Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte-macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma

Proceedings of the National Academy of Sciences of the United States of America

Volumn 95, Issue 22, 1998, Pages 13141-13146

  Soiffer, Robert ^a   Lynch, Thomas ^b   Mihm, Martin ^b   Jung, Ken ^a   Rhuda, Catherine ^a   Schmollinger, Jan C ^a   Hodi, F Stephen ^a   Liebster, Laura ^b   Lam, Prudence ^b   Mentzer, Steven ^c   Singer, Samuel ^c   Tanabe, Kenneth K ^b   Cosimi, A Benedict ^b   Duda, Rosemary ^d   Sober, Arthur ^b   Bhan, Atul ^b   Daley, John ^a   Neuberg, Donna ^a   Parry, Gordon ^e   Rokovich, Joseph ^e   Richards, Laurie ^e   Drayer, Jan ^e   Berns, Anton ^e   Clift, Shirley ^e   Cohen, Lawrence K ^e   Mulligan, Richard C ^f   Drangf, Glenn ^a,g   more..

^a HARVARD MEDICAL SCHOOL   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^e CELL GENESYS INC   (United States)

^f BOSTON CHILDREN S HOSPITAL   (United States)

^g DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER ANTIBODY; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; TUMOR VACCINE;

ADULT; AGED; ANTIBODY RESPONSE; ANTIGEN PRESENTATION; ARTICLE; CELL INFILTRATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DENDRITIC CELL; EOSINOPHILIA; ERYTHEMA; FEMALE; HISTOPATHOLOGY; HUMAN; IMMUNOSTIMULATION; INTRADERMAL DRUG ADMINISTRATION; IRRADIATION; MACROPHAGE; MALE; MELANOMA CELL; METASTASIS; PHASE 1 CLINICAL TRIAL; PRIORITY JOURNAL; PRURITUS; T LYMPHOCYTE; TUMOR IMMUNITY;

CANCER VACCINES; CYTOKINES; DENDRITIC CELLS; EOSINOPHILS; GENETIC ENGINEERING; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; HYPERSENSITIVITY, DELAYED; LYMPHOCYTES; LYMPHOCYTES, TUMOR-INFILTRATING; MACROPHAGES; MELANOMA; NEOPLASM METASTASIS; T-LYMPHOCYTES; TRANSPLANTATION, AUTOLOGOUS;

EID: 0032573225     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.95.22.13141     Document Type: Article

References (34)

1. Clark, W., From, L., Bernardino, E. & Mihm, M. (1969) Cancer Res. 29, 705-726.
2. Ferradini, L., Mackensen, A., Genevee, C., Bosq, J., Duvillard, P., Avril, M.-F. & Hercend, T. (1993) J. Clin. Invest. 91, 1183-1190.
3. Mackensen, A., Carcelain, G., Viel, S., Raynal, M.-C., Michalaki, H., Triebel, F., Bosq, J. & Hercend, T. (1994) J. Clin. Invest. 93, 1397-1402.
4. Clark, W., Elder, D., Guerry, D., Braitman, L., Trock, B., Schultz, D., Synnestvedt, M. & Halpern, A. (1989) J. Natl. Cancer Inst. 81, 1893-1904.
5. Clemente, C., Mihm, M., Bufalino, R., Zurrida, S., Collini, P. & Cascinelli, N. (1996) Cancer (Phila.) 77, 1303-1310.
6. Mihm, M., Clemente, C. & Cascinelli, N. (1996) Lab. Invest. 74, 43-47.
7. Bulkley, G., Cohen, M., Banks, P., Char, D. & Ketcham, A. (1975) Cancer (Phila.) 36, 485-494.
8. Dranoff, G. & Mulligan, R. C. (1995) Adv. Immunol. 58, 417-454.
9. Dranoff, G., Jaffee, E., Lazenby, A., Golumbek, P., Levitsky, H., Brose, K., Jackson, V., Hamada, H., Pardoll, D. & Mulligan, R. C. (1993) Proc. Natl. Acad. Sci. USA 90, 3539-3543.
10. Soiffer, R., Lynch, T., Mihm, M., Jung, K., Kolesar, K., Liebster, L., Lam, P., Duda, R., Mentzer, S., Singer, S., et al. (1997) Hum. Gene Ther. 8, 111-123.
11. Ellem, K. A. O., O'Rourke, M. G. E., Johnson, G. R., Parry, G., Misko, I. S., Schmidt, C. W., Parsons, P. G., Burrows, S. R., Cross, S., Fell, A., et al. (1997) Cancer Immunol. Immunother. 44, 10-20.
12. Simons, J. W., Jaffee, E. M., Weber, C. E., Levitsky, H. I., Nelson, W. G., Carducci, M. A., Lazenby, A. J., Cohen, L. K., Finn, C. C., Clift, S. M., et al. (1997) Cancer Res. 57, 1537-1546.
13. Coligan, J. E., Kruisbeek, A. M., Margulies, D. H., Shevach, E. M. & Strober, W. (1991) Current Protocols in Immunology (Wiley, New York).
14. Coffman, R. L., Seymour, B. W., Hudak, S., Jackson, J. & Rennick, D. (1989) Science 245, 308-310.
15. Arai, K.-I., Lee, F., Miyajima, A., Miyatake, S., Arai, N. & Yokota, T. (1990) Annu. Rev. Biochem. 59, 783-836.
16. Moore, K. W., O'Garra, A., de Waal Malefyt, R., Vieira, P. & Mosmann, T. R. (1993) Annu. Rev. Immunol. 11, 165-190.
17. Berd, D., Murphy, G., Maguire, H. C. & Mastrangelo, M. J. (1991) Cancer Res. 51, 2731-2734.
18. Oratz, R., Cockerill, C., Speyer, J., Harris, M., Roses, D. & Bystryn, J.-C. (1989) J. Biol. Response Modif. 8, 355-358.
19. Mitchell, M. S., Harel, W., Kempf, R. A., Hu, E., Kan-Mitchell, J., Boswell, W. D., Dean, G. & Stevenson, L. (1990) J. Clin. Oncol. 8, 856-869.
20. Hersey, P., Edwards, A., Coates, A., Shaw, H., McCarthy, W. & Milton, G. (1987) Cancer Immunol. Immunother. 25, 257-265.
21. Morton, D. L., Foshag, L. J., Hoon, D. S. B., Nizze, J. A., Wanek, L. A., Chang, C., Davtyan, D. G., Gupta, R. K., Elashoff, R. & Irie, R. F. (1992) Ann. Surg. 216, 463-482.
22. Slinghuff, C., Vollmer, R. & Siegler, H. (1988) J. Surg. Oncol. 39, 139-147.
23. Livingston, P., Wong, G., Adluri, S., Tao, Y., Padavan, M., Parente, R., Hanlon, C., Calves, M., Helling, F., Ritter, G., et al. (1994) J. Clin. Oncol. 12, 1036-1044.
24. Mukherji, B., Chakraborty, N., Yamasaki, S., Okino, T., Yamase, H., Sporn, J., Kurtzman, S., Ergin, M., Ozols, J., Meehan, J., et al. (1995) Proc. Natl. Acad. Sci. USA 92, 8078-8082.
25. Marchand, M., Weynants, P., Rankin, E., Arjenti, F., Belli, F., Parmiani, G., Cascinelli, N., Bourlond, A., Vanwijck, R., Humblet, Y., et al. (1995) Int. J. Cancer 63, 883-885.
26. Jager, E., Ringhoffer, M., Dienes, H. P., Arand, M., Karbach, J., Jager, D., Ilsemann, C., Hagedorn, M., Oesch, F. & Knuth, A. (1996) Int. J. Cancer 67, 54-62.
27. Berd, D., Maguire, H., Mastrangelo, M. J. & Murphy, G. (1994) Cancer Immunol. Immunother. 39, 141-147.
28. Berd, D., Maguire, H. C., Schuchter, L. M., Hamilton, R., Hauck, W. W., Sato, T. & Mastrangelo, M. J. (1997) J. Clin. Oncol. 15, 2359-2370.
29. Lattime, E., Mastrangelo, M. J., Bagastra, O., Li, W. & Berd, D. (1995) Cancer Immunol. Immunother. 41, 151-156.
30. Sensi, M., Farina, C., Maccalli, C., Lupetti, R., Nicolinin, G., Anichini, A., Parmiani, G. & Berd, D. (1997) J. Clin. Invest. 99, 710-717.
31. Murphy, G., Radu, A., Kaminer, M. & Berd, D. (1993) J. Invest. Dermatol. 100, Suppl., 335S-341S.
32. Barth, A., Hoon, D. S. B., Foshag, L. J., Nizze, J. A., Famatiga, E., Okun, E. & Morton, D. L. (1994) Cancer Res. 54, 3342-3345.
33. Hsu, S., Hsu, H., Penick, G., Lust, G. & Osborne, J. (1974) J. Allergy Clin. Immunol. 54, 339-349.
34. Gleich, G. J. & Adolphson, C. R. (1986) Adv. Immunol. 39, 177-253.