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Volumn 46, Issue 7, 2010, Pages 1232-1240

Targeting the transforming growth factor-β signalling pathway in metastatic cancer

Author keywords

Cancer; Metastasis; Molecular therapeutics; TGF

Indexed keywords

4 [4 (1,3 BENZODIOXOL 5 YL) 5 (2 PYRIDINYL) 1H IMIDAZOL 2 YL]BENZAMIDE; AP 12009; CYTOTOXIC AGENT; DOXORUBICIN; GC 1008; IMMUNOSUPPRESSIVE AGENT; KI 26894; LIGAND; LY 2109761; LY 2157299; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 1D11; MONOCLONAL ANTIBODY 2G7; RAPAMYCIN; SD 208; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 2; UNCLASSIFIED DRUG;

EID: 77950595599     PISSN: 09598049     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejca.2010.02.040     Document Type: Article
Times cited : (85)

References (87)
  • 1
    • 0031685620 scopus 로고    scopus 로고
    • TGF-beta signal transduction
    • Massague J. TGF-beta signal transduction. Annu Rev Biochem 67 (1998) 753-791
    • (1998) Annu Rev Biochem , vol.67 , pp. 753-791
    • Massague, J.1
  • 2
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in cancer
    • Massague J. TGFbeta in cancer. Cell 134 2 (2008) 215-230
    • (2008) Cell , vol.134 , Issue.2 , pp. 215-230
    • Massague, J.1
  • 3
    • 33745515023 scopus 로고    scopus 로고
    • Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer
    • Bierie B., and Moses H.L. Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer. Nat Rev Cancer 6 7 (2006) 506-520
    • (2006) Nat Rev Cancer , vol.6 , Issue.7 , pp. 506-520
    • Bierie, B.1    Moses, H.L.2
  • 4
    • 0030793645 scopus 로고    scopus 로고
    • Transforming growth factor-beta in breast cancer: a working hypothesis
    • Reiss M., and Barcellos-Hoff M.H. Transforming growth factor-beta in breast cancer: a working hypothesis. Breast Cancer Res Treat 45 1 (1997) 81-95
    • (1997) Breast Cancer Res Treat , vol.45 , Issue.1 , pp. 81-95
    • Reiss, M.1    Barcellos-Hoff, M.H.2
  • 5
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-b signaling from cell membrane to the nucleus
    • Shi Y., and Massague J. Mechanisms of TGF-b signaling from cell membrane to the nucleus. Cell 113 (2003) 685-700
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massague, J.2
  • 6
    • 33746510500 scopus 로고    scopus 로고
    • Pro-metastasis function of TGFbeta mediated by the Smad pathway
    • Kang Y. Pro-metastasis function of TGFbeta mediated by the Smad pathway. J Cell Biochem 98 6 (2006) 1380-1390
    • (2006) J Cell Biochem , vol.98 , Issue.6 , pp. 1380-1390
    • Kang, Y.1
  • 7
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-beta family signalling
    • Derynck R., and Zhang Y.E. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 425 6958 (2003) 577-584
    • (2003) Nature , vol.425 , Issue.6958 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 8
    • 0038369998 scopus 로고    scopus 로고
    • A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells
    • Kang Y., Chen C.R., and Massague J. A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol Cell 11 4 (2003) 915-926
    • (2003) Mol Cell , vol.11 , Issue.4 , pp. 915-926
    • Kang, Y.1    Chen, C.R.2    Massague, J.3
  • 9
    • 0034785348 scopus 로고    scopus 로고
    • TGF-beta signaling in tumor suppression and cancer progression
    • Derynck R., Akhurst R.J., and Balmain A. TGF-beta signaling in tumor suppression and cancer progression. Nat Genet 29 2 (2001) 117-129
    • (2001) Nat Genet , vol.29 , Issue.2 , pp. 117-129
    • Derynck, R.1    Akhurst, R.J.2    Balmain, A.3
  • 10
    • 0034644472 scopus 로고    scopus 로고
    • TGFbeta signaling in growth control, cancer, and heritable disorders
    • Massague J., Blain S.W., and Lo R.S. TGFbeta signaling in growth control, cancer, and heritable disorders. Cell 103 2 (2000) 295-309
    • (2000) Cell , vol.103 , Issue.2 , pp. 295-309
    • Massague, J.1    Blain, S.W.2    Lo, R.S.3
  • 11
    • 0030598681 scopus 로고    scopus 로고
    • TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice
    • Cui W., Fowlis D.J., Bryson S., et al. TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice. Cell 86 4 (1996) 531-542
    • (1996) Cell , vol.86 , Issue.4 , pp. 531-542
    • Cui, W.1    Fowlis, D.J.2    Bryson, S.3
  • 12
    • 0029010734 scopus 로고
    • Mammary tumor suppression by transforming growth factor beta 1 transgene expression
    • Pierce Jr. D.F., Gorska A.E., Chytil A., et al. Mammary tumor suppression by transforming growth factor beta 1 transgene expression. Proc Natl Acad Sci USA 92 10 (1995) 4254-4258
    • (1995) Proc Natl Acad Sci USA , vol.92 , Issue.10 , pp. 4254-4258
    • Pierce Jr., D.F.1    Gorska, A.E.2    Chytil, A.3
  • 13
    • 2642614530 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency
    • Tang B., Bottinger E.P., Jakowlew S.B., et al. Transforming growth factor-beta1 is a new form of tumor suppressor with true haploid insufficiency. Nat Med 4 7 (1998) 802-807
    • (1998) Nat Med , vol.4 , Issue.7 , pp. 802-807
    • Tang, B.1    Bottinger, E.P.2    Jakowlew, S.B.3
  • 14
    • 33646537475 scopus 로고    scopus 로고
    • Loss of transforming growth factor-beta type II receptor promotes metastatic head-and-neck squamous cell carcinoma
    • Lu S.L., Herrington H., Reh D., et al. Loss of transforming growth factor-beta type II receptor promotes metastatic head-and-neck squamous cell carcinoma. Genes Dev 20 10 (2006) 1331-1342
    • (2006) Genes Dev , vol.20 , Issue.10 , pp. 1331-1342
    • Lu, S.L.1    Herrington, H.2    Reh, D.3
  • 15
    • 33750565444 scopus 로고    scopus 로고
    • Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation
    • Munoz N.M., Upton M., Rojas A., et al. Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation. Cancer Res 66 20 (2006) 9837-9844
    • (2006) Cancer Res , vol.66 , Issue.20 , pp. 9837-9844
    • Munoz, N.M.1    Upton, M.2    Rojas, A.3
  • 16
    • 33751247898 scopus 로고    scopus 로고
    • Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression
    • Ijichi H., Chytil A., Gorska A.E., et al. Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression. Genes Dev 20 22 (2006) 3147-3160
    • (2006) Genes Dev , vol.20 , Issue.22 , pp. 3147-3160
    • Ijichi, H.1    Chytil, A.2    Gorska, A.E.3
  • 17
    • 35148832173 scopus 로고    scopus 로고
    • Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia
    • Guasch G., Schober M., Pasolli H.A., et al. Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia. Cancer Cell 12 4 (2007) 313-327
    • (2007) Cancer Cell , vol.12 , Issue.4 , pp. 313-327
    • Guasch, G.1    Schober, M.2    Pasolli, H.A.3
  • 18
    • 16844373628 scopus 로고    scopus 로고
    • Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis
    • Forrester E., Chytil A., Bierie B., et al. Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis. Cancer Res 65 6 (2005) 2296-2302
    • (2005) Cancer Res , vol.65 , Issue.6 , pp. 2296-2302
    • Forrester, E.1    Chytil, A.2    Bierie, B.3
  • 20
    • 54249093237 scopus 로고    scopus 로고
    • Transforming growth factor-beta signaling-deficient fibroblasts enhance hepatocyte growth factor signaling in mammary carcinoma cells to promote scattering and invasion
    • Cheng N., Chytil A., Shyr Y., Joly A., and Moses H.L. Transforming growth factor-beta signaling-deficient fibroblasts enhance hepatocyte growth factor signaling in mammary carcinoma cells to promote scattering and invasion. Mol Cancer Res 6 10 (2008) 1521-1533
    • (2008) Mol Cancer Res , vol.6 , Issue.10 , pp. 1521-1533
    • Cheng, N.1    Chytil, A.2    Shyr, Y.3    Joly, A.4    Moses, H.L.5
  • 21
    • 0035902141 scopus 로고    scopus 로고
    • The microenvironment of the tumour-host interface
    • Liotta L.A., and Kohn E.C. The microenvironment of the tumour-host interface. Nature 411 6835 (2001) 375-379
    • (2001) Nature , vol.411 , Issue.6835 , pp. 375-379
    • Liotta, L.A.1    Kohn, E.C.2
  • 22
    • 0842288323 scopus 로고    scopus 로고
    • TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
    • Bhowmick N.A., Chytil A., Plieth D., et al. TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science 303 5659 (2004) 848-851
    • (2004) Science , vol.303 , Issue.5659 , pp. 848-851
    • Bhowmick, N.A.1    Chytil, A.2    Plieth, D.3
  • 23
    • 23744452875 scopus 로고    scopus 로고
    • Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networks
    • Cheng N., Bhowmick N.A., Chytil A., et al. Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networks. Oncogene 24 32 (2005) 5053-5068
    • (2005) Oncogene , vol.24 , Issue.32 , pp. 5053-5068
    • Cheng, N.1    Bhowmick, N.A.2    Chytil, A.3
  • 24
    • 0028875562 scopus 로고
    • Allelotype of pancreatic adenocarcinoma using xenograft enrichment
    • Hahn S.A., Seymour A.B., Hoque A.T., et al. Allelotype of pancreatic adenocarcinoma using xenograft enrichment. Cancer Res 55 20 (1995) 4670-4675
    • (1995) Cancer Res , vol.55 , Issue.20 , pp. 4670-4675
    • Hahn, S.A.1    Seymour, A.B.2    Hoque, A.T.3
  • 25
    • 15844390729 scopus 로고    scopus 로고
    • Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers
    • Thiagalingam S., Lengauer C., Leach F.S., et al. Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers. Nat Genet 13 3 (1996) 343-346
    • (1996) Nat Genet , vol.13 , Issue.3 , pp. 343-346
    • Thiagalingam, S.1    Lengauer, C.2    Leach, F.S.3
  • 26
    • 0242499448 scopus 로고    scopus 로고
    • Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer
    • Siegel P.M., and Massague J. Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat Rev Cancer 3 11 (2003) 807-821
    • (2003) Nat Rev Cancer , vol.3 , Issue.11 , pp. 807-821
    • Siegel, P.M.1    Massague, J.2
  • 27
    • 0035970035 scopus 로고    scopus 로고
    • Defective repression of c-myc in breast cancer cells: a loss at the core of the transforming growth factor beta growth arrest program
    • Chen C.R., Kang Y., and Massague J. Defective repression of c-myc in breast cancer cells: a loss at the core of the transforming growth factor beta growth arrest program. Proc Natl Acad Sci USA 98 3 (2001) 992-999
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.3 , pp. 992-999
    • Chen, C.R.1    Kang, Y.2    Massague, J.3
  • 28
    • 0025316140 scopus 로고
    • Transforming growth factor beta 1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane
    • Yang E.Y., and Moses H.L. Transforming growth factor beta 1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane. J Cell Biol 111 2 (1990) 731-741
    • (1990) J Cell Biol , vol.111 , Issue.2 , pp. 731-741
    • Yang, E.Y.1    Moses, H.L.2
  • 29
    • 0027137485 scopus 로고
    • Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression
    • Arteaga CL, Hurd SD, Winnier AR, et al. Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer progression. J Clin Invest 1993;92(6):2569-76.
    • (1993) J Clin Invest , vol.92 , Issue.6 , pp. 2569-2576
    • Arteaga, C.L.1    Hurd, S.D.2    Winnier, A.R.3
  • 30
    • 0031944290 scopus 로고    scopus 로고
    • Regulation of immune responses by TGF-beta
    • Letterio J.J., and Roberts A.B. Regulation of immune responses by TGF-beta. Annu Rev Immunol 16 (1998) 137-161
    • (1998) Annu Rev Immunol , vol.16 , pp. 137-161
    • Letterio, J.J.1    Roberts, A.B.2
  • 31
    • 0029662049 scopus 로고    scopus 로고
    • TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells
    • Oft M., Peli J., Rudaz C., et al. TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. Genes Dev 10 19 (1996) 2462-2477
    • (1996) Genes Dev , vol.10 , Issue.19 , pp. 2462-2477
    • Oft, M.1    Peli, J.2    Rudaz, C.3
  • 32
    • 58149236744 scopus 로고    scopus 로고
    • Roles of TGFb in metastasis
    • Padua D., and Massague J. Roles of TGFb in metastasis. Cell Res 19 (2009) 89-102
    • (2009) Cell Res , vol.19 , pp. 89-102
    • Padua, D.1    Massague, J.2
  • 33
    • 33846821916 scopus 로고    scopus 로고
    • High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene
    • Bruna A., Darken R.S., Rojo F., et al. High TGFbeta-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene. Cancer Cell 11 2 (2007) 147-160
    • (2007) Cancer Cell , vol.11 , Issue.2 , pp. 147-160
    • Bruna, A.1    Darken, R.S.2    Rojo, F.3
  • 34
    • 30644467227 scopus 로고    scopus 로고
    • Inhibition of TGFbeta signaling in cancer therapy
    • Arteaga C.L. Inhibition of TGFbeta signaling in cancer therapy. Curr Opin Genet Dev 16 1 (2006) 30-37
    • (2006) Curr Opin Genet Dev , vol.16 , Issue.1 , pp. 30-37
    • Arteaga, C.L.1
  • 35
    • 0242552529 scopus 로고    scopus 로고
    • Increased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor beta1
    • Muraoka R.S., Koh Y., Roebuck L.R., et al. Increased malignancy of Neu-induced mammary tumors overexpressing active transforming growth factor beta1. Mol Cell Biol 23 23 (2003) 8691-8703
    • (2003) Mol Cell Biol , vol.23 , Issue.23 , pp. 8691-8703
    • Muraoka, R.S.1    Koh, Y.2    Roebuck, L.R.3
  • 36
    • 0037816160 scopus 로고    scopus 로고
    • Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis
    • Siegel P.M., Shu W., Cardiff R.D., Muller W.J., and Massague J. Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis. Proc Natl Acad Sci USA 100 14 (2003) 8430-8435
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.14 , pp. 8430-8435
    • Siegel, P.M.1    Shu, W.2    Cardiff, R.D.3    Muller, W.J.4    Massague, J.5
  • 37
    • 33644534795 scopus 로고    scopus 로고
    • The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells
    • Deckers M., van Dinther M., Buijs J., et al. The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells. Cancer Res 66 4 (2006) 2202-2209
    • (2006) Cancer Res , vol.66 , Issue.4 , pp. 2202-2209
    • Deckers, M.1    van Dinther, M.2    Buijs, J.3
  • 38
    • 25444479744 scopus 로고    scopus 로고
    • Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway
    • Kang Y., He W., Tulley S., et al. Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway. Proc Natl Acad Sci USA 102 39 (2005) 13909-13914
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.39 , pp. 13909-13914
    • Kang, Y.1    He, W.2    Tulley, S.3
  • 39
    • 68349160814 scopus 로고    scopus 로고
    • Imaging transforming growth factor-beta signaling dynamics and therapeutic response in breast cancer bone metastasis
    • Korpal M., Yan J., Lu X., et al. Imaging transforming growth factor-beta signaling dynamics and therapeutic response in breast cancer bone metastasis. Nat Med 15 8 (2009) 960-966
    • (2009) Nat Med , vol.15 , Issue.8 , pp. 960-966
    • Korpal, M.1    Yan, J.2    Lu, X.3
  • 40
    • 0347626102 scopus 로고    scopus 로고
    • Reduction in Smad2/3 signaling enhances tumorigenesis but suppresses metastasis of breast cancer cell lines
    • Tian F., DaCosta Byfield S., Parks W.T., et al. Reduction in Smad2/3 signaling enhances tumorigenesis but suppresses metastasis of breast cancer cell lines. Cancer Res 63 23 (2003) 8284-8292
    • (2003) Cancer Res , vol.63 , Issue.23 , pp. 8284-8292
    • Tian, F.1    DaCosta Byfield, S.2    Parks, W.T.3
  • 41
    • 0032918414 scopus 로고    scopus 로고
    • TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development
    • Yin J.J., Selander K., Chirgwin J.M., et al. TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development. J Clin Invest 103 2 (1999) 197-206
    • (1999) J Clin Invest , vol.103 , Issue.2 , pp. 197-206
    • Yin, J.J.1    Selander, K.2    Chirgwin, J.M.3
  • 42
    • 0038488950 scopus 로고    scopus 로고
    • A multigenic program mediating breast cancer metastasis to bone
    • Kang Y., Siegel P.M., Shu W., et al. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 3 6 (2003) 537-549
    • (2003) Cancer Cell , vol.3 , Issue.6 , pp. 537-549
    • Kang, Y.1    Siegel, P.M.2    Shu, W.3
  • 43
    • 41149157649 scopus 로고    scopus 로고
    • TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4
    • Padua D., Zhang X.H., Wang Q., et al. TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell 133 (2008) 66-77
    • (2008) Cell , vol.133 , pp. 66-77
    • Padua, D.1    Zhang, X.H.2    Wang, Q.3
  • 44
    • 33746763680 scopus 로고    scopus 로고
    • TGF-beta in cancer and as a therapeutic target
    • Pinkas J., and Teicher B.A. TGF-beta in cancer and as a therapeutic target. Biochem Pharmacol 72 5 (2006) 523-529
    • (2006) Biochem Pharmacol , vol.72 , Issue.5 , pp. 523-529
    • Pinkas, J.1    Teicher, B.A.2
  • 45
    • 33745685865 scopus 로고    scopus 로고
    • Bone sialoprotein mediates the tumor cell-targeted prometastatic activity of transforming growth factor beta in a mouse model of breast cancer
    • Nam J.S., Suchar A.M., Kang M.J., et al. Bone sialoprotein mediates the tumor cell-targeted prometastatic activity of transforming growth factor beta in a mouse model of breast cancer. Cancer Res 66 12 (2006) 6327-6335
    • (2006) Cancer Res , vol.66 , Issue.12 , pp. 6327-6335
    • Nam, J.S.1    Suchar, A.M.2    Kang, M.J.3
  • 46
    • 77950593325 scopus 로고    scopus 로고
    • Morris J, Shapiro G, Tan AR, et al. Phase 1/2 study of GC1008: a human anti transforming growth factor-beta (TGFb) monoclonal antibody (MAb) in patients with advanced malignant melanoma or renal cell carcinoma. J Clin Oncol 2008;26 (Abstract#9028).
    • Morris J, Shapiro G, Tan AR, et al. Phase 1/2 study of GC1008: a human anti transforming growth factor-beta (TGFb) monoclonal antibody (MAb) in patients with advanced malignant melanoma or renal cell carcinoma. J Clin Oncol 2008;26 (Abstract#9028).
  • 47
    • 67349091089 scopus 로고    scopus 로고
    • Transforming growth factor-b signaling: emerging stem cell target in metastatic breast cancer?
    • Tan A.R., Alexe G., and Reiss M. Transforming growth factor-b signaling: emerging stem cell target in metastatic breast cancer?. Breast Cancer Res Treat 115 3 (2009) 453-495
    • (2009) Breast Cancer Res Treat , vol.115 , Issue.3 , pp. 453-495
    • Tan, A.R.1    Alexe, G.2    Reiss, M.3
  • 48
    • 0027531528 scopus 로고
    • Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death
    • Kulkarni A.B., Huh C.G., Becker D., et al. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci USA 90 2 (1993) 770-774
    • (1993) Proc Natl Acad Sci USA , vol.90 , Issue.2 , pp. 770-774
    • Kulkarni, A.B.1    Huh, C.G.2    Becker, D.3
  • 49
    • 0037570729 scopus 로고    scopus 로고
    • Minimal effects on immune parameters following chronic anti-TGF-beta monoclonal antibody administration to normal mice
    • Ruzek M.C., Hawes M., Pratt B., et al. Minimal effects on immune parameters following chronic anti-TGF-beta monoclonal antibody administration to normal mice. Immunopharmacol Immunotoxicol 25 2 (2003) 235-257
    • (2003) Immunopharmacol Immunotoxicol , vol.25 , Issue.2 , pp. 235-257
    • Ruzek, M.C.1    Hawes, M.2    Pratt, B.3
  • 50
    • 0032547895 scopus 로고    scopus 로고
    • TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis
    • Oft M., Heider K.H., and Beug H. TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis. Curr Biol 8 23 (1998) 1243-1252
    • (1998) Curr Biol , vol.8 , Issue.23 , pp. 1243-1252
    • Oft, M.1    Heider, K.H.2    Beug, H.3
  • 51
    • 0036086409 scopus 로고    scopus 로고
    • Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases
    • Muraoka R.S., Dumont N., Ritter C.A., et al. Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases. J Clin Invest 109 12 (2002) 1551-1559
    • (2002) J Clin Invest , vol.109 , Issue.12 , pp. 1551-1559
    • Muraoka, R.S.1    Dumont, N.2    Ritter, C.A.3
  • 52
    • 0036050857 scopus 로고    scopus 로고
    • Soluble type II transforming growth factor-beta receptor attenuates expression of metastasis-associated genes and suppresses pancreatic cancer cell metastasis
    • Rowland-Goldsmith M.A., Maruyama H., Matsuda K., et al. Soluble type II transforming growth factor-beta receptor attenuates expression of metastasis-associated genes and suppresses pancreatic cancer cell metastasis. Mol Cancer Therapy 1 3 (2002) 161-167
    • (2002) Mol Cancer Therapy , vol.1 , Issue.3 , pp. 161-167
    • Rowland-Goldsmith, M.A.1    Maruyama, H.2    Matsuda, K.3
  • 53
    • 0036087521 scopus 로고    scopus 로고
    • Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects
    • Yang Y.A., Dukhanina O., Tang B., et al. Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects. J Clin Invest 109 12 (2002) 1607-1615
    • (2002) J Clin Invest , vol.109 , Issue.12 , pp. 1607-1615
    • Yang, Y.A.1    Dukhanina, O.2    Tang, B.3
  • 54
    • 0030977137 scopus 로고    scopus 로고
    • Expression of transforming growth factor beta (TGFbeta) type III receptor restores autocrine TGFbeta1 activity in human breast cancer MCF-7 cells
    • Chen C., Wang X.F., and Sun L. Expression of transforming growth factor beta (TGFbeta) type III receptor restores autocrine TGFbeta1 activity in human breast cancer MCF-7 cells. J Biol Chem 272 19 (1997) 12862-12867
    • (1997) J Biol Chem , vol.272 , Issue.19 , pp. 12862-12867
    • Chen, C.1    Wang, X.F.2    Sun, L.3
  • 55
    • 0025989562 scopus 로고
    • Expression cloning and characterization of the TGF-beta type III receptor
    • Wang X.F., Lin H.Y., Ng-Eaton E., et al. Expression cloning and characterization of the TGF-beta type III receptor. Cell 67 4 (1991) 797-805
    • (1991) Cell , vol.67 , Issue.4 , pp. 797-805
    • Wang, X.F.1    Lin, H.Y.2    Ng-Eaton, E.3
  • 56
    • 0033215194 scopus 로고    scopus 로고
    • A soluble transforming growth factor beta type III receptor suppresses tumorigenicity and metastasis of human breast cancer MDA-MB-231 cells
    • Bandyopadhyay A., Zhu Y., Cibull M.L., et al. A soluble transforming growth factor beta type III receptor suppresses tumorigenicity and metastasis of human breast cancer MDA-MB-231 cells. Cancer Res 59 19 (1999) 5041-5046
    • (1999) Cancer Res , vol.59 , Issue.19 , pp. 5041-5046
    • Bandyopadhyay, A.1    Zhu, Y.2    Cibull, M.L.3
  • 57
    • 0037118579 scopus 로고    scopus 로고
    • Extracellular domain of TGFbeta type III receptor inhibits angiogenesis and tumor growth in human cancer cells
    • Bandyopadhyay A., Zhu Y., Malik S.N., et al. Extracellular domain of TGFbeta type III receptor inhibits angiogenesis and tumor growth in human cancer cells. Oncogene 21 22 (2002) 3541-3551
    • (2002) Oncogene , vol.21 , Issue.22 , pp. 3541-3551
    • Bandyopadhyay, A.1    Zhu, Y.2    Malik, S.N.3
  • 58
    • 0037102289 scopus 로고    scopus 로고
    • Antitumor activity of a recombinant soluble betaglycan in human breast cancer xenograft
    • Bandyopadhyay A., Lopez-Casillas F., Malik S.N., et al. Antitumor activity of a recombinant soluble betaglycan in human breast cancer xenograft. Cancer Res 62 16 (2002) 4690-4695
    • (2002) Cancer Res , vol.62 , Issue.16 , pp. 4690-4695
    • Bandyopadhyay, A.1    Lopez-Casillas, F.2    Malik, S.N.3
  • 59
    • 10844224603 scopus 로고    scopus 로고
    • Conditional overexpression of active transforming growth factor beta1 in vivo accelerates metastases of transgenic mammary tumors
    • Muraoka-Cook R.S., Kurokawa H., Koh Y., et al. Conditional overexpression of active transforming growth factor beta1 in vivo accelerates metastases of transgenic mammary tumors. Cancer Res 64 24 (2004) 9002-9011
    • (2004) Cancer Res , vol.64 , Issue.24 , pp. 9002-9011
    • Muraoka-Cook, R.S.1    Kurokawa, H.2    Koh, Y.3
  • 60
    • 0027944080 scopus 로고
    • Antisense oligodeoxyribonucleotide inhibition of TGF-beta 1 gene expression and alterations in the growth and malignant properties of mouse fibrosarcoma cells
    • Spearman M., Taylor W.R., Greenberg A.H., and Wright J.A. Antisense oligodeoxyribonucleotide inhibition of TGF-beta 1 gene expression and alterations in the growth and malignant properties of mouse fibrosarcoma cells. Gene 149 1 (1994) 25-29
    • (1994) Gene , vol.149 , Issue.1 , pp. 25-29
    • Spearman, M.1    Taylor, W.R.2    Greenberg, A.H.3    Wright, J.A.4
  • 61
    • 0034926056 scopus 로고    scopus 로고
    • Comparative analysis of IFN-gamma B7.1 and antisense TGF-beta gene transfer on the tumorigenicity of a poorly immunogenic metastatic mammary carcinoma
    • Wu RS, Kobie JJ, Besselsen DG, et al. Comparative analysis of IFN-gamma B7.1 and antisense TGF-beta gene transfer on the tumorigenicity of a poorly immunogenic metastatic mammary carcinoma. Cancer Immunol Immunother 2001;50(5):229-40.
    • (2001) Cancer Immunol Immunother , vol.50 , Issue.5 , pp. 229-240
    • Wu, R.S.1    Kobie, J.J.2    Besselsen, D.G.3
  • 62
    • 34547187636 scopus 로고    scopus 로고
    • Inhibition of TGF-beta2 with AP 12009 in recurrent malignant gliomas: from preclinical to phase I/II studies
    • Hau P., Jachimczak P., Schlingensiepen R., et al. Inhibition of TGF-beta2 with AP 12009 in recurrent malignant gliomas: from preclinical to phase I/II studies. Oligonucleotides 17 2 (2007) 201-212
    • (2007) Oligonucleotides , vol.17 , Issue.2 , pp. 201-212
    • Hau, P.1    Jachimczak, P.2    Schlingensiepen, R.3
  • 63
    • 0037141103 scopus 로고    scopus 로고
    • Disruption of transforming growth factor beta signaling by a novel ligand-dependent mechanism
    • Fernandez T., Amoroso S., Sharpe S., et al. Disruption of transforming growth factor beta signaling by a novel ligand-dependent mechanism. J Exp Med 195 10 (2002) 1247-1255
    • (2002) J Exp Med , vol.195 , Issue.10 , pp. 1247-1255
    • Fernandez, T.1    Amoroso, S.2    Sharpe, S.3
  • 64
    • 0025580020 scopus 로고
    • Suppression of carcinogenesis: a role for TGF-beta and related molecules in prevention of cancer
    • Wakefield L.M., and Sporn M.B. Suppression of carcinogenesis: a role for TGF-beta and related molecules in prevention of cancer. Immunol Ser 51 (1990) 217-243
    • (1990) Immunol Ser , vol.51 , pp. 217-243
    • Wakefield, L.M.1    Sporn, M.B.2
  • 65
    • 38449103630 scopus 로고    scopus 로고
    • Antisense therapeutics for tumor treatment: the TGF-beta2 inhibitor AP 12009 in clinical development against malignant tumors
    • Schlingensiepen K.H., Fischer-Blass B., Schmaus S., and Ludwig S. Antisense therapeutics for tumor treatment: the TGF-beta2 inhibitor AP 12009 in clinical development against malignant tumors. Recent Results Cancer Res 177 (2008) 137-150
    • (2008) Recent Results Cancer Res , vol.177 , pp. 137-150
    • Schlingensiepen, K.H.1    Fischer-Blass, B.2    Schmaus, S.3    Ludwig, S.4
  • 66
    • 20244383986 scopus 로고    scopus 로고
    • Progressive transforming growth factor beta1-induced lung fibrosis is blocked by an orally active ALK5 kinase inhibitor
    • Bonniaud P., Margetts P.J., Kolb M., et al. Progressive transforming growth factor beta1-induced lung fibrosis is blocked by an orally active ALK5 kinase inhibitor. Am J Respir Crit Care Med 171 8 (2005) 889-898
    • (2005) Am J Respir Crit Care Med , vol.171 , Issue.8 , pp. 889-898
    • Bonniaud, P.1    Margetts, P.J.2    Kolb, M.3
  • 67
    • 7444226411 scopus 로고    scopus 로고
    • SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo
    • Uhl M., Aulwurm S., Wischhusen J., et al. SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo. Cancer Res 64 21 (2004) 7954-7961
    • (2004) Cancer Res , vol.64 , Issue.21 , pp. 7954-7961
    • Uhl, M.1    Aulwurm, S.2    Wischhusen, J.3
  • 68
    • 33751320565 scopus 로고    scopus 로고
    • Inhibition of growth and metastasis of mouse mammary carcinoma by selective inhibitor of transforming growth factor-beta type I receptor kinase in vivo
    • Ge R, Rajeev V, Ray P, et al. Inhibition of growth and metastasis of mouse mammary carcinoma by selective inhibitor of transforming growth factor-beta type I receptor kinase in vivo. Clin Cancer Res 2006;12(14 Pt 1):4315-30.
    • (2006) Clin Cancer Res , vol.12 , Issue.14 PART 1 , pp. 4315-4330
    • Ge, R.1    Rajeev, V.2    Ray, P.3
  • 69
    • 33751328068 scopus 로고    scopus 로고
    • Ki26894, a novel transforming growth factor-beta type I receptor kinase inhibitor, inhibits in vitro invasion and in vivo bone metastasis of a human breast cancer cell line
    • Ehata S., Hanyu A., Fujime M., et al. Ki26894, a novel transforming growth factor-beta type I receptor kinase inhibitor, inhibits in vitro invasion and in vivo bone metastasis of a human breast cancer cell line. Cancer Sci 98 1 (2007) 127-133
    • (2007) Cancer Sci , vol.98 , Issue.1 , pp. 127-133
    • Ehata, S.1    Hanyu, A.2    Fujime, M.3
  • 70
    • 10444261212 scopus 로고    scopus 로고
    • Development of TGF-beta signalling inhibitors for cancer therapy
    • Yingling J.M., Blanchard K.L., and Sawyer J.S. Development of TGF-beta signalling inhibitors for cancer therapy. Nat Rev Drug Discov 3 12 (2004) 1011-1022
    • (2004) Nat Rev Drug Discov , vol.3 , Issue.12 , pp. 1011-1022
    • Yingling, J.M.1    Blanchard, K.L.2    Sawyer, J.S.3
  • 71
    • 42249099019 scopus 로고    scopus 로고
    • LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis
    • Melisi D., Ishiyama S., Sclabas G.M., et al. LY2109761, a novel transforming growth factor beta receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis. Mol Cancer Therapy 7 4 (2008) 829-840
    • (2008) Mol Cancer Therapy , vol.7 , Issue.4 , pp. 829-840
    • Melisi, D.1    Ishiyama, S.2    Sclabas, G.M.3
  • 72
    • 61849183646 scopus 로고    scopus 로고
    • Targeting transforming growth factor-beta signaling in liver metastasis of colon cancer
    • Zhang B., Halder S.K., Zhang S., and Datta P.K. Targeting transforming growth factor-beta signaling in liver metastasis of colon cancer. Cancer Lett 277 1 (2009) 114-120
    • (2009) Cancer Lett , vol.277 , Issue.1 , pp. 114-120
    • Zhang, B.1    Halder, S.K.2    Zhang, S.3    Datta, P.K.4
  • 73
    • 77950596058 scopus 로고    scopus 로고
    • Calvo-Aller EBJ, Glatt S, Cleverly A, et al. First human dose escalation study in patients with metastatic malignancies to determine safety and pharmacokinetics of LY2157299, a small molecule inhibitor of the transforming growth factor-beta receptor I kinase. J Clin Oncol 2008;26 (Abstract#14554).
    • Calvo-Aller EBJ, Glatt S, Cleverly A, et al. First human dose escalation study in patients with metastatic malignancies to determine safety and pharmacokinetics of LY2157299, a small molecule inhibitor of the transforming growth factor-beta receptor I kinase. J Clin Oncol 2008;26 (Abstract#14554).
  • 74
    • 45549088943 scopus 로고    scopus 로고
    • Transforming growth factor beta subverts the immune system into directly promoting tumor growth through interleukin-17
    • Nam J.S., Terabe M., Kang M.J., et al. Transforming growth factor beta subverts the immune system into directly promoting tumor growth through interleukin-17. Cancer Res 68 10 (2008) 3915-3923
    • (2008) Cancer Res , vol.68 , Issue.10 , pp. 3915-3923
    • Nam, J.S.1    Terabe, M.2    Kang, M.J.3
  • 75
    • 33947246042 scopus 로고    scopus 로고
    • A novel small-molecule inhibitor of transforming growth factor beta type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection
    • Suzuki E., Kim S., Cheung H.K., et al. A novel small-molecule inhibitor of transforming growth factor beta type I receptor kinase (SM16) inhibits murine mesothelioma tumor growth in vivo and prevents tumor recurrence after surgical resection. Cancer Res 67 5 (2007) 2351-2359
    • (2007) Cancer Res , vol.67 , Issue.5 , pp. 2351-2359
    • Suzuki, E.1    Kim, S.2    Cheung, H.K.3
  • 76
    • 0037446966 scopus 로고    scopus 로고
    • Transforming growth factor beta inhibits the antigen-presenting functions and antitumor activity of dendritic cell vaccines
    • Kobie J.J., Wu R.S., Kurt R.A., et al. Transforming growth factor beta inhibits the antigen-presenting functions and antitumor activity of dendritic cell vaccines. Cancer Res 63 8 (2003) 1860-1864
    • (2003) Cancer Res , vol.63 , Issue.8 , pp. 1860-1864
    • Kobie, J.J.1    Wu, R.S.2    Kurt, R.A.3
  • 77
    • 0030036344 scopus 로고    scopus 로고
    • Modulation of B16 melanoma growth and metastasis by anti-transforming growth factor beta antibody and interleukin-2
    • Wojtowicz-Praga S., Verma U.N., Wakefield L., et al. Modulation of B16 melanoma growth and metastasis by anti-transforming growth factor beta antibody and interleukin-2. J Immunother Emphasis Tumor Immunol 19 3 (1996) 169-175
    • (1996) J Immunother Emphasis Tumor Immunol , vol.19 , Issue.3 , pp. 169-175
    • Wojtowicz-Praga, S.1    Verma, U.N.2    Wakefield, L.3
  • 78
    • 33751047033 scopus 로고    scopus 로고
    • Phase I clinical trial of a TGF-beta antisense-modified tumor cell vaccine in patients with advanced glioma
    • Fakhrai H., Mantil J.C., Liu L., et al. Phase I clinical trial of a TGF-beta antisense-modified tumor cell vaccine in patients with advanced glioma. Cancer Gene Therapy 13 12 (2006) 1052-1060
    • (2006) Cancer Gene Therapy , vol.13 , Issue.12 , pp. 1052-1060
    • Fakhrai, H.1    Mantil, J.C.2    Liu, L.3
  • 79
    • 33750586798 scopus 로고    scopus 로고
    • Phase II study of belagenpumatucel-L, a transforming growth factor beta-2 antisense gene-modified allogeneic tumor cell vaccine in non-small-cell lung cancer
    • Nemunaitis J., Dillman R.O., Schwarzenberger P.O., et al. Phase II study of belagenpumatucel-L, a transforming growth factor beta-2 antisense gene-modified allogeneic tumor cell vaccine in non-small-cell lung cancer. J Clin Oncol 24 29 (2006) 4721-4730
    • (2006) J Clin Oncol , vol.24 , Issue.29 , pp. 4721-4730
    • Nemunaitis, J.1    Dillman, R.O.2    Schwarzenberger, P.O.3
  • 80
    • 39149089610 scopus 로고    scopus 로고
    • Defective TGF-beta signaling sensitizes human cancer cells to rapamycin
    • Gadir N., Jackson D.N., Lee E., and Foster D.A. Defective TGF-beta signaling sensitizes human cancer cells to rapamycin. Oncogene 27 8 (2008) 1055-1062
    • (2008) Oncogene , vol.27 , Issue.8 , pp. 1055-1062
    • Gadir, N.1    Jackson, D.N.2    Lee, E.3    Foster, D.A.4
  • 81
    • 0027742864 scopus 로고
    • Immunocytochemical localization of secreted transforming growth factor-beta 1 to the advancing edges of primary tumors and to lymph node metastases of human mammary carcinoma
    • Dalal B.I., Keown P.A., and Greenberg A.H. Immunocytochemical localization of secreted transforming growth factor-beta 1 to the advancing edges of primary tumors and to lymph node metastases of human mammary carcinoma. Am J Pathol 143 2 (1993) 381-389
    • (1993) Am J Pathol , vol.143 , Issue.2 , pp. 381-389
    • Dalal, B.I.1    Keown, P.A.2    Greenberg, A.H.3
  • 82
    • 68849126304 scopus 로고    scopus 로고
    • Multimodality imaging of TGFbeta signaling in breast cancer metastases
    • Serganova I., Moroz E., Vider J., et al. Multimodality imaging of TGFbeta signaling in breast cancer metastases. FASEB J 23 8 (2009) 2662-2672
    • (2009) FASEB J , vol.23 , Issue.8 , pp. 2662-2672
    • Serganova, I.1    Moroz, E.2    Vider, J.3
  • 83
    • 4444341835 scopus 로고    scopus 로고
    • SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility
    • Hjelmeland M.D., Hjelmeland A.B., Sathornsumetee S., et al. SB-431542, a small molecule transforming growth factor-beta-receptor antagonist, inhibits human glioma cell line proliferation and motility. Mol Cancer Therapy 3 6 (2004) 737-745
    • (2004) Mol Cancer Therapy , vol.3 , Issue.6 , pp. 737-745
    • Hjelmeland, M.D.1    Hjelmeland, A.B.2    Sathornsumetee, S.3
  • 84
    • 0036085920 scopus 로고    scopus 로고
    • SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
    • Inman G.J., Nicolas F.J., Callahan J.F., et al. SB-431542 is a potent and specific inhibitor of transforming growth factor-beta superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7. Mol Pharmacol 62 1 (2002) 65-74
    • (2002) Mol Pharmacol , vol.62 , Issue.1 , pp. 65-74
    • Inman, G.J.1    Nicolas, F.J.2    Callahan, J.F.3
  • 85
    • 33748305561 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARA
    • Zhao B.M., and Hoffmann F.M. Inhibition of transforming growth factor-beta1-induced signaling and epithelial-to-mesenchymal transition by the Smad-binding peptide aptamer Trx-SARA. Mol Biol Cell 17 9 (2006) 3819-3831
    • (2006) Mol Biol Cell , vol.17 , Issue.9 , pp. 3819-3831
    • Zhao, B.M.1    Hoffmann, F.M.2
  • 86
    • 34848891816 scopus 로고    scopus 로고
    • Targeting transforming growth factor-b signaling
    • Pennison M., and Pasche B. Targeting transforming growth factor-b signaling. Curr Opin Oncol 19 6 (2007) 579-585
    • (2007) Curr Opin Oncol , vol.19 , Issue.6 , pp. 579-585
    • Pennison, M.1    Pasche, B.2
  • 87
    • 0033135109 scopus 로고    scopus 로고
    • Transforming growth factor beta1 is a target for the von Hippel-Lindau tumor suppressor and a critical growth factor for clear cell renal carcinoma
    • Ananth S., Knebelmann B., Gruning W., et al. Transforming growth factor beta1 is a target for the von Hippel-Lindau tumor suppressor and a critical growth factor for clear cell renal carcinoma. Cancer Res 59 9 (1999) 2210-2216
    • (1999) Cancer Res , vol.59 , Issue.9 , pp. 2210-2216
    • Ananth, S.1    Knebelmann, B.2    Gruning, W.3


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