메뉴 건너뛰기




Volumn 8, Issue 8, 2008, Pages 604-617

Integrins in angiogenesis and lymphangiogenesis

Author keywords

[No Author keywords available]

Indexed keywords

ABEGRIN; ANTINEOPLASTIC AGENT; BEVACIZUMAB; CILENGITIDE; CNTO 95; DACARBAZINE; INTEGRIN; LAMININ BINDING PROTEIN; MONOCLONAL ANTIBODY LM 609; N ACETYLPROLYLHISTIDYLSERYLCYSTEINYLASPARAGINE AMIDE; VOLOCIXIMAB;

EID: 47949114114     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc2353     Document Type: Review
Times cited : (891)

References (150)
  • 1
    • 30744479430 scopus 로고    scopus 로고
    • Angiogenesis in life, disease and medicine
    • Carmeliet, P. Angiogenesis in life, disease and medicine, Nature 42, 932-936 (2005).
    • (2005) Nature , vol.42 , pp. 932-936
    • Carmeliet, P.1
  • 2
    • 34249689753 scopus 로고    scopus 로고
    • Molecular regulation of angiogenesis and lymphangiogenesis
    • Adams, R. H. & Alitalo, K. Molecular regulation of angiogenesis and lymphangiogenesis. Nature Rev. Mol. Cell Biol. 8, 464-478 (2007).
    • (2007) Nature Rev. Mol. Cell Biol , vol.8 , pp. 464-478
    • Adams, R.H.1    Alitalo, K.2
  • 3
    • 0035160312 scopus 로고    scopus 로고
    • Lyden, D. et al. Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nature Med. 11, 1194-1201 (2001). This article established the concept that bone marrow-derived cells in lung and other tissues could help create an environment that attracts metastatic tumour cells.
    • Lyden, D. et al. Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nature Med. 11, 1194-1201 (2001). This article established the concept that bone marrow-derived cells in lung and other tissues could help create an environment that attracts metastatic tumour cells.
  • 4
    • 33947590932 scopus 로고    scopus 로고
    • Myeloid cell trafficking and tumor angiogenesis
    • Schmid, M. C. & Varner, J. A. Myeloid cell trafficking and tumor angiogenesis. Cancer Lett. 250, 1-8 (2007).
    • (2007) Cancer Lett , vol.250 , pp. 1-8
    • Schmid, M.C.1    Varner, J.A.2
  • 5
    • 34347226359 scopus 로고    scopus 로고
    • Tumor-associated macrophages press the angiogenic switch in breast cancer
    • This article shows that macrophages have crucial roles in altering the fate of tumours by secreting pro-angiogenic growth factors
    • Lin, E. Y. & Pollard, J. W. Tumor-associated macrophages press the angiogenic switch in breast cancer. Cancer Res. 67, 5064-5066 (2007). This article shows that macrophages have crucial roles in altering the fate of tumours by secreting pro-angiogenic growth factors.
    • (2007) Cancer Res , vol.67 , pp. 5064-5066
    • Lin, E.Y.1    Pollard, J.W.2
  • 6
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • Ferrara, N. & Kerbel, R. S. Angiogenesis as a therapeutic target. Nature 438, 967-974 (2005).
    • (2005) Nature , vol.438 , pp. 967-974
    • Ferrara, N.1    Kerbel, R.S.2
  • 7
    • 33244490973 scopus 로고    scopus 로고
    • Peritumoral lymphatic invasion is associated with regional lymph node metastases in prostate adenocarcinoma
    • Roma, A. A. et. al. Peritumoral lymphatic invasion is associated with regional lymph node metastases in prostate adenocarcinoma. Mod. Pathol. 19, 392-398 (2006).
    • (2006) Mod. Pathol , vol.19 , pp. 392-398
    • Roma, A.A.1    et., al.2
  • 8
    • 27344443222 scopus 로고    scopus 로고
    • Tumor lymphangiogenesis predicts melanoma metastasis to sentinel lymph nodes
    • Dadras, S. S. et al. Tumor lymphangiogenesis predicts melanoma metastasis to sentinel lymph nodes. Mod. Pathol. 18, 1232-1242 (2005).
    • (2005) Mod. Pathol , vol.18 , pp. 1232-1242
    • Dadras, S.S.1
  • 9
    • 17144402207 scopus 로고    scopus 로고
    • Hirakawa, S. et al. VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis. J. Exp. Med. 201, 1089-1099 (2005). This article showed for the first time that tumors induce lymphangiogenesis not only in the peritumoural space but also in draining lymph nodes.
    • Hirakawa, S. et al. VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis. J. Exp. Med. 201, 1089-1099 (2005). This article showed for the first time that tumors induce lymphangiogenesis not only in the peritumoural space but also in draining lymph nodes.
  • 10
    • 0037145037 scopus 로고    scopus 로고
    • Integrins: Bidirectional, allosteric signaling machines
    • Hynes, R. O. Integrins: bidirectional, allosteric signaling machines. Cell 110, 673-687 (2002).
    • (2002) Cell , vol.110 , pp. 673-687
    • Hynes, R.O.1
  • 11
    • 0034698147 scopus 로고    scopus 로고
    • Ligand binding to integrins
    • Plow, E. F. et al. Ligand binding to integrins. J. Biol. Chem. 275, 21785-21788 (2000).
    • (2000) J. Biol. Chem , vol.275 , pp. 21785-21788
    • Plow, E.F.1
  • 12
    • 0028142840 scopus 로고
    • Integrin-ligand interactions: A year in review
    • Haas, T. A. & Plow, E. F. Integrin-ligand interactions: a year in review. Curr Opin Cell Biol. 6, 656-662 (1994).
    • (1994) Curr Opin Cell Biol , vol.6 , pp. 656-662
    • Haas, T.A.1    Plow, E.F.2
  • 13
    • 0025777183 scopus 로고
    • The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine
    • Komoriya, A. et al. The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine. J. Biol. Chem. 266, 15075-15079 (1991).
    • (1991) J. Biol. Chem , vol.266 , pp. 15075-15079
    • Komoriya, A.1
  • 14
    • 1542269303 scopus 로고    scopus 로고
    • Integrins: Roles in cancer development and as treatment targets
    • Jin, H. & Varner, J. Integrins: roles in cancer development and as treatment targets. Br. J. Cancer 90, 561-565 (2004).
    • (2004) Br. J. Cancer , vol.90 , pp. 561-565
    • Jin, H.1    Varner, J.2
  • 16
    • 33748286819 scopus 로고    scopus 로고
    • Integrin-regulated FAK-Src signaling in normal and cancer cells
    • Mitra, S.K & Schlaepfer, D. D. Integrin-regulated FAK-Src signaling in normal and cancer cells. Curr. Opin. Cell Biol. 18, 516-523 (2006).
    • (2006) Curr. Opin. Cell Biol , vol.18 , pp. 516-523
    • Mitra, S.K.1    Schlaepfer, D.D.2
  • 17
    • 23044451988 scopus 로고    scopus 로고
    • Integrins as a distinct subtype of dependence receptors
    • Stupack, D. G. Integrins as a distinct subtype of dependence receptors. Cell Death Differ. 12, 1021-1030 (2005).
    • (2005) Cell Death Differ , vol.12 , pp. 1021-1030
    • Stupack, D.G.1
  • 18
    • 0035984003 scopus 로고    scopus 로고
    • β8 integrins are required for vascular morphogenesis in mouse embryos
    • This article shows that integrin αvβ8 is required for the formation of normal brain blood vessels
    • Zhu, J. et al. β8 integrins are required for vascular morphogenesis in mouse embryos. Development 129, 2891-2903 (2002). This article shows that integrin αvβ8 is required for the formation of normal brain blood vessels.
    • (2002) Development , vol.129 , pp. 2891-2903
    • Zhu, J.1
  • 19
    • 0005306564 scopus 로고
    • Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor
    • Cheresh, D. A. Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor. Proc. Natl Acad. Sci. USA 84, 6471-6475 (1987).
    • (1987) Proc. Natl Acad. Sci. USA , vol.84 , pp. 6471-6475
    • Cheresh, D.A.1
  • 20
    • 0028362876 scopus 로고
    • Requirement of vascular integrin αvβ3 for angiogenesis
    • This is the first article demonstrating a role for an integrin in angiogenesis
    • Brooks, P. C., Clark, R. A. & Cheresh, D. A. Requirement of vascular integrin αvβ3 for angiogenesis. Science 264, 569-571 (1994). This is the first article demonstrating a role for an integrin in angiogenesis.
    • (1994) Science , vol.264 , pp. 569-571
    • Brooks, P.C.1    Clark, R.A.2    Cheresh, D.A.3
  • 21
    • 0028670833 scopus 로고
    • Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
    • Brooks, P. C. et al. Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79, 1157-1164 (1994).
    • (1994) Cell , vol.79 , pp. 1157-1164
    • Brooks, P.C.1
  • 22
    • 0028972105 scopus 로고
    • Antiintegrin αvβ3 blocks human breast cancer growth and angiogenesis in human skin
    • Brooks, P. C. et al. Antiintegrin αvβ3 blocks human breast cancer growth and angiogenesis in human skin. J. Clin. Invest. 96, 1815-1822 (1995).
    • (1995) J. Clin. Invest , vol.96 , pp. 1815-1822
    • Brooks, P.C.1
  • 23
    • 0029610677 scopus 로고
    • Definition of two angiogenic pathways by distinct αv integrins
    • This article established that two unique pathways of angiogenesis are regulated by two distinct αv integrins
    • Friedlander, M. et al. Definition of two angiogenic pathways by distinct αv integrins. Science 270, 1500-1502 (1995). This article established that two unique pathways of angiogenesis are regulated by two distinct αv integrins.
    • (1995) Science , vol.270 , pp. 1500-1502
    • Friedlander, M.1
  • 24
    • 0029843947 scopus 로고    scopus 로고
    • Involvement of integrins αvβ3 and αvβ5 in ocular neovascular diseases
    • Friedlander, M. et al. Involvement of integrins αvβ3 and αvβ5 in ocular neovascular diseases. Proc. Natl Acad. Sci. USA 93, 9764-9769 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 9764-9769
    • Friedlander, M.1
  • 25
    • 38449113574 scopus 로고    scopus 로고
    • Angiogenesis inhibition and choroidal neovascularization suppression by sustained delivery of an integrin antagonist, EMD478761
    • Friedlander, M. et al. Angiogenesis inhibition and choroidal neovascularization suppression by sustained delivery of an integrin antagonist, EMD478761. Invest. Ophthalmol. Vis. Sci. 48, 5184-5190 (2007).
    • (2007) Invest. Ophthalmol. Vis. Sci , vol.48 , pp. 5184-5190
    • Friedlander, M.1
  • 26
    • 0028981497 scopus 로고
    • An antagonist of integrin αvβ3 prevents maturation of blood vessels during embryonic neovascularization
    • Drake, C. J., Cheresh, D. A. & Little, C. D. An antagonist of integrin αvβ3 prevents maturation of blood vessels during embryonic neovascularization. J. Cell Sci. 108, 2655-2661 (1995).
    • (1995) J. Cell Sci , vol.108 , pp. 2655-2661
    • Drake, C.J.1    Cheresh, D.A.2    Little, C.D.3
  • 28
    • 0035851912 scopus 로고    scopus 로고
    • Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins
    • This article established the concept of integrin-mediated death by showing that unligated integrins promote cell death
    • Stupack, D. G., Puente, X. S., Boutsaboualoy, S., Storgard, C. M. & Cheresh, D. A. Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins. J. Cell Biol. 155, 459-470 (2001). This article established the concept of integrin-mediated death by showing that unligated integrins promote cell death.
    • (2001) J. Cell Biol , vol.155 , pp. 459-470
    • Stupack, D.G.1    Puente, X.S.2    Boutsaboualoy, S.3    Storgard, C.M.4    Cheresh, D.A.5
  • 29
    • 0032498640 scopus 로고    scopus 로고
    • Integrin αvβ3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis
    • Eliceiri, B.P, Klemke, R., Strömblad, S. & Cheresh, D. A. Integrin αvβ3 requirement for sustained mitogen-activated protein kinase activity during angiogenesis. J. Cell Biol. 140, 1255-1263 (1998).
    • (1998) J. Cell Biol , vol.140 , pp. 1255-1263
    • Eliceiri, B.P.1    Klemke, R.2    Strömblad, S.3    Cheresh, D.A.4
  • 30
    • 0036544562 scopus 로고    scopus 로고
    • Src-mediated coupling of focal adhesion kinase to integrin αvβ5 in vascular endothelial growth factor signaling
    • Eliceiri, B. P. et al. Src-mediated coupling of focal adhesion kinase to integrin αvβ5 in vascular endothelial growth factor signaling. J. Cell Biol. 157, 149-160 (2002).
    • (2002) J. Cell Biol , vol.157 , pp. 149-160
    • Eliceiri, B.P.1
  • 31
    • 30144445125 scopus 로고    scopus 로고
    • Expression of integrins in cerebral arteriovenous and cavernous malformations
    • Seker, A. et al. Expression of integrins in cerebral arteriovenous and cavernous malformations. Neurosurgery 58, 159-168 (2006).
    • (2006) Neurosurgery , vol.58 , pp. 159-168
    • Seker, A.1
  • 32
    • 0028803509 scopus 로고
    • Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity
    • Alon, T. et al. Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity. Nature Med. 1, 1024-1028 (1995).
    • (1995) Nature Med , vol.1 , pp. 1024-1028
    • Alon, T.1
  • 33
    • 7244247062 scopus 로고    scopus 로고
    • Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis
    • Weis, S., Cui, J., Barnes, L. & Cheresh, D. Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis. J. Cell Biol. 167, 223-232 (2004).
    • (2004) J. Cell Biol , vol.167 , pp. 223-232
    • Weis, S.1    Cui, J.2    Barnes, L.3    Cheresh, D.4
  • 34
    • 13544252467 scopus 로고    scopus 로고
    • Tumor metastasis but not tumor growth is dependent on Src-mediated vascular permeability
    • Criscuoli, M. L., Nguyen, M. & Eliceiri, B. P. Tumor metastasis but not tumor growth is dependent on Src-mediated vascular permeability. Blood 105, 1508-1514 (2005).
    • (2005) Blood , vol.105 , pp. 1508-1514
    • Criscuoli, M.L.1    Nguyen, M.2    Eliceiri, B.P.3
  • 35
    • 0032590042 scopus 로고    scopus 로고
    • β3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival
    • Hodivala-Dilke, K. M. et al. β3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J. Clin. Invest. 103, 229-238 (1999).
    • (1999) J. Clin. Invest , vol.103 , pp. 229-238
    • Hodivala-Dilke, K.M.1
  • 36
    • 33847350777 scopus 로고    scopus 로고
    • Cooperation between VEGF and β3 integrin during cardiac vascular development
    • Weis, S. M. et al. Cooperation between VEGF and β3 integrin during cardiac vascular development. Blood 109, 1962-1970 (2007).
    • (2007) Blood , vol.109 , pp. 1962-1970
    • Weis, S.M.1
  • 37
    • 0036152857 scopus 로고    scopus 로고
    • Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins
    • Reynolds, L. E. et al. Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins. Nature Med. 8, 27-34 (2002).
    • (2002) Nature Med , vol.8 , pp. 27-34
    • Reynolds, L.E.1
  • 38
    • 9244231286 scopus 로고    scopus 로고
    • Elevated Flk1 (vascular endothelial growth factor receptor 2) signaling mediates enhanced angiogenesis in β3-integrin-deficient mice
    • This study established the concept that developmental loss of an integrin could lead to enhanced angiogenesis through compensatory mechanisms
    • Reynolds, A. R. et al. Elevated Flk1 (vascular endothelial growth factor receptor 2) signaling mediates enhanced angiogenesis in β3-integrin-deficient mice. Cancer Res. 64, 8643-8650 (2004). This study established the concept that developmental loss of an integrin could lead to enhanced angiogenesis through compensatory mechanisms.
    • (2004) Cancer Res , vol.64 , pp. 8643-8650
    • Reynolds, A.R.1
  • 39
    • 0033982574 scopus 로고    scopus 로고
    • Normal development, wound healing, and adenovirus susceptibility in β5-deficient mice
    • This article showed that loss of αvβ5 during development has no significant effect on angiogenesis
    • Huang, X., Griffiths, M., Wu, J., Farese, R. V. Jr & Sheppard, D. Normal development, wound healing, and adenovirus susceptibility in β5-deficient mice. Mol. Cell Biol. 20, 755-759 (2000). This article showed that loss of αvβ5 during development has no significant effect on angiogenesis.
    • (2000) Mol. Cell Biol , vol.20 , pp. 755-759
    • Huang, X.1    Griffiths, M.2    Wu, J.3    Farese Jr, R.V.4    Sheppard, D.5
  • 40
    • 0032514841 scopus 로고    scopus 로고
    • Bader, B. L., Rayburn, H., Crowley, D. & Hynes, R. O. Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all αv integrins. Cell 95, 507-519 (1998). This study shows that αv integrins are essential for development in most animals but that some animals can survive in ovo loss of αv integrins until the early post-natal period.
    • Bader, B. L., Rayburn, H., Crowley, D. & Hynes, R. O. Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all αv integrins. Cell 95, 507-519 (1998). This study shows that αv integrins are essential for development in most animals but that some animals can survive in ovo loss of αv integrins until the early post-natal period.
  • 41
    • 13444249941 scopus 로고    scopus 로고
    • Selective ablation of α v integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death
    • McCarty, J. H. et al. Selective ablation of α v integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development 132, 165-176 (2005).
    • (2005) Development , vol.132 , pp. 165-176
    • McCarty, J.H.1
  • 42
    • 0036837873 scopus 로고    scopus 로고
    • Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking αv integrins
    • McCarty, J. H. et al. Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking αv integrins. Mol. Cell. Biol. 22, 7667-7677 (2002).
    • (2002) Mol. Cell. Biol , vol.22 , pp. 7667-7677
    • McCarty, J.H.1
  • 43
    • 33750499985 scopus 로고    scopus 로고
    • Integrin signaling is critical for pathological angiogenesis
    • This study shows that animals with an intact but non-functional β3 integrin exhibit defective angiogenesis
    • Mahabeleshwar, G. H., Feng, W., Phillips, D. R. & Byzova, T. V. Integrin signaling is critical for pathological angiogenesis. J. Exp. Med. 203, 2495-2507 (2006). This study shows that animals with an intact but non-functional β3 integrin exhibit defective angiogenesis.
    • (2006) J. Exp. Med , vol.203 , pp. 2495-2507
    • Mahabeleshwar, G.H.1    Feng, W.2    Phillips, D.R.3    Byzova, T.V.4
  • 44
    • 0028670298 scopus 로고
    • Integrin αvβ3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen
    • Montgomery, A. M., Reisfeld, R. A. & Cheresh, D. A. Integrin αvβ3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen. Proc. Natl Acad. Sci. USA 91, 8856-8860 (1994).
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 8856-8860
    • Montgomery, A.M.1    Reisfeld, R.A.2    Cheresh, D.A.3
  • 45
    • 0020315282 scopus 로고
    • Blood vessel fibronectin increases in conjunction with endothelial cell proliferation and capillary ingrowth during wound healing
    • Clark, R. A. et al. Blood vessel fibronectin increases in conjunction with endothelial cell proliferation and capillary ingrowth during wound healing. J. Invest. Dermatol. 79, 269-276 (1982).
    • (1982) J. Invest. Dermatol , vol.79 , pp. 269-276
    • Clark, R.A.1
  • 46
    • 0033843942 scopus 로고    scopus 로고
    • Regulation of angiogenesis in vivo by ligation of integrin α5β1 with the central cell-binding domain of fibronectin
    • This is the first article showing a role for integrin α5β1 in angiogenesis
    • Kim, S., Bell, K., Mousa, S. A. & Varner, J. A. Regulation of angiogenesis in vivo by ligation of integrin α5β1 with the central cell-binding domain of fibronectin. Am. J. Pathol. 156, 1345-1362 (2000). This is the first article showing a role for integrin α5β1 in angiogenesis.
    • (2000) Am. J. Pathol , vol.156 , pp. 1345-1362
    • Kim, S.1    Bell, K.2    Mousa, S.A.3    Varner, J.A.4
  • 47
    • 0037177894 scopus 로고    scopus 로고
    • The EIIIA segment of fibronectin is a ligand for integrins α9β1 and α4β1 providing a novel mechanism for regulating cell adhesion by alternative splicing
    • Liao, Y. F., Gotwals, P. J., Koteliansky, V. E., Sheppard, D. & Van De Water, L. The EIIIA segment of fibronectin is a ligand for integrins α9β1 and α4β1 providing a novel mechanism for regulating cell adhesion by alternative splicing. J. Biol. Chem. 277, 14467-14474 (2002).
    • (2002) J. Biol. Chem , vol.277 , pp. 14467-14474
    • Liao, Y.F.1    Gotwals, P.J.2    Koteliansky, V.E.3    Sheppard, D.4    Van De Water, L.5
  • 48
    • 0030818072 scopus 로고    scopus 로고
    • Fibronectins are essential for heart and blood vessel morphogenesis but are dispensable for initial specification of precursor cells
    • George, E. L., Baldwin, H. S. & Hynes, R. O. Fibronectins are essential for heart and blood vessel morphogenesis but are dispensable for initial specification of precursor cells. Blood 90, 3073-3081 (1997).
    • (1997) Blood , vol.90 , pp. 3073-3081
    • George, E.L.1    Baldwin, H.S.2    Hynes, R.O.3
  • 49
    • 35348890874 scopus 로고    scopus 로고
    • Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin
    • Astrof, S., Crowley, D. & Hynes, R. O. Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin. Dev. Biol. 311, 11-24 (2007).
    • (2007) Dev. Biol , vol.311 , pp. 11-24
    • Astrof, S.1    Crowley, D.2    Hynes, R.O.3
  • 50
    • 0028979154 scopus 로고
    • Consequences of lack of β1 integrin gene expression in mice
    • Fassler, R. & Meyer, M. Consequences of lack of β1 integrin gene expression in mice. Genes Dev. 9, 1896-1908 (1995).
    • (1995) Genes Dev , vol.9 , pp. 1896-1908
    • Fassler, R.1    Meyer, M.2
  • 51
    • 0028979153 scopus 로고
    • Deletion of β1 integrins in mice results in inner cell mass failure and peri-implantation lethality
    • Stephens, L. E. et al. Deletion of β1 integrins in mice results in inner cell mass failure and peri-implantation lethality. Genes Dev. 9, 1883-1895 (1995).
    • (1995) Genes Dev , vol.9 , pp. 1883-1895
    • Stephens, L.E.1
  • 52
    • 38149004289 scopus 로고    scopus 로고
    • β1 integrin expression on endothelial cells is required for angiogenesis but not for vasculogenesis
    • Tanjore, H., Zeisberg, E. M., Gerami-Naini, B. & Kalluri, R. β1 integrin expression on endothelial cells is required for angiogenesis but not for vasculogenesis. Dev. Dyn. 237, 75-82 (2007).
    • (2007) Dev. Dyn , vol.237 , pp. 75-82
    • Tanjore, H.1    Zeisberg, E.M.2    Gerami-Naini, B.3    Kalluri, R.4
  • 53
    • 0030608876 scopus 로고    scopus 로고
    • β1 integrin is essential for teratoma growth and angiogenesis
    • Bloch, W. et al. β1 integrin is essential for teratoma growth and angiogenesis. J. Cell Biol. 139, 265-278 (1997).
    • (1997) J. Cell Biol , vol.139 , pp. 265-278
    • Bloch, W.1
  • 54
    • 34547862458 scopus 로고    scopus 로고
    • The role of integrin α5β1 in the regulation of corneal neovascularization
    • Muether, P. S. et al. The role of integrin α5β1 in the regulation of corneal neovascularization. Exp. Eye Res. 85, 356-365 (2007).
    • (2007) Exp. Eye Res , vol.85 , pp. 356-365
    • Muether, P.S.1
  • 55
    • 1042301376 scopus 로고    scopus 로고
    • The homeobox transcription factor Hox D3 promotes integrin α5β1 expression and function during angiogenesis
    • Boudreau, N. J. & Varner, J. A. The homeobox transcription factor Hox D3 promotes integrin α5β1 expression and function during angiogenesis. J. Biol. Chem. 279, 4862-4868 (2004).
    • (2004) J. Biol. Chem , vol.279 , pp. 4862-4868
    • Boudreau, N.J.1    Varner, J.A.2
  • 56
    • 33745137492 scopus 로고    scopus 로고
    • Suppression and regression of choroidal neovascularization by systemic administration of an α5β1 integrin antagonist
    • Umeda, N. et al. Suppression and regression of choroidal neovascularization by systemic administration of an α5β1 integrin antagonist. Mol. Pharmacol. 69, 1820-1828 (2006).
    • (2006) Mol. Pharmacol , vol.69 , pp. 1820-1828
    • Umeda, N.1
  • 57
    • 0034721888 scopus 로고    scopus 로고
    • Regulation of integrin αvβ3-mediated endothelial cell migration and angiogenesis by integrin α5β1 and protein kinase A
    • Kim, S., Harris, M. & Varner, J. A. Regulation of integrin αvβ3-mediated endothelial cell migration and angiogenesis by integrin α5β1 and protein kinase A. J. Biol. Chem. 275, 33920-33928 (2000).
    • (2000) J. Biol. Chem , vol.275 , pp. 33920-33928
    • Kim, S.1    Harris, M.2    Varner, J.A.3
  • 58
    • 0036792466 scopus 로고    scopus 로고
    • Inhibition of endothelial cell survival and angiogenesis by protein kinase, A
    • Kim, S., Bakre, M., Yin, H. & Varner, J. A. Inhibition of endothelial cell survival and angiogenesis by protein kinase, A. J. Clin. Invest. 110, 933-941 (2002).
    • (2002) J. Clin. Invest , vol.110 , pp. 933-941
    • Kim, S.1    Bakre, M.2    Yin, H.3    Varner, J.A.4
  • 59
    • 0027371908 scopus 로고
    • Embryonic mesodermal defects in α5 integrin-deficient mice
    • This article shows that integrin α5 is required during embryonic development of early blood vessels and other tissues
    • Yang, J. T., Rayburn, H. & Hynes, R. O. Embryonic mesodermal defects in α5 integrin-deficient mice. Development 119, 1093-1105 (1993). This article shows that integrin α5 is required during embryonic development of early blood vessels and other tissues.
    • (1993) Development , vol.119 , pp. 1093-1105
    • Yang, J.T.1    Rayburn, H.2    Hynes, R.O.3
  • 60
    • 0035394235 scopus 로고    scopus 로고
    • Reduced blood vessel formation and tumor growth in α5-integrin-negative teratocarcinomas and embryoid bodies
    • Taverna, D. & Hynes, R. O. Reduced blood vessel formation and tumor growth in α5-integrin-negative teratocarcinomas and embryoid bodies. Cancer Res. 61, 5255-5261 (2001).
    • (2001) Cancer Res , vol.61 , pp. 5255-5261
    • Taverna, D.1    Hynes, R.O.2
  • 61
    • 0035983579 scopus 로고    scopus 로고
    • Central roles of α5β1 integrin and fibronectin in vascular development in mouse embryos and embryoid bodies
    • Francis, S. E. et al. Central roles of α5β1 integrin and fibronectin in vascular development in mouse embryos and embryoid bodies. Arterioscler. Thromb. Vasc. Biol. 22, 927-933 (2002).
    • (2002) Arterioscler. Thromb. Vasc. Biol , vol.22 , pp. 927-933
    • Francis, S.E.1
  • 62
    • 0028955748 scopus 로고
    • Cell adhesion events mediated by α 4 integrins are essential in placental and cardiac development
    • Yang, J. T., Rayburn, H. & Hynes, R. O. Cell adhesion events mediated by α 4 integrins are essential in placental and cardiac development. Development 121, 549-560 (1995).
    • (1995) Development , vol.121 , pp. 549-560
    • Yang, J.T.1    Rayburn, H.2    Hynes, R.O.3
  • 63
    • 20444483652 scopus 로고    scopus 로고
    • Garmy-Susini, B. et al. Integrin α4β1-VCAM-1-mediated adhesion between endothelial and mural cells is required for blood vessel maturation. J. Clin. Invest. 115, 1542-1551 (2005). This article demonstrates that integrin α4β1 on endothelium promotes endothelial cell motility and angiogenesis as well as a transient association of pericytes with endothelium.
    • Garmy-Susini, B. et al. Integrin α4β1-VCAM-1-mediated adhesion between endothelial and mural cells is required for blood vessel maturation. J. Clin. Invest. 115, 1542-1551 (2005). This article demonstrates that integrin α4β1 on endothelium promotes endothelial cell motility and angiogenesis as well as a transient association of pericytes with endothelium.
  • 64
    • 34447502532 scopus 로고    scopus 로고
    • Integrin α9β1 directly binds to vascular endothelial growth factor (VEGF)-A and contributes to VEGF-A-induced angiogenesis
    • Vlahakis, N. E. et al. Integrin α9β1 directly binds to vascular endothelial growth factor (VEGF)-A and contributes to VEGF-A-induced angiogenesis. J. Biol. Chem. 282, 15187-15196 (2007).
    • (2007) J. Biol. Chem , vol.282 , pp. 15187-15196
    • Vlahakis, N.E.1
  • 65
    • 34248376549 scopus 로고    scopus 로고
    • Interaction of α9β1 integrin with thrombospondin-1 promotes angiogenesis
    • Staniszewska, I. et al. Interaction of α9β1 integrin with thrombospondin-1 promotes angiogenesis. Circ. Res. 100, 1308-1316 (2007).
    • (2007) Circ. Res , vol.100 , pp. 1308-1316
    • Staniszewska, I.1
  • 66
    • 0037177894 scopus 로고    scopus 로고
    • The EIIIA segment of fibronectin is a ligand for integrins α9β1 and α4β1 providing a novel mechanism for regulating cell adhesion by alternative splicing
    • Liao, Y. F. et al. The EIIIA segment of fibronectin is a ligand for integrins α9β1 and α4β1 providing a novel mechanism for regulating cell adhesion by alternative splicing. J. Biol. Chem. 277, 14467-14474 (2002).
    • (2002) J. Biol. Chem , vol.277 , pp. 14467-14474
    • Liao, Y.F.1
  • 67
    • 0034644725 scopus 로고    scopus 로고
    • Inhibitory effects of MLDG-containing heterodimeric disintegrins reveal distinct structural requirements for interaction of the integrin α9β1 with VCAM-1, tenascin-C, and osteopontin
    • Marcinkiewicz, C. et al. Inhibitory effects of MLDG-containing heterodimeric disintegrins reveal distinct structural requirements for interaction of the integrin α9β1 with VCAM-1, tenascin-C, and osteopontin. J. Biol. Chem. 275, 31930-31937 (2000).
    • (2000) J. Biol. Chem , vol.275 , pp. 31930-31937
    • Marcinkiewicz, C.1
  • 68
    • 0033948027 scopus 로고    scopus 로고
    • Fatal bilateral chylothorax in mice lacking the integrin α9β1
    • This study demonstrates that integrin α9β1 is required for proper development of the lymphatic system
    • Huang, X. Z. et al. Fatal bilateral chylothorax in mice lacking the integrin α9β1. Mol. Cell. Biol. 20, 5208-5215 (2000). This study demonstrates that integrin α9β1 is required for proper development of the lymphatic system.
    • (2000) Mol. Cell. Biol , vol.20 , pp. 5208-5215
    • Huang, X.Z.1
  • 69
    • 0031459892 scopus 로고    scopus 로고
    • Angiogenesis promoted by vascular endothelial growth factor: Regulation through α1β1 and α2β1 integrins
    • Senger, D. R. et al. Angiogenesis promoted by vascular endothelial growth factor: regulation through α1β1 and α2β1 integrins. Proc. Natl Acad. Sci. USA 94, 13612-13617 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 13612-13617
    • Senger, D.R.1
  • 70
    • 0034007381 scopus 로고    scopus 로고
    • Elevated matrix metalloprotease and angiostatin levels in integrin α1-knockout mice cause reduced tumor vascularization
    • Pozzi, A. et al. Elevated matrix metalloprotease and angiostatin levels in integrin α1-knockout mice cause reduced tumor vascularization. Proc. Natl Acad. Sci. USA 97, 2202-2207 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 2202-2207
    • Pozzi, A.1
  • 71
    • 41349111883 scopus 로고    scopus 로고
    • α2β1 integrin expression in the tumor microenvironment enhances tumor angiogenesis in a tumor-cell specific manner
    • This paper shows that integrin α2β1-null mice exhibit distinct tumour growth patterns that are dependent upon the growth factors that are intrinsically expressed by individual tumour cells
    • Zhang, Z. et al. α2β1 integrin expression in the tumor microenvironment enhances tumor angiogenesis in a tumor-cell specific manner. Blood 111, 1980-1988 (2008). This paper shows that integrin α2β1-null mice exhibit distinct tumour growth patterns that are dependent upon the growth factors that are intrinsically expressed by individual tumour cells.
    • (2008) Blood , vol.111 , pp. 1980-1988
    • Zhang, Z.1
  • 72
    • 33846004471 scopus 로고    scopus 로고
    • Integrin regulation by vascular endothelial growth factor in human brain microvascular endothelial cells: Role of α6β1 integrin in angiogenesis
    • Lee, T. H. et al. Integrin regulation by vascular endothelial growth factor in human brain microvascular endothelial cells: role of α6β1 integrin in angiogenesis. J. Biol. Chem. 281, 40450-40460 (2006).
    • (2006) J. Biol. Chem , vol.281 , pp. 40450-40460
    • Lee, T.H.1
  • 73
    • 7944224012 scopus 로고    scopus 로고
    • Integrin β4 signaling promotes tumor angiogenesis
    • This paper shows the important role of integrin α6β4 in angiogenesis
    • Nikolopoulos, S. N., Blaikie, P., Yoshioka, T., Guo, W. & Giancotti, F. G. Integrin β4 signaling promotes tumor angiogenesis. Cancer Cell 6, 471-483 (2004). This paper shows the important role of integrin α6β4 in angiogenesis.
    • (2004) Cancer Cell , vol.6 , pp. 471-483
    • Nikolopoulos, S.N.1    Blaikie, P.2    Yoshioka, T.3    Guo, W.4    Giancotti, F.G.5
  • 74
  • 75
    • 0029908558 scopus 로고    scopus 로고
    • Absence of integrin α6 leads to epidermolysis bullosa and neonatal death in mice
    • Georges-Labouesse, E. et al. Absence of integrin α6 leads to epidermolysis bullosa and neonatal death in mice. Nature Genet. 13, 370-373 (1996).
    • (1996) Nature Genet , vol.13 , pp. 370-373
    • Georges-Labouesse, E.1
  • 76
    • 0029666420 scopus 로고    scopus 로고
    • β4 integrin is required for hemidesmosome formation, cell adhesion and cell survival
    • Dowling, J., Yu, Q. C. & Fuchs, E. β4 integrin is required for hemidesmosome formation, cell adhesion and cell survival. J. Cell Biol. 134, 559-572 (1996).
    • (1996) J. Cell Biol , vol.134 , pp. 559-572
    • Dowling, J.1    Yu, Q.C.2    Fuchs, E.3
  • 77
    • 0035847016 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of the β4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated kinase and antagonizes formation of hemidesmosomes
    • Dans, M., et al. Tyrosine phosphorylation of the β4 integrin cytoplasmic domain mediates Shc signaling to extracellular signal-regulated kinase and antagonizes formation of hemidesmosomes. J. Biol. Chem. 276, 1494-1502 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 1494-1502
    • Dans, M.1
  • 78
    • 0141706652 scopus 로고    scopus 로고
    • Identification of a novel integrin α6β1 binding site in the angiogenic inducer CCN1 (CYR61)
    • Leu, S. J. et al. Identification of a novel integrin α6β1 binding site in the angiogenic inducer CCN1 (CYR61). J. Biol. Chem. 278, 33801-33808 (2003).
    • (2003) J. Biol. Chem , vol.278 , pp. 33801-33808
    • Leu, S.J.1
  • 79
    • 33644650332 scopus 로고    scopus 로고
    • A homing mechanism for bone marrow-derived progenitor cell recruitment to the neovasculature
    • This paper shows that integrin α4β1 on bone marrow-derived cells promotes monocyte and endothelial precursor cell homing to tumours
    • Jin, H. et al. A homing mechanism for bone marrow-derived progenitor cell recruitment to the neovasculature. J. Clin. Invest. 116, 652-662 (2006). This paper shows that integrin α4β1 on bone marrow-derived cells promotes monocyte and endothelial precursor cell homing to tumours.
    • (2006) J. Clin. Invest , vol.116 , pp. 652-662
    • Jin, H.1
  • 80
    • 33644555196 scopus 로고    scopus 로고
    • Integrin α4β1 promotes monocyte trafficking and angiogenesis in tumors
    • Jin, H., Su, J., Garmy-Susini, B., Kleeman, J. & Varner, J. Integrin α4β1 promotes monocyte trafficking and angiogenesis in tumors. Cancer Res. 66, 2146-2152 (2006).
    • (2006) Cancer Res , vol.66 , pp. 2146-2152
    • Jin, H.1    Su, J.2    Garmy-Susini, B.3    Kleeman, J.4    Varner, J.5
  • 81
    • 33746845201 scopus 로고    scopus 로고
    • Essential role of ICAM-1/CD18 in mediating EPC recruitment, angiogenesis, and repair to the infarcted myocardium
    • Wu, Y. et al. Essential role of ICAM-1/CD18 in mediating EPC recruitment, angiogenesis, and repair to the infarcted myocardium. Circ. Res. 99, 315-322 (2006).
    • (2006) Circ. Res , vol.99 , pp. 315-322
    • Wu, Y.1
  • 82
    • 19944431202 scopus 로고    scopus 로고
    • Role of β2-integrins for homing and neovascularization capacity of endothelial progenitor cells
    • Chavakis, E. et al. Role of β2-integrins for homing and neovascularization capacity of endothelial progenitor cells. J. Exp. Med. 1, 63-72 (2005).
    • (2005) J. Exp. Med , vol.1 , pp. 63-72
    • Chavakis, E.1
  • 83
    • 33845296579 scopus 로고    scopus 로고
    • The sticky truth about angiogenesis and thrombospondins
    • Varner, J. A. The sticky truth about angiogenesis and thrombospondins. J. Clin. Invest. 116, 3111-3113 (2006).
    • (2006) J. Clin. Invest , vol.116 , pp. 3111-3113
    • Varner, J.A.1
  • 84
    • 34548458187 scopus 로고    scopus 로고
    • Thrombopoietic cells and the bone marrow vascular niche
    • Kopp, H. G. & Rafii, S. Thrombopoietic cells and the bone marrow vascular niche. Ann. NY Acad. Sci. 1106, 175-179 (2007).
    • (2007) Ann. NY Acad. Sci , vol.1106 , pp. 175-179
    • Kopp, H.G.1    Rafii, S.2
  • 85
    • 0033593793 scopus 로고    scopus 로고
    • LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan
    • Banerji, S. et al. LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan. J. Cell Biol. 144, 789-801 (1999).
    • (1999) J. Cell Biol , vol.144 , pp. 789-801
    • Banerji, S.1
  • 86
    • 0033578853 scopus 로고    scopus 로고
    • Prox1 function is required for the development of the murine lymphatic system
    • Wigle, J. T. & Oliver, G. Prox1 function is required for the development of the murine lymphatic system. Cell 98, 769-778 (1999).
    • (1999) Cell , vol.98 , pp. 769-778
    • Wigle, J.T.1    Oliver, G.2
  • 87
    • 0032937233 scopus 로고    scopus 로고
    • Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: Podoplanin as a specific marker for lymphatic endothelium
    • Breiteneder-Geleff, S. et al. Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium. Am. J. Pathol. 154, 385-394 (1999).
    • (1999) Am. J. Pathol , vol.154 , pp. 385-394
    • Breiteneder-Geleff, S.1
  • 88
    • 34247198981 scopus 로고    scopus 로고
    • Prox1 induces lymphatic endothelial differentiation via integrin α9 and other signaling cascades
    • Mishima, K. et al. Prox1 induces lymphatic endothelial differentiation via integrin α9 and other signaling cascades. Mol. Biol. Cell. 18, 1421-1429 (2007).
    • (2007) Mol. Biol. Cell , vol.18 , pp. 1421-1429
    • Mishima, K.1
  • 89
    • 14244269759 scopus 로고    scopus 로고
    • The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin α9β1
    • Vlahakis, N. E., Young, B. A., Atakilit, A. & Sheppard, D. The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin α9β1. J. Biol. Chem. 280, 4544-4552 (2005).
    • (2005) J. Biol. Chem , vol.280 , pp. 4544-4552
    • Vlahakis, N.E.1    Young, B.A.2    Atakilit, A.3    Sheppard, D.4
  • 90
    • 6944228960 scopus 로고    scopus 로고
    • VEGF-A promotes tissue repair-associated lymphatic vessel formation via VEGFR-2 and the α1β1 and α2β1 integrins
    • This article established the role of integrins α1β1 and α2β1 in lymphangiogenesis
    • Hong, Y. K. et al. VEGF-A promotes tissue repair-associated lymphatic vessel formation via VEGFR-2 and the α1β1 and α2β1 integrins. FASEB J. 18, 1111-1113 (2004). This article established the role of integrins α1β1 and α2β1 in lymphangiogenesis.
    • (2004) FASEB J , vol.18 , pp. 1111-1113
    • Hong, Y.K.1
  • 91
    • 34547687853 scopus 로고    scopus 로고
    • Inhibition of inflammatory lymphangiogenesis by integrin α5 blockade
    • Dietrich, T. et al. Inhibition of inflammatory lymphangiogenesis by integrin α5 blockade. Am. J. Pathol. 171, 361-372 (2007).
    • (2007) Am. J. Pathol , vol.171 , pp. 361-372
    • Dietrich, T.1
  • 93
    • 0033870756 scopus 로고    scopus 로고
    • Targeted antiangiogenic therapy for cancer using Vitaxin: A humanized monoclonal antibody to the integrin αvβ3
    • Gutheil, J. C. et al. Targeted antiangiogenic therapy for cancer using Vitaxin: a humanized monoclonal antibody to the integrin αvβ3. Clin. Cancer Res. 6, 3056-3061 (2000).
    • (2000) Clin. Cancer Res , vol.6 , pp. 3056-3061
    • Gutheil, J.C.1
  • 94
    • 27744563296 scopus 로고    scopus 로고
    • Phase I trial of a monoclonal antibody specific for αvβ3 integrin (MEDI-522) in patients with advanced malignancies, including an assessment of effect on tumor perfusion
    • McNeel, D. G. et al. Phase I trial of a monoclonal antibody specific for αvβ3 integrin (MEDI-522) in patients with advanced malignancies, including an assessment of effect on tumor perfusion. Clin Cancer Res. 11, 7851-7860 (2005).
    • (2005) Clin Cancer Res , vol.11 , pp. 7851-7860
    • McNeel, D.G.1
  • 95
    • 33645549711 scopus 로고    scopus 로고
    • A phase II, randomized, open-label study evaluating the antitumor activity of MEDI-522, a humanized monoclonal antibody directed against the human αvβ3 (αvβ3) integrin, ± dacarbazine (DTIC) in patients with metastatic melanoma
    • Hersey, P. et al. A phase II, randomized, open-label study evaluating the antitumor activity of MEDI-522, a humanized monoclonal antibody directed against the human αvβ3 (αvβ3) integrin, ± dacarbazine (DTIC) in patients with metastatic melanoma. J. Clin. Oncol. 2005 ASCO Annu. Meeting Proc. 23, 7507 (2005).
    • (2005) J. Clin. Oncol. 2005 ASCO Annu. Meeting Proc , vol.23 , pp. 7507
    • Hersey, P.1
  • 96
    • 33750453376 scopus 로고    scopus 로고
    • Effects of a monoclonal anti-αvβ3 integrin antibody on blood vessels - a pharmacodynamic study
    • Zhang, D., Pier, T., McNeel, D. G., Wilding, G. & Friedl, A. Effects of a monoclonal anti-αvβ3 integrin antibody on blood vessels - a pharmacodynamic study. Invest. New Drugs 25, 49-55 (2007).
    • (2007) Invest. New Drugs , vol.25 , pp. 49-55
    • Zhang, D.1    Pier, T.2    McNeel, D.G.3    Wilding, G.4    Friedl, A.5
  • 97
    • 2442488748 scopus 로고    scopus 로고
    • CNTO 95, a fully human monoclonal antibody that inhibits αv integrins, has antitumor and antiangiogenic activity in vivo
    • Trikha, M. et al. CNTO 95, a fully human monoclonal antibody that inhibits αv integrins, has antitumor and antiangiogenic activity in vivo. Int. J. Cancer 110, 326-335 (2004).
    • (2004) Int. J. Cancer , vol.110 , pp. 326-335
    • Trikha, M.1
  • 98
    • 26444548107 scopus 로고    scopus 로고
    • Absence of adverse effects in cynomolgus macaques treated with CNTO 95, a fully human anti-αv integrin monoclonal antibody, despite widespread tissue binding
    • Martin, P. L. et al. Absence of adverse effects in cynomolgus macaques treated with CNTO 95, a fully human anti-αv integrin monoclonal antibody, despite widespread tissue binding. Clin. Cancer Res. 11, 6959-6965 (2005).
    • (2005) Clin. Cancer Res , vol.11 , pp. 6959-6965
    • Martin, P.L.1
  • 99
    • 34247504971 scopus 로고    scopus 로고
    • Phase I evaluation of a fully human anti-αv integrin monoclonal antibody (CNTO 95) in patients with advanced solid tumors
    • Mullamitha, S. A. et al. Phase I evaluation of a fully human anti-αv integrin monoclonal antibody (CNTO 95) in patients with advanced solid tumors. Clin. Cancer Res. 13, 2128-2135 (2007).
    • (2007) Clin. Cancer Res , vol.13 , pp. 2128-2135
    • Mullamitha, S.A.1
  • 100
    • 0030901145 scopus 로고    scopus 로고
    • Insulin-like growth factor receptor cooperates with integrin αvβ5 to promote tumor cell dissemination in vivo
    • Brooks, P. C. et al. Insulin-like growth factor receptor cooperates with integrin αvβ5 to promote tumor cell dissemination in vivo. J. Clin. Invest. 99, 1390-1398 (1997).
    • (1997) J. Clin. Invest , vol.99 , pp. 1390-1398
    • Brooks, P.C.1
  • 101
    • 34249087162 scopus 로고    scopus 로고
    • Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma
    • Nabors, L. B. et al. Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma. J. Clin. Oncol. 25, 1651-1657 (2007).
    • (2007) J. Clin. Oncol , vol.25 , pp. 1651-1657
    • Nabors, L.B.1
  • 102
    • 33748574545 scopus 로고    scopus 로고
    • Integrin α v β 3 antagonist Cilengitide enhances efficacy of radiotherapy in endothelial cell and non-small-cell lung cancer models
    • Albert, J. M. et al. Integrin α v β 3 antagonist Cilengitide enhances efficacy of radiotherapy in endothelial cell and non-small-cell lung cancer models. Int. J. Radiat. Oncol. Biol. Phys. 65, 1536-1543 (2006).
    • (2006) Int. J. Radiat. Oncol. Biol. Phys , vol.65 , pp. 1536-1543
    • Albert, J.M.1
  • 103
    • 33846604223 scopus 로고    scopus 로고
    • A randomized multi-center phase II trial of the angiogenesis inhibitor Cilengitide (EMD 121974) and gemcitabine compared with gemcitabine alone in advanced unresectable pancreatic cancer
    • Friess, H. et al. A randomized multi-center phase II trial of the angiogenesis inhibitor Cilengitide (EMD 121974) and gemcitabine compared with gemcitabine alone in advanced unresectable pancreatic cancer. BMC Cancer 6, 285 (2006).
    • (2006) BMC Cancer , vol.6 , pp. 285
    • Friess, H.1
  • 104
    • 33646859981 scopus 로고    scopus 로고
    • Phase II evaluations of cilengitide in asymptomatic patients with androgen-independent prostate cancer: Scientific rationale and study design
    • Beekman, K. W. et al. Phase II evaluations of cilengitide in asymptomatic patients with androgen-independent prostate cancer: scientific rationale and study design. Clin. Genitourin. Cancer 4, 299-302 (2006).
    • (2006) Clin. Genitourin. Cancer , vol.4 , pp. 299-302
    • Beekman, K.W.1
  • 105
    • 38349108587 scopus 로고    scopus 로고
    • EMD121974 (NSC 707544, cilengitide) in asymptomatic metastatic androgen independent prostate cancer (AIPCa) patients (pts): A randomized trial by the Prostate Cancer Clinical Trials Consortium (NCI 6372)
    • Bradley, D. A. et. al. EMD121974 (NSC 707544, cilengitide) in asymptomatic metastatic androgen independent prostate cancer (AIPCa) patients (pts): A randomized trial by the Prostate Cancer Clinical Trials Consortium (NCI 6372). J. Clin. Oncol. 2007 ASCO Annu. Meeting Proc. 25, 5137 (2007).
    • (2007) J. Clin. Oncol. 2007 ASCO Annu. Meeting Proc , vol.25 , pp. 5137
    • Bradley, D.A.1    et., al.2
  • 106
    • 33845351712 scopus 로고    scopus 로고
    • Phase II study of volociximab (M200), an α5β1 anti-integrin antibody in refractory metastatic clear cell renal cell cancer (RCC)
    • Figlin, R. A., Kondagunta, G. V., Yazji, S., Motzer, R. J. & Bukowski, R. M. Phase II study of volociximab (M200), an α5β1 anti-integrin antibody in refractory metastatic clear cell renal cell cancer (RCC). J. Clin. Oncol. ASCO Annu. Meeting Proc. 24, 4535 (2006).
    • (2006) J. Clin. Oncol. ASCO Annu. Meeting Proc , vol.24 , pp. 4535
    • Figlin, R.A.1    Kondagunta, G.V.2    Yazji, S.3    Motzer, R.J.4    Bukowski, R.M.5
  • 107
    • 33947306264 scopus 로고    scopus 로고
    • Drug evaluation: Volociximab, an angiogenesis-inhibiting chimeric monoclonal antibody
    • Kuwada, S. K. Drug evaluation: Volociximab, an angiogenesis-inhibiting chimeric monoclonal antibody. Curr. Opin. Mol. Ther. 9, 92-98 (2007).
    • (2007) Curr. Opin. Mol. Ther , vol.9 , pp. 92-98
    • Kuwada, S.K.1
  • 108
    • 0037457423 scopus 로고    scopus 로고
    • Inhibition of integrin α5β1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice
    • Stoeltzing, O. et al. Inhibition of integrin α5β1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice. Int. J. Cancer 104, 496-503 (2003).
    • (2003) Int. J. Cancer , vol.104 , pp. 496-503
    • Stoeltzing, O.1
  • 109
    • 33745240059 scopus 로고    scopus 로고
    • 2), a β integrin antagonist, in patients with solid tumours
    • 2), a β integrin antagonist, in patients with solid tumours. Br. J. Cancer 94, 1621-1626 (2006).
    • (2006) Br. J. Cancer , vol.94 , pp. 1621-1626
    • Cianfrocca, M.E.1
  • 110
    • 33745495366 scopus 로고    scopus 로고
    • A review: Integrin αvβ3-targeted molecular imaging and therapy in angiogenesis
    • Lim, E. H., Danth, N., Bednarski, M. & Li, K. C. A review: Integrin αvβ3-targeted molecular imaging and therapy in angiogenesis. Nanomedicine 1, 110-114 (2005).
    • (2005) Nanomedicine , vol.1 , pp. 110-114
    • Lim, E.H.1    Danth, N.2    Bednarski, M.3    Li, K.C.4
  • 111
    • 35748963560 scopus 로고    scopus 로고
    • Garanger, E., Boturyn, D. & Dumy, P. Tumor targeting with RGD peptide ligands-design of new molecular conjugates for imaging and therapy of cancers. Anticancer Agents Med. Chem. 7, 552-558 (2007).
    • Garanger, E., Boturyn, D. & Dumy, P. Tumor targeting with RGD peptide ligands-design of new molecular conjugates for imaging and therapy of cancers. Anticancer Agents Med. Chem. 7, 552-558 (2007).
  • 112
    • 0031862889 scopus 로고    scopus 로고
    • Detection of tumor angiogenesis in vivo by αvβ3-targeted magnetic resonance imaging
    • Sipkins, D. A. et al. Detection of tumor angiogenesis in vivo by αvβ3-targeted magnetic resonance imaging. Nature Med. 4, 623-626 (1998).
    • (1998) Nature Med , vol.4 , pp. 623-626
    • Sipkins, D.A.1
  • 113
    • 0037469182 scopus 로고    scopus 로고
    • Noninvasive assessment of angiogenesis by ultrasound and microbubbles targeted to αv-integrins
    • Leong-Poi, H. et al. Noninvasive assessment of angiogenesis by ultrasound and microbubbles targeted to αv-integrins. Circulation 107, 455-460 (2003).
    • (2003) Circulation , vol.107 , pp. 455-460
    • Leong-Poi, H.1
  • 114
    • 0037189380 scopus 로고    scopus 로고
    • Tumor regression by targeted gene delivery to the neovasculature
    • This landmark paper established the potential of integrin-targeted nanoparticles in cancer therapy
    • Hood, J. D. et al. Tumor regression by targeted gene delivery to the neovasculature. Science 296, 2404-2407 (2002). This landmark paper established the potential of integrin-targeted nanoparticles in cancer therapy.
    • (2002) Science , vol.296 , pp. 2404-2407
    • Hood, J.D.1
  • 115
    • 28444497446 scopus 로고    scopus 로고
    • Integrin structure, allostery, and bidirectional signaling
    • Arnaout, M. A., Mahalingam, B. & Xiong, J. P. Integrin structure, allostery, and bidirectional signaling. Annu. Rev. Cell Dev. Biol. 21, 381-410 (2005).
    • (2005) Annu. Rev. Cell Dev. Biol , vol.21 , pp. 381-410
    • Arnaout, M.A.1    Mahalingam, B.2    Xiong, J.P.3
  • 116
    • 0035805633 scopus 로고    scopus 로고
    • Association of the membrane proximal regions of the α and β subunit cytoplasmic domains constrains an integrin in the inactive state
    • Lu, C., Takagi, J. & Springer, T. A. Association of the membrane proximal regions of the α and β subunit cytoplasmic domains constrains an integrin in the inactive state. J. Biol. Chem. 276, 14642-14648 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 14642-14648
    • Lu, C.1    Takagi, J.2    Springer, T.A.3
  • 117
    • 0036220127 scopus 로고    scopus 로고
    • Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation
    • Beglova, N., Blacklow, S. C., Takagi, J. & Springer, T. A. Cysteine-rich module structure reveals a fulcrum for integrin rearrangement upon activation. Nature Struct. Biol. 9, 282-287 (2002).
    • (2002) Nature Struct. Biol , vol.9 , pp. 282-287
    • Beglova, N.1    Blacklow, S.C.2    Takagi, J.3    Springer, T.A.4
  • 118
    • 0037031551 scopus 로고    scopus 로고
    • A structural mechanism of integrin αIIbβ3 "inside-out" activation as regulated by its cytoplasmic face
    • Vinogradova, O. et al. A structural mechanism of integrin αIIbβ3 "inside-out" activation as regulated by its cytoplasmic face. Cell 110, 587-597 (2002).
    • (2002) Cell , vol.110 , pp. 587-597
    • Vinogradova, O.1
  • 119
    • 0034698511 scopus 로고    scopus 로고
    • Subsecond induction of α4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions
    • Grabovsky, V. et al. Subsecond induction of α4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions. J. Exp. Med. 192, 495-506 (2000).
    • (2000) J. Exp. Med , vol.192 , pp. 495-506
    • Grabovsky, V.1
  • 120
    • 0028285015 scopus 로고
    • Integrin cytoplasmic domains mediate inside-out signal transduction
    • O'Toole, T. E. et al. Integrin cytoplasmic domains mediate inside-out signal transduction. J. Cell Biol. 124, 1047-1059 (1994).
    • (1994) J. Cell Biol , vol.124 , pp. 1047-1059
    • O'Toole, T.E.1
  • 121
    • 33845767868 scopus 로고    scopus 로고
    • Macrophages regulate the angiogenic switch in a mouse model of breast cancer
    • Lin, E. Y. et al. Macrophages regulate the angiogenic switch in a mouse model of breast cancer. Cancer Res. 66, 11238-11246 (2006).
    • (2006) Cancer Res , vol.66 , pp. 11238-11246
    • Lin, E.Y.1
  • 122
    • 34347226359 scopus 로고    scopus 로고
    • Tumor-associated macrophages press the angiogenic switch in breast cancer
    • Lin, E. Y. & Pollard, J. W. Tumor-associated macrophages press the angiogenic switch in breast cancer. Cancer Res. 67, 5064-5066 (2007).
    • (2007) Cancer Res , vol.67 , pp. 5064-5066
    • Lin, E.Y.1    Pollard, J.W.2
  • 123
    • 8644263977 scopus 로고    scopus 로고
    • Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice
    • Peng, X. et al. Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice. Cardiovasc. Res. 64, 421-430 (2004).
    • (2004) Cardiovasc. Res , vol.64 , pp. 421-430
    • Peng, X.1
  • 124
    • 22344434300 scopus 로고    scopus 로고
    • Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis
    • Shen, T. L. et al. Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. J. Cell Biol. 169, 941-952 (2005).
    • (2005) J. Cell Biol , vol.169 , pp. 941-952
    • Shen, T.L.1
  • 125
    • 0034194470 scopus 로고    scopus 로고
    • The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo
    • Lai, K. M. & Pawson, T. The ShcA phosphotyrosine docking protein sensitizes cardiovascular signaling in the mouse embryo. Genes Dev. 14, 1132-1145 (2000).
    • (2000) Genes Dev , vol.14 , pp. 1132-1145
    • Lai, K.M.1    Pawson, T.2
  • 126
    • 17744378364 scopus 로고    scopus 로고
    • MEK kinase activity is not necessary for Raf-1 function
    • Hüser, M. et al. MEK kinase activity is not necessary for Raf-1 function. EMBO J. 20, 1940-1951 (2001).
    • (2001) EMBO J , vol.20 , pp. 1940-1951
    • Hüser, M.1
  • 127
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens, L. M. & Werb, Z. Inflammation and cancer. Nature 420, 860-867 (2002).
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 128
    • 33751098783 scopus 로고    scopus 로고
    • Microvessel density, VEGF expression, and tumor-associated macrophages in breast tumors: Correlations with prognostic parameters
    • Bolat, F. et al. Microvessel density, VEGF expression, and tumor-associated macrophages in breast tumors: correlations with prognostic parameters. J. Exp. Clin. Cancer Res. 25, 365-372 (2006).
    • (2006) J. Exp. Clin. Cancer Res , vol.25 , pp. 365-372
    • Bolat, F.1
  • 129
    • 24744454660 scopus 로고    scopus 로고
    • Macrophage infiltration and its prognostic implications in breast cancer: The relationship with VEGF expression and microvessel density
    • Tsutsui, S. et al. Macrophage infiltration and its prognostic implications in breast cancer: the relationship with VEGF expression and microvessel density. Oncol. Rep. 14, 425-431 (2005).
    • (2005) Oncol. Rep , vol.14 , pp. 425-431
    • Tsutsui, S.1
  • 130
    • 0036329210 scopus 로고    scopus 로고
    • Correlation between vascular endothelial growth factor, angiogenesis, and tumor-associated macrophages in invasive ductal breast carcinoma
    • Valkovíc, T. et al. Correlation between vascular endothelial growth factor, angiogenesis, and tumor-associated macrophages in invasive ductal breast carcinoma. Virchows Arch. 440, 583-588 (2002).
    • (2002) Virchows Arch , vol.440 , pp. 583-588
    • Valkovíc, T.1
  • 131
    • 2642547301 scopus 로고    scopus 로고
    • Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinomas
    • Esposito, I. et al. Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinomas. J. Clin. Pathol. 6, 630-636 (2004).
    • (2004) J. Clin. Pathol , vol.6 , pp. 630-636
    • Esposito, I.1
  • 133
    • 0032926784 scopus 로고    scopus 로고
    • Macrophage infiltration and heme oxygenase-1 expression correlate with angiogenesis in human gliomas
    • Nishie, A. Macrophage infiltration and heme oxygenase-1 expression correlate with angiogenesis in human gliomas. Clin. Cancer Res. 5, 1107-1113 (1999).
    • (1999) Clin. Cancer Res , vol.5 , pp. 1107-1113
    • Nishie, A.1
  • 134
    • 0028116948 scopus 로고
    • Tumor-derived monocyte chemoattractant protein-1 induces intratumoral infiltration of monocyte-derived macrophage subpopulation in transplanted rat tumors
    • Yamashiro, S. et al. Tumor-derived monocyte chemoattractant protein-1 induces intratumoral infiltration of monocyte-derived macrophage subpopulation in transplanted rat tumors. Am. J. Pathol. 4, 856-867 (1994).
    • (1994) Am. J. Pathol , vol.4 , pp. 856-867
    • Yamashiro, S.1
  • 135
    • 0033780453 scopus 로고    scopus 로고
    • Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomas
    • Lewis, J. S. et al. Expression of vascular endothelial growth factor by macrophages is up-regulated in poorly vascularized areas of breast carcinomas. J. Pathol. 2, 150-158 (2000).
    • (2000) J. Pathol , vol.2 , pp. 150-158
    • Lewis, J.S.1
  • 136
    • 34248172324 scopus 로고    scopus 로고
    • Altered macrophage differentiation and immune dysfunction in tumor development
    • Sica, A. & Bronte, V. Altered macrophage differentiation and immune dysfunction in tumor development. J. Clin. Invest. 117, 1155-1166 (2007).
    • (2007) J. Clin. Invest , vol.117 , pp. 1155-1166
    • Sica, A.1    Bronte, V.2
  • 137
    • 17144430502 scopus 로고    scopus 로고
    • The contribution of bone marrow-derived cells to the tumor vasculature in neuroblastoma is matrix metalloproteinase-9 dependent
    • Jodele, S. et al. The contribution of bone marrow-derived cells to the tumor vasculature in neuroblastoma is matrix metalloproteinase-9 dependent. Cancer Res. 65, 3200-3208 (2005).
    • (2005) Cancer Res , vol.65 , pp. 3200-3208
    • Jodele, S.1
  • 138
    • 4944239035 scopus 로고    scopus 로고
    • An aminobisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis
    • Giraudo, E., Inoue, M. & Hanahan, D. An aminobisphosphonate targets MMP-9-expressing macrophages and angiogenesis to impair cervical carcinogenesis. J. Clin. Invest. 5, 623-633 (2004).
    • (2004) J. Clin. Invest , vol.5 , pp. 623-633
    • Giraudo, E.1    Inoue, M.2    Hanahan, D.3
  • 139
    • 0033903714 scopus 로고    scopus 로고
    • Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer
    • Ueno, T. et al. Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer. Clin. Cancer Res. 8, 3282-3289 (2000).
    • (2000) Clin. Cancer Res , vol.8 , pp. 3282-3289
    • Ueno, T.1
  • 140
    • 0035120421 scopus 로고    scopus 로고
    • Correlation of tissue and plasma RANTES levels with disease course in patients with breast or cervical cancer
    • Niwa, Y. et al. Correlation of tissue and plasma RANTES levels with disease course in patients with breast or cervical cancer. Clin. Cancer Res. 2, 285-289 (2001).
    • (2001) Clin. Cancer Res , vol.2 , pp. 285-289
    • Niwa, Y.1
  • 141
    • 4944244259 scopus 로고    scopus 로고
    • Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues
    • Murdoch, C., Giannoudis, A. & Lewis, C. E. Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood 8, 2224-2234 (2004).
    • (2004) Blood , vol.8 , pp. 2224-2234
    • Murdoch, C.1    Giannoudis, A.2    Lewis, C.E.3
  • 142
    • 0033594416 scopus 로고    scopus 로고
    • MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions
    • Gerszten, R. E. et al. MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature 398, 718-723 (1999).
    • (1999) Nature , vol.398 , pp. 718-723
    • Gerszten, R.E.1
  • 143
    • 20444436815 scopus 로고    scopus 로고
    • Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop
    • Goswami, S. et al. Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop. Cancer Res. 12, 5278-5283 (2005).
    • (2005) Cancer Res , vol.12 , pp. 5278-5283
    • Goswami, S.1
  • 144
    • 34247274248 scopus 로고    scopus 로고
    • Nuclear cytokine-activated IKKα controls prostate cancer metastasis by repressing Maspin
    • Luo, J. L. et al. Nuclear cytokine-activated IKKα controls prostate cancer metastasis by repressing Maspin. Nature 446, 690-694 (2007).
    • (2007) Nature , vol.446 , pp. 690-694
    • Luo, J.L.1
  • 145
    • 4043088499 scopus 로고    scopus 로고
    • IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    • Greten, F. R. et al. IKKβ links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118, 285-296 (2004).
    • (2004) Cell , vol.118 , pp. 285-296
    • Greten, F.R.1
  • 146
    • 36849017497 scopus 로고    scopus 로고
    • Schafer, Z. T. & Brugge, J. S. IL-6 involvement in epithelial cancers. J. Clin. Invest. 117, 3660-3663 (2007).
    • Schafer, Z. T. & Brugge, J. S. IL-6 involvement in epithelial cancers. J. Clin. Invest. 117, 3660-3663 (2007).
  • 147
    • 36849039660 scopus 로고    scopus 로고
    • Il-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland
    • Sansone, P. et al. Il-6 triggers malignant features in mammospheres from human ductal breast carcinoma and normal mammary gland. J. Clin. Invest. 117, 3988-4002 (2007).
    • (2007) J. Clin. Invest , vol.117 , pp. 3988-4002
    • Sansone, P.1
  • 148
    • 36849012237 scopus 로고    scopus 로고
    • Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas
    • Gao, S. P. et al. Mutations in the EGFR kinase domain mediate STAT3 activation via IL-6 production in human lung adenocarcinomas J. Clin. Invest. 117, 3846-3856 (2007).
    • (2007) J. Clin. Invest , vol.117 , pp. 3846-3856
    • Gao, S.P.1
  • 149
    • 0035911221 scopus 로고    scopus 로고
    • Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy
    • Lin, E. Y., Nguyen, A. V., Russell, R. G. & Pollard, J. W. Colony-stimulating factor 1 promotes progression of mammary tumors to malignancy. J. Exp. Med. 6, 727-740 (2001).
    • (2001) J. Exp. Med , vol.6 , pp. 727-740
    • Lin, E.Y.1    Nguyen, A.V.2    Russell, R.G.3    Pollard, J.W.4
  • 150
    • 0031000635 scopus 로고    scopus 로고
    • LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice
    • Lu, H. et al. LFA-1 is sufficient in mediating neutrophil emigration in Mac-1-deficient mice. J. Clin. Invest. 99, 1340-1350 (1997).
    • (1997) J. Clin. Invest , vol.99 , pp. 1340-1350
    • Lu, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.