-
1
-
-
50549218525
-
The limited in vitro lifetime of human diploid cell strains
-
L. Hayflick The limited in vitro lifetime of human diploid cell strains Exp Cell Res 37 1965 614 636
-
(1965)
Exp Cell Res
, vol.37
, pp. 614-636
-
-
Hayflick, L.1
-
2
-
-
0025145238
-
Replicative senescence: The human fibroblast comes of age
-
S. Goldstein Replicative senescence: the human fibroblast comes of age Science 249 1990 1129 1133
-
(1990)
Science
, vol.249
, pp. 1129-1133
-
-
Goldstein, S.1
-
3
-
-
0037667702
-
Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
-
DOI 10.1016/S0092-8674(03)00401-X
-
M. Narita, S. Nunez, E. Heard, A.W. Lin, S.A. Hearn, and D.L. Spector Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence Cell 113 2003 703 716 (Pubitemid 36724935)
-
(2003)
Cell
, vol.113
, Issue.6
, pp. 703-716
-
-
Narita, M.1
Nunez, S.2
Heard, E.3
Narita, M.4
Lin, A.W.5
Hearn, S.A.6
Spector, D.L.7
Hannon, G.J.8
Lowe, S.W.9
-
4
-
-
0029111404
-
Increased activity of p53 in senescing fibroblasts
-
P. Atadja, H. Wong, I. Garkavtsev, C. Veillette, and K. Riabowol Increased activity of p53 in senescing fibroblasts Proc Natl Acad Sci USA 92 1995 8348 8352
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 8348-8352
-
-
Atadja, P.1
Wong, H.2
Garkavtsev, I.3
Veillette, C.4
Riabowol, K.5
-
5
-
-
0037011958
-
p53 mutant mice that display early ageing-associated phenotypes
-
DOI 10.1038/415045a
-
S.D. Tyner, S. Venkatachalam, J. Choi, S. Jones, N. Ghebranious, and H. Igelmann p53 mutant mice that display early ageing-associated phenotypes Nature 415 2002 45 53 (Pubitemid 34062443)
-
(2002)
Nature
, vol.415
, Issue.6867
, pp. 45-53
-
-
Tyner, S.D.1
Venkatachalam, S.2
Choi, J.3
Jones, S.4
Ghebranious, N.5
Igelmann, H.6
Lu, X.7
Soron, G.8
Cooper, B.9
Brayton, C.10
Sang, H.P.11
Thompson, T.12
Karsenty, G.13
Bradley, A.14
Donehower, L.A.15
-
6
-
-
0033539169
-
Microarray analysis of replicative senescence
-
DOI 10.1016/S0960-9822(99)80420-5
-
D.N. Shelton, E. Chang, P.S. Whittier, D. Choi, and W.D. Funk Microarray analysis of replicative senescence Curr Biol 9 1999 939 945 (Pubitemid 29442477)
-
(1999)
Current Biology
, vol.9
, Issue.17
, pp. 939-945
-
-
Shelton, D.N.1
Chang, E.2
Whittier, P.S.3
Choi, D.4
Funk, W.D.5
-
7
-
-
0036829854
-
Characterization of epithelial senescence by serial analysis of gene expression: Identification of genes potentially involved in prostate cancer
-
G. Untergasser, H.B. Koch, A. Menssen, and H. Hermeking Characterization of epithelial senescence by serial analysis of gene expression: identification of genes potentially involved in prostate cancer Cancer Res 62 2002 6255 6262 (Pubitemid 35244479)
-
(2002)
Cancer Research
, vol.62
, Issue.21
, pp. 6255-6262
-
-
Untergasser, G.1
Koch, H.B.2
Menssen, A.3
Hermeking, H.4
-
8
-
-
77950486542
-
Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence
-
A. Chicas, X. Wang, C. Zhang, M. McCurrach, Z. Zhao, and O. Mert Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence Cancer Cell 17 2010 376 387
-
(2010)
Cancer Cell
, vol.17
, pp. 376-387
-
-
Chicas, A.1
Wang, X.2
Zhang, C.3
McCurrach, M.4
Zhao, Z.5
Mert, O.6
-
9
-
-
0029047362
-
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
-
G.P. Dimri, X. Lee, G. Basile, M. Acosta, G. Scott, and C. Roskelley A biomarker that identifies senescent human cells in culture and in aging skin in vivo Proc Natl Acad Sci USA 92 1995 9363 9367
-
(1995)
Proc Natl Acad Sci USA
, vol.92
, pp. 9363-9367
-
-
Dimri, G.P.1
Lee, X.2
Basile, G.3
Acosta, M.4
Scott, G.5
Roskelley, C.6
-
10
-
-
0025279931
-
Telomeres shorten during ageing of human fibroblasts
-
C.B. Harley, A.B. Futcher, and C.W. Greider Telomeres shorten during ageing of human fibroblasts Nature 345 1990 458 460
-
(1990)
Nature
, vol.345
, pp. 458-460
-
-
Harley, C.B.1
Futcher, A.B.2
Greider, C.W.3
-
11
-
-
0344441890
-
A DNA damage checkpoint response in telomere-initiated senescence
-
DOI 10.1038/nature02118
-
F. d'Adda di Fagagna, P.M. Reaper, L. Clay-Farrace, H. Fiegler, P. Carr, and T. Von Zglinicki A DNA damage checkpoint response in telomere-initiated senescence Nature 426 2003 194 198 (Pubitemid 37442589)
-
(2003)
Nature
, vol.426
, Issue.6963
, pp. 194-198
-
-
D'Adda Di Fagagna, F.1
Reaper, P.M.2
Clay-Farrace, L.3
Fiegler, H.4
Carr, P.5
Von Zglinicki, T.6
Saretzki, G.7
Carter, N.P.8
Jackson, S.P.9
-
12
-
-
0030944985
-
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16(INK4a)
-
DOI 10.1016/S0092-8674(00)81902-9
-
M. Serrano, A.W. Lin, M.E. McCurrach, D. Beach, and S.W. Lowe Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a Cell 88 1997 593 602 (Pubitemid 27152402)
-
(1997)
Cell
, vol.88
, Issue.5
, pp. 593-602
-
-
Serrano, M.1
Lin, A.W.2
McCurrach, M.E.3
Beach, D.4
Lowe, S.W.5
-
13
-
-
23244460597
-
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
-
DOI 10.1038/nature03918
-
Z. Chen, L.C. Trotman, D. Shaffer, H.K. Lin, Z.A. Dotan, and M. Niki Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis Nature 436 2005 725 730 (Pubitemid 41117277)
-
(2005)
Nature
, vol.436
, Issue.7051
, pp. 725-730
-
-
Chen, Z.1
Trotman, L.C.2
Shaffer, D.3
Lin, H.-K.4
Dotan, Z.A.5
Niki, M.6
Koutcher, J.A.7
Scher, H.I.8
Ludwig, T.9
Gerald, W.10
Cordon-Cardo, C.11
Pandolfi, P.P.12
-
14
-
-
0031030325
-
Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF
-
D.E. Quelle, M. Cheng, R.A. Ashmun, and C.J. Sherr Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF Proc Natl Acad Sci USA 94 1997 669 673
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 669-673
-
-
Quelle, D.E.1
Cheng, M.2
Ashmun, R.A.3
Sherr, C.J.4
-
15
-
-
0032549711
-
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
-
DOI 10.1016/S0092-8674(00)81401-4
-
Y. Zhang, Y. Xiong, and W.G. Yarbrough ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways Cell 92 1998 725 734 (Pubitemid 28155312)
-
(1998)
Cell
, vol.92
, Issue.6
, pp. 725-734
-
-
Zhang, Y.1
Xiong, Y.2
Yarbrough, W.G.3
-
16
-
-
33847047461
-
Epigenetics: A Landscape Takes Shape
-
DOI 10.1016/j.cell.2007.02.006, PII S0092867407001869
-
A.D. Goldberg, C.D. Allis, and E. Bernstein Epigenetics: a landscape takes shape Cell 128 2007 635 638 (Pubitemid 46273578)
-
(2007)
Cell
, vol.128
, Issue.4
, pp. 635-638
-
-
Goldberg, A.D.1
Allis, C.D.2
Bernstein, E.3
-
17
-
-
0037148271
-
Telomerase in the human organism
-
DOI 10.1038/sj/onc/1205083
-
K. Collins, and J.R. Mitchell Telomerase in the human organism Oncogene 21 2002 564 579 (Pubitemid 34146256)
-
(2002)
Oncogene
, vol.21
, Issue.4 REV. ISS. 1
, pp. 564-579
-
-
Collins, K.1
Mitchell, J.R.2
-
19
-
-
23244447893
-
Tumour biology: Senescence in premalignant tumours
-
DOI 10.1038/436642a
-
M. Collado, J. Gil, A. Efeyan, C. Guerra, A.J. Schuhmacher, and M. Barradas Tumour biology: senescence in premalignant tumours Nature 436 2005 642 (Pubitemid 41117258)
-
(2005)
Nature
, vol.436
, Issue.7051
, pp. 642
-
-
Collado, M.1
Gil, J.2
Efeyan, A.3
Guerra, C.4
Schuhmacher, A.J.5
Barradas, M.6
Benguria, A.7
Zaballos, A.8
Flores, J.M.9
Barbacid, M.10
Beach, D.11
Serrano, M.12
-
20
-
-
33847261047
-
Modeling INK4/ARF tumor suppression in the mouse
-
DOI 10.2174/156652407779940477
-
J.H. Berger, and N. Bardeesy Modeling INK4/ARF tumor suppression in the mouse Curr Mol Med 7 2007 63 75 (Pubitemid 46322279)
-
(2007)
Current Molecular Medicine
, vol.7
, Issue.1
, pp. 63-75
-
-
Berger, J.H.1
Bardeesy, N.2
-
21
-
-
34548176271
-
Ink4a
-
DOI 10.1038/nature06084, PII NATURE06084
-
P. Krimpenfort, A. Ijpenberg, J.Y. Song, M. van der Valk, M. Nawijn, and J. Zevenhoven p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a Nature 448 2007 943 946 (Pubitemid 47312779)
-
(2007)
Nature
, vol.448
, Issue.7156
, pp. 943-946
-
-
Krimpenfort, P.1
Ijpenberg, A.2
Song, J.-Y.3
Van Der Valk, M.4
Nawijn, M.5
Zevenhoven, J.6
Berns, A.7
-
22
-
-
33750030758
-
The Regulation of INK4/ARF in Cancer and Aging
-
DOI 10.1016/j.cell.2006.10.003, PII S0092867406012840
-
W.Y. Kim, and N.E. Sharpless The regulation of INK4/ARF in cancer and aging Cell 127 2006 265 275 (Pubitemid 44572384)
-
(2006)
Cell
, vol.127
, Issue.2
, pp. 265-275
-
-
Kim, W.Y.1
Sharpless, N.E.2
-
23
-
-
33747587608
-
Regulation of the INK4b-ARF-INK4a tumour suppressor locus: All for one or one for all
-
DOI 10.1038/nrm1987, PII NRM1987
-
J. Gil, and G. Peters Regulation of the INK4b-ARF-INK4a tumour suppressor locus: all for one or one for all Nat Rev Mol Cell Biol 7 2006 667 677 (Pubitemid 44268212)
-
(2006)
Nature Reviews Molecular Cell Biology
, vol.7
, Issue.9
, pp. 667-677
-
-
Gil, J.1
Peters, G.2
-
24
-
-
77954758157
-
Polycomb group protein-mediated repression of transcription
-
L. Morey, and K. Helin Polycomb group protein-mediated repression of transcription Trends Biochem Sci 35 2010 323 332
-
(2010)
Trends Biochem Sci
, vol.35
, pp. 323-332
-
-
Morey, L.1
Helin, K.2
-
25
-
-
1342332096
-
Polycomb CBX7 has a unifying role in cellular lifespan
-
DOI 10.1038/ncb1077
-
J. Gil, D. Bernard, D. Martinez, and D. Beach Polycomb CBX7 has a unifying role in cellular lifespan Nat Cell Biol 6 2004 67 72 (Pubitemid 38425732)
-
(2004)
Nature Cell Biology
, vol.6
, Issue.1
, pp. 67-72
-
-
Gil, J.1
Bernard, D.2
Martinez, D.3
Beach, D.4
-
26
-
-
33947576177
-
Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus
-
DOI 10.1038/sj.emboj.7601632, PII 7601632
-
N. Dietrich, A.P. Bracken, E. Trinh, C.K. Schjerling, H. Koseki, and J. Rappsilber Bypass of senescence by the polycomb group protein CBX8 through direct binding to the INK4A-ARF locus EMBO J 26 2007 1637 1648 (Pubitemid 46480949)
-
(2007)
EMBO Journal
, vol.26
, Issue.6
, pp. 1637-1648
-
-
Dietrich, N.1
Bracken, A.P.2
Trinh, E.3
Schjerling, C.K.4
Koseki, H.5
Rappsilber, J.6
Helin, K.7
Hansen, K.H.8
-
27
-
-
33947134834
-
The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells
-
DOI 10.1101/gad.415507
-
A.P. Bracken, D. Kleine-Kohlbrecher, N. Dietrich, D. Pasini, G. Gargiulo, and C. Beekman The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells Genes Dev 21 2007 525 530 (Pubitemid 46409467)
-
(2007)
Genes and Development
, vol.21
, Issue.5
, pp. 525-530
-
-
Bracken, A.P.1
Kleine-Kohlbrecher, D.2
Dietrich, N.3
Pasini, D.4
Gargiulo, G.5
Beekman, C.6
Theilgaard-Monch, K.7
Minucci, S.8
Porse, B.T.9
Marine, J.-C.10
Hansen, K.H.11
Helin, K.12
-
28
-
-
66149138053
-
The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence
-
K. Agger, P.A. Cloos, L. Rudkjaer, K. Williams, G. Andersen, and J. Christensen The H3K27me3 demethylase JMJD3 contributes to the activation of the INK4A-ARF locus in response to oncogene- and stress-induced senescence Genes Dev 23 2009 1171 1176
-
(2009)
Genes Dev
, vol.23
, pp. 1171-1176
-
-
Agger, K.1
Cloos, P.A.2
Rudkjaer, L.3
Williams, K.4
Andersen, G.5
Christensen, J.6
-
29
-
-
43249130490
-
SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus
-
DOI 10.1128/MCB.02019-07
-
S.K. Kia, M.M. Gorski, S. Giannakopoulos, and C.P. Verrijzer SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus Mol Cell Biol 28 2008 3457 3464 (Pubitemid 351657107)
-
(2008)
Molecular and Cellular Biology
, vol.28
, Issue.10
, pp. 3457-3464
-
-
Kia, S.K.1
Gorski, M.M.2
Giannakopoulos, S.3
Verrijzer, C.P.4
-
30
-
-
77954830569
-
Setting and resetting of epigenetic marks in malignant transformation and development
-
H. Richly, M. Lange, E. Simboeck, and L. Di Croce Setting and resetting of epigenetic marks in malignant transformation and development Bioessays 32 2010 669 679
-
(2010)
Bioessays
, vol.32
, pp. 669-679
-
-
Richly, H.1
Lange, M.2
Simboeck, E.3
Di Croce, L.4
-
31
-
-
0035876388
-
Histone deacetylases in replicative senescence: Evidence for a senescence-specific form of HDAC-2
-
DOI 10.1016/S0014-5793(01)02524-8, PII S0014579301025248
-
M. Wagner, G. Brosch, W. Zwerschke, E. Seto, P. Loidl, and P. Jansen-Durr Histone deacetylases in replicative senescence: evidence for a senescence-specific form of HDAC-2 FEBS Lett 499 2001 101 106 (Pubitemid 32539330)
-
(2001)
FEBS Letters
, vol.499
, Issue.1-2
, pp. 101-106
-
-
Wagner, M.1
Brosch, G.2
Zwerschke, W.3
Seto, E.4
Loidl, P.5
Jansen-Durr, P.6
-
32
-
-
75049084999
-
Preclinical antileukemia activity of JNJ-26481585, a potent second-generation histone deacetylase inhibitor
-
W.G. Tong, Y. Wei, W. Stevenson, S.Q. Kuang, Z. Fang, and M. Zhang Preclinical antileukemia activity of JNJ-26481585, a potent second-generation histone deacetylase inhibitor Leuk Res 34 2010 221 228
-
(2010)
Leuk Res
, vol.34
, pp. 221-228
-
-
Tong, W.G.1
Wei, Y.2
Stevenson, W.3
Kuang, S.Q.4
Fang, Z.5
Zhang, M.6
-
33
-
-
0037131426
-
Postsynthetic trimethylation of histone H4 at lysine 20 in mammalian tissues is associated with aging
-
DOI 10.1074/jbc.M205166200
-
B. Sarg, E. Koutzamani, W. Helliger, I. Rundquist, and H.H. Lindner Postsynthetic trimethylation of histone H4 at lysine 20 in mammalian tissues is associated with aging J Biol Chem 277 2002 39195 39201 (Pubitemid 35190888)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.42
, pp. 39195-39201
-
-
Sarg, B.1
Koutzamani, E.2
Helliger, W.3
Rundquist, I.4
Lindner, H.H.5
-
34
-
-
55549147132
-
The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b)
-
J. He, E.M. Kallin, Y. Tsukada, and Y. Zhang The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15(Ink4b) Nat Struct Mol Biol 15 2008 1169 1175
-
(2008)
Nat Struct Mol Biol
, vol.15
, pp. 1169-1175
-
-
He, J.1
Kallin, E.M.2
Tsukada, Y.3
Zhang, Y.4
-
35
-
-
77953096072
-
Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a
-
K.L. Yap, S. Li, A.M. Munoz-Cabello, S. Raguz, L. Zeng, and S. Mujtaba Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a Mol Cell 38 2010 662 674
-
(2010)
Mol Cell
, vol.38
, pp. 662-674
-
-
Yap, K.L.1
Li, S.2
Munoz-Cabello, A.M.3
Raguz, S.4
Zeng, L.5
Mujtaba, S.6
-
36
-
-
79955468280
-
Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene
-
Y. Kotake, T. Nakagawa, K. Kitagawa, S. Suzuki, N. Liu, and M. Kitagawa Long non-coding RNA ANRIL is required for the PRC2 recruitment to and silencing of p15(INK4B) tumor suppressor gene Oncogene 30 2011 1956 1962
-
(2011)
Oncogene
, vol.30
, pp. 1956-1962
-
-
Kotake, Y.1
Nakagawa, T.2
Kitagawa, K.3
Suzuki, S.4
Liu, N.5
Kitagawa, M.6
-
37
-
-
77951169806
-
Distinctive patterns of age-dependent hypomethylation in interspersed repetitive sequences
-
Jintaridth P, Mutirangura A. Distinctive patterns of age-dependent hypomethylation in interspersed repetitive sequences. Physiol Genomics.
-
Physiol Genomics
-
-
Jintaridth, P.1
Mutirangura, A.2
-
38
-
-
0037224722
-
DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells
-
DOI 10.1038/ng1068
-
M.F. Robert, S. Morin, N. Beaulieu, F. Gauthier, I.C. Chute, and A. Barsalou DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells Nat Genet 33 2003 61 65 (Pubitemid 36068683)
-
(2003)
Nature Genetics
, vol.33
, Issue.1
, pp. 61-65
-
-
Robert, M.-F.1
Morin, S.2
Beaulieu, N.3
Gauthier, F.4
Chute, I.C.5
Barsalou, A.6
MacLeod, A.R.7
-
39
-
-
0036186811
-
DNA methyltransferase and demethylase in human prostate cancer
-
DOI 10.1002/mc.10033
-
S.K. Patra, A. Patra, H. Zhao, and R. Dahiya DNA methyltransferase and demethylase in human prostate cancer Mol Carcinog 33 2002 163 171 (Pubitemid 34195197)
-
(2002)
Molecular Carcinogenesis
, vol.33
, Issue.3
, pp. 163-171
-
-
Patra, S.K.1
Patra, A.2
Zhao, H.3
Dahiya, R.4
-
40
-
-
0037013280
-
Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatoma
-
DOI 10.1074/jbc.M111662200
-
S. Majumder, K. Ghoshal, J. Datta, S. Bai, X. Dong, and N. Quan Role of de novo DNA methyltransferases and methyl CpG-binding proteins in gene silencing in a rat hepatoma J Biol Chem 277 2002 16048 16058 (Pubitemid 34967889)
-
(2002)
Journal of Biological Chemistry
, vol.277
, Issue.18
, pp. 16048-16058
-
-
Majumder, S.1
Ghoshal, K.2
Datta, J.3
Bai, S.4
Dong, X.5
Quan, N.6
Plass, C.7
Jacob, S.T.8
-
41
-
-
0034904625
-
Dna methylation and ovarian cancer: I. Analysis of CpG island hypermethylation in human ovarian cancer using differential methylation hybridization
-
DOI 10.1006/gyno.2001.6291
-
A. Ahluwalia, P. Yan, J.A. Hurteau, R.M. Bigsby, S.H. Jung, and T.H. Huang DNA methylation and ovarian cancer I. Analysis of CpG island hypermethylation in human ovarian cancer using differential methylation hybridization Gynecol Oncol 82 2001 261 268 (Pubitemid 32730601)
-
(2001)
Gynecologic Oncology
, vol.82
, Issue.2
, pp. 261-268
-
-
Ahluwalia, A.1
Yan, P.2
Hurteau, J.A.3
Bigsby, R.M.4
Jung, S.H.5
Huang, T.-M.6
Nephew, K.P.7
-
42
-
-
0024365892
-
Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma
-
V. Greger, E. Passarge, W. Hopping, E. Messmer, and B. Horsthemke Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma Hum Genet 83 1989 155 158 (Pubitemid 19234564)
-
(1989)
Human Genetics
, vol.83
, Issue.2
, pp. 155-158
-
-
Greger, V.1
Passarge, E.2
Hopping, W.3
Messmer, E.4
Horsthemke, B.5
-
43
-
-
0035870248
-
A gene hypermethylation profile of human cancer
-
M. Esteller, P.G. Corn, S.B. Baylin, and J.G. Herman A gene hypermethylation profile of human cancer Cancer Res 61 2001 3225 3229 (Pubitemid 32695003)
-
(2001)
Cancer Research
, vol.61
, Issue.8
, pp. 3225-3229
-
-
Esteller, M.1
Corn, P.G.2
Baylin, S.B.3
Herman, J.G.4
-
44
-
-
21744452988
-
An association of DNMT3b protein expression with P16INK4a promoter hypermethylation in non-smoking female lung cancer with human papillomavirus infection
-
DOI 10.1016/j.canlet.2004.12.031, PII S030438350400984X
-
T.S. Lin, H. Lee, R.A. Chen, M.L. Ho, C.Y. Lin, and Y.H. Chen An association of DNMT3b protein expression with P16INK4a promoter hypermethylation in non-smoking female lung cancer with human papillomavirus infection Cancer Lett 226 2005 77 84 (Pubitemid 40943432)
-
(2005)
Cancer Letters
, vol.226
, Issue.1
, pp. 77-84
-
-
Lin, T.-S.1
Lee, H.2
Chen, R.-A.3
Ho, M.-L.4
Lin, C.-Y.5
Chen, Y.-H.6
Tsai, Y.Y.7
Chou, M.-C.8
Cheng, Y.-W.9
-
45
-
-
1242329250
-
INK4A gene in human gastric cancer cell lines
-
J.Y. Fang, L. Yang, H.Y. Zhu, Y.X. Chen, J. Lu, and R. Lu 5-Aza-2′-deoxycitydine induces demethylation and up-regulates transcription of p16INK4A gene in human gastric cancer cell lines Chin Med J (Engl) 117 2004 99 103 (Pubitemid 38240240)
-
(2004)
Chinese Medical Journal
, vol.117
, Issue.1
, pp. 99-103
-
-
Fang, J.-Y.1
Yang, L.2
Zhu, H.-Y.3
Chen, Y.-X.4
Lu, J.5
Lu, R.6
Cheng, Z.7
Xiao, S.-D.8
-
46
-
-
79955921676
-
DNA methyltransferase controls stem cell aging by regulating BMI1 and EZH2 through microRNAs
-
A.Y. So, J.W. Jung, S. Lee, H.S. Kim, and K.S. Kang DNA methyltransferase controls stem cell aging by regulating BMI1 and EZH2 through microRNAs PLoS One 6 2011 e19503
-
(2011)
PLoS One
, vol.6
, pp. 19503
-
-
So, A.Y.1
Jung, J.W.2
Lee, S.3
Kim, H.S.4
Kang, K.S.5
-
47
-
-
33947301272
-
Epigenetic signatures of stem-cell identity
-
DOI 10.1038/nrg2046, PII NRG2046
-
M. Spivakov, and A.G. Fisher Epigenetic signatures of stem-cell identity Nat Rev Genet 8 2007 263 271 (Pubitemid 46439288)
-
(2007)
Nature Reviews Genetics
, vol.8
, Issue.4
, pp. 263-271
-
-
Spivakov, M.1
Fisher, A.G.2
-
48
-
-
0028361374
-
Regulation of two E2F-related genes in presenescent and senescent human fibroblasts
-
G.P. Dimri, E. Hara, and J. Campisi Regulation of two E2F-related genes in presenescent and senescent human fibroblasts J Biol Chem 269 1994 16180 16186 (Pubitemid 24209309)
-
(1994)
Journal of Biological Chemistry
, vol.269
, Issue.23
, pp. 16180-16186
-
-
Dimri, G.P.1
Hara, E.2
Campisi, J.3
-
49
-
-
0030003153
-
Inhibition of E2F activity by the cyclin-dependent protein kinase inhibitor p21 in cells expressing or lacking a functional retinoblastoma protein
-
G.P. Dimri, M. Nakanishi, P.Y. Desprez, J.R. Smith, and J. Campisi Inhibition of E2F activity by the cyclin-dependent protein kinase inhibitor p21 in cells expressing or lacking a functional retinoblastoma protein Mol Cell Biol 16 1996 2987 2997 (Pubitemid 26161305)
-
(1996)
Molecular and Cellular Biology
, vol.16
, Issue.6
, pp. 2987-2997
-
-
Dimri, G.P.1
Nakanishi, M.2
Desprez, P.-Y.3
Smith, J.R.4
Campisi, J.5
-
50
-
-
23244461708
-
Oncogene-induced senescence as an initial barrier in lymphoma development
-
DOI 10.1038/nature03841
-
M. Braig, S. Lee, C. Loddenkemper, C. Rudolph, A.H. Peters, and B. Schlegelberger Oncogene-induced senescence as an initial barrier in lymphoma development Nature 436 2005 660 665 (Pubitemid 41117262)
-
(2005)
Nature
, vol.436
, Issue.7051
, pp. 660-665
-
-
Braig, M.1
Lee, S.2
Loddenkemper, C.3
Rudolph, C.4
Peters, A.H.F.M.5
Schlegelberger, B.6
Stein, H.7
Dorken, B.8
Jenuwein, T.9
Schmitt, C.A.10
-
51
-
-
19944427674
-
Formation of macroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA
-
DOI 10.1016/j.devcel.2004.10.019, PII S1534580704004083
-
R. Zhang, M.V. Poustovoitov, X. Ye, H.A. Santos, W. Chen, and S.M. Daganzo Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA Dev Cell 8 2005 19 30 (Pubitemid 40058002)
-
(2005)
Developmental Cell
, vol.8
, Issue.1
, pp. 19-30
-
-
Zhang, R.1
Poustovoitov, M.V.2
Ye, X.3
Santos, H.A.4
Chen, W.5
Daganzo, S.M.6
Erzberger, J.P.7
Serebriiskii, I.G.8
Canutescu, A.A.9
Dunbrack, R.L.10
Pehrson, J.R.11
Berger, J.M.12
Kaufman, P.D.13
Adams, P.D.14
-
52
-
-
33746752125
-
A Novel Role for High-Mobility Group A Proteins in Cellular Senescence and Heterochromatin Formation
-
DOI 10.1016/j.cell.2006.05.052, PII S0092867406009135
-
M. Narita, V. Krizhanovsky, S. Nunez, A. Chicas, S.A. Hearn, and M.P. Myers A novel role for high-mobility group a proteins in cellular senescence and heterochromatin formation Cell 126 2006 503 514 (Pubitemid 44163608)
-
(2006)
Cell
, vol.126
, Issue.3
, pp. 503-514
-
-
Narita, M.1
Narita, M.2
Krizhanovsky, V.3
Nunez, S.4
Chicas, A.5
Hearn, S.A.6
Myers, M.P.7
Lowe, S.W.8
-
53
-
-
79851493300
-
Senescenceassociated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a)
-
M. Kosar, J. Bartkova, S. Hubackova, Z. Hodny, J. Lukas, and J. Bartek Senescenceassociated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a) Cell Cycle 10 2011 457 468
-
(2011)
Cell Cycle
, vol.10
, pp. 457-468
-
-
Kosar, M.1
Bartkova, J.2
Hubackova, S.3
Hodny, Z.4
Lukas, J.5
Bartek, J.6
-
54
-
-
77953675074
-
Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci
-
A.L. Kennedy, T. McBryan, G.H. Enders, F.B. Johnson, R. Zhang, and P.D. Adams Senescent mouse cells fail to overtly regulate the HIRA histone chaperone and do not form robust Senescence Associated Heterochromatin Foci Cell Div 5 2010 16
-
(2010)
Cell Div
, vol.5
, pp. 16
-
-
Kennedy, A.L.1
McBryan, T.2
Enders, G.H.3
Johnson, F.B.4
Zhang, R.5
Adams, P.D.6
-
55
-
-
0037089689
-
E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex
-
DOI 10.1101/gad.969202
-
J.B. Rayman, Y. Takahashi, V.B. Indjeian, J.H. Dannenberg, S. Catchpole, and R.J. Watson E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex Genes Dev 16 2002 933 947 (Pubitemid 34408543)
-
(2002)
Genes and Development
, vol.16
, Issue.8
, pp. 933-947
-
-
Rayman, J.B.1
Takahashi, Y.2
Indjeian, V.B.3
Dannenberg, J.-H.4
Catchpole, S.5
Watson, R.J.6
Riele, H.7
Dynlacht, B.D.8
-
56
-
-
0034175616
-
Analysis of promoter binding by the E2F and pRB families in vivo: Distinct E2F proteins mediate activation and repression
-
Y. Takahashi, J.B. Rayman, and B.D. Dynlacht Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression Genes Dev 14 2000 804 816 (Pubitemid 30215000)
-
(2000)
Genes and Development
, vol.14
, Issue.7
, pp. 804-816
-
-
Takahashi, Y.1
Rayman, J.B.2
Dynlacht, B.D.3
-
57
-
-
34648816970
-
Cellular senescence and chromatin structure
-
DOI 10.1007/s00412-007-0115-7
-
R. Funayama, and F. Ishikawa Cellular senescence and chromatin structure Chromosoma 116 2007 431 440 (Pubitemid 47456911)
-
(2007)
Chromosoma
, vol.116
, Issue.5
, pp. 431-440
-
-
Funayama, R.1
Ishikawa, F.2
-
58
-
-
33947236204
-
Molecular dissection of formation of senescence-associated heterochromatin foci
-
DOI 10.1128/MCB.02019-06
-
R. Zhang, W. Chen, and P.D. Adams Molecular dissection of formation of senescence-associated heterochromatin foci Mol Cell Biol 27 2007 2343 2358 (Pubitemid 46418486)
-
(2007)
Molecular and Cellular Biology
, vol.27
, Issue.6
, pp. 2343-2358
-
-
Zhang, R.1
Chen, W.2
Adams, P.D.3
-
59
-
-
33845687060
-
Loss of linker histone H1 in cellular senescence
-
DOI 10.1083/jcb.200604005
-
R. Funayama, M. Saito, H. Tanobe, and F. Ishikawa Loss of linker histone H1 in cellular senescence J Cell Biol 175 2006 869 880 (Pubitemid 44969193)
-
(2006)
Journal of Cell Biology
, vol.175
, Issue.6
, pp. 869-880
-
-
Funayama, R.1
Saito, M.2
Tanobe, H.3
Ishikawa, F.4
-
60
-
-
0019308155
-
Age-related decline in histone H1 fraction in human diploid fibroblast cultures
-
DOI 10.1016/0014-4827(80)90267-0
-
Y. Mitsui, H. Sakagami, S. Murota, and M. Yamada Age-related decline in histone H1 fraction in human diploid fibroblast cultures Exp Cell Res 126 1980 289 298 (Pubitemid 10041163)
-
(1980)
Experimental Cell Research
, vol.126
, Issue.2
, pp. 289-298
-
-
Mitsui, Y.1
Sakagami, H.2
Murota, I.3
Yamada, M.A.4
-
61
-
-
0035904395
-
Molecular biology of HMGA proteins: Hubs of nuclear function
-
DOI 10.1016/S0378-1119(01)00689-8, PII S0378111901006898
-
R. Reeves Molecular biology of HMGA proteins: hubs of nuclear function Gene 277 2001 63 81 (Pubitemid 32972109)
-
(2001)
Gene
, vol.277
, Issue.1-2
, pp. 63-81
-
-
Reeves, R.1
-
62
-
-
4444288119
-
Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer
-
DOI 10.1016/j.febslet.2004.08.013, PII S0014579304010063
-
R. Sgarra, A. Rustighi, M.A. Tessari, J. Di Bernardo, S. Altamura, and A. Fusco Nuclear phosphoproteins HMGA and their relationship with chromatin structure and cancer FEBS Lett 574 2004 1 8 (Pubitemid 39200885)
-
(2004)
FEBS Letters
, vol.574
, Issue.1-3
, pp. 1-8
-
-
Sgarra, R.1
Rustighi, A.2
Tessari, M.A.3
Di Bernardo, J.4
Altamura, S.5
Fusco, A.6
Manfioletti, G.7
Giancotti, V.8
-
64
-
-
33947127598
-
The histone chaperone Asf1 at the crossroads of chromatin and DNA checkpoint pathways
-
DOI 10.1007/s00412-006-0087-z
-
F. Mousson, F. Ochsenbein, and C. Mann The histone chaperone Asf1 at the crossroads of chromatin and DNA checkpoint pathways Chromosoma 116 2007 79 93 (Pubitemid 46404505)
-
(2007)
Chromosoma
, vol.116
, Issue.2
, pp. 79-93
-
-
Mousson, F.1
Ochsenbein, F.2
Mann, C.3
-
65
-
-
0036299092
-
The histone variant H3.3 marks active chromatin by replication- independent nucleosome assembly
-
DOI 10.1016/S1097-2765(02)00542-7
-
K. Ahmad, and S. Henikoff The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly Mol Cell 9 2002 1191 1200 (Pubitemid 34722299)
-
(2002)
Molecular Cell
, vol.9
, Issue.6
, pp. 1191-1200
-
-
Ahmad, K.1
Henikoff, S.2
-
66
-
-
0031858054
-
Hir proteins are required for position-dependent gene silencing in Saccharomyces cerevisiae in the absence of chromatin assembly factor I
-
P.D. Kaufman, J.L. Cohen, and M.A. Osley Hir proteins are required for position-dependent gene silencing in Saccharomyces cerevisiae in the absence of chromatin assembly factor I Mol Cell Biol 18 1998 4793 4806 (Pubitemid 28343064)
-
(1998)
Molecular and Cellular Biology
, vol.18
, Issue.8
, pp. 4793-4806
-
-
Kaufman, P.D.1
Cohen, J.L.2
Osley, M.A.3
-
67
-
-
0037108055
-
Histone chaperone ASF1 cooperates with the Brahma chromatin-remodelling machinery
-
Y.M. Moshkin, J.A. Armstrong, R.K. Maeda, J.W. Tamkun, P. Verrijzer, and J.A. Kennison Histone chaperone ASF1 cooperates with the Brahma chromatin-remodelling machinery Genes Dev 16 2002 2621 2626
-
(2002)
Genes Dev
, vol.16
, pp. 2621-2626
-
-
Moshkin, Y.M.1
Armstrong, J.A.2
Maeda, R.K.3
Tamkun, J.W.4
Verrijzer, P.5
Kennison, J.A.6
-
68
-
-
0036141054
-
Chromatin assembly factor I and Hir proteins contribute to building functional kinetochores in S. cerevisiae
-
DOI 10.1101/gad.925302
-
J.A. Sharp, A.A. Franco, M.A. Osley, and P.D. Kaufman Chromatin assembly factor I and Hir proteins contribute to building functional kinetochores in S. cerevisiae Genes Dev 16 2002 85 100 (Pubitemid 34049640)
-
(2002)
Genes and Development
, vol.16
, Issue.1
, pp. 85-100
-
-
Sharp, J.A.1
Franco, A.A.2
Osley, M.A.3
Kaufman, P.D.4
-
69
-
-
0031658303
-
Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae
-
M.S. Singer, A. Kahana, A.J. Wolf, L.L. Meisinger, S.E. Peterson, and C. Goggin Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae Genetics 150 1998 613 632 (Pubitemid 28463040)
-
(1998)
Genetics
, vol.150
, Issue.2
, pp. 613-632
-
-
Singer, M.S.1
Kahana, A.2
Wolf, A.J.3
Meisinger, L.L.4
Peterson, S.E.5
Goggin, C.6
Mahowald, M.7
Gottschling, D.E.8
-
70
-
-
2942550662
-
Chromatin disassembly mediated by the histone chaperone Asf1 is essential for transcriptional activation of the yeast PHO5 and PHO8 genes
-
DOI 10.1016/j.molcel.2004.05.016, PII S1097276504003004
-
M.W. Adkins, S.R. Howar, and J.K. Tyler Chromatin disassembly mediated by the histone chaperone Asf1 is essential for transcriptional activation of the yeast PHO5 and PHO8 genes Mol Cell 14 2004 657 666 (Pubitemid 38739087)
-
(2004)
Molecular Cell
, vol.14
, Issue.5
, pp. 657-666
-
-
Adkins, M.W.1
Howar, S.R.2
Tyler, J.K.3
-
71
-
-
34447343780
-
Downregulation of Wnt Signaling Is a Trigger for Formation of Facultative Heterochromatin and Onset of Cell Senescence in Primary Human Cells
-
DOI 10.1016/j.molcel.2007.05.034, PII S1097276507003589
-
X. Ye, B. Zerlanko, A. Kennedy, G. Banumathy, R. Zhang, and P.D. Adams Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells Mol Cell 27 2007 183 196 (Pubitemid 47058300)
-
(2007)
Molecular Cell
, vol.27
, Issue.2
, pp. 183-196
-
-
Ye, X.1
Zerlanko, B.2
Kennedy, A.3
Banumathy, G.4
Zhang, R.5
Adams, PeterD.6
-
72
-
-
1542285168
-
PML is a direct p53 target that modulates p53 effector functions
-
DOI 10.1016/S1097-2765(04)00062-0, PII S1097276504000620
-
E. de Stanchina, E. Querido, M. Narita, R.V. Davuluri, P.P. Pandolfi, and G. Ferbeyre PML is a direct p53 target that modulates p53 effector functions Mol Cell 13 2004 523 535 (Pubitemid 38299380)
-
(2004)
Molecular Cell
, vol.13
, Issue.4
, pp. 523-535
-
-
De Stanchina, E.1
Querido, E.2
Narita, M.3
Davuluri, R.V.4
Pandolfi, P.P.5
Ferbeyre, G.6
Lowe, S.W.7
-
73
-
-
0034663873
-
PML is induced by oncogenic ras and promotes premature senescence
-
G. Ferbeyre, E. de Stanchina, E. Querido, N. Baptiste, C. Prives, and S.W. Lowe PML is induced by oncogenic ras and promotes premature senescence Genes Dev 14 2000 2015 2027 (Pubitemid 30637352)
-
(2000)
Genes and Development
, vol.14
, Issue.16
, pp. 2015-2027
-
-
Ferbeyre, G.1
De Stanchina, E.2
Querido, E.3
Baptiste, N.4
Prives, C.5
Lowe, S.W.6
-
74
-
-
0034644274
-
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
-
DOI 10.1038/35018127
-
M. Pearson, R. Carbone, C. Sebastiani, M. Cioce, M. Fagioli, and S. Saito PML regulates p53 acetylation and premature senescence induced by oncogenic Ras Nature 406 2000 207 210 (Pubitemid 30469006)
-
(2000)
Nature
, vol.406
, Issue.6792
, pp. 207-210
-
-
Pearson, M.1
Carbone, R.2
Sebastiani, C.3
Cloce, M.4
Fagloll, M.5
Saito, S.6
Higashimoto, Y.7
Appella, E.8
Minucci, S.9
Pandolfi, P.P.10
Pellcci, P.G.11
-
75
-
-
0028179010
-
A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein
-
DOI 10.1016/0092-8674(94)90340-9
-
J.A. Dyck, G.G. Maul, W.H. Miller Jr., J.D. Chen, A. Kakizuka, and R.M. Evans A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein Cell 76 1994 333 343 (Pubitemid 24046695)
-
(1994)
Cell
, vol.76
, Issue.2
, pp. 333-343
-
-
Dyck, J.A.1
Maul, G.G.2
Miller Jr., W.H.3
Chen, J.D.4
Kakizuka, A.5
Evans, R.M.6
-
76
-
-
0034669124
-
Regulation of p53 activity in nuclear bodies by a specific PML isoform
-
V. Fogal, M. Gostissa, P. Sandy, P. Zacchi, T. Sternsdorf, and K. Jensen Regulation of p53 activity in nuclear bodies by a specific PML isoform EMBO J 19 2000 6185 6195
-
(2000)
EMBO J
, vol.19
, pp. 6185-6195
-
-
Fogal, V.1
Gostissa, M.2
Sandy, P.3
Zacchi, P.4
Sternsdorf, T.5
Jensen, K.6
-
77
-
-
0034306019
-
The function of PML in p53-dependent apoptosis
-
A. Guo, P. Salomoni, J. Luo, A. Shih, S. Zhong, and W. Gu The function of PML in p53-dependent apoptosis Nat Cell Biol 2 2000 730 736
-
(2000)
Nat Cell Biol
, vol.2
, pp. 730-736
-
-
Guo, A.1
Salomoni, P.2
Luo, J.3
Shih, A.4
Zhong, S.5
Gu, W.6
-
78
-
-
34147095342
-
Protein composition of catalytically active human telomerase from immortal cells
-
DOI 10.1126/science.1138596
-
S.B. Cohen, M.E. Graham, G.O. Lovrecz, N. Bache, P.J. Robinson, and R.R. Reddel Protein composition of catalytically active human telomerase from immortal cells Science 315 2007 1850 1853 (Pubitemid 46580145)
-
(2007)
Science
, vol.315
, Issue.5820
, pp. 1850-1853
-
-
Cohen, S.B.1
Graham, M.E.2
Lovrecz, G.O.3
Bache, N.4
Robinson, P.J.5
Reddel, R.R.6
-
79
-
-
33947317206
-
The epigenetic regulation of mammalian telomeres
-
DOI 10.1038/nrg2047, PII NRG2047
-
M.A. Blasco The epigenetic regulation of mammalian telomeres Nat Rev Genet 8 2007 299 309 (Pubitemid 46439289)
-
(2007)
Nature Reviews Genetics
, vol.8
, Issue.4
, pp. 299-309
-
-
Blasco, M.A.1
-
80
-
-
34447543913
-
Cellular Senescence in Cancer and Aging
-
DOI 10.1016/j.cell.2007.07.003, PII S0092867407008902
-
M. Collado, M.A. Blasco, and M. Serrano Cellular senescence in cancer and aging Cell 130 2007 223 233 (Pubitemid 47081143)
-
(2007)
Cell
, vol.130
, Issue.2
, pp. 223-233
-
-
Collado, M.1
Blasco, M.A.2
Serrano, M.3
-
81
-
-
0035874977
-
Telomere position effect in human cells
-
DOI 10.1126/science.1062329
-
J.A. Baur, Y. Zou, J.W. Shay, and W.E. Wright Telomere position effect in human cells Science 292 2001 2075 2077 (Pubitemid 32691573)
-
(2001)
Science
, vol.292
, Issue.5524
, pp. 2075-2077
-
-
Baur, J.A.1
Zou, Y.2
Shay, J.W.3
Wright, W.E.4
-
82
-
-
0036867444
-
Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity
-
DOI 10.1093/embo-reports/kvf215
-
C.E. Koering, A. Pollice, M.P. Zibella, S. Bauwens, A. Puisieux, and M. Brunori Human telomeric position effect is determined by chromosomal context and telomeric chromatin integrity EMBO Rep 3 2002 1055 1061 (Pubitemid 35469897)
-
(2002)
EMBO Reports
, vol.3
, Issue.11
, pp. 1055-1061
-
-
Koering, C.E.1
Pollice, A.2
Zibella, M.P.3
Bauwens, S.4
Puisieux, A.5
Brunori, M.6
Brun, C.7
Martins, L.8
Sabatier, L.9
Pulitzer, J.F.10
Gilson, E.11
-
83
-
-
0347988045
-
Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases
-
DOI 10.1038/ng1278
-
M. Garcia-Cao, R. O'Sullivan, A.H. Peters, T. Jenuwein, and M.A. Blasco Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases Nat Genet 36 2004 94 99 (Pubitemid 38056214)
-
(2004)
Nature Genetics
, vol.36
, Issue.1
, pp. 94-99
-
-
Garcia-Cao, M.1
O'Sullivan, R.2
Peters, A.H.F.M.3
Jenuwein, T.4
Blasco, M.A.5
-
84
-
-
34548827379
-
Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination
-
DOI 10.1083/jcb.200703081
-
R. Benetti, S. Gonzalo, I. Jaco, G. Schotta, P. Klatt, and T. Jenuwein Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination J Cell Biol 178 2007 925 936 (Pubitemid 47443317)
-
(2007)
Journal of Cell Biology
, vol.178
, Issue.6
, pp. 925-936
-
-
Benetti, R.1
Gonzalo, S.2
Jaco, I.3
Schotta, G.4
Klatt, P.5
Jenuwein, T.6
Blasco, M.A.7
-
85
-
-
20244376464
-
Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin
-
DOI 10.1038/ncb1235
-
S. Gonzalo, M. Garcia-Cao, M.F. Fraga, G. Schotta, A.H. Peters, and S.E. Cotter Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin Nat Cell Biol 7 2005 420 428 (Pubitemid 40533133)
-
(2005)
Nature Cell Biology
, vol.7
, Issue.4
, pp. 420-428
-
-
Gonzalo, S.1
Garcia-Cao, M.2
Fraga, M.F.3
Schotta, G.4
Peters, A.H.F.M.5
Cotter, S.E.6
Eguia, R.7
Dean, D.C.8
Esteller, M.9
Jenuwein, T.10
Blasco, M.A.11
-
86
-
-
33644502519
-
Telomere position effect and silencing of transgenes near telomeres in the mouse
-
M. Pedram, C.N. Sprung, Q. Gao, A.W. Lo, G.E. Reynolds, and J.P. Murnane Telomere position effect and silencing of transgenes near telomeres in the mouse Mol Cell Biol 26 2006 1865 1878
-
(2006)
Mol Cell Biol
, vol.26
, pp. 1865-1878
-
-
Pedram, M.1
Sprung, C.N.2
Gao, Q.3
Lo, A.W.4
Reynolds, G.E.5
Murnane, J.P.6
-
87
-
-
33645702660
-
DNA methyltransferases control telomere length and telomere recombination in mammalian cells
-
S. Gonzalo, I. Jaco, M.F. Fraga, T. Chen, E. Li, and M. Esteller DNA methyltransferases control telomere length and telomere recombination in mammalian cells Nat Cell Biol 8 2006 416 424
-
(2006)
Nat Cell Biol
, vol.8
, pp. 416-424
-
-
Gonzalo, S.1
Jaco, I.2
Fraga, M.F.3
Chen, T.4
Li, E.5
Esteller, M.6
-
88
-
-
78650889400
-
Chromatin regulation and genome maintenance by mammalian SIRT6
-
R.I. Tennen, and K.F. Chua Chromatin regulation and genome maintenance by mammalian SIRT6 Trends Biochem Sci 36 2011 39 46
-
(2011)
Trends Biochem Sci
, vol.36
, pp. 39-46
-
-
Tennen, R.I.1
Chua, K.F.2
-
89
-
-
31044445366
-
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6
-
DOI 10.1016/j.cell.2005.11.044, PII S0092867406000493
-
R. Mostoslavsky, K.F. Chua, D.B. Lombard, W.W. Pang, M.R. Fischer, and L. Gellon Genomic instability and aging-like phenotype in the absence of mammalian SIRT6 Cell 124 2006 315 329 (Pubitemid 43121980)
-
(2006)
Cell
, vol.124
, Issue.2
, pp. 315-329
-
-
Mostoslavsky, R.1
Chua, K.F.2
Lombard, D.B.3
Pang, W.W.4
Fischer, M.R.5
Gellon, L.6
Liu, P.7
Mostoslavsky, G.8
Franco, S.9
Murphy, M.M.10
Mills, K.D.11
Patel, P.12
Hsu, J.T.13
Hong, A.L.14
Ford, E.15
Cheng, H.-L.16
Kennedy, C.17
Nunez, N.18
Bronson, R.19
Frendewey, D.20
Auerbach, W.21
Valenzuela, D.22
Karow, M.23
Hottiger, M.O.24
Hursting, S.25
Barrett, J.C.26
Guarente, L.27
Mulligan, R.28
Demple, B.29
Yancopoulos, G.D.30
Alt, F.W.31
more..
-
90
-
-
41349090663
-
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin
-
DOI 10.1038/nature06736, PII NATURE06736
-
E. Michishita, R.A. McCord, E. Berber, M. Kioi, H. Padilla-Nash, and M. Damian SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin Nature 452 2008 492 496 (Pubitemid 351450840)
-
(2008)
Nature
, vol.452
, Issue.7186
, pp. 492-496
-
-
Michishita, E.1
McCord, R.A.2
Berber, E.3
Kioi, M.4
Padilla-Nash, H.5
Damian, M.6
Cheung, P.7
Kusumoto, R.8
Kawahara, T.L.A.9
Barrett, J.C.10
Chang, H.Y.11
Bohr, V.A.12
Ried, T.13
Gozani, O.14
Chua, K.F.15
-
91
-
-
78650747994
-
SIRT1 contributes to telomere maintenance and augments global homologous recombination
-
J.A. Palacios, D. Herranz, M.L. De Bonis, S. Velasco, M. Serrano, and M.A. Blasco SIRT1 contributes to telomere maintenance and augments global homologous recombination J Cell Biol 191 2010 1299 1313
-
(2010)
J Cell Biol
, vol.191
, pp. 1299-1313
-
-
Palacios, J.A.1
Herranz, D.2
De Bonis, M.L.3
Velasco, S.4
Serrano, M.5
Blasco, M.A.6
-
92
-
-
33646526019
-
Chromosome territories - A functional nuclear landscape
-
T. Cremer, M. Cremer, S. Dietzel, S. Muller, I. Solovei, and S. Fakan Chromosome territories - a functional nuclear landscape Curr Opin Cell Biol 18 2006 307 316
-
(2006)
Curr Opin Cell Biol
, vol.18
, pp. 307-316
-
-
Cremer, T.1
Cremer, M.2
Dietzel, S.3
Muller, S.4
Solovei, I.5
Fakan, S.6
-
93
-
-
84879171166
-
Evolutionary origin of the cell nucleus and its functional architecture
-
J. Postberg, H.J. Lipps, and T. Cremer Evolutionary origin of the cell nucleus and its functional architecture Essays Biochem 48 2010 1 24
-
(2010)
Essays Biochem
, vol.48
, pp. 1-24
-
-
Postberg, J.1
Lipps, H.J.2
Cremer, T.3
-
94
-
-
0033553877
-
Differences in the localization and morphology of chromosomes in the human nucleus
-
DOI 10.1083/jcb.145.6.1119
-
J.A. Croft, J.M. Bridger, S. Boyle, P. Perry, P. Teague, and W.A. Bickmore Differences in the localization and morphology of chromosomes in the human nucleus J Cell Biol 145 1999 1119 1131 (Pubitemid 29293625)
-
(1999)
Journal of Cell Biology
, vol.145
, Issue.6
, pp. 1119-1131
-
-
Croft, J.A.1
Bridger, J.M.2
Boyle, S.3
Perry, P.4
Teague, P.5
Bickmore, W.A.6
-
95
-
-
34250166469
-
Lamins and lamin-associated proteins in aging and disease
-
DOI 10.1016/j.ceb.2007.04.001, PII S0955067407000531, Nucleus and Gene Expression
-
S. Vlcek, and R. Foisner Lamins and lamin-associated proteins in aging and disease Curr Opin Cell Biol 19 2007 298 304 (Pubitemid 46899504)
-
(2007)
Current Opinion in Cell Biology
, vol.19
, Issue.3
, pp. 298-304
-
-
Vlcek, S.1
Foisner, R.2
-
96
-
-
0026343513
-
II with chromatin in Vitro mediated by a sequence element in the carboxyterminal domain
-
T.H. Hoger, G. Krohne, and J.A. Kleinschmidt Interaction of Xenopus lamins A and LII with chromatin in vitro mediated by a sequence element in the carboxyterminal domain Exp Cell Res 197 1991 280 289 (Pubitemid 121006434)
-
(1991)
Experimental Cell Research
, vol.197
, Issue.2
, pp. 280-289
-
-
Hoger, T.H.1
Krohne, G.2
Kleinschmidt, J.A.3
-
97
-
-
34249788998
-
"Laminopathies": A wide spectrum of human diseases
-
DOI 10.1016/j.yexcr.2007.03.028, PII S0014482707001279
-
H.J. Worman, and G. Bonne Laminopathies: a wide spectrum of human diseases Exp Cell Res 313 2007 2121 2133 (Pubitemid 46850729)
-
(2007)
Experimental Cell Research
, vol.313
, Issue.10
, pp. 2121-2133
-
-
Worman, H.J.1
Bonne, G.2
-
98
-
-
10744229294
-
Lamin A truncation in Hutchinson-Gilford progeria
-
DOI 10.1126/science.1084125
-
A. De Sandre-Giovannoli, R. Bernard, P. Cau, C. Navarro, J. Amiel, and I. Boccaccio Lamin a truncation in Hutchinson-Gilford progeria Science 300 2003 2055 (Pubitemid 36760124)
-
(2003)
Science
, vol.300
, Issue.5628
, pp. 2055
-
-
De Sandre-Giovannoli, A.1
Bernard, R.2
Cau, P.3
Navarro, C.4
Amiel, J.5
Boccaccio, I.6
Lyonnet, S.7
Stewart, C.L.8
Munnich, A.9
Le Merrer, M.10
Levy, N.11
-
99
-
-
0037673950
-
Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome
-
DOI 10.1038/nature01629
-
M. Eriksson, W.T. Brown, L.B. Gordon, M.W. Glynn, J. Singer, and L. Scott Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome Nature 423 2003 293 298 (Pubitemid 40852699)
-
(2003)
Nature
, vol.423
, Issue.6937
, pp. 293-298
-
-
Eriksson, M.1
Brown, W.T.2
Gordon, L.B.3
Glynn, M.W.4
Singer, J.5
Scott, L.6
Erdos, M.R.7
Robbins, C.M.8
Moses, T.Y.9
Berglund, P.10
Dutra, A.11
Pak, E.12
Durkin, S.13
Csoka, A.B.14
Boehnke, M.15
Glover, T.W.16
Collins, F.S.17
-
100
-
-
28344445866
-
Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment
-
DOI 10.1007/s00018-005-5318-6
-
M. Columbaro, C. Capanni, E. Mattioli, G. Novelli, V.K. Parnaik, and S. Squarzoni Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment Cell Mol Life Sci 62 2005 2669 2678 (Pubitemid 41721238)
-
(2005)
Cellular and Molecular Life Sciences
, vol.62
, Issue.22
, pp. 2669-2678
-
-
Columbaro, M.1
Capanni, C.2
Mattioli, E.3
Novelli, G.4
Parnaik, V.K.5
Squarzoni, S.6
Maraldi, N.M.7
Lattanzi, G.8
-
101
-
-
17644373758
-
Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome
-
DOI 10.1038/nm1204
-
P. Scaffidi, and T. Misteli Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome Nat Med 11 2005 440 445 (Pubitemid 40562336)
-
(2005)
Nature Medicine
, vol.11
, Issue.4
, pp. 440-445
-
-
Scaffidi, P.1
Misteli, T.2
-
102
-
-
33745016642
-
Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging
-
DOI 10.1073/pnas.0602569103
-
D.K. Shumaker, T. Dechat, A. Kohlmaier, S.A. Adam, M.R. Bozovsky, and M.R. Erdos Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging Proc Natl Acad Sci USA 103 2006 8703 8708 (Pubitemid 43878083)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.23
, pp. 8703-8708
-
-
Shumaker, D.K.1
Dechat, T.2
Kohlmaier, A.3
Adam, S.A.4
Bozovsky, M.R.5
Erdos, M.R.6
Eriksson, M.7
Goldman, A.E.8
Khuon, S.9
Collins, F.S.10
Jenuwein, T.11
Goldman, R.D.12
-
103
-
-
33646745137
-
Lamin A-dependent nuclear defects in human aging
-
P. Scaffidi, and T. Misteli Lamin A-dependent nuclear defects in human aging Science 312 2006 1059 1063
-
(2006)
Science
, vol.312
, pp. 1059-1063
-
-
Scaffidi, P.1
Misteli, T.2
-
104
-
-
58049195492
-
The A- and B-type nuclear lamin networks: Microdomains involved in chromatin organization and transcription
-
T. Shimi, K. Pfleghaar, S. Kojima, C.G. Pack, I. Solovei, and A.E. Goldman The A- and B-type nuclear lamin networks: microdomains involved in chromatin organization and transcription Genes Dev 22 2008 3409 3421
-
(2008)
Genes Dev
, vol.22
, pp. 3409-3421
-
-
Shimi, T.1
Pfleghaar, K.2
Kojima, S.3
Pack, C.G.4
Solovei, I.5
Goldman, A.E.6
-
105
-
-
0028064990
-
Complex formation between lamin A and the retinoblastoma gene product: Identification of the domain on lamin A required for its interaction
-
T. Ozaki, M. Saijo, K. Murakami, H. Enomoto, Y. Taya, and S. Sakiyama Complex formation between lamin A and the retinoblastoma gene product: identification of the domain on lamin A required for its interaction Oncogene 9 1994 2649 2653 (Pubitemid 24254041)
-
(1994)
Oncogene
, vol.9
, Issue.9
, pp. 2649-2653
-
-
Ozaki, T.1
Saijo, M.2
Murakami, K.3
Enomoto, H.4
Taya, Y.5
Sakiyama, S.6
-
106
-
-
3042829496
-
A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation
-
DOI 10.1073/pnas.0403250101
-
B.R. Johnson, R.T. Nitta, R.L. Frock, L. Mounkes, D.A. Barbie, and C.L. Stewart A-type lamins regulate retinoblastoma protein function by promoting subnuclear localization and preventing proteasomal degradation Proc Natl Acad Sci USA 101 2004 9677 9682 (Pubitemid 38869295)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.26
, pp. 9677-9682
-
-
Johnson, B.R.1
Nitta, R.T.2
Frock, R.L.3
Mounkes, L.4
Barbie, D.A.5
Stewart, C.L.6
Harlow, E.7
Kennedy, B.K.8
-
107
-
-
38049081151
-
Retinoblastoma tumor suppressor protein-dependent methylation of histone H3 lysine 27 is associated with irreversible cell cycle exit
-
A. Blais, C.J. van Oevelen, R. Margueron, D. Acosta-Alvear, and B.D. Dynlacht Retinoblastoma tumor suppressor protein-dependent methylation of histone H3 lysine 27 is associated with irreversible cell cycle exit J Cell Biol 179 2007 1399 1412
-
(2007)
J Cell Biol
, vol.179
, pp. 1399-1412
-
-
Blais, A.1
Van Oevelen, C.J.2
Margueron, R.3
Acosta-Alvear, D.4
Dynlacht, B.D.5
-
108
-
-
34548186667
-
Cellular senescence: When bad things happen to good cells
-
DOI 10.1038/nrm2233, PII NRM2233
-
J. Campisi, and F. d'Adda di Fagagna Cellular senescence: when bad things happen to good cells Nat Rev Mol Cell Biol 8 2007 729 740 (Pubitemid 47312822)
-
(2007)
Nature Reviews Molecular Cell Biology
, vol.8
, Issue.9
, pp. 729-740
-
-
Campisi, J.1
D'Adda Di Fagagna, F.2
-
109
-
-
79959635610
-
Senescent cells develop a PARP-1 and nuclear factor-{kappa}B-associated secretome (PNAS)
-
M. Ohanna, S. Giuliano, C. Bonet, V. Imbert, V. Hofman, and J. Zangari Senescent cells develop a PARP-1 and nuclear factor-{kappa}B-associated secretome (PNAS) Genes Dev 25 2011 1245 1261
-
(2011)
Genes Dev
, vol.25
, pp. 1245-1261
-
-
Ohanna, M.1
Giuliano, S.2
Bonet, C.3
Imbert, V.4
Hofman, V.5
Zangari, J.6
-
110
-
-
77953567284
-
Exploiting cellular senescence to treat cancer and circumvent drug resistance
-
Q. Yan, and N. Wajapeyee Exploiting cellular senescence to treat cancer and circumvent drug resistance Cancer Biol Ther 9 2010 166 175
-
(2010)
Cancer Biol Ther
, vol.9
, pp. 166-175
-
-
Yan, Q.1
Wajapeyee, N.2
-
111
-
-
14044263532
-
MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1
-
DOI 10.1074/jbc.M407155200
-
J.W. Voncken, H. Niessen, B. Neufeld, U. Rennefahrt, V. Dahlmans, and N. Kubben MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1 J Biol Chem 280 2005 5178 5187 (Pubitemid 40279988)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.7
, pp. 5178-5187
-
-
Voncken, J.W.1
Niessen, H.2
Neufeld, B.3
Rennefahrt, U.4
Dahlmans, V.5
Kubben, N.6
Holzer, B.7
Ludwig, S.8
Rapp, U.R.9
-
112
-
-
77949424341
-
Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients
-
S. Agarwal, Y.H. Loh, E.M. McLoughlin, J. Huang, I.H. Park, and J.D. Miller Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients Nature 464 2010 292 296
-
(2010)
Nature
, vol.464
, pp. 292-296
-
-
Agarwal, S.1
Loh, Y.H.2
McLoughlin, E.M.3
Huang, J.4
Park, I.H.5
Miller, J.D.6
|