The significance of cancer cell expression of the chemokine receptor CXCR4

Seminars in Cancer Biology

Volumn 14, Issue 3, 2004, Pages 171-179

  Balkwill, Fran ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

CXCL12; CXCR4; Invasion; Metastasis

Indexed keywords

ALPHA CHEMOKINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CXCR4;

CANCER CELL; CANCER GROWTH; CANCER INVASION; CANCER RESEARCH; CELL MIGRATION; CELL SURVIVAL; CYTOKINE PRODUCTION; EMBRYO DEVELOPMENT; HOMEOSTASIS; HUMAN; INFLAMMATION; INFLAMMATORY DISEASE; METASTASIS; NONHUMAN; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; STEM CELL;

EID: 2342591450     PISSN: 1044579X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.semcancer.2003.10.003     Document Type: Article

References (96)

1. Balkwill F. Chemokine biology in cancer. Sem Immunol. 15:2003;49-55
2. Muller A., Homey B., Soto H., Ge N., Catron D., Buchanan M.E., et al. Involvement of chemokine receptors in breast cancer metastasis. Nature. 410:2001;50-56
3. Murphy P.M. Chemokines and molecular basis of cancer metastasis. N. Engl. J. Med. 354:2001;833-835
4. Rossi D., Zlotnik A. The biology of chemokines and their receptors. Annu. Rev. Immunol. 18:2000;217-242
5. Feng Y., Broder C.C., Kennedy P.E., Berger E.A. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science. 272:1996;872-877
6. Tachibana K., Hirota S., Lizasa H., Yoshida H., Kawabata K., Kataoka Y., et al. The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract. Nature. 393:1998;591
7. Zou Y.-R., Kottmann A.H., Kuroda M., Taniuchi I., Littman D.R. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development. Nature. 393:1998;595
8. David N.B., Sapede D., Saint-Etienne L., Thisse C., Thisse B., Dambly-Chaudiere C., et al. Molecular basis of cell migration in the fish lateral line: role of the chemokine receptor CXCR4 and of its ligand, SDF1. PNAS. 99:2002;16297-16302
9. Doitsidou M., Reichman-Fried M., Stebler J., Koprunner M., Dorries J., Meyer D., et al. Guidance of primordial germ cell migration by the chemokine SDF-1. Cell. 111:2002;647-659
10. Knaut H., Werz C., Geisler R., Nusslein-Volhard C., Consortium T.S., et al. A zebrafish homologue of the chemokine receptor Cxcr4 is a germ-cell guidance receptor. Nature. 421:2003;279-282
11. Ara T., Nakamura Y., Egawa T., Sugiyama T., Abe K., Kishimoto T., et al. Impaired colonization of the gonads by primordial germ cells in mice lacking a chemokine, stromal cell-derived factor-1 (SDF-1). PNAS. 100:2003;5319-5323
12. Bleul C.C., Wu L., Hoxie J.A., Springer T.A., Mackay C.R. The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc. Natl. Acad. Sci. USA. 94:1997;1925-1930
13. Bleul C.C., Farzan M., Choe H., Parolin C., Clark-Lewis I., Sodroski J., et al. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature. 382:1996;829-833
14. Nakayama T., Hieshima K., Izawa D., Tatsumi Y., Kanamaru A., Yoshie O. Profile of chemokine receptor expression on human plasma cells accounts for their efficient recruitment to target tissues. J. Immunol. 170:2003;1136-1140
15. Hauser A.E., Debes G.F., Arce S., Cassese G., Hamann A., Radbruch A., et al. Chemotactic responsiveness towards ligands for CXCR3 and CXCR4 is regulated on plasma blasts during the time course of a memory immune response. J. Immunol. 169:2002;1277-1282
16. Hanna J, Wald O, Goldman-Wohl D, Prus D., Markel G., Gazit R., et al. CXCL12 expression by invasive trophoblasts induces the specific migration of CD16 negative human natural killer cells. Blood 2003.
17. Zoeteweij J.P., Golding H., Mostowski H., Blauvelt A. Cytokines regulate expression and function of the HIV coreceptor CXCR4 on human mature dendritic cells. J. Immunol. 161:1998;3219-3223
18. Juremalm M., Hjertson M., Olsson N., Harvima I., Nilsson K., Nilsson G. The chemokine receptor CXCR4 is expressed within the mast cell lineage and its ligand stromal cell-derived factor-1a acts as a mast cell chemotaxin. Eur. J. Immunol. 30:2000;3614-3622
19. Aiuti A., Webb I.J., Bleul C., Springer T., Guttierrez-Ramos J.C. The chemokine SDF-1 is a chemoattractant for human CD34+ hematopoietic progenitor cells and provides a new mechanism to explain the mobilisation of CD34+ progenitors to peripheral blood. J. Exp. Med. 185:1997;111-120
20. Schecter A.D., Berman A.B., Taubman M.B. Chemokine receptors in vascular smooth muscle. Microcirculation. 10:2003;265-272
21. Gupta S.K., Lysko P.G., Pillarisetti K., Ohlstein E., Stadel J.M. Chemokine receptors in human endothelial cells. J. Biol. Chem. 273:1998;4282-4287
22. Salcedo R., Wasserman K., Young H.A., Grimm M.C., Howard O.M.Z., Anver M.R., et al. Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells. Am. J. Pathol. 154:1999;1125-1135
23. Crane I.J., Wallace C.A., McKillop-Smith S., Forrester J.V. CXCR4 receptor expression on human retinal pigment epithelial cells from the blood-retina barrier leads to chemokine secretion and migration in response to stromal cell-derived factor 1a. J. Immunol. 165:2000;4372-4378
24. Dwinell M.B., Eckmann L., Leopard J.D., Varki N.M., Kagnoff M.F., et al. Chemokine receptor expression by human intestinal epithelial cells. Gastroenterology. 117:1999;359-367
25. Murdoch C., Monk P.N., Finn A. Functional expression of chemokine receptor CXCR4 on human epithelial cells. Immunology. 98:1999;36-41
26. Broxmeyer H.E., Cooper S., Kohli L., Hangoc G., Lee Y., Mantel C., et al. Transgenic expression of stromal cell-derived factor-1/CXC chemokine ligand 12 enhances myeloid progenitor cell survival/antiapoptosis in vitro in response to growth factor withdrawal and enhances myelopoiesis in vivo. J. Immunol. 170:2003;421-429
27. De Clercq E. The bicyclam AMD3100 story. Nat Rev. 2:2003;581-587
28. Liles WC, Broxmeyer HE, Rodger E, Wood B., Hubel K., Cooper S., et al. Mobilisation of hematopoietic progenitor cells in healthy volunteers by AMD3100, a CXCR4 antagonist. Blood 2003.
29. Bleul C.C., Schultze J.L., Springer T.A. B lymphocyte chemotaxis regulated in association with microanatomic localization, differentiation state, and B cell receptor engagement. J. Exp. Med. 187:1998;753-762
30. Jordan N.J., Kolios G., Abbot S.E., Sinai M.A., Thompson D.A., Petraki K., et al. Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells. J. Clin. Invest. 104:1999;1061-1069
31. Allavena P., Sica A., Vecchi A., Locati M., Sozzani S., Mantovani A. The chemokine receptor switch paradigm and dendritic cell migration: its significance in tumor tissues. Immunol. Rev. 177:2000;141-149
32. Petit I., Szyper-Kravitz M., Nagler A., Lahav M., Peled A., Habler L., et al. G-CSF induces stem cell mobilisation by decreasing bone marrow SDF-1 and up-regulating CXCR4. Nat. Immunol. 3:2002;687-694
33. Levesque J.-P., Hendy J., Takamatsu Y., Simmons P.J., Bendall L.J., et al. Disruption of the CXCR4/CXCL12 chemotactic interaction during hematopoietic stem cell mobilisation induced by GCSF or cyclophosphamide. J. Clin. Invest. 111:2003;187-196
34. Kollet O., Shivtiel S., Chen Y.Q., Suriawinata J., Thung S.N., Dabeva M.D., et al. HGF, SDF-1, and MMP-9 are involved in stress induced CD34+ stem cell recruitment to the liver. J. Clin. Invest. 112:2003;160-169
35. Ganju R.K., Brubaker S.A., Meyer J., Dutt P., Yang Y., Qin S., et al. The alpha-chemokine, stromal cell-derived factor-1alpha, binds to the transmembrane G-protein-coupled CXCR-4 receptor and activates multiple signal transduction pathways. J. Biol. Chem. 273:1998;23169-23175
36. Tilton B., Ho L., Oberlin E., Loetscher P., Baleux F., Clarke-Lewis I., et al. Signal transduction by CXC chemokine receptor 4. Stromal cell-derived factor 1 stimulates prolonged protein kinase B and extracellular signal-regulated kinase 2 activation in T lymphocytes. J. Exp. Med. 192:2000;313-324
37. Curnock A.P., Sotsios Y., Wright K.L., Ward S.G. Optimal chemotactic responses of leukemic T cells to stromal cell-derived factor-1 requires the activation of both class 1A and 1B phosphoinositide 3-kinases. J. Immunol. 170:2003;4021-4030
38. Shimonaka M., Katagiri K., Nakayama T., Fujita N., Tsuruo T., Yoshie O., et al. Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow. J. Cell Biol. 161:2003;417-427
39. i2 are differentially expressed in vivo. Eur. J. Immunol. 27:1997;2102-2112
40. Gupta S.K., Pillarisetti K. CXCR4-Lo: molecular cloning and functional expression of a novel human CXCR4 splice variant. J. Immunol. 163:1999;2368-2372
41. Baribaud F., Edwards T.G., Sharron M., Brelot A., Heveker N., Price K., et al. Antigenically distinct conformations of CXCR4. J. Virol. 75:2001;8957-8967
42. Hernandez P.A., Gorlin R.J., Lukens J.N., Taniuchi S., Bohinjec J., Francois F., et al. Mutations in the chemokine receptor gene CXCR4 are associated with WHIM syndrome, a combined immunodeficiency disease. Nat. Genet. 34:2003;70-74
43. Terada R., Yamamoto K., Hadoka T., Shimada N., Okano N., Baba N., et al. Stromal cell-derived factor-1 from biliary epithelial cells recruits CXCR4-positive cells: implications for inflammatory liver disease. Lab. Invest. 83:2003;665-672
44. Eddleston J., Christiansen S.C., Zuraw B.L. Functional expression of the C-X-C chemokine receptor CXCR4 by human bronchial epithelial cells: regulation by proinflammatory mediators. J. Immunol. 169:2002;6445-6451
45. Pablos J.L., Santiago B., Galindo M., Torres C., Brehmer M.T., Blanco F.J., et al. Synoviocyte-derived CXCL12 is displayed on endothelium and induces angiogenesis in rheumatoid arthritis. J. Immunol. 170:2003;2147-2152
46. Buckley C.D., Amft N., Bradfield P.F., Pilling D., Ross E., Arenzana-Seisdedos F., et al. Persistent induction of the chemokine receptor CXCR4 by TGF-b1 on synovial T cells contributes to their accumulation within the rheumatoid synovium. J. Immunol. 165:2000;3423-3429
47. Matthys P., Hatse S., Vermeire K., Wuyts A., Bridger G., Henson G.W., et al. AMD31000, a potent and specific antagonist of the stromal cell-derived factor-1 chemokine receptor CXCR4, inhibits autoimmune joint inflammation in IFN-γ receptor-deficient mice. J. Immunol. 167:2001;4686-4692
48. Nagase H., Miyamasu M., Yamaguchi M., Fujisawa T., Ohta K., Yamamoto K., et al. Expression of CXCR4 eosinophils: functional analyses and cytokine-mediated regulation. J. Immunol. 164:2000;5935-5943
49. Bezzi P., Domercq M., Brambilla L., Galli R., Schols D., De Clercq E., et al. CXCR4-activated astrocyte glutamate release via TNFa: amplification by microglia triggers neurotoxicity. Nat Neurosci. 4:2001;702-710
50. Libura J., Drukala J., Majka M., Tomescu O., Navenot J.M., Kucia M., et al. CXCR4-SDF-1 signaling is active in rhabdomyosarcoma cells and regulates locomotion, chemotaxis, and adhesion. Blood. 100:2002;2597-2606
51. Han Y., He T., Huang D., Pardo C.A., Ransohoff R.M. TNF-α mediates SDF-1α-induced NF-κB activation and cytotoxic effects in primary astrocytes. J Clin Invest. 108:2001;425-435
52. Scotton C.J., Wilson J.L., Milliken D., Stamp G., Balkwill F.R. Epithelial cancer cell migration: a role for chemokine receptors? Cancer Res. 61:2001;4961-4965
53. Scotton C.J., Wilson J.L., Scott K., Stamp G., Wilbanks G.D., Fricker S., et al. Multiple actions of the chemokine CXCL12 on epithelial tumor cells in human ovarian cancer. Cancer Res. 62:2002;5930-5938
54. Koshiba T., Hosotani R., Miyamoto Y., Ida J., Tsuji S., Nakajima S., et al. Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: a possible role for tumor progression. Clin. Cancer Res. 6:2000;3530-3535
55. Geminder H., Sagi-Assif O., Goldberg L., Meshel T., Rechavi G., Witz I.P., et al. A possible role for CXCR4 and its ligand, the CXC chemokine stromal cell-derived factor-1, in the development of bone marrow metastases and neuroblastoma. J. Immunol. 167:2001;4747-4757
56. Chen T., Triplett J., Dehner B., Hurst B., Colligan B., Pemberton J., et al. Transforming growth factor-b receptor type 1 gene is frequently mutated in ovarian carcinomas. Cancer. 61:2001;4679-4682
57. Semizarov D., Frost L., Sarthy A., Kroeger P., Halbert D.N., Fesik S.W. Specificity of short interfering RNA determined through gene expression signatures. PNAS. 100:2003;6347-6352
58. Hwang J.H., Hwang J.H., Chung H.K., Kim D.W., Hwang E.S., Suh J.M., et al. CXC chemokine receptor 4 expression and function in human anaplastic thyroid cancer cells. J. Clin. Endocrinol. Metab. 88:2003;408-416
59. Corcione A., Ottonello L., Tortolina G., Facchetti P., Airoldi I., Gugliemino R., et al. Stromal cell-derived factor-1 as a chemoattractant for follicular center lymphoma B cells. JNCI. 92:2000;628-635
60. Scotton C., Milliken D., Wilson J., Raju S., Balkwill F. Analysis of CC chemokine and chemokine receptor expression in solid ovarian tumours. Br. J. Cancer. 85:2001;891-897
61. Darash-Yahana M., Pikarsky E., Karplus R., Kasem S., Pal B., Zeira E., et al. Human prostate cancer growth, vascularisation and metastasis is stimulated via high expression levels of the chemokine receptor CXCR4. Proc. AACR. 44:2003;789
62. Kang Y., Siegel P.M., Shu W., Drobnjak M., Kakonen S.M., Cordon-Cardo C., et al. A multigenic program mediating breast cancer metastasis to bone. Cancer Cell. 3:2003;537-549
63. Helbig G., Christopherson K.Wn, Bhat-Nakshatri P., Kumar S., Kishimoto H., Miller K.D., et al. NF-kappaB promotes breast cancer cell migration and metastasis by inducing the expression of the chemokine receptor CXCR4. J. Biol. Chem. 278:2003;21631-21638
64. Murakami T., Maki W., Cardones A.R., Fang H., Kyi A.T., Nestle F.O., et al. Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells. Cancer Res. 62:2002;7328-7334
65. Zhou Y., Larsen P.H., Hao C., Yong V.W. CXCR4 is a major chemokine receptor on glioma cells and mediates their survival. J. Biol. Chem. 277:2002;49481-49487
66. Schrader A.J., Lechner O., Templin M., Dittmar K.E.J., Machtens S., Mengel M., et al. CXCR4/CXCL12 expression and signalling in kidney cancer. Br. J. Cancer. 86:2002;1250-1256
67. Sun Y.-X., Wang J., Shelburne C.E., Lopatin D.E., Chinnaiyan A.M., Rubin M.A., et al. Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivo. J. Cell Biochem. 89:2003;462-473
68. Barbero S., Bonavia R., Bajetto A., Porcile C., Pirani P., Ravettti J.L., et al. Stromal cell-derived factor 1a stimulates human glioblastoma cell growth through the activation of both extracellular signal-regulated kinases 1/2 and Akt. Cancer Res. 63:2003;1969-1974
69. Robledo M.M., Bartolome R.A., Longo N., Rodriguez-Frade J.M., Mellado M., Longo I., et al. Expression of functional chemokine receptors CXCR3 and CXCR4 on human melanoma cells. J. Biol. Chem. 276:2001;45098-45105
70. Kijima T., Maulik G., Ma P.C., Tibaldi E.V., Turner R.E., Rollins B., et al. Regulation of cellular proliferation, cytoskeletal function, and signal transduction through CXCR4 and c-Kit in small cell lung cancer cells. Cancer Res. 62:2002;6304-6311
71. Szlosarek P., Balkwill F. Tumour necrosis factor-a: a potential target in the therapy of solid tumours. Lancet Oncol. 4:2003;565-573
72. Bachelder R.E., Wendt M.A., Mercurio A.M. Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4. Cancer Res. 62:2002;7203-7206
73. Hall J.M., Korach K.S. Stromal cell-derived factor 1, novel target of estrogen receptor action, mediates the mitogenic effects of estradiol in ovarian and breast cancer cells. Mol. Enocrinol. 17:2003;792-803
74. Zou W., Machelon V., Coulomb-l'Hermin A., Borvak J., Nome F., Isaeva T., et al. Stromal-derived factor-1 in human tumours recruits and alters the function of plasmacytoid precursor dendritic cells. Nat. Med. 7:2001;1339-1346
75. Ptasznik A., Urbanowska E., Chinta S., Costa M.A., Katz B.A., Stanislaus M.A., et al. Crosstalk between BCR/ABL oncoprotein and CXCR4 signaling through a Src family kinase in human leukemia cells. J. Exp. Med. 196:2002;667-678
76. Mashino K., Sadanaga N., Yamaguchi H., Tanaka F., Ohto M., Shibuta K., et al. Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma. Cancer Res. 62:2002;2937-2941
77. Zeelenberg I.S., Ruuls-Van Stalle L., Roos E. Retention of CXCR4 in the endoplasmic reticulum blocks dissemination of a cell hybridoma. J. Clin. Invest. 108:2001;269-277
78. Zeelenberg I.S., Ruuls-Van Stalle L., Roos E. The chemokine receptor CXCR4 is required for outgrowth of colon carcinoma micrometastases. Cancer Res. 63:2003;3833-3839
79. Bertolini F., Dell'Agnola C., Mancuso P., Rabascio C., Burlini A., Monestiroli S., et al. CXCR4 neutralization, a novel therapeutic approach for non-Hodgkin's lymphoma. Cancer Res. 62:2002;3106-3112
80. Chen Y.C., Stamatoyannopoulos G., Song C.-Z. Down-regulation of CXCR4 by inducible small interfering RNA inhibits breast cancer cell invasion in vitro. Cancer Res. 63:2003;4801-4804
81. Rempel S.A., Dudas S., Ge S., Gutierrez J.A. Identification and localization of the cytokine SDF1 and its receptor, CXC chemokine receptor 4, to regions of necrosis and angiogenesis in human glioblastoma. Clin. Cancer Res. 6:2000;102-111
82. Rubin J.B., Kung A.L., Klein R.S., Chan J.A., Sun Y., Schmidt K., et al. Systemic delivery of a small molecule inhibitor of CXCR4 blocks the growth of intracranial xenografts of glioblastoma multiforme. Proc. Am. Assoc. Cancer Res. 44:2003;544
83. Mohle R., Failenschmid C., Bautz F., Kanz L. Overexpression of the chemokine receptor CXCR4 in B cell chronic lymphocytic leukemia is associated with increased functional response to stromal cell-derived factor-1 (SDF-1). Leukemia. 13:1999;1954-1959
84. Barretina J, Junca J, Llano A, Gutierrez A., Flores A., Blanco J., et al. CXCR4 and SDF-1 expression in B-cell chronic lymphocytic leukemia and stage of the disease. Ann Hematol 2003;29.
85. Mohle R., Schittenhelm M., Failenschmid C., Bautz F., Kratz-Albers K., Serve H., et al. Functional response of leukaemic blasts to stromal cell-derived factor-1 correlates with preferential expression of the chemokine receptor CXCR4 in acute myelomonocytic and lymphoblastic leukaemia. Br. J. Haematol. 110:2000;563-572
86. Crazzolara R., Kreczy A., Mann G., Heitger A., Eibl G., Fink F.M., et al. High expression of the chemokine receptor CXCR4 predicts extramedullary organ infiltration in childhood acute lymphoblastic leukaemia. Br. J. Haematol. 115:2001;545-553
87. Barbero S., Bajetto A., Bonavia R., Porcile C., Piccioli P., Pirani P., et al. Expression of the chemokine receptor CXCR and its ligand stromal cell-derived factor 1 in human brain tumours and their involvement in glial proliferation in vitro. Ann. N. Y. Acad. Sci. 973:2002;60-69
88. Weng A.P., Shahsafaei A., Dorfman D.M. CXCR4/CD184 immunoreactivity in T-cell non-Hodgkin lymphomas with an overall TH1- Th2+ immunophenotype. Am. J. Clin. Pathol. 119:2003;424-430
89. Peled A., Hardan I., Trakhtenbrot L., et al. Immature leukemic CX34+CXCR4+ cells from CML patients have lower integrin-dependent migration and adhesion in response to the chemokine SDF-1. Stem Cells. 20:2002;259-266
90. Moller C., Stromberg T., Juremalm M., Nilsson G., Nilsson K. Expression and function of chemokine receptors in human multiple myeloma. Leukemia. 17:2003;203-210
91. Taichman R.S., Cooper C., Keller Et., Pienta K.J., Taichman N.S., McCauley L.K. Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone. Cancer Res. 62:2002;1832-1837
92. Uchida D., Begum N.-M., Almofti A., Kawamata H., Nakashiro K.-I., Tateishi Y., et al. Involvement of stromal cell derived factoro-1/CXCR4 signaling in lymph node metastasis of oral squamous cell carcinoma. Proc. Am. Assoc. Cancer Res. 44:2003;452
93. Phillips R.J., Burdick M.D., Lutz M., Belperio J.A., Keane M.P., Strieter R.M. The stromal derived factor-1/CXCL12-CXC chemokine receptor 4 biological axis in non-small cell lung cancer metastases. Am. J. Respir. Crit. Care Med. 167:2003;1676-1686
94. Payne A.S., Cornelius L.A. The role of chemokines in melanoma tumor growth and metastasis. J. Invest Dermatol. 118:2002;915-922
95. Singh S., Hannah P.S., Singh U.P., Grizzle W.E., Lillard J.W. Jr. Differential CXCR4 and CCR9 expression by prostate cancer. Proceedings of American Association for Cancer Res. 44:2003;772
96. Hannah P.S., Singh S., Singh U.P., Partridge E.E., Lillard J.W. Jr. Role of CXCR4 and CCR9 in ovarian cancer progression. Proc. Am. Assoc. Cancer Res. 44:2003;772