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β8 integrins are required for vascular morphogenesis in mouse embryos
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This article shows that integrin αvβ8 is required for the formation of normal brain blood vessels
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Zhu, J.1
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Human endothelial cells synthesize and express an Arg-Gly-Asp-directed adhesion receptor involved in attachment to fibrinogen and von Willebrand factor
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Requirement of vascular integrin αvβ3 for angiogenesis
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Brooks, P. C., Clark, R. A. & Cheresh, D. A. Requirement of vascular integrin αvβ3 for angiogenesis. Science 264, 569-571 (1994). This is the first article demonstrating a role for an integrin in angiogenesis.
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Tumor metastasis but not tumor growth is dependent on Src-mediated vascular permeability
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β3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival
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Hodivala-Dilke, K. M. et al. β3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. J. Clin. Invest. 103, 229-238 (1999).
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Elevated Flk1 (vascular endothelial growth factor receptor 2) signaling mediates enhanced angiogenesis in β3-integrin-deficient mice
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Reynolds, A. R. et al. Elevated Flk1 (vascular endothelial growth factor receptor 2) signaling mediates enhanced angiogenesis in β3-integrin-deficient mice. Cancer Res. 64, 8643-8650 (2004). This study established the concept that developmental loss of an integrin could lead to enhanced angiogenesis through compensatory mechanisms.
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Reynolds, A.R.1
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This article showed that loss of αvβ5 during development has no significant effect on angiogenesis
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Huang, X., Griffiths, M., Wu, J., Farese, R. V. Jr & Sheppard, D. Normal development, wound healing, and adenovirus susceptibility in β5-deficient mice. Mol. Cell Biol. 20, 755-759 (2000). This article showed that loss of αvβ5 during development has no significant effect on angiogenesis.
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Bader, B. L., Rayburn, H., Crowley, D. & Hynes, R. O. Extensive vasculogenesis, angiogenesis, and organogenesis precede lethality in mice lacking all αv integrins. Cell 95, 507-519 (1998). This study shows that αv integrins are essential for development in most animals but that some animals can survive in ovo loss of αv integrins until the early post-natal period.
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41
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Selective ablation of α v integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death
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McCarty, J. H. et al. Selective ablation of α v integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development 132, 165-176 (2005).
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Integrin signaling is critical for pathological angiogenesis
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This study shows that animals with an intact but non-functional β3 integrin exhibit defective angiogenesis
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Mahabeleshwar, G. H., Feng, W., Phillips, D. R. & Byzova, T. V. Integrin signaling is critical for pathological angiogenesis. J. Exp. Med. 203, 2495-2507 (2006). This study shows that animals with an intact but non-functional β3 integrin exhibit defective angiogenesis.
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Integrin αvβ3 rescues melanoma cells from apoptosis in three-dimensional dermal collagen
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Kim, S., Bell, K., Mousa, S. A. & Varner, J. A. Regulation of angiogenesis in vivo by ligation of integrin α5β1 with the central cell-binding domain of fibronectin. Am. J. Pathol. 156, 1345-1362 (2000). This is the first article showing a role for integrin α5β1 in angiogenesis.
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The EIIIA segment of fibronectin is a ligand for integrins α9β1 and α4β1 providing a novel mechanism for regulating cell adhesion by alternative splicing
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