-
1
-
-
0036274359
-
The fundamental role of epigenetic events in cancer
-
Jones, P.A. & Baylin, S.B. The fundamental role of epigenetic events in cancer. Nat. Rev. Genet. 3, 415-428 (2002).
-
(2002)
Nat. Rev. Genet.
, vol.3
, pp. 415-428
-
-
Jones, P.A.1
Baylin, S.B.2
-
2
-
-
0036145156
-
Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours
-
Esteller, M. & Herman, J.G. Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumours. J. Pathol. 196, 1-7 (2002).
-
(2002)
J. Pathol.
, vol.196
, pp. 1-7
-
-
Esteller, M.1
Herman, J.G.2
-
3
-
-
0035962632
-
DNA methylation, chromatin inheritance, and cancer
-
Rountree, M.R., Bachman, K.E., Herman, J.G. & Baylin, S.B. DNA methylation, chromatin inheritance, and cancer. Oncogene 20, 3156-3165 (2001).
-
(2001)
Oncogene
, vol.20
, pp. 3156-3165
-
-
Rountree, M.R.1
Bachman, K.E.2
Herman, J.G.3
Baylin, S.B.4
-
4
-
-
0035962631
-
DNA methylation, methyltransferases, and cancer
-
Robertson, K.D. DNA methylation, methyltransferases, and cancer. Oncogene 20, 3139-3155 (2001).
-
(2001)
Oncogene
, vol.20
, pp. 3139-3155
-
-
Robertson, K.D.1
-
5
-
-
0026708177
-
Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
-
Li, E., Bestor, T.H. & Jaenisch, R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69, 915-926 (1992).
-
(1992)
Cell
, vol.69
, pp. 915-926
-
-
Li, E.1
Bestor, T.H.2
Jaenisch, R.3
-
6
-
-
0029001154
-
Suppression of intestinal neoplasia by DNA hypomethylation
-
Laird, P.W. et al. Suppression of intestinal neoplasia by DNA hypomethylation. Cell 81, 197-205 (1995).
-
(1995)
Cell
, vol.81
, pp. 197-205
-
-
Laird, P.W.1
-
7
-
-
0033588232
-
Downregulation of human DNA-(cytosine-5) methyltransferase induces cell cycle regulators p16(ink4A) and p21(WAF/Cip1) by distinct mechanisms
-
Fournel, M., Sapieha, P., Beaulieu, N., Besterman, J.M. & MacLeod, A.R. Downregulation of human DNA-(cytosine-5) methyltransferase induces cell cycle regulators p16(ink4A) and p21(WAF/Cip1) by distinct mechanisms. J. Biol. Chem. 274, 24250-24256 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 24250-24256
-
-
Fournel, M.1
Sapieha, P.2
Beaulieu, N.3
Besterman, J.M.4
MacLeod, A.R.5
-
8
-
-
0034720284
-
CpG methylation is maintained in human cancer cells lacking DNMT 1
-
Rhee, I. et al. CpG methylation is maintained in human cancer cells lacking DNMT1. Nature 404, 1003-1007 (2000).
-
(2000)
Nature
, vol.404
, pp. 1003-1007
-
-
Rhee, I.1
-
9
-
-
18344390653
-
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
-
Rhee, I. et al. DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Nature 416, 552-556 (2002).
-
(2002)
Nature
, vol.416
, pp. 552-556
-
-
Rhee, I.1
-
10
-
-
0037008775
-
An essential role for DNA methyltransferase DNMT 3B in cancer cell survival
-
Beaulieu, N. et al. An essential role for DNA methyltransferase DNMT3B in cancer cell survival. J. Biol. Chem. 277, 28176-28181 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 28176-28181
-
-
Beaulieu, N.1
-
11
-
-
0033615717
-
DNA methyltransferases DNMT3a and DNMT3b are essential for de novo methylation and mammalian development
-
Okano, M., Bell, D.W., Haber, D.A. & Li, E. DNA methyltransferases DNMT3a and DNMT3b are essential for de novo methylation and mammalian development. Cell 99, 247-257 (1999).
-
(1999)
Cell
, vol.99
, pp. 247-257
-
-
Okano, M.1
Bell, D.W.2
Haber, D.A.3
Li, E.4
-
12
-
-
0027378582
-
Role for DNA methylation in genomic imprinting
-
Li, E., Beard, C. & Jaenisch, R. Role for DNA methylation in genomic imprinting. Nature 366, 362-365 (1993).
-
(1993)
Nature
, vol.366
, pp. 362-365
-
-
Li, E.1
Beard, C.2
Jaenisch, R.3
-
13
-
-
0031577334
-
DNA (cytosine-5)-methyltransferases in mouse cells and tissues. Studies with a mechanism-based probe
-
Yoder, J.A., Soman, N.S., Verdine, G.L. & Bestor, T.H. DNA (cytosine-5)-methyltransferases in mouse cells and tissues. Studies with a mechanism-based probe. J. Mol. Biol. 270, 385-395 (1997).
-
(1997)
J. Mol. Biol.
, vol.270
, pp. 385-395
-
-
Yoder, J.A.1
Soman, N.S.2
Verdine, G.L.3
Bestor, T.H.4
-
14
-
-
0028875205
-
Methylation of the 5′ CpG island of the p16/CDKN 2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing
-
Gonzalez-Zulueta, M. et al. Methylation of the 5′ CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing. Cancer Res. 55, 4531-4535 (1995).
-
(1995)
Cancer Res.
, vol.55
, pp. 4531-4535
-
-
Gonzalez-Zulueta, M.1
-
15
-
-
0029011539
-
5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
-
Merlo, A. et al. 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nat. Med. 1, 633-634 (1995).
-
(1995)
Nat. Med.
, vol.1
, pp. 633-634
-
-
Merlo, A.1
-
16
-
-
0343953594
-
Hypermethylation can selectively silence individual CDKN2A alleles in neoplasia
-
Myohanen, S.K., Baylin, S.B. & Herman, J.G. Hypermethylation can selectively silence individual CDKN2A alleles in neoplasia. Cancer Res. 58, 591-593 (1998).
-
(1998)
Cancer Res.
, vol.58
, pp. 591-593
-
-
Myohanen, S.K.1
Baylin, S.B.2
Herman, J.G.3
-
17
-
-
13144266670
-
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
-
Herman, J.G. et al. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc. Natl. Acad. Sci. USA 95, 6870-6875 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 6870-6875
-
-
Herman, J.G.1
-
18
-
-
0031017268
-
Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines
-
Kane, M.F. et al. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res. 57, 808-811 (1997).
-
(1997)
Cancer Res.
, vol.57
, pp. 808-811
-
-
Kane, M.F.1
-
19
-
-
0001119305
-
Hmlh1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability
-
Leung, S.Y. et al. hMLH1 promoter methylation and lack of hMLH1 expression in sporadic gastric carcinomas with high-frequency microsatellite instability. Cancer Res. 59, 159-164 (1999).
-
(1999)
Cancer Res.
, vol.59
, pp. 159-164
-
-
Leung, S.Y.1
-
20
-
-
0033533384
-
A sensitive new method for rapid detection of abnormal methylation patterns in global DNA and within CpG islands
-
Pogribny, I., Yi, P. & James, S.J. A sensitive new method for rapid detection of abnormal methylation patterns in global DNA and within CpG islands. Biochem. Biophys. Res. Commun. 262, 624-628 (1999).
-
(1999)
Biochem. Biophys. Res. Commun.
, vol.262
, pp. 624-628
-
-
Pogribny, I.1
Yi, P.2
James, S.J.3
-
21
-
-
0028151343
-
Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation
-
Jutterman, R., Li, E. & Jaenisch, R. Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation. Proc. Natl. Acad. Sci. USA 981, 11797 (1994).
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.981
, pp. 11797
-
-
Jutterman, R.1
Li, E.2
Jaenisch, R.3
-
22
-
-
0021954650
-
Formation of highly stable complexes between 5-azacytosine-tosine-substituted DNA and specific non-histone nuclear proteins. Implications for 5-azacytidine-mediated effects on DNA methylation and gene expression
-
Christman, J.K., Schneiderman, N. & Acs, G. Formation of highly stable complexes between 5-azacytosine-tosine-substituted DNA and specific non-histone nuclear proteins. Implications for 5-azacytidine-mediated effects on DNA methylation and gene expression. J. Biol. Chem. 260, 4059-4068 (1985).
-
(1985)
J. Biol. Chem.
, vol.260
, pp. 4059-4068
-
-
Christman, J.K.1
Schneiderman, N.2
Acs, G.3
-
23
-
-
0024711822
-
5′-Azadeoxycytidine-induced undercondensation in the giant X chromosomes of Microtus agrestis
-
Haaf, T. & Schmid, M. 5′-Azadeoxycytidine-induced undercondensation in the giant X chromosomes of Microtus agrestis. Chromosoma 98, 93-98 (1989).
-
(1989)
Chromosoma
, vol.98
, pp. 93-98
-
-
Haaf, T.1
Schmid, M.2
-
24
-
-
0028947749
-
The effects of 5-azacytidine and 5-azadeoxycytidine on chromosome structure and function: Implications for methylation-associated cellular processes
-
Haaf, T. The effects of 5-azacytidine and 5-azadeoxycytidine on chromosome structure and function: Implications for methylation-associated cellular processes. Pharmacol. Ther. 65, 19-46 (1995).
-
(1995)
Pharmacol. Ther.
, vol.65
, pp. 19-46
-
-
Haaf, T.1
-
25
-
-
0036135014
-
Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements
-
Liang, G. et al. Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements. Mol. Cell Biol. 22, 480-491 (2002).
-
(2002)
Mol. Cell Biol.
, vol.22
, pp. 480-491
-
-
Liang, G.1
-
26
-
-
0036549015
-
Conditional mouse models of sporadic cancer
-
Jonkers, J. & Berns, A. Conditional mouse models of sporadic cancer. Nat. Rev. Cancer 2, 251-265 (2002).
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 251-265
-
-
Jonkers, J.1
Berns, A.2
-
27
-
-
0035943709
-
Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin
-
Bachman, K.E., Rountree, M.R. & Baylin, S.B. Dnmt3a and Dnmt3b are transcriptional repressors that exhibit unique localization properties to heterochromatin. J. Biol. Chem, 276, 32282-32287 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 32282-32287
-
-
Bachman, K.E.1
Rountree, M.R.2
Baylin, S.B.3
-
28
-
-
0034766776
-
Mammalian DNA methyltransferases show different subnuclear distributions
-
Margot, J.B., Cardoso, M.C. & Leonhardt. H. Mammalian DNA methyltransferases show different subnuclear distributions. J. Cell. Biochem. 83, 373-379 (2001).
-
(2001)
J. Cell. Biochem.
, vol.83
, pp. 373-379
-
-
Margot, J.B.1
Cardoso, M.C.2
Leonhardt, H.3
-
29
-
-
0029843950
-
Methylation-specific PCR a novel PCR assay for methylation status of CpG islands
-
Herman, J.G., Graff, J.R., Myohanen, S., Nelkin, B.D. & Baylin, S.B. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc. Natl. Acad. Sci. USA 93, 9821-9826 (1996).
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 9821-9826
-
-
Herman, J.G.1
Graff, J.R.2
Myohanen, S.3
Nelkin, B.D.4
Baylin, S.B.5
-
30
-
-
0035932393
-
Methylation-associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours
-
Agathanggelou, A. et al. Methylation-associated inactivation of RASSF1A from region 3p21.3 in lung, breast and ovarian tumours. Oncogene 20, 1509-1518 (2001).
-
(2001)
Oncogene
, vol.20
, pp. 1509-1518
-
-
Agathanggelou, A.1
|