Radicicol, an inhibitor of Hsp90, enhances TRAIL-induced apoptosis in human epithelial ovarian carcinoma cells by promoting activation of apoptosis-related proteins

Molecular and Cellular Biochemistry

Volumn 359, Issue 1-2, 2012, Pages 33-43

  Kim, Yun Jeong ^a   Lee, Seon Ae ^a   Myung, Soon Chul ^b   Kim, Wonyong ^a   Lee, Chung Soo ^a  

^a Chung Ang University   (South Korea)

^b Chung Ang University College of Medicine   (South Korea)

Author keywords

Apoptosis related proteins; Epithelial ovarian adenocarcinoma cells; Promoting effect; Radiciciol; TRAIL

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; HEAT SHOCK PROTEIN 90 INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN BID; PROTEIN P53; RADICICOL; SURVIVIN; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER CELL CULTURE; CELL DAMAGE; CELL DEATH; CELL VIABILITY; CONCENTRATION (PARAMETERS); DNA FRAGMENTATION; ENZYME ACTIVATION; FEMALE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN EPITHELIAL OVARIAN CARCINOMA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; QUANTITATIVE ANALYSIS;

ANTINEOPLASTIC AGENTS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CASPASES; CELL LINE, TUMOR; ENZYME INHIBITORS; FEMALE; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MACROLIDES; MITOCHONDRIA; NEOPLASMS, GLANDULAR AND EPITHELIAL; OVARIAN NEOPLASMS; TNF-RELATED APOPTOSIS-INDUCING LIGAND;

EID: 83555174308     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-011-0997-9     Document Type: Article

References (35)

1. GS Wu 2009 TRAIL as a target in anti-cancer therapy Cancer Lett 285 1 5 10.1016/j.canlet.2009.02.029 19299078 10.1016/j.canlet.2009.02.029 1:CAS:528:DC%2BD1MXhtFyqs7fM
2. Z Mahmood Y Shukla 2010 Death receptors: targets for cancer therapy Exp Cell Res 316 887 899 10.1016/j.excr.2009.12.011 20026107 10.1016/j.yexcr.2009. 12.011 1:CAS:528:DC%2BC3cXivFKgtbk%3D
3. Z Jin WS El-Deiry 2005 Overview of cell death signaling pathways Cancer Biol Ther 4 139 163 15725726 10.4161/cbt.4.2.1508 1:CAS:528:DC%2BD28XhvFKgs7k%3D (Pubitemid 41351311)
4. MP Goetz DO Toft MM Ames C Erlichman 2003 The Hsp90 chaperone complex as a novel target for cancer therapy Ann Oncol 14 1169 1176 10.1093/annonc/mdg316 12881371 10.1093/annonc/mdg316 1:STN:280:DC%2BD3szkvVaktA%3D%3D (Pubitemid 37039035)
5. D Mahalingam R Swords JS Carew ST Nawrocki K Bhalla FJ Giles 2009 Targeting HSP90 for cancer therapy Br J Cancer 100 1523 1529 10.1038/sj.bjc.6605066 19401686 10.1038/sj.bjc.6605066 1:CAS:528: DC%2BD1MXlslChtrY%3D
6. JC Young VR Agashe K Siegers FU Harti 2004 Pathways of chaperone-mediated protein folding in the cytosol Nat Rev Mol Cell Biol 5 781 791 10.1038/nrm1492 15459659 10.1038/nrm1492 1:CAS:528:DC%2BD2cXotVSlsrg%3D (Pubitemid 39336272)
7. L Whitesell SL Lindquist 2005 HSP90 and the chaperoning of cancer Nat Rev Cancer 5 761 772 10.1038/nrc1716 16175177 10.1038/nrc1716 1:CAS:528: DC%2BD2MXhtVGjs7bF (Pubitemid 41400776)
8. C Moser SA Lang O Stoeltzing 2009 Heat-shock protein 90 (Hsp90) as a molecular target for therapy of gastrointestinal cancer Anticancer Res 29 2031 2042 19528462 1:CAS:528:DC%2BD1MXos1Wmsrs%3D
9. H Reikvam E Ersvaer O Bruserud 2009 Heat shock protein 90-a potential target in the treatment of human acute myelogenous leukemia Curr Cancer Drug Targets 9 761 776 19754360 10.2174/156800909789271486 1:CAS:528: DC%2BD1MXhtlKnurrJ
10. M Hwang L Moretti B Lu 2009 HSP90 inhibitors: multi-targeted antitumor effects and novel combinatorial therapeutic approaches in cancer therapy Curr Med Chem 16 3081 3092 19689285 10.2174/092986709788802999 1:CAS:528: DC%2BD1MXpvVynurk%3D
11. A Fedier A Stuedii D Fink 2005 Presence of MLH1 protein aggravates the potential of the HSP90 inhibitor radicicol to sensitize tumor cells to cisplatin Int J Oncol 27 1697 1705 16273226 1:CAS:528:DC%2BD2MXhtlSru7rK
12. S Ohba Y Hirose K Yoshida T Yazaki T Kawase 2010 Inhibition of 90-kD heat shock protein potentiates the cytotoxicity of chemotherapeutic agents in human glioma cells J Neurosurg 112 33 42 10.3171/2009.3.JNS081146 19408974 10.3171/2009.3.JNS081146 1:CAS:528:DC%2BC3cXhtVWlt7Y%3D
13. MV Powers P Workman 2006 Targeting of multiple signalling pathways by heat shock protein 90 molecular chaperone inhibitors Endocr Relat Cancer Suppl 1 S125 S135 10.1677/erc.1.01324 10.1677/erc.1.01324 (Pubitemid 46219254)
14. M Sano 2001 Radicicol and geldanamycin prevents neurotoxic effects of anti-cancer drugs on cultured embryonic sensory neurons Neuropharmacology 40 947 953 10.1016/S0028-3908(01)00018-1 11378165 10.1016/S0028-3908(01)00018-1 1:CAS:528:DC%2BD3MXjvV2gurs%3D (Pubitemid 32510808)
15. MJ Sohn HJ Noh ID Yoo WG Kim 2007 Protective effect of radicicol against LPS/IFN-γ-induced neuronal cell death in rat cortical neuron-glia cultures Life Sci 80 1706 1712 10.1016/j.lfs.2007.01.054 17337278 10.1016/j.lfs.2007.01. 054 1:CAS:528:DC%2BD2sXjsVCjsbw%3D (Pubitemid 46441271)
16. T Högberg B Glimelius P Nygren 2001 A systematic overview of chemotherapy effects in ovarian cancer Acta Oncol 40 340 360 11441940 10.1080/02841860151116420 (Pubitemid 32588127)
17. MA Bookman 2003 Developmental chemotherapy and management of recurrent ovarian cancer J Clin Oncol 21 149s 167s 10.1200/JCO.2003.02.553 17633784 10.1200/JCO.2003.02.553
18. T Mosmann 1983 Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays J Immunol Methods 65 55 63 10.1016/0022-1759(83)90303-4 6606682 10.1016/0022-1759(83)90303-4 1:STN:280:DyaL2c%2FovFSmtw%3D%3D (Pubitemid 14203433)
19. Y Dai M Liu W Tang Y Li J Lian TS Lawrence L Xu 2009 A Smac-mimetic sensitizes prostate cancer cells to TRAIL-induced apoptosis via modulating both IAPs and NF-κB BMC Cancer 9 392 10.1186/1471-2407-9-392 19895686 10.1186/1471-2407-9-392
20. S Huang K Okumura FA Sinicrope 2009 BH3 mimetic obatoclax enhances TRAIL-mediated apoptosis in human pancreatic cancer cells Clin Cancer Res 15 150 159 10.1158/1078-0432.CCR-08-1575 19118042 10.1158/1078-0432.CCR-08-1575 1:CAS:528:DC%2BD1MXhs1eluw%3D%3D
21. V Andrisano R Ballardini P Hrelia N Cameli A Tosti R Gotti V Cavrini 2001 Studies on the photostability and in vitro phototoxicity of labetalol Eur J Pharm Sci 12 495 504 10.1016/S0928-0987(00)00218-9 11231117 10.1016/S0928- 0987(00)00218-9 1:CAS:528:DC%2BD3MXhsFSgs7w%3D (Pubitemid 32170766)
22. FA Oberhammer M Pavelka S Sharma R Tiefenbacher AF Purchio W Bursch R Schulte-Hermann 1992 Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor β1 Proc Natl Acad Sci USA 89 5408 5412 1608949 10.1073/pnas.89.12.5408 1:CAS:528:DyaK38XksVGqu7o%3D
23. H Wu GN Rao B Dai P Singh 2000 Autocrine gastrins in colon cancer cells up-regulate cytochrome c oxidase Vb and down-regulate efflux of cytochrome c and activation of caspase-8 J Biol Chem 275 32491 32498 10.1074/jbc.M002458200 10915781 10.1074/jbc.M002458200 1:CAS:528:DC%2BD3cXnslOitro%3D
24. A Berthier S Lemaire-Ewing C Prunet S Monier A Athias G Bessede JP Pais de Barros A Laubriet P Gambert G Lizard D Néel 2004 Involvement of a calcium-dependent dephosphorylation of BAD associated with the localization of Trpc-1 within lipid rafts in 7-ketocholesterol-induced THP-1 cell apoptosis Cell Death Differ 11 897 905 10.1038/sj.cdd.4401434 15105836 10.1038/sj.cdd.4401434 1:CAS:528:DC%2BD2cXlslGnsLs%3D (Pubitemid 39139748)
25. JE Chipuk DR Green 2006 Dissecting p53-dependent apoptosis Cell Death Differ 13 994 1002 10.1038/sj.cdd.4401908 16543937 10.1038/sj.cdd.4401908 1:CAS:528:DC%2BD28Xks1Ortb4%3D
26. JS Armstrong 2006 Mitochondria: a target for cancer therapy Br J Pharmacol 147 239 248 10.1038/sj.bjp.0706556 16331284 10.1038/sj.bjp.0706556 1:CAS:528:DC%2BD28XhtVygsbs%3D (Pubitemid 43214681)
27. W Hu JJ Kavanagh 2003 Anticancer therapy targeting the apoptotic pathway Lancet Oncol 4 721 729 10.1016/S1470-2045(03)01277-4 14662428 10.1016/S1470-2045(03)01277-4 1:CAS:528:DC%2BD3sXps1OgsL0%3D (Pubitemid 37527207)
28. M MacFarlane 2003 TRAIL-induced signaling and apoptosis Toxicol Lett 139 89 97 10.1016/S0378-4274(02)00422-8 12628743 10.1016/S0378-4274(02)00422-8 1:CAS:528:DC%2BD3sXhvFeqsr0%3D (Pubitemid 36298966)
29. PE Czabotar PM Colman DC Huang 2009 Bax activation by Bim? Cell Death Differ 16 1187 1191 10.1038/cdd.2009.83 19557009 10.1038/cdd.2009.83 1:CAS:528:DC%2BD1MXhtVamur7I
30. A Camins M Pallas JS Silvestre 2008 Apoptotic mechanisms involved in neurodegenerative diseases: experimental and therapeutic approaches Methods Fin Exp Clin Pharmacol 30 43 65 10.1358/mf.2008.30.1.1090962 10.1358/mf.2008.30.1. 1090962 1:CAS:528:DC%2BD1cXkt1Ojtr8%3D (Pubitemid 351397455)
31. R Kim M Emi K Tanabe 2006 Role of mitochondria as the gardens of cell death Cancer Chemother Pharmacol 57 545 553 10.1007/s00280-005-0111-7 16175394 10.1007/s00280-005-0111-7 1:CAS:528:DC%2BD28XhsVartb8%3D (Pubitemid 43237837)
32. V Borutaite 2010 Mitochondria as decision-makers in cell death Environ Mol Mutagen 51 406 416 10.1002/em.20564 20209625 1:CAS:528:DC%2BC3cXnsVWgt70%3D
33. KG Wiman 2006 Strategies for therapeutic targeting of the p53 pathway in cancer Cell Death Differ 13 921 926 10.1038/sj.cdd.4401921 16557267 10.1038/sj.cdd.4401921 1:CAS:528:DC%2BD28Xks1OrtbY%3D
34. F Chen W Wang WS El-Deiry 2010 Current strategies to target p53 in cancer Biochem Pharmacol 80 724 730 10.1016/j.bcp.2010.04.031 20450892 10.1016/j.bcp.2010.04.031 1:CAS:528:DC%2BC3cXosV2isLg%3D
35. B Zhivotovsky S Orrenius 2010 Cell death mechanisms: cross-talk and role in disease Exp Cell Res 316 1374 1383 10.1016/j.yexcr.2010.02.037 20211164 10.1016/j.yexcr.2010.02.037 1:CAS:528:DC%2BC3cXlvVartbw%3D