Regulation of p53 activity in nuclear bodies by a specific PML isoform

EMBO Journal

Volumn 19, Issue 22, 2000, Pages 6185-6195

  Fogal, Valentina ^a   Gostissa, Monica ^a   Sandy, Peter ^a   Zacchi, Paola ^a   Sternsdorf, Thomas ^b   Jensen, Kirsten ^b   Pandolfi, Pier Paolo ^c   Will, Hans ^b   Schneider, Claudio ^a,d   Sal, Giannino Del ^a,e  

^a Laboratorio Nazionale CIB   (Italy)

^b LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d UNIVERSITY OF UDINE   (Italy)

^e UNIVERSITY OF TRIESTE   (Italy)

Author keywords

Nuclear bodies; p53; PML3; Sumolation; Transcription

Indexed keywords

ISOPROTEIN; ONCOPROTEIN; PROTEIN P53;

ARTICLE; CANCER CELL CULTURE; CELL NUCLEUS INCLUSION BODY; CELL SURVIVAL; CELLULAR DISTRIBUTION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; TRANSACTIVATION;

EID: 0034669124     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/19.22.6185     Document Type: Article

References (52)

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2. Recruitment of p300/CBP in p53-dependent signal pathways
3. Rho-dependent regulation of cell spreading by the tetraspan membrane protein Gas3/PMP22
4. 3 exerts dose-dependent dual effects on APL cells
5. The growth arrest-specific gene, gas1, is involved in growth suppression
6. The PML-RARα fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR
7. A novel macromolecular structure is a target of the promyelocyte-retinoic acid receptor oncoprotein
8. WAF-1, a potential mediator of p53 tumor suppression
9. Alternative splicing of PML transcripts predicts coexpression of several carboxy-terminally different protein isoforms
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11. The complexity of p53 modulation: Emerging patterns from divergent signals
12. Activation of p53 by conjugation to the ubiquitin-like protein SUMO-1
13. Structure, organization and dynamics of promyelocytic leukemia protein nuclear bodies
14. Covalent modification of the transactivator protein IE2-p86 of human cytomegalovirus by conjugation to the ubiquitin-homologous proteins SUMO-1 and hSMT3b
15. PML is critical for ND10 formation and recruits the PML-interacting protein daxx to this nuclear structure when modified by SUMO-1
16. Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARα with a novel putative transcription factor, PML
17. Identification of three major sentrinization sites in PML
18. p53: Puzzle and paradigm
19. The t(15;17) translocation alters a nuclear body in a retinoic acid-reversible fashion
20. An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs
21. Localization of nascent RNA and CREB binding protein with the PML-containing nuclear body
22. The acute promyelocytic leukaemia-associated PML gene is induced by interferon
23. p53, the cellular gatekeeper for growth and division
24. Molecular genetics of acute promyelocytic leukemia
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26. A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2
27. Nuclear domain 10, the site of DNA virus transcription and replication
28. The p66shc adaptor protein controls oxidative stress response and life span in mammals
29. 1 checkpoint after DNA damage
30. Conjugation with the ubiquitin-related modifier SUMO-1 regulates the partitioning of PML within the nucleus
31. Trivalent antimonials induce degradation of the PML-RAR oncoprotein and reorganization of the promyelocytic leukemia nuclear bodies in acute promyelocytic leukemia NB4 cells
32. c-Jun and p53 activity is modulated by SUMO-1 modification
33. Cytoplasmically sequestered wild-type p53 protein in neuroblastoma is relocated to the nucleus by a C-terminal peptide
34. PML regulates p53 acetylation and premature senescence by oncogenic Ras
35. A model for p53-induced apoptosis
36. PML induces a novel caspase-independent death process
37. SUMO-1 modification activates the transcriptional response of p53
38. p53 Is involved in the p120E4F-mediated growth arrest
39. The PML nuclear bodies: Actors or extras?
40. Interaction of SP100 with HP1 proteins: A link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment
41. The cellular response to p53: The decision between life and death
42. Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1
43. The nuclear dot protein Sp100, characterization of domains necessary for dimerization, subcellular localization and modification by small ubiquitin-like modifiers
44. Human p53 binds DNA as a protein homodimer but monomeric variants retain full transcription transactivation activity
45. Human Daxx regulates Fas-induced apoptosis from nuclear PML oncogenic domains (PODs)
46. Role of PML in cell growth and the retinoic acid pathway
47. PML is essential for multiple apoptotic pathways
48. Retinoic acid regulates aberrant nuclear localization of PML-RARα in acute promyelocytic leukemia cells
49. Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53
50. Role of SUMO-1-modified PML in nuclear body formation
51. The transcriptional role of PML and the nuclear body
52. COOH-terminal domain of p53 modulates p53-mediated transcriptional transactivation, cell growth and apoptosis