Mechanisms of resistance to Hsp90 inhibitor drugs: A complex mosaic emerges

Pharmaceuticals

Volumn 4, Issue 11, 2011, Pages 1400-1422

  Piper, Peter W ^a   Millson, Stefan H ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

Apoptosis; Cancer drug resistance; Heat shock response; Hsp90 inhibitors

Indexed keywords

ANSAMYCIN DERIVATIVE; ANTINEOPLASTIC AGENT; AZETIDINE; BENZOQUINONE ANSAMYCIN; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BIIB 021; BORTEZOMIB; CANAVANINE; CELASTROL; CELL CYCLE PROTEIN 37; ES 936; GELDANAMYCIN; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; HEAT SHOCK TRANSCRIPTION FACTOR 1; HERBIMYCIN A; HYPOXIA INDUCIBLE FACTOR 1; KNK 437; LACTACYSTIN; PROTEASOME; PROTEIN P23; PUROMYCIN; QUERCETIN; RETASPIMYCIN; SMALL INTERFERING RNA; TANESPIMYCIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 1; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ADRENAL CORTEX CARCINOMA; AMINO TERMINAL SEQUENCE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; CANCER CELL CULTURE; CANCER RESEARCH; CELL SURVIVAL; CELL TYPE; CELLULAR STRESS RESPONSE; DNA MODIFICATION; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG EFFECT; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG RESEARCH; DRUG SELECTIVITY; DRUG SENSITIZATION; DRUG TARGETING; GENE MUTATION; GENE OVEREXPRESSION; HEAT SHOCK RESPONSE; HUMAN; INTRACELLULAR SIGNALING; LIVER TOXICITY; MULTIDRUG RESISTANCE; MULTIPLE MYELOMA; NONHUMAN; OXIDATION REDUCTION REACTION; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN SYNTHESIS REGULATION; REVIEW; RNA INTERFERENCE;

EID: 80455131276     PISSN: None     EISSN: 14248247     Source Type: Journal    
DOI: 10.3390/ph4111400     Document Type: Review

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