)
-
(2006)
Advanced Drug Delivery Reviews
, vol.58
, Issue.8
, pp. 975-990
-
-
Nowak, A.K.1
Lake, R.A.2
Robinson, B.W.S.3
-
190
-
-
18344375283
-
Immunotherapy and chemotherapy-α practical partnership
-
Lake RA, Robinson BW. Immunotherapy and chemotherapy-α practical partnership. Nat. Rev. Cancer 5(5), 397-405 (2005).
-
(2005)
Nat. Rev. Cancer
, vol.5
, Issue.5
, pp. 397-405
-
-
Lake, R.A.1
Robinson, B.W.2
-
191
-
-
15944410592
-
+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide
-
DOI 10.1182/blood-2004-06-2410
-
Lutsiak ME, Semnani RT, De Pascalis R, Kashmiri SV, Schlom J, Sabzevari H. Inhibition of CD4(+)25+ T regulatory cell function implicated in enhanced immune response by low-dose cyclophosphamide. Blood 105(7), 2862-2868 (2005). (Pubitemid 40446280)
-
(2005)
Blood
, vol.105
, Issue.7
, pp. 2862-2868
-
-
Lutsiak, M.E.C.1
Semnani, R.T.2
De Pascalis, R.3
Kashmiri, S.V.S.4
Schlom, J.5
Sabzevari, H.6
-
192
-
-
33847368549
-
+ regulatory T cells and restores T and NK effector functions in end stage cancer patients
-
DOI 10.1007/s00262-006-0225-8
-
+ regulatory T cells and restores T and NK effector functions in end stage cancer patients. Cancer Immunol. Immunother. 56(5), 641-648 (2007). (Pubitemid 46348738)
-
(2007)
Cancer Immunology, Immunotherapy
, vol.56
, Issue.5
, pp. 641-648
-
-
Ghiringhelli, F.1
Menard, C.2
Puig, P.E.3
Ladoire, S.4
Roux, S.5
Martin, F.6
Solary, E.7
Le Cesne, A.8
Zitvogel, L.9
Chauffert, B.10
-
193
-
-
33646704729
-
Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy
-
DOI 10.1084/jem.20052494
-
Reits EA, Hodge JW, Herberts CA et al. Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy. J. Exp. Med. 203(5), 1259-1271 (2006). (Pubitemid 43736595)
-
(2006)
Journal of Experimental Medicine
, vol.203
, Issue.5
, pp. 1259-1271
-
-
Reits, E.A.1
Hodge, J.W.2
Herberts, C.A.3
Groothuis, T.A.4
Chakraborty, M.5
Wansley, E.K.6
Camphausen, K.7
Luiten, R.M.8
De Ru, A.H.9
Neijssen, J.10
Griekspoor, A.11
Mesman, E.12
Verreck, F.A.13
Spits, H.14
Schlom, J.15
Van Veelen, P.16
Neefjes, J.J.17
-
194
-
-
0036494443
-
Combination of T-cell therapy and trigger of inflammation induces remodeling of the vasculature and tumor eradication
-
Ganss R, Ryschich E, Klar E, Arnold B, Hammerling GJ. Combination of T cell therapy and trigger of inflammation induces remodeling of the vasculature and tumor eradication. Cancer Res. 62(5), 1462-1470 (2002). (Pubitemid 34407808)
-
(2002)
Cancer Research
, vol.62
, Issue.5
, pp. 1462-1470
-
-
Ganss, R.1
Ryschich, E.2
Klar, E.3
Arnold, B.4
Hammerling, G.J.5
-
195
-
-
77953422225
-
Combination approaches to immunotherapy: The radiotherapy example
-
Gough MJ Crittenden MR. Combination approaches to immunotherapy: the radiotherapy example. Immunotherapy 1(6), 1025-1037 (2009).
-
(2009)
Immunotherapy
, vol.1
, Issue.6
, pp. 1025-1037
-
-
Gough, M.J.1
Crittenden, M.R.2
-
196
-
-
67649359533
-
Systemic effects of local radiotherapy
-
Formenti SC, Demaria S. Systemic effects of local radiotherapy. Lancet Oncol. 10(7), 718-726 (2009).
-
(2009)
Lancet Oncol.
, vol.10
, Issue.7
, pp. 718-726
-
-
Formenti, S.C.1
Demaria, S.2
-
197
-
-
20944441967
-
Combining a recombinant cancer vaccine with standard definitive radiotherapy in patients with localized prostate cancer
-
Gulley JL, Arlen PM, Bastian A et al. Combining a recombinant cancer vaccine with standard definitive radiotherapy in patients with localized prostate cancer. Clin. Cancer Res. 11(9), 3353-3362 (2005).
-
(2005)
Clin. Cancer Res.
, vol.11
, Issue.9
, pp. 3353-3362
-
-
Gulley, J.L.1
Arlen, P.M.2
Bastian, A.3
-
198
-
-
14744275172
-
Combination of conformal radiotherapy and intratumoral injection of adoptive dendritic cell immunotherapy in refractory hepatoma
-
Chi Kh, Liu SJ, Li CP et al. Combination of conformal radiotherapy and intratumoral injection of adoptive dendritic cell immunotherapy in refractory hepatoma. J. Immunother. 28(2), 129-135 (2005).
-
(2005)
J. Immunother.
, vol.28
, Issue.2
, pp. 129-135
-
-
Chi, Kh.1
Liu, S.J.2
Li, C.P.3
-
199
-
-
70949103794
-
Cancer associated fibroblasts promote tumor growth and metastasis by modulating the tumor immune microenvironment in a 4T1 murine breast cancer model
-
Liao D, Luo Y, Markowitz D, Xiang R, Reisfeld RA. Cancer associated fibroblasts promote tumor growth and metastasis by modulating the tumor immune microenvironment in a 4T1 murine breast cancer model. PLoS ONE 4(11), E7965 (2009).
-
(2009)
PLoS ONE
, vol.4
, Issue.11
-
-
Liao, D.1
Luo, Y.2
Markowitz, D.3
Xiang, R.4
Reisfeld, R.A.5
-
200
-
-
33644769210
-
Systemic anti-hepatocyte growth factor monoclonal antibody therapy induces the regression of intracranial glioma xenografts
-
DOI 10.1158/1078-0432.CCR-05-1793
-
Kim KJ, Wang L, Su YC et al. Systemic anti-hepatocyte growth factor monoclonal antibody therapy induces the regression of intracranial glioma xenografts. Clin. Cancer Res. 12(4), 1292-1298 (2006). (Pubitemid 43342521)
-
(2006)
Clinical Cancer Research
, vol.12
, Issue.4
, pp. 1292-1298
-
-
Kim, K.J.1
Wang, L.2
Su, Y.-C.3
Gillespie, G.Y.4
Salhotra, A.5
Lal, B.6
Laterra, J.7
-
201
-
-
2942555478
-
Hepatic gene expression of NK4, an HGF-antagonist/angiogenesis inhibitor, suppresses liver metastasis and invasive growth of colon cancer in mice
-
DOI 10.1038/sj.cgt.7700705
-
Wen J, Matsumoto K, Taniura N, Tomioka D, Nakamura T. Hepatic gene expression of NK4, an HGF-antagonist/angiogenesis inhibitor, suppresses liver metastasis and invasive growth of colon cancer in mice. Cancer Gene. Ther. 11(6), 419-430 (2004). (Pubitemid 38747373)
-
(2004)
Cancer Gene Therapy
, vol.11
, Issue.6
, pp. 419-430
-
-
Wen, J.1
Matsumoto, K.2
Taniura, N.3
Tomioka, D.4
Nakamura, T.5
-
202
-
-
33947583623
-
Reprogramming metastatic tumour cells with embryonic microenvironments
-
DOI 10.1038/nrc2108, PII NRC2108
-
Hendrix MJ, Seftor EA, Seftor RE, Kasemeier-Kulesa J, Kulesa PM, Postovit LM. Reprogramming metastatic tumour cells with embryonic microenvironments. Nat. Rev. Cancer 7(4), 246-255 (2007). (Pubitemid 46480969)
-
(2007)
Nature Reviews Cancer
, vol.7
, Issue.4
, pp. 246-255
-
-
Hendrix, M.J.C.1
Seftor, E.A.2
Seftor, R.E.B.3
Kasemeier-Kulesa, J.4
Kulesa, P.M.5
Postovit, L.-M.6
-
203
-
-
0020030895
-
Specificity of the control of tumor formation by the blastocyst
-
Pierce GB, Pantazis CG, Caldwell JE, Wells RS. Specificity of the control of tumor formation by the blastocyst. Cancer Res. 42(3), 1082-1087 (1982). (Pubitemid 12141223)
-
(1982)
Cancer Research
, vol.42
, Issue.3
, pp. 1082-1087
-
-
Pierce, G.B.1
Pantazis, C.G.2
Caldwell, J.E.3
Wells, R.S.4
-
204
-
-
2942653327
-
Regulation of melanoma by the embryonic skin
-
DOI 10.1073/pnas.83.19.7307
-
Gerschenson M, Graves K, Carson SD, Wells RS, Pierce GB. Regulation of melanoma by the embryonic skin. Proc. Natl Acad. Sci. USA 83(19), 7307-7310 (1986). (Pubitemid 16000510)
-
(1986)
Proceedings of the National Academy of Sciences of the United States of America
, vol.83
, Issue.19
, pp. 7307-7310
-
-
Gerschenson, M.1
Graves, K.2
Carson, S.D.3
-
205
-
-
33744990640
-
A three-dimensional model to study the epigenetic effects induced by the microenvironment of human embryonic stem cells
-
DOI 10.1634/stemcells.2005-0459
-
Postovit LM, Seftor EA, Seftor RE, Hendrix MJ. A three-dimensional model to study the epigenetic effects induced by the microenvironment of human embryonic stem cells. Stem Cells 24(3), 501-505 (2006). (Pubitemid 44464753)
-
(2006)
Stem Cells
, vol.24
, Issue.3
, pp. 501-505
-
-
Postovit, L.-M.1
Seftor, E.A.2
Seftor, R.E.B.3
Hendrix, M.J.C.4
-
206
-
-
33644864757
-
Reprogramming metastatic melanoma cells to assume a neural crest cell-like pnenotype in an embryonic microenvironment
-
DOI 10.1073/pnas.0506977103
-
Kulesa PM, Kasemeier-Kulesa JC, Teddy JM et al. Reprogramming metastatic melanoma cells to assume a neural crest cell-like phenotype in an embryonic microenvironment. Proc. Natl Acad. Sci. USA 103(10), 3752-3757 (2006). (Pubitemid 43376627)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.10
, pp. 3752-3757
-
-
Kulesa, P.M.1
Kasemeier-Kulesa, J.C.2
Teddy, J.M.3
Margaryan, N.V.4
Seftor, E.A.5
Seftor, R.E.B.6
Hendrix, M.J.C.7
-
207
-
-
33746846469
-
Embryonic and tumorigenic pathways converge via Nodal signaling: Role in melanoma aggressiveness
-
DOI 10.1038/nm1448, PII NM1448
-
Topczewska JM, Postovit LM, Margaryan NV et al. Embryonic and tumorigenic pathways converge via Nodal signaling: role in melanoma aggressiveness. Nat. Med. 12(8), 925-932 (2006). (Pubitemid 44175144)
-
(2006)
Nature Medicine
, vol.12
, Issue.8
, pp. 925-932
-
-
Topczewska, J.M.1
Postovit, L.-M.2
Margaryan, N.V.3
Sam, A.4
Hess, A.R.5
Wheaton, W.W.6
Nickoloff, B.J.7
Topczewski, J.8
Hendrix, M.J.C.9
-
208
-
-
85047693731
-
Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo
-
DOI 10.1172/JCI200317788
-
Adkins HB, Bianco C, Schiffer SG et al. Antibody blockade of the Cripto CFC domain suppresses tumor cell growth in vivo. J. Clin. Invest. 112(4), 575-587 (2003). (Pubitemid 38056342)
-
(2003)
Journal of Clinical Investigation
, vol.112
, Issue.4
, pp. 575-587
-
-
Adkins, H.B.1
Bianco, C.2
Schiffer, S.G.3
Rayhorn, P.4
Zafari, M.5
Cheung, A.E.6
Orozco, O.7
Olson, D.8
De Luca, A.9
Chen, L.L.10
Miatkowski, K.11
Benjamin, C.12
Normanno, N.13
Williams, K.P.14
Jarpe, M.15
LePage, D.16
Salomon, D.17
Sanicola, M.18
-
209
-
-
2542588518
-
Cripto: A novel target for antibody-based cancer immunotherapy
-
DOI 10.1158/0008-5472.CAN-03-3888
-
Xing PX, Hu XF, Pietersz GA, Hosick HL, Mckenzie IF. Cripto: a novel target for antibody-based cancer immunotherapy. Cancer Res. 64(11), 4018-4023 (2004). (Pubitemid 38697318)
-
(2004)
Cancer Research
, vol.64
, Issue.11
, pp. 4018-4023
-
-
Xing, P.X.1
Hu, X.F.2
Pietersz, G.A.3
Hosick, H.4
McKenzie, I.F.C.5
-
210
-
-
77953169923
-
ADAMTS1 contributes to the acquisition of an endothelial-like phenotype in plastic tumor cells
-
Casal C, Torres-Collado AX, Plaza-Calonge Mdel C et al. ADAMTS1 contributes to the acquisition of an endothelial-like phenotype in plastic tumor cells. Cancer Res. 70(11), 4676-4686 (2010).
-
(2010)
Cancer Res.
, vol.70
, Issue.11
, pp. 4676-4686
-
-
Casal, C.1
Torres-Collado, A.X.2
Plaza-Calonge Mdel, C.3
-
211
-
-
53549102755
-
The tumor microenvironment and its role in promoting tumor growth
-
Whiteside TL. The tumor microenvironment and its role in promoting tumor growth. Oncogene 27(45), 5904-5912 (2008).
-
(2008)
Oncogene
, vol.27
, Issue.45
, pp. 5904-5912
-
-
Whiteside, T.L.1
-
212
-
-
0038519360
-
Tumors as elusive targets of T cell-based active immunotherapy
-
Marincola FM, Wang E, Herlyn M, Seliger B, Ferrone S. Tumors as elusive targets of T cell-based active immunotherapy. Trends Immunol. 24(6), 335-342 (2003).
-
(2003)
Trends Immunol.
, vol.24
, Issue.6
, pp. 335-342
-
-
Marincola, F.M.1
Wang, E.2
Herlyn, M.3
Seliger, B.4
Ferrone, S.5
-
213
-
-
33748756028
-
TGF-β: A mobile purveyor of immune privilege
-
DOI 10.1111/j.1600-065X.2006.00437.x
-
Wahl SM, Wen J, Moutsopoulos N. TGF β: a mobile purveyor of immune privilege. Immunol. Rev. 213, 213-227 (2006). (Pubitemid 44401503)
-
(2006)
Immunological Reviews
, vol.213
, Issue.1
, pp. 213-227
-
-
Wahl, S.M.1
Wen, J.2
Moutsopoulos, N.3
-
214
-
-
0027811130
-
Tissue barriers immunosuppressive microenvironments and privileged sites: The eye's point of view
-
Streilein JW. Tissue barriers, immunosuppressive microenvironments, and privileged sites: the eye's point of view. Reg. Immunol. 5(5), 253-268 (1993). (Pubitemid 24095090)
-
(1993)
Regional Immunology
, vol.5
, Issue.5
, pp. 253-268
-
-
Streilein, J.W.1
-
215
-
-
0025326373
-
The blood-brain barrier protects foreign antigens in the brain form immune attack
-
DOI 10.1016/0014-4886(90)90017-M
-
Pollack IF, Lund RD. The blood-brain barrier protects foreign antigens in the brain from immune attack. Exp. Neurol. 108(2), 114-121 (1990). (Pubitemid 20153931)
-
(1990)
Experimental Neurology
, vol.108
, Issue.2
, pp. 114-121
-
-
Pollack, I.F.1
Lund, R.D.2
-
216
-
-
0021849837
-
Immune privilege in the testis II evaluation of potential local factors
-
Head JR, Billingham RE. Immune privilege in the testis. II. Evaluation of potential local factors. Transplantation 40(3), 269-275 (1985). (Pubitemid 15023186)
-
(1985)
Transplantation
, vol.40
, Issue.3
, pp. 269-275
-
-
Head, J.R.1
Billingham, R.E.2
-
217
-
-
35748943826
-
Anti-cancer therapies targeting the tumor stroma
-
DOI 10.1007/s00262-007-0365-5
-
Hofmeister V, Schrama D, Becker JD. Anti-cancer therapies targeting the tumor stroma. Cancer Immunol. Immunother. 57(1), 1-17 (2008). (Pubitemid 350043655)
-
(2008)
Cancer Immunology Immunotherapy
, vol.57
, Issue.1
, pp. 1-17
-
-
Hofmeister, V.1
Schrama, D.2
Becker, J.C.3
-
218
-
-
75849132379
-
Tumor-stroma co-evolution in prostate cancer progression and metastasis
-
Josson S, Matsuoka Y, Chung LW, Zhau HE, Wang R. Tumor-stroma co-evolution in prostate cancer progression and metastasis. Semin. Cell Dev. Biol. 21(1), 26-32 (2010).
-
(2010)
Semin. Cell Dev. Biol.
, vol.21
, Issue.1
, pp. 26-32
-
-
Josson, S.1
Matsuoka, Y.2
Chung, L.W.3
Zhau, H.E.4
Wang, R.5
-
219
-
-
79953327275
-
Leukocytes as paracrine regulators of metastasis and determinants of organ-specific colonization
-
Erez N, Coussens LM. Leukocytes as paracrine regulators of metastasis and determinants of organ-specific colonization. Int. J. Cancer 128(11) 2536-2544 (2011).
-
(2011)
Int. J. Cancer
, vol.128
, Issue.11
, pp. 2536-2544
-
-
Erez, N.1
Coussens, L.M.2
-
220
-
-
58149331694
-
Designing ageing conditions in tumor microenvironment - A new possible modality for cancer treatment
-
Leibovici J, Itzhaki O, Kaptzan T. et al. Designing ageing conditions in tumor microenvironment - a new possible modality for cancer treatment. Mech. Ageing Dev. 130 (1-2), 76-85 (2009).
-
(2009)
Mech. Ageing Dev.
, vol.130
, Issue.1-2
, pp. 76-85
-
-
Leibovici, J.1
Itzhaki, O.2
Kaptzan, T.3
-
221
-
-
77957272243
-
Cancer immunotherapy: Focusing on the young, neglecting the old
-
Lustgarten J. Cancer immunotherapy: focusing on the young, neglecting the old. Future Oncol. 6(6), 873-876 (2010).
-
(2010)
Future Oncol.
, vol.6
, Issue.6
, pp. 873-876
-
-
Lustgarten, J.1
-
222
-
-
0021362723
-
B16 murine melanoma and aging: Slower growth and longer survival in old mice
-
Ershler WB, Stewart JA, Hacker MP, Moore AL, Tindle BH. B16 murine melanoma and aging: slower growth and longer survival in old mice. J. Natl Cancer Inst. 72(1), 161-164 (1984). (Pubitemid 14159243)
-
(1984)
Journal of the National Cancer Institute
, vol.72
, Issue.1
, pp. 161-164
-
-
Ershler, W.B.1
Stewart, J.A.2
Hacker, M.P.3
-
223
-
-
0030853588
-
Comparison of growth rate of two B16 melanomas differing in metastatic potential in young versus middle-aged mice
-
Donin N, Sinai J, Staroselsky A, Mahlin T, Nordenberg J, Leibovici J. Comparison of growth rate of two B16 melanomas differing in metastatic potential in young versus middle-aged mice. Cancer Invest. 15(5), 416-421 (1997). (Pubitemid 27439227)
-
(1997)
Cancer Investigation
, vol.15
, Issue.5
, pp. 416-421
-
-
Donin, N.1
Sinai, J.2
Staroselsky, A.3
Mahlin, T.4
Nordenberg, J.5
Leibovici, J.6
-
225
-
-
0031045693
-
Histopathology of breast cancer in relation to age
-
Fisher CJ, Egan MK, Smith P, Wicks K, Millis RR, Fentiman IS. Histopathology of breast cancer in relation to age. Br. J. Cancer 75(4), 593-596 (1997). (Pubitemid 27085305)
-
(1997)
British Journal of Cancer
, vol.75
, Issue.4
, pp. 593-596
-
-
Fisher, C.J.1
Egan, M.K.2
Smith, P.3
Wicks, K.4
Millis, R.R.5
Fentiman, I.S.6
-
226
-
-
0015322138
-
Cell proliferation and renewal in aging mice
-
Cameron IL. Cell proliferation and renewal in aging mice. J. Gerontol. 27(2), 162-172 (1972).
-
(1972)
J. Gerontol.
, vol.27
, Issue.2
, pp. 162-172
-
-
Cameron, I.L.1
-
227
-
-
10744231700
-
Age-adjusted antitumoral therapy based on the demonstration of increased apoptosis as a mechanism underlying the reduced malignancy of tumors in the aged
-
DOI 10.1016/j.bbadis.2003.11.009
-
Itzhaki O, Kaptzan T, Skutelsky E et al. Age-adjusted antitumoral therapy based on the demonstration of increased apoptosis as a mechanism underlying the reduced malignancy of tumors in the aged. Biochim. Biophys. Acta 1688(2), 145-159 (2004). (Pubitemid 38264409)
-
(2004)
Biochimica et Biophysica Acta - Molecular Basis of Disease
, vol.1688
, Issue.2
, pp. 145-159
-
-
Itzhaki, O.1
Kaptzan, T.2
Skutelsky, E.3
Sinai, J.4
Michowitz, M.5
Siegal, A.6
Schibi, G.7
Huszar, M.8
Ben-Dor, L.9
Leibovici, J.10
-
228
-
-
0028129545
-
Altered angiogenesis underlying age-dependent changes in tumor growth
-
Pili R, Guo Y, Chang J, Nakanishi H, Martin GR, Passaniti A. Altered angiogenesis underlying age-dependent changes in tumor growth. J. Natl Cancer Inst. 86(17), 1303-1314 (1994). (Pubitemid 24276792)
-
(1994)
Journal of the National Cancer Institute
, vol.86
, Issue.17
, pp. 1303-1314
-
-
Pili, R.1
Guo, Y.2
Chang, J.3
Nakanishi, H.4
Martin, G.R.5
Passaniti, A.6
-
229
-
-
33344471570
-
Efficacy of anti-angiogenic treatment of tumors in old versus young mice
-
DOI 10.1016/j.mad.2005.12.011, PII S0047637406000030
-
Kaptzan T, Skutelsky E, Itzhaki O et al. Efficacy of anti-angiogenic treatment of tumors in old versus young mice. Mech. Ageing Dev. 127(4), 398-409 (2006). (Pubitemid 43290544)
-
(2006)
Mechanisms of Ageing and Development
, vol.127
, Issue.4
, pp. 398-409
-
-
Kaptzan, T.1
Skutelsky, E.2
Itzhaki, O.3
Sinai, J.4
Huszar, M.5
Siegal, A.6
Ben-Zvi, R.7
Jossiphov, J.8
Michowitz, M.9
Schiby, G.10
Leibovici, J.11
-
230
-
-
0024447506
-
The importance of immunesenescence in the incidence and malignant properties of cancer in hosts of advanced age
-
Kaesberg PR, Ershler WB. The importance of immunesenescence in the incidence and malignant properties of cancer in hosts of advanced age. J. Gerontol. 44(6), 63-66 (1989). (Pubitemid 19282270)
-
(1989)
Journals of Gerontology
, vol.44
, Issue.6
, pp. 63-66
-
-
Kaesberg, P.R.1
Ershler, W.B.2
-
231
-
-
3242657279
-
Age-dependent differences in the efficacy of cancer immunotherapy in C57BL and AKR mouse strains
-
DOI 10.1016/j.exger.2004.03.035, PII S0531556504001251
-
Kaptzan T, Skutelsky E, Itzhaki O et al. Age-dependent differences in the efficacy of cancer immunotherapy in C57BL and AKR mouse strains. Exp. Gerontol. 39(7), 1035-1048 (2004). (Pubitemid 38952884)
-
(2004)
Experimental Gerontology
, vol.39
, Issue.7
, pp. 1035-1048
-
-
Kaptzan, T.1
Skutelsky, E.2
Itzhaki, O.3
Sinai, J.4
Michowitz, M.5
Yossipov, Y.6
Schiby, G.7
Leibovici, J.8
-
232
-
-
0029015724
-
Role of immune response as determinant of tumor progression in function of host age in the B16 melanoma
-
Donin N, Sinai J, Michowitz M, Hiss J, Nordenberg J, Leibovici J. Role of immune response as determinant of tumor progression in function of host age in the B16 melanoma. Mech. Ageing Dev. 80(2), 121-137 (1995).
-
(1995)
Mech. Ageing Dev.
, vol.80
, Issue.2
, pp. 121-137
-
-
Donin, N.1
Sinai, J.2
Michowitz, M.3
Hiss, J.4
Nordenberg, J.5
Leibovici, J.6
-
233
-
-
0032442416
-
Aging and the adrenal cortex
-
DOI 10.1016/S0531-5565(98)00046-1
-
Yen SS, Laughlin GA. Aging and the adrenal cortex. Exp. Gerontol. 33(7-8), 897-910 (1998). (Pubitemid 29019344)
-
(1998)
Experimental Gerontology
, vol.33
, Issue.7-8
, pp. 897-910
-
-
Yen, S.S.C.1
Laughlin, G.A.2
-
234
-
-
0032566405
-
Inhibitory effects of antioxidants on neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-α and angiotensin II
-
Nakamura K, Fushimi K, Kouchi H et al. Inhibitory effects of antioxidants on neonatal rat cardiac myocyte hypertrophy induced by tumor necrosis factor-α and angiotensin II. Circulation 98(8), 794-799 (1998). (Pubitemid 28391845)
-
(1998)
Circulation
, vol.98
, Issue.8
, pp. 794-799
-
-
Nakamura, K.1
Fushimi, K.2
Kouchi, H.3
Mihara, K.4
Miyazaki, M.5
Ohe, T.6
Namba, M.7
-
236
-
-
0033975581
-
Human immunosenescence: The prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space
-
DOI 10.1016/S0264-410X(99)00513-7, PII S0264410X99005137
-
Franceschi C, Bonafe M, Valensin S. Human immunosenescence: the prevailing of innate immunity, the failing of clonotypic immunity, and the filling of immunological space. Vaccine 18(16), 1717-1720 (2000). (Pubitemid 30109535)
-
(2000)
Vaccine
, vol.18
, Issue.16
, pp. 1717-1720
-
-
Franceschi, C.1
Bonafe, M.2
Valensin, S.3
-
237
-
-
76749151403
-
Immune responses to malignancies
-
Whiteside TL. Immune responses to malignancies. J. Allergy Clin. Immunol. 125(2 Suppl. 2), S272-S283 (2010).
-
(2010)
J. Allergy Clin. Immunol.
, vol.125
, Issue.2 SUPPL. 2
-
-
Whiteside, T.L.1
-
238
-
-
0020661233
-
A model for the study of the long duration pathogenesis of cancer and its relevance to therapy
-
DOI 10.1016/0306-9877(83)90056-7
-
Leibovici J. A model for the study of the long duration pathogenesis of cancer and its relevance to therapy. Med. Hypotheses 10(1), 105-112 (1983). (Pubitemid 13155223)
-
(1983)
Medical Hypotheses
, vol.10
, Issue.1
, pp. 105-112
-
-
Leibovici, J.1
-
239
-
-
0021342614
-
Serial passage of tumors in mice in the study of tumor progression and testing of antineoplastic drugs
-
Leibovici J. Serial passage of tumors in mice in the study of tumor progression and testing of antineoplastic drugs. Cancer Res. 44(5), 1981-1984 (1984). (Pubitemid 14145142)
-
(1984)
Cancer Research
, vol.44
, Issue.5
, pp. 1981-1984
-
-
Leibovici, J.1
-
240
-
-
41149148269
-
Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: Mechanisms and therapeutic perspectives
-
DOI 10.1111/j.1600-065X.2008.00608.x
-
Rodriguez PC, Ochoa AC. Arginine regulation by myeloid-derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives. Immunol. Rev. 222, 180-191 (2008). (Pubitemid 351430370)
-
(2008)
Immunological Reviews
, vol.222
, Issue.1
, pp. 180-191
-
-
Rodriguez, P.C.1
Ochoa, A.C.2
-
241
-
-
69249222379
-
Polarization of tumor-associated neutrophil phenotype by TGF-b: N1 versus N2 TAN
-
Fridlender ZG, Sun J, Kim S et al. Polarization of tumor-associated neutrophil phenotype by TGF-b: "N1" versus N2 TAN. Cancer Cell 16(3), 183-194 (2009).
-
(2009)
Cancer Cell
, vol.16
, Issue.3
, pp. 183-194
-
-
Fridlender, Z.G.1
Sun, J.2
Kim, S.3
|