Hsp90 inhibition transiently activates Src kinase and promotes Src-dependent Akt and Erk activation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 30, 2006, Pages 11318-11322

  Koga, Fumitaka ^a   Xu, Wanping ^a   Karpova, Tatiana S ^a   McNally, James G ^a   Baron, Roland ^b   Neckers, Len ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cancer; Chaperone; Geldanamycin

Indexed keywords

CBL PROTEIN; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; INSULIN; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P85; PROTEIN TYROSINE KINASE; SOMATOMEDIN C;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TUMOR GROWTH;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANTINEOPLASTIC AGENTS; BENZOQUINONES; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; COS CELLS; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HSP90 HEAT-SHOCK PROTEINS; HUMANS; LACTAMS, MACROCYCLIC; MOLECULAR CHAPERONES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SRC-FAMILY KINASES; TIME FACTORS;

EID: 33746628448     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0604705103     Document Type: Article

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