Rescue of heterochromatin organization in Hutchinson-Gilford progeria by drug treatment

Cellular and Molecular Life Sciences

Volumn 62, Issue 22, 2005, Pages 2669-2678

  Columbaro, M ^a   Capanni, C ^b   Mattioli, E ^a   Novelli, G ^c   Parnaik, V K ^d   Squarzoni, S ^b   Maraldi, N M ^a,b   Lattanzi, G ^b  

^a Laboratory of Cell Biology   (Italy)

^b CNR   (Italy)

^c UNIVERSITY OF ROME TOR VERGATA   (Italy)

^d CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

Drug treatment; Heterochromatin; Hutchinson Gilford progeria; Lamin A C; Pre lamin A

Indexed keywords

HISTONE DEACETYLASE INHIBITOR; MEVINOLIN; PROGERIN; PROTEIN; TRICHOSTATIN A; UNCLASSIFIED DRUG;

ARTICLE; CELL CULTURE; CHEMICAL REACTION; CHROMATIN; CONTROLLED STUDY; FARNESYLATION; FIBROBLAST; HETEROCHROMATIN; HUMAN; HUMAN CELL; PHENOTYPE; PROGERIA;

CELL NUCLEUS; CELLS, CULTURED; CHILD; DNA METHYLATION; HETEROCHROMATIN; HISTONES; HUMANS; HYDROXAMIC ACIDS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LAMIN TYPE A; LOVASTATIN; PROGERIA; PROTEIN PRECURSORS; RIBONUCLEOPROTEINS;

EID: 28344445866     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-005-5318-6     Document Type: Article

References (30)

1. De Sandre-Giovannoli A., Bernard R., Cau P., Navarro C., Amiel J., Boccaccio I. et al. (2003) Lamin A truncation in Hutchinson-Gilford progeria. Science. 300: 2055
2. Eriksson M., Brown W.T., Gordon L.B., Glynn M.W., Singer J., Scott L. et al. (2003) Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature. 423: 293-298
3. Cao H. and Hegele R.A. (2003) LMNA is mutated in Hutchinson-Gilford progeria (MIM 176670) but not in Wiedemann-Rautenstrauch progeroid syndrome (MIM 264090). J. Hum. Genet. 48: 271-274
4. D'Apice M.R., Tenconi R., Mammi I., Ende J. van den and Novelli G. (2004) Paternal origin of LMNA mutations in Hutchinson-Gilford progeria. Clin. Genet. 65: 52-54
5. Csoka A.B., Cao H., Sammak P.J., Constantinescu D., Schatten G. and Hegele R. A. (2004) Novel lamin A/C gene (LMNA) mutations in atypical progeroid syndromes. J. Med. Genet. 41: 304-308
6. Goldman R.D., Shumaker D.K., Erdos M.R., Eriksson M., Goldman A.E., Gordon L.B. et al. (2004) Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson-Gilford progeria syndrome. Proc. Natl. Acad. Sci. USA 101: 8963-8968
7. Haaf T. and Schmid M. (2000) Experimental condensation inhibition in constitutive and facultative heterochromatin of mammalian chromosomes. Cytogenet. Cell. Genet. 91: 113-123
8. Bandyopadhyay D., Okan N.A., Bales E., Nascimento L., Cole P.A. and Medrano EE.(2002) Down-regulation of p300/CBP histone acetyltransferase activates a senescence checkpoint in human melanocytes. Cancer Res. 62: 6231-6239
9. Pendas A.M., Zhou Z., Cadinanos J., Freije J.M., Wang J., Hultenby K. et al. (2002) Defective prelamin A processing and muscular and adipocyte alterations in Zmpste24 metalloproteinase-deficient mice. Nat. Genet. 31: 94-99
10. Capanni C., Cenni V., Mattioli E., Sabatelli P., Ognibene A., Columbaro M. et al. (2003) Failure of lamin A/C to functionally assemble in R482L mutated familial partial lipodystrophy fibroblasts: altered intermolecular interaction with emerin and implications for gene transcription. Exp. Cell Res. 291: 122-134
11. Bernhard W. (1969) A new staining procedure for electron microscopical cytology. J. Ultrastruct. Res. 27: 250-265
12. Rice J. C., Briggs S.D., Ueberheide B., Barber C. M., Shabanowitz J., Hunt, D. F. et al. (2003) Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains. Mol. Cell 12: 1591-1598
13. Fong L. G., Ng J. K., Meta M., Cote N., Yang S. H., Stewart C. L. et al. (2004) Heterozygosity for Lmna deficiency eliminates the progeria-like phenotypes in Zmpste24-deficient mice. Proc. Natl. Acad. Sci. USA 101: 18111-18116
14. Scaffidi P. and Misteli T.(2005) Reversal of the cellular phenotype in the premature aging disease Hutchinson-Gilford progeria syndrome. Nat. Med. 11: 440-445
15. Bergo M. O., Gavino B., Ross J., Schmidt W. K., Hong C., Kendall L. V. et. al. (2002) Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect. Proc. Natl. Acad. Sci. USA 99: 13049-13054
16. Agarwal A. K., Fryns J. P., Auchus R. J. and Garg A. (2003) Zinc metalloproteinase, ZMPSTE24, is mutated in mandibuloacral dysplasia. Hum. Mol. Genet. 12: 1995-2001
17. Liu B., Wang J., Chan K. M., Tjia W. M., Deng W., Guan X. et. al (2005) Genomic instability in laminopathy-based premature aging. Nat. Med. 11: 780-785
18. Capanni C., Mattioli E., Columbaro M., Lucarelli E., Parnaik V. K., Novelli G. et al. (2005) Altered pre-lamin A processing is a common mechanism leading to lipodystrophy. Hum. Mol. Genet. 14: 1489-1502
19. Glynn M. W. and Glover T.W. (2005) Incomplete processing of mutant lamin A in Hutchinson-Gilford progeria leads to nuclear abnormalities, which are reversed by farnesyltransferase inhibition. Hum. Mol. Genet. 14: 1489-1502
20. Capell B. C., Erdos M. R., Madigan J. P., Fiordalisi J. J., Varga R., Conneely K. N. et al. (2005) Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome. Proc. Natl. Acad. Sci. USA 102: 12879-12884
21. Toth J. I., Yang S. H., Qiao X., Beigneux A. P., Gelb M. H., Moulson C. L. et al.(2005) Blocking protein farnesyltransferase improves nuclear shape in fibroblasts from humans with progeroid syndromes. Proc. Natl. Acad. Sci. USA 102: 12873-12878
22. Yang S. H., Bergo M. O., Toth J. I., Qiao X., Hu Y., Sandoval S. et al. (2005) Blocking protein farnesyltransferase improves nuclear blebbing in mouse fibroblasts with a targeted Hutchinson-Gilford progeria syndrome mutation. Proc. Natl. Acad. Sci. USA 102: 10291-10296
23. Markiewicz E., Dechat T., Foisner R., Quinlan R. A. and Hutchison C. J. (2002) Lamin A/C binding protein LAP2alpha is required for nuclear anchorage of retinoblastoma protein. Mol. Biol. Cell. 13: 4401-1413
24. Maraldi N. M., Squarzoni S., Sabatelli P., Capanni C., Mattioli E., Ognibene A. et al. (2005) Laminopathies: involvement of structural nuclear proteins in the pathogenesis of an increasing number of human diseases. J. Cell. Physiol. 203: 319-332
25. Sasseville A. M. and Raymond Y. (1995) Lamin A precursor is localized to intranuclear foci. J. Cell. Sci. 108: 273-285
26. Stierlé V. V., Couprie J., Ostlund C., Krimm I., Zinn-Justin S., Hossenlopp P. et al. (2003) The carboxyl-terminal region common to lamins A and C contains a DNA binding domain. Biochemistry 42: 4819-182
27. Filesi I., Gullotta F., Lattanzi G., d'Apice M.R., Capanni C., Nardone A.M. et al. (2005) Alterations of nuclear envelope and chromatin organization in mandibuloacral dysplasia, a rare form of laminopathy, Physiol Genomics Jul 26; [Epub ahead of print].
28. Ognibene A., Sabatelli P., Petrini S., Squarzoni S., Riccio M., Santi S. et al.(1999) Nuclear changes in a case of X-linked Emery-Dreifuss muscular dystrophy. Muscle Nerve 22: 864-869
29. Sullivan T., Escalante-Alcalde D., Bhatt H., Anver M., Bhat N., Nagashima K. et al. (1999) Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy. J. Cell Biol. 147: 913-920
30. Sabatelli P., Lattanzi G., Ognibene A., Columbaro M., Capanni C., Merlini L. et al. (2001) Nuclear alterations in autosomal-dominant Emery-Dreifuss muscular dystrophy. Muscle Nerve 24: 826-829