Powerful technique to test selectivity of agents acting on cardiac ion Channels: The action potential voltage-clamp

Current Medicinal Chemistry

Volumn 18, Issue 24, 2011, Pages 3737-3756

  Szentandrassy N ^a   Nagy, D ^a   Ruzsnavszky, F ^a   Harmati, G ^a   Banyasz T ^a   Magyar, J ^a   Szentmiklosi A J ^a   Nanasi P P ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Action potential; Action potential voltage clamp; Calcium channel; Chemical structure; Ion channel blocker; Ion current; Selective calcium channel blocker

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; 2 [4 (2,5 DIFLUOROBENZYLOXY)PHENOXY] 5 ETHOXYANILINE; 4 AMINOPYRIDINE; 4,4' DIISOTHIOCYANATOSTILBENE 2,2' DISULFONIC ACID; 9 ANTHROIC ACID; BARIUM CHLORIDE; CAFFEINE; CALCIUM CHANNEL L TYPE; CHLORIDE; CHROMANOL 293B; DILTIAZEM; DOFETILIDE; GALLOPAMIL; ION CHANNEL; LITHIUM; N [3 HYDROXY 2,2 DIMETHYL 6 (4,4,4 TRIFLUOROBUTOXY)CHROMAN 4 YL] N METHYLMETHANESULFONAMIDE; NICARDIPINE; NIFEDIPINE; NISOLDIPINE; POTASSIUM; SAXITOXIN; SODIUM; SOTALOL; TETRODOTOXIN; VERAPAMIL; VERATRIDINE;

ACTION POTENTIAL VOLTAGE CLAMP; ARTICLE; CALCIUM CELL LEVEL; CALCIUM CURRENT; CELL SIZE; CHANNEL GATING; CHLORIDE CURRENT; DIASTOLE; DRUG DESIGN; DRUG SELECTIVITY; DRUG STRUCTURE; HEART ATRIUM; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HEART VENTRICLE; INHIBITION KINETICS; NONHUMAN; OOCYTE; PACEMAKER; PURKINJE FIBER; RECEPTOR BLOCKING; SIGNAL PROCESSING; SINUS NODE; SODIUM CALCIUM EXCHANGE; SODIUM CURRENT; SPONTANEOUS TRANSIENT OUTWARD CURRENT; STRUCTURE ACTIVITY RELATION; VOLTAGE CLAMP;

ACTION POTENTIALS; ANIMALS; CALCIUM CHANNEL BLOCKERS; CARDIOVASCULAR AGENTS; DOGS; HUMANS; ION CHANNELS; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; SODIUM CHANNEL BLOCKERS;

EID: 80052003680     PISSN: 09298673     EISSN: 1875533X     Source Type: Journal    
DOI: 10.2174/092986711796642418     Document Type: Article

References (184)

1. Hamill, OP.; Marty, A.; Neher, E.; Sakmann, B.; Sigworth, FJ. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch., 1981, 391(2), 85-100. (Pubitemid 11012976)
2. Fischmeister, R.; DeFelice, LJ.; Ayer, RK.; Levi, R.; DeHaan, RL. Channel currents during spontaneous action potentials in embryonic chick heart cells. The action potential patch clamp. Biophys. J., 1984, 46(2), 267-271.
3. Doerr, T.; Denger, R.; Trautwein, W. Calcium currents in single SA nodal cells of the rabbit heart studied with action potential clamp. Pflugers Arch. 1989, 413(6), 599-603. (Pubitemid 19121706)
4. Doerr, T.; Denger, R.; Doerr, A.; Trautwein W. Ionic currents contributing to the action potential in single ventricular myocytes of the guinea pig studied with action potential clamp. Pflugers Arch. 1990, 416(3), 230-237. (Pubitemid 20183290)
5. Bányász, T.; Fülöp, L.; Magyar, J.; Szentandrássy, N.; Varró, A.; Nánási, PP. Endocardial versus epicardial differences in L-type calcium current in canine ventricular myocytes studied by action potential voltage clamp. Cardiovasc. Res. 2003, 58, 66-75. (Pubitemid 36351623)
6. + currents in canine cardiomyocytes: their role in ventricular repolarization. 2007, Acta Physiol. 190, 189-198. (Pubitemid 46934656)
7. + channels. J. Physiol. 2001, 537(3), 843-851. (Pubitemid 34026612)
8. Hancox, JC.; Levi, AJ.; Witchel, HJ. Time course and voltage dependence of expressed HERG current compared with native "rapid" delayed rectifier K current during the cardiac ventricular action potential. Pflugers Arch. 1998, 436(6), 843-853.
9. + channels in the mouse heart exerts anti-arrhythmic activity. Cardiovasc. Res. 2005, 65(1), 128-137. (Pubitemid 40038485)
10. + currents by the new repolarization delaying agent H 345/52. J. Cardiovasc. Electrophysiol. 2003, 14(6), 651-658. (Pubitemid 36724392)
11. Cordeiro, JM.; Brugada, R.; Wu, YS.; Hong, K.; Dumaine, R. Modulation of I(Kr) inactivation by mutation N588K in KCNH2: a link to arrhythmogenesis in short QT syndrome. Cardiovasc. Res. 2005, 67(3), 498-509. (Pubitemid 41019557)
12. + channel current during ventricular, Purkinje fibre and atrial action potentials: an action potential clamp study. J. Physiol Pharmacol. 2009, 60(1), 23-41.
13. McPate, MJ.; Zhang, H.; Cordeiro, JM.; Dempsey, CE.; Witchel, HJ.; Hancox, JC. hERG1a/1b heteromeric currents exhibit amplified attenuation of inactivation in variant 1 short QT syndrome. Biochem. Biophys. Res. Commun. 2009, 386(1), 111-117.
14. Paulussen, AD.; Raes, A.; Jongbloed, RJ.; Gilissen, RA.; Wilde, AA.; Snyders, DJ.; Smeets, HJ.; Aerssens, J. HERG mutation predicts short QT based on channel kinetics but causes long QT by heterotetrameric trafficking deficiency. Cardiovasc. Res. 2005, 67(3), 467-475. (Pubitemid 41019554)
15. Dong, MQ.; Lau, CP.; Gao, Z.; Tseng, GN.; Li, GR.; Characterization of Recombinant Human Cardiac KCNQ1/KCNE1 Channels (IKs) Stably Expressed in HEK 293 Cells. J. Membr. Biol. 2006, 210(3), 183-192. (Pubitemid 44306223)
16. El Harchi, A.; McPate, MJ.; Zhang, YH.; Zhang, H.; Hancox, JC. Action potential clamp and mefloquine sensitivity of recombinant 'IKS' channels incorporating the V307L KCNQ1 mutation. J. Physiol Pharmacol. 2010, 61(2), 123-131.
17. El Harchi, A.; McPate, MJ.; Zhang, Y.; Zhang, H.; Hancox, JC. Action potential clamp and chloroquine sensitivity of mutant Kir2.1 channels responsible for variant 3 short QT syndrome. J. Mol. Cell. Cardiol. 2009, 47(5), 743-747.
18. Oginosawa, Y.; Nagatomo, T.; Abe, H.; Makita, N.; Makielski, JC.; Nakashima, Y. Intrinsic mechanism of the enhanced rate-dependent QT shortening in the R1623Q mutant of the LQT3 syndrome. Cardiovasc. Res. 2005, 65(1), 138-147. (Pubitemid 40038486)
19. Berecki, G.; Zegers, JG.; Bhuiyan, ZA.; Verkerk, AO.; Wilders, R.; van Ginneken, AC. Long-QT syndrome-related sodium channel mutations probed by the dynamic action potential clamp technique. J. Physiol. 2006, 570(2), 237-250.
20. Nánási, PP.; Szentandrássy, N.; Tóth, A.; Bányász, T. In: Advances in Car-diomyocyte Research; Nánási, PP., Ed.; Research Signpost: Kerala, 2009, pp. 93-119.
21. 2+-exchange. Cardiovasc. Res. 2007, 73(1), 37-47. (Pubitemid 44937207)
22. + current in sinoatrial node pacemaker activity. Am. J. Physiol. 1995, 269(2), H453-H462.
23. Zaza, A.; Micheletti, M.; Brioschi, A.; Rocchetti, M. Ionic currents during sustained pacemaker activity in rabbit sino-atrial myocytes. J. Physiol. 1997, 505(3), 677-688. (Pubitemid 28022368)
24. - current in rabbit sinoatrial node cells. J. Physiol. 2002, 540(1), 105-117. (Pubitemid 35174989)
25. Toyoda, F.; Ding, WG.; Matsuura, H. Responses of the sustained inward current to autonomic agonists in guinea-pig sino-atrial node pacemaker cells. Br. J. Pharmacol. 2005, 144(5), 660-668. (Pubitemid 40445614)
26. Yue, L.; Feng, J.; Gaspo, R.; Li, GR.; Wang, Z.; Nattel, S. Ionic remodeling underlying action potential changes in a canine model of atrial fibrillation. Circ. Res. 1997, 81(4), 512-525. (Pubitemid 27432738)
27. Sun, ZQ.; Ojamaa, K.; Nakamura, TY.; Artman, M.; Klein, I.; Coetzee, WA. Thyroid hormone increases pacemaker activity in rat neonatal atrial myocytes. J. Mol. Cell. Cardiol. 2001, 33(4), 811-824. (Pubitemid 32538993)
28. Yeh, YH.; Wakili, R.; Qi, XY.; Chartier, D.; Boknik, P.; Kääb, S.; Ravens, U.; Coutu, P.; Dobrev, D.; Nattel, S. Calcium-handling abnormalities underlying atrial arrhythmogenesis and contractile dysfunction in dogs with congestive heart failure. Circ. Arrhythm. Electrophysiol. 2008, 1(2), 93-102.
29. + current in pacemaker cells isolated from rabbit sinoatrial node. Am. J. Physiol. 1996, 270(6), H2108-H2119.
30. Lei, M.; Jones, SA.; Liu, J.; Lancaster, MK.; Fung, SS.; Dobrzynski, H.; Camelliti, P.; Maier, SK.; Noble, D.; Boyett, MR. Requirement of neuronaland cardiac-type sodium channels for murine sinoatrial node pacemaking. J. Physiol. 2004, 559(3), 835-848. (Pubitemid 39276172)
31. Chorvatova, A.; Snowdon, R.; Hart, G.; Hussain, M. Effects of pressure overload-induced hypertrophy on TTX-sensitive inward currents in guinea pig left ventricle. Mol. Cell. Biochem. 2004, 261(1-2), 217-226. (Pubitemid 39004534)
32. 2+ transients under action potential clamp in guinea pig ventricular myocytes. Am. J. Physiol. 1991, 261(2), C393-C397.
33. 2+ current: a cellular mechanism for long Q-T arrhythmias. Am. J. Physiol. 1999, 276(6), H2168-H2178. (Pubitemid 29323505)
34. Cooper, PJ.; Soeller, C.; Cannell, MB. Excitation-contraction coupling in human heart failure examined by action potential clamp in rat cardiac myocytes. J. Mol. Cell. Cardiol. 2010, 49(6), 911-917.
35. 2+ content during the cardiac cycle in guinea pig and rat ventricular myocytes. Biophys. J. 1997, 72(3), 1319-1326. (Pubitemid 27113654)
36. 2+ influx in rat cardiac myocytes of endo-and epicardial origin. J. Physiol. 1999, 519(3), 841-850. (Pubitemid 29462447)
37. 2+ channels in rabbit ventricular myocytes during action potential clamp: influence of temperature. Circ. Res. 1999, 85(6), e7-e16.
38. Fülöp, L.; Bányász, T.; Magyar, J.; Szentandrássy, N.; Varró, A.; Nánási, PP. Reopening of L-type calcium channels in human ventricular myocytes during applied epicardial action potentials. Acta Physiol. Scand. 2004, 180(1), 39-47. (Pubitemid 38175064)
39. Li, GR.; Yang, B.; Feng, J.; Bosch, RF.; Carrier, M.; Nattel, S. Transmembrane ICa contributes to rate-dependent changes of action potentials in human ventricular myocytes. Am. J. Physiol. 1999, 276(1), H98-H106. (Pubitemid 29065627)
40. Linz, KW.; Meyer, R. Control of L-type calcium current during the action potential of guinea-pig ventricular myocytes. J. Physiol. 1998, 513(2), 425-442. (Pubitemid 28562959)
41. + current during the action potential of guinea pig ventricular myocytes. Biophys. J. 1991, 60(6), 1534-1539.
42. Shimoni, Y.; Clark, RB.; Giles, WR. Role of an inwardly rectifying potassium current in rabbit ventricular action potential. J. Physiol. 1992, 448, 709-727.
43. Cl(Ca) during early repolarization of canine ventricle. Am. J. Physiol. 1997, 273(3), H1096-H1106.
44. Dong, M.; Yan, S.; Chen, Y.; Niklewski, PJ.; Sun, X.; Chenault, K.; Wang, HS. Role of the transient outward current in regulating mechanical properties of canine ventricular myocytes. J. Cardiovasc. Electrophysiol. 2010, 21(6), 697-703.
45. Rocchetti, M.; Besana, A.; Gurrola, GB.; Possani, LD.; Zaza, A. Rate dependency of delayed rectifier currents during the guinea-pig ventricular action potential. J. Physiol. 2001, 534(3), 721-732. (Pubitemid 32700870)
46. Bouchard, RA.; Clark, RB.; Giles, WR. Effects of action potential duration on excitation-contraction coupling in rat ventricular myocytes. Action potential voltage-clamp measurements. Circ. Res. 1995, 76(5), 790-801.
47. 2+ exchange current in the ferret ventricular action potential. J. Physiol. 1997, 498(3), 611-625. (Pubitemid 27089458)
48. 2+ concentration and temperature. Am. J. Physiol. 1999, 277(2), H488-498. (Pubitemid 29415961)
49. Boyett, MR.; Honjo, H.; Kodama, I. The sinoatrial node, a heterogeneous pacemaker structure. Cardiovasc. Res. 2000, 47(4), 658-675.
50. Mitcheson, JS.; Hancox, JC. An investigation of the role played by the E-4031-sensitive (rapid delayed rectifier) potassium current in isolated rabbit atrioventricular nodal and ventricular myocytes. Pflugers Arch. 1999, 438(6), 843-850. (Pubitemid 29500996)
51. Stengl, M.; Bartak, F.; Sykora, R.; Chvojka, J.; Benes, J.; Krouzecky, A.; Novak, I.; Sviglerova, J.; Kuncova, J.; Matejovic, M. Reduced L-type calcium current in ventricular myocytes from pigs with hyperdynamic septic shock. Crit. Care Med. 2010, 38(2), 579-587.
52. Wettwer, E.; Amos, GJ.; Posival, H.; Ravens, U. Transient outward current in human ventricular myocytes of subepicardial and subendocardial origin. Circ. Res. 1994, 75(3), 473-482. (Pubitemid 24256408)
53. + current in human ventricular myocytes. Circ. Res. 1996, 78(4), 689-696. (Pubitemid 26106881)
54. Näbauer, M.; Beuckelmann, DJ.; Uberfuhr, P.; Steinbeck, G. Regional differences in current density and rate-dependent properties of the transient outward current in subepicardial and subendocardial myocytes of human left ventricle. Circulation. 1996, 93(1), 168-177. (Pubitemid 26006581)
55. Iost, N.; Virág, L.; Opincariu, M.; Szécsi, J.; Varró, A.; Papp, JG. Delayed rectifier potassium current in undiseased human ventricular myocytes. Cardiovasc. Res. 1998, 40(3), 508-515. (Pubitemid 28557291)
56. Szentadrassy, N.; Banyasz, T.; Biro, T.; Szabo, G.; Toth, BI.; Magyar, J.; Lazar, J.; Varro, A.; Kovacs, L.; Nanasi, P P. Apico-basal inhomogeneity in distribution of ion channels in canine and human ventricular myocardium. Cardiovasc. Res. 2005, 65(4), 851-860. (Pubitemid 40249729)
57. Szabó, G.; Szentandrássy, N.; Bíró, T.; Tóth, BI.; Czifra, G.; Magyar, J.; Bányász, T.; Varró, A.; Kovács, L.; Nánási, P P. Asymmetrical distribution of ion channels in canine and human left-ventricular wall: epicardium versus midmyocardium. Pflugers Arch. 2005, 450(5), 307-316. (Pubitemid 41204177)
58. + current in rabbit sinoatrial node cells. Cardiovasc. Res. 2000, 46(3), 433-441. (Pubitemid 30319329)
59. Yue, L.; Feng, J.; Li, GR.; Nattel, S. Characterization of an ultrarapid delayed rectifier potassium channel involved in canine atrial repolarization. J. Physiol. 1996, 496(3), 647-662. (Pubitemid 26387850)
60. Li, GR.; Sun, H.; To, J.; Tse, HF.; Lau, CP. Demonstration of calcium-activated transient outward chloride current and delayed rectifier potassium currents in Swine atrial myocytes. J. Mol. Cell. Cardiol. 2004, 36(4), 495-504. (Pubitemid 38469940)
61. Ehrlich, JR.; Hoche, C.; Coutu, P.; Metz-Weidmann, C.; Dittrich, W.; Hohnloser, SH.; Nattel, S.;, Gögelein, H. Properties of a time-dependent potassium current in pig atrium: evidence for a role of Kv1.5 in repolarization. J. Pharmacol. Exp. Ther. 2006, 319(2), 898-906. (Pubitemid 44794210)
62. Aréchiga-Figueroa, IA.; Rodríguez-Martínez, M.; Albarado, A.; Torres-Jácome, J.; Sánchez-Chapula, JA. Multiple effects of 4-aminopyridine on feline and rabbit sinoatrial node myocytes and multicellular preparations. Pflugers Arch. 2010, 459(3), 345-355.
63. + current and prolongation of the guinea-pig ventricular action potential by 4-aminopyridine. J. Physiol. 2003, 549(3), 667-672. (Pubitemid 36889760)
64. Litovsky, SH.; Antzelevitch, C. Transient outward current prominent in canine ventricular epicardium but not endocardium. Circ. Res. 1988, 62(1), 116-126. (Pubitemid 18032082)
65. Liu, DW.; Gintant, GA.; Antzelevitch C. Ionic bases for electrophysiological distinctions among epicardial, midmyocardial, and endocardial myocytes from the free wall of the canine left ventricle. Circ. Res. 1993, 72(3), 671-687. (Pubitemid 23052164)
66. + current with inward rectification in canine ventricular myocytes. Am. J. Physiol. 1998, 274(3), C577-C585.
67. + current in guinea pig cardiac myocytes. Am. J. Physiol. Heart Circ. Physiol. 2000, 279(1), H130-H138. (Pubitemid 30623434)
68. Ryder, KO.; Bryant, SM.; Hart, G. Membrane current changes in left ventricular myocytes isolated from guinea pigs after abdominal aortic coarctation. Cardiovasc. Res. 1993, 27(7), 1278-1287. (Pubitemid 23250909)
69. Hirano, Y.; Hiraoka, M. Barium-induced automatic activity in isolated ventricular myocytes from guinea-pig hearts. J. Physiol. 1988, 395, 455-472. (Pubitemid 18029207)
70. + current. Differential sensitivity to block by class III antiarrhythmic agents. J. Gen. Physiol. 1990, 96(1), 195-215. (Pubitemid 20227082)
71. Faivre, JF.; Rouanet, S.; Bril, A. Comparative effects of glibenclamide, tedisamil, dofetilide, E-4031, and BRL-32872 on protein kinase A-activated chloride current in guinea pig ventricular myocytes. J. Cardiovasc. Pharmacol. 1998, 31(4), 551-557. (Pubitemid 28153132)
72. Feng, J.; Wang, Z.; Li, GR.; Nattel, S. Effects of class III antiarrhythmic drugs on transient outward and ultra-rapid delayed rectifier currents in human atrial myocytes. J. Pharmacol. Exp. Ther. 1997, 281(1), 384-392. (Pubitemid 27203092)
73. Mori, K.; Hara, Y.; Saito, T.; Masuda, Y.; Nakaya, H. Anticholinergic effects of class III antiarrhythmic drugs in guinea pig atrial cells. Different molecular mechanisms. Circulation. 1995, 91(11), 2834-2843.
74. + channels in guinea-pig ventricular cells. Br. J. Pharmacol. 1996, 119(1), 133-141. (Pubitemid 26294532)
75. + current (IKr) in AT-1 cells. Concentration-, time-, voltage-, and use-dependent effects. Circulation. 1995, 91(6), 1799-1806.
76. Brandts, B.; Van Bracht, M.; Dirkmann, D.; Borchard, R.; Wickenbrock, I.; Prull, MW.; Meine, M.; Trappe, HJ. Perspectives and limitations in the treatment of vagus-induced atrial fibrillation. Insights from cellular pharmacology. Med. Klin. (Munich). 2004, 99(7), 341-346. (Pubitemid 38962937)
77. Srivastava, S.; Collis, L.; Go, A.; Mancarella, S.; Coetzee, WA.; Artman, M. Paradoxical effect of dofetilide on action potential duration and calcium transient amplitude in newborn rabbit ventricular myocytes. J. Cardiovasc. Pharmacol. 2005, 45(2), 165-174. (Pubitemid 40170680)
78. 2+ exchange. Cardiovasc. Drugs. Ther. 2009, 23(3), 207-214.
79. Kiehn, J.; Villena, P.; Beyer, T.; Brachmann, J. Differential effects of the new class III agent dofetilide on potassium currents in guinea pig cardiomyocytes. J. Cardiovasc. Pharmacol. 1994, 24(4), 566-572. (Pubitemid 24303156)
80. Gwilt, M.; Arrowsmith, JE.; Blackburn, KJ.; Burges, RA.; Cross, PE.; Dalrymple, HW.; Higgins, AJ. UK-68,798: a novel, potent and highly selective class III antiarrhythmic agent which blocks potassium channels in cardiac cells. J. Pharmacol. Exp. Ther. 1991, 256(1), 318-324.
81. Paul, AA.; Leishman, DJ.; Witchel, HJ.; Hancox, JC. Effects of the class III antiarrhythmic agent dofetilide (UK-68,798) on L-type calcium current from rabbit ventricular myocytes. J. Pharm. Pharmacol. 2001, 53(12), 1671-1678. (Pubitemid 34044255)
82. Carmeliet, E. Electrophysiologic and voltage clamp analysis of the effects of sotalol on isolated cardiac muscle and Purkinje fibers. J. Pharmacol. Exp. Ther. 1985, 232(3), 817-825. (Pubitemid 15135875)
83. Ks) to potassium channel blockers: implications for clinical reverse use-dependent effects. J. Biomed. Sci. 1999, 6(4), 251-259. (Pubitemid 29339740)
84. + channel blockers and muscarinic receptor stimulation. J. Pharmacol. Exp. Ther. 1995, 273(3), 1095-1104.
85. Antonaccio, MJ.; Gomoll, A. Pharmacologic basis of the antiarrhythmic and hemodynamic effects of sotalol. Am. J. Cardiol. 1993, 72(4), 27A-37A. (Pubitemid 23238409)
86. Vaughan Williams, EM. A classification of antiarrhythmic actions reassessed after a decade of new drugs. J. Clin. Pharmacol. 1984, 24(4), 129-147. (Pubitemid 14108816)
87. Jost, N.; Acsai, K.; Horváth, B.; Bányász, T.; Baczkó, I.; Bitay, M.; Bogáts, G.; Nánási, P P. Contribution of I Kr and I K1 to ventricular repolarization in canine and human myocytes: is there any influence of action potential duration? Basic. Res. Cardiol. 2009, 104(1), 33-41.
88. Kr to rate-dependent action potential dynamics in canine endocardium. Circ. Res. 2004, 94(6), 810-819. (Pubitemid 38451743)
89. Gintant, GA. Two components of delayed rectifier current in canine atrium and ventricle. Does IKs play a role in the reverse rate dependence of class III agents? Circ. Res. 1996, 78(1), 26-37.
90. Liu, DW.; Antzelevitch, C. Characteristics of the delayed rectifier current (IKr and IKs) in canine ventricular epicardial, midmyocardial, and endocardial myocytes. A weaker IKs contributes to the longer action potential of the M cell. Circ. Res. 1995, 76(3), 351-365.
91. Varro, A.; Baláti, B.; Iost, N.; Takács, J.; Virág, L.; Lathrop, DA.; Csaba, L.; Tálosi, L.; Papp, JG. The role of the delayed rectifier component IKs in dog ventricular muscle and Purkinje fibre repolarization. J. Physiol. 2000, 523, 67-81. (Pubitemid 30135822)
92. Bányász, T.; Koncz, R.; Fülöp, L.; Szentandrássy, N.; Magyar, J.; Nánási, PP. Profile of I(Ks) during the action potential questions the therapeutic value of I(Ks) blockade. Curr. Med. Chem. 2004, 11(1), 45-60. (Pubitemid 38081734)
93. Horváth, B.; Magyar, J.; Szentandrássy, N.; Birinyi, P; Nánási, PP.; Bányász, T. Contribution of I Ks to ventricular repolarization in canine myocytes. Pflugers Arch. 2006, 452(6), 698-706. (Pubitemid 44337905)
94. Stengl, M.; Volders, PG.; Thomsen, MB.; Spätjens, RL.; Sipido, KR.; Vos, MA. Accumulation of slowly activating delayed rectifier potassium current (IKs) in canine ventricular myocytes. J. Physiol. 2003, 551(3), 777-786. (Pubitemid 37221072)
95. + current, on repolarization in human and guinea pig ventricular myocytes. Cardiovasc. Res. 1998, 38(2), 441-450. (Pubitemid 28294162)
96. Sun, ZQ.; Thomas, GP.; Antzelevitch, C. Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes. J. Cardiovasc. Electrophysiol. 2001, 12(4), 472-478. (Pubitemid 32324664)
97. Du, XL.; Lau, CP.; Chiu, SW.; Tse, HF.; Gerlach, U.; Li, GR. Effects of chromanol 293B on transient outward and ultra-rapid delayed rectifier potassium currents in human atrial myocytes. J. Mol. Cell. Cardiol. 2003, 35(3), 293-300. (Pubitemid 36379173)
98. - current. Naunyn Schmiedebergs Arch. Pharmacol. 2001, 363(6), 590-596. (Pubitemid 32477266)
99. Thomas, GP.; Gerlach, U.; Antzelevitch, C. HMR 1556, a potent and selective blocker of slowly activating delayed rectifier potassium current. J. Cardiovasc. Pharmacol. 2003, 41(1), 140-147. (Pubitemid 36015066)
100. + current during the ventricular action potential. Circ. Res. 1998, 82(9), 947-956. (Pubitemid 28225935)
101. + channels Kir2.1 expressed in Xenopus oocytes. Biophys. J. 1998, 75(5), 2313-2322. (Pubitemid 28492114)
102. + current. Am. J. Physiol. Heart. Circ. Physiol. 2000, 278(1), H295-299. (Pubitemid 30101884)
103. Armstrong, CM.; Swenson, RP.; Taylor SR. Block of squid axon K channels by internally and externally applied barium ions. J. Gen. Physiol. 1982, 80(5), 663-682. (Pubitemid 13202074)
104. Josephson, IR.; Sanchez-Chapula, J.; Brown, AM. Early outward current in rat single ventricular cells. Circ. Res. 1984, 54(2), 157-162. (Pubitemid 14152835)
105. + channels in rabbit sino-atrial node cells. J. Physiol. 1994, 476(1), 55-68. (Pubitemid 24127548)
106. Zygmunt, AC. Intracellular calcium activates a chloride current in canine ventricular myocytes. Am. J. Physiol. 1994, 267(5), H1984-H1995.
107. Szigeti, G.; Rusznák, Z.; Kovács, L.; Papp, Z. Calcium-activated transient membrane currents are carried mainly by chloride ions in isolated atrial, ventricular and Purkinje cells of rabbit heart. Exp. Physiol. 1998, 83(2), 137-153. (Pubitemid 28135076)
108. i-dependent chloride current in single Purkinje cells from rabbit heart. J. Physiol. 1993, 468, 641-667. (Pubitemid 23254467)
109. Tseng, GN.; Hoffman, BF. Two components of transient outward current in canine ventricular myocytes. Circ. Res. 1989, 64(4), 633-647. (Pubitemid 19105300)
110. Trafford, AW.; Díaz, ME.; Eisner, DA. Ca-activated chloride current and Na-Ca exchange have different timecourses during sarcoplasmic reticulum Ca release in ferret ventricular myocytes. Pflugers Arch. 1998, 435(5), 743-745. (Pubitemid 28098658)
111. Fülöp, L.; Fiák, E.; Szentandrássy, N.; Magyar, J.; Nánási, PP.; Bányász, T. The role of transmembrane chloride current in afterdepolarisations in canine ventricular cardiomyocytes. Gen. Physiol. Biophys. 2003, 22(3), 341-353. (Pubitemid 38008153)
112. Hume, JR.; Duan, D.; Collier, ML.; Yamazaki, J.; Horowitz, B. Anion transport in heart. Physiol. Rev. 2000, 80(1), 31-81. (Pubitemid 30060561)
113. Vandenberg, JI.; Yoshida, A.; Kirk, K.; Powell, T. Swelling-activated and isoprenaline-activated chloride currents in guinea pig cardiac myocytes have distinct electrophysiology and pharmacology. J. Gen. Physiol. 1994, 104(6), 997-1017.
114. Harvey, RD.; Clark, CD.; Hume, JR. Chloride current in mammalian cardiac myocytes. Novel mechanism for autonomic regulation of action potential duration and resting membrane potential. J. Gen. Physiol. 1990, 95(6), 1077-1102. (Pubitemid 20217304)
115. Walsh, KB.; Wang, C. Effect of chloride channel blockers on the cardiac CFTR chloride and L-type calcium currents. Cardiovasc. Res. 1996, 32(2), 391-399. (Pubitemid 26246886)
116. 2+-activated chloride current in isolated smooth muscle cells of the sheep urethra. J. Physiol. 1997, 505(1), 121-131. (Pubitemid 27504286)
117. - current in rat vascular smooth muscle cells in short-term primary culture. Pflugers Arch. 1991, 419(6), 553-558.
118. Hogg, RC.; Wang, Q.; Large, WA. Effects of Cl channel blockers on Ca-activated chloride and potassium currents in smooth muscle cells from rabbit portal vein. Br. J. Pharmacol. 1994, 111(4), 1333-1341. (Pubitemid 24148810)
119. Kocic I. Modulators of ion channels activated by hypotonic swelling in cardiomyocytes: new perspectives for pharmacological treatment of life-threatening arrhythmias. Curr. Med. Chem. Cardiovasc. Hematol. Agents. 2005, 3(4), 333-339. (Pubitemid 41264270)
120. 2+-sensitive transient outward current in rabbit ventricular myocytes. J. Physiol. 1995, 486(3), 593-604.
121. Sorota, S. Pharmacologic properties of the swelling-induced chloride current of dog atrial myocytes. J. Cardiovasc. Electrophysiol. 1994, 5(12), 1006-1016.
122. - activity in guinea-pig heart. Eur. J. Pharmacol. 1992, 212(2-3), 267-270.
123. Harvey, RD. Effects of stilbenedisulfonic acid derivatives on the cAMPregulated chloride current in cardiac myocytes. Pflugers Arch. 1993, 422(5), 436-442. (Pubitemid 23068200)
124. ATP channels. B r. J. Pharmacol. 2001, 132(5), 973-982. (Pubitemid 32238903)
125. ATP channels to inhibition by DIDS: dependence on the sul-phonylurea receptor subunit. B r. J. Pharmacol. 2002, 137(4), 429-440. (Pubitemid 35221896)
126. + channels in guinea pig ventricular myocytes. J. Membr. Biol. 1993, 136(3), 289-302. (Pubitemid 24005389)
127. Hill, AP.; Sitsapesan, R. DIDS modifies the conductance, gating, and inactivation mechanisms of the cardiac ryanodine receptor. Biophys. J. 2002, 82(6), 3037-3047. (Pubitemid 34547646)
128. Liu, J.; Lai, ZF.; Wang, XD.; Tokutomi, N.; Nishi, K. Inhibition of sodium current by chloride channel blocker 4,4'-diisothiocyanatostilbene-2,2'- disulfonic acid (DIDS) in guinea pig cardiac ventricular cells. J. Cardiovasc. Pharmacol. 1998, 31(4), 558-567. (Pubitemid 28153133)
129. Busch, AE.; Busch, GL.; Ford, E.; Suessbrich, H.; Lang, HJ.; Greger, R.; Kunzelmann, K.; Attali, B.; Stühmer, W. The role of the IsK protein in the specific pharmacological properties of the IKs channel complex. B r. J. Pharmacol. 1997, 122(2), 187-189. (Pubitemid 27397187)
130. Tanaka, H.; Nishimaru, K.; Aikawa, T.; Hirayama, W.; Tanaka, Y.; Shigenobu, K. Effect of SEA0400, a novel inhibitor of sodium-calcium exchanger, on myocardial ionic currents. B r. J. Pharmacol. 2002, 135(5), 1096-1100. (Pubitemid 34259108)
131. 2+ exchange (NCX1) inhibition by SEA0400. J. Biol. Chem. 2004, 279(9), 7544-7553. (Pubitemid 38294633)
132. 2+ current in canine ventricular cardiomyocytes. Naunyn Schmiedebergs Arch. Pharmacol. 2005, 372(1), 63-70. (Pubitemid 41414046)
133. 2+ exchanger inhibition exerts a positive inotropic effect in the rat heart, but fails to influence the contractility of the rabbit
134. Nagy, ZA.; Virág, L.; Tóth, A.; Biliczki, P.; Acsai, K.; Bányász, T.; Nánási, P.; Papp, JG.; Varró, A. Selective inhibition of sodium-calcium exchanger by SEA-0400 decreases early and delayed after depolarization in canine heart. Br. J. Pharmacol. 2004, 143(7), 827-831. (Pubitemid 39664841)
135. 2+ handling in isolated rat ventricular myocytes. Eur. J. Pharmacol. 2007, 576(1-3), 1-6. (Pubitemid 47588247)
136. Zeng, D.; Kyle, JW.; Martin, RL.; Ambler, KS.; Hanck, DA. Cardiac sodium channels expressed in a peripheral neurotumor-derived cell line, RT4-B8. Am. J. Physiol. 1996, 270(5), C1522-C1531.
137. Yotsu-Yamashita, M.; Kim, YH.; Dudley, SC. Jr.; Choudhary, G; Pfahnl, A.; Oshima, Y.; Daly, J W. The structure of zetekitoxin AB, a saxitoxin analog from the Panamanian golden frog Atelopus zeteki: a potent sodium-channel blocker. Proc. Natl. Acad. Sci. U S A. 2004, 101(13), 4346-4351. (Pubitemid 38437414)
138. Ca. J. Pharmacol. Exp. Ther. 2004, 308(1), 324-329. (Pubitemid 38090734)
139. + channels. J. Gen. Physiol. 2003, 121(6), 583-598. (Pubitemid 36682922)
140. 2+ currents in human atrial cells. Receptors Channels. 1995, 3(2), 71-81.
141. Zong, XG.; Dugas, M.; Honerjäger, P. Relation between veratridine reaction dynamics and macroscopic Na current in single cardiac cells. J. Gen. Physiol. 1992, 99(5), 683-697.
142. Nánási, PP.; Varró, A.; Bryant, SH.; Lathrop, DA. Effects of veratrine on ion currents in single rabbit cardiomyocytes. Gen. Pharmacol. 1994, 25(8), 1667-1672.
143. Nánási, PP.; Varró, A.; Lathrop, DA.; Bryant, SH. Effects of veratridine on Na and Ca currents in frog skeletal muscle. Gen. Pharmacol. 1994, 25(8), 1661-1666.
144. 2+ antagonists. Am. J. Physiol. 1987, 253(1), C162-C170.
145. Horackova, M.; Vassort, G. Transmembrane sodium movement and regulation of contraction in frog atrial muscle during the inotropic effect of veratrine. Recent. Adv. Stud. Cardiac. Struct. Metab. 1975, 5, 51-57.
146. Yang. L.; Vassalle, M. Effects of strophanthidin on the slow inward current in guinea-pig isolated ventricular myocytes. Clin. Exp. Pharmacol. Physiol. 1990, 17(2), 105-120. (Pubitemid 20095550)
147. Marban, E.; Tsien, RW. Enhancement of calcium current during digitalis inotropy in mammalian heart: positive feed-back regulation by intracellular calcium? J. Physiol. 1982, 329, 589-614. (Pubitemid 12057934)
148. Tsai, HY.; Lin, YT.; Chen, YF.; Chen, CF. The interactions of paeoniflorin and veratrine on isolated rat atria. J. Ethnopharmacol. 1997, 57(3), 169-176.
149. Linz, KW.; Meyer, R. Profile and kinetics of L-type calcium current during the cardiac ventricular action potential compared in guinea-pigs, rats and rabbits. Pflugers Arch. 2000, 439(5), 588-599. (Pubitemid 30140152)
150. 2+ channels to early afterdepolarizations induced by I Kr and I Ks channel suppression in guinea pig ventricular myocytes. J. Membr. Biol. 2008, 222(3), 151-166.
151. 2+ currents by efonidipine: possible mechanism for its chronotropic effect. Eur. J. Pharmacol. 1998, 349(2-3), 351-357. (Pubitemid 28277107)
152. Liu, QY.; Wang, XL. The blocking effects of six antiarrhythmic drugs on transient outward current in rat ventricular myocytes. Yao. Xue. Xue. Bao. 1997, 32(3), 183-187. (Pubitemid 127464780)
153. 2+ antagonists and agonists in rabbit cardiac myocytes. Am. J. Physiol. 1991, 260(5), H1737-H1742.
154. Zhang, X.; Anderson, JW.; Fedida, D. Characterization of nifedipine block of the human heart delayed rectifier, hKv1.5. J. Pharmacol. Exp. Ther. 1997, 281(3), 1247-1256. (Pubitemid 27258384)
155. Zhang, S.; Zhou, Z.; Gong, Q.; Makielski, JC.; January, CT. Mechanism of block and identification of the verapamil binding domain to HERG potassium channels. Circ. Res. 1999, 84(9), 989-998. (Pubitemid 29227678)
156. + currents by nifedipine. Eur. J. Pharmacol. 2000, 401(2), 137-143. (Pubitemid 30488188)
157. + currents by nisoldipine. Br. J. Pharmacol. 2003, 140(5), 863-870. (Pubitemid 37464068)
158. + channels. J. Pharmacol. Exp. Ther. 1985, 234(1), 134-140. (Pubitemid 15034901)
159. Charnet, P.; Ouadid, H.; Richard, S.; Nargeot, J. Electrophysiological analysis of the action of nifedipine and nicardipine on myocardial fibers. Fundam. Clin. Pharmacol. 1987, 1(6), 413-431. (Pubitemid 18060731)
160. Calmels, TP.; Faivre, JF.; Cheval, B.; Javré, JL.; Rouanet, S.; Bril, A. hKv4.3 channel characterization and regulation by calcium channel antagonists. Biochem. Biophys. Res. Commun. 2001, 281(2), 452-460. (Pubitemid 32928177)
161. + channels expressed in HEK293 cells. Br. J. Pharmacol. 2003, 139(3), 533-544. (Pubitemid 36819623)
162. 2+ exchange in frog atrial fibres. J. Mol. Cell. Cardiol. 1988, 20(12), 1133-1140. (Pubitemid 19059023)
163. Noguchi, K.; Masumiya, H.; Takahashi, K.; Kaneko, K.; Higuchi, S.; Tanaka, H.; Shigenobu, K. Comparative effects of gallopamil and verapamil on the mechanical and electrophysiological parameters of isolated guinea-pig myocardium. Can. J. Physiol. Pharmacol. 1997, 75(12), 1316-1321. (Pubitemid 28130371)
164. Zahradníková, A.; Minarovic, I.; Zahradník, I. Competitive and cooperative effects of Bay K8644 on the L-type calcium channel current inhibition by calcium channel antagonists. J. Pharmacol. Exp. Ther. 2007, 322(2), 638-645. (Pubitemid 47105781)
165. + current by verapamil in human atrial myocytes. J. Mol. Cell. Cardiol. 2004, 36(2), 257-263. (Pubitemid 38202354)
166. Yue, L.; Feng. JL.; Wang, Z.; Nattel, S. Effects of ambasilide, quinidine, flecainide and verapamil on ultra-rapid delayed rectifier potassium currents in canine atrial myocytes. Cardiovasc. Res. 2000, 46(1), 151-161. (Pubitemid 30155955)
167. Zhang, S.; Sawanobori, T.; Hirano, Y.; Hiraoka, M. Multiple modulations of action potential duration by different calcium channel blocking agents in guinea pig ventricular myocytes. J. Cardiovasc. Pharmacol. 1997, 30(4), 489-496. (Pubitemid 27527585)
168. + channels in Xenopus oocytes. Br. J. Pharmacol. 1992, 107(4), 1061-1067.
169. -channels in ventricular myocytes. Eur. J. Pharmacol. 2004, 491(2-3), 111-120. (Pubitemid 38609468)
170. 2+ channel blocker tiapamil. J. Cardiovasc. Pharmacol. 1986, 8(6), 1101-1106. (Pubitemid 17211571)
171. Prakash, P.; Tripathi, O. Verapamil and TTX inhibit +Vmax but differentially alter the duration of action potential of adult chicken ventricular myocardium. Indian. J. Biochem. Biophys. 1998, 35(2), 123-130. (Pubitemid 128374875)
172. 2+ exchange in frog heart. Can. J. Physiol. Pharmacol. 1985, 63(11), 1404-1410. (Pubitemid 16204574)
173. Lefevre, IA.; Coulombe, A.; Coraboeuf, E. The calcium antagonist D600 inhibits calcium-independent transient outward current in isolated rat ventricular myocytes. J. Physiol. 1991, 432, 65-80.
174. Galper, JB.; Catterall, WA. Inhibition of sodium channels by D600. Mol. Pharmacol. 1979, 15(1), 174-178. (Pubitemid 9150369)
175. Hashimoto, Y.; Yabana, H.; Murata, S. Electrophysiological effect of l-cis-diltiazem, the stereoisomer of d-cis-diltiazem, on isolated guinea-pig left ventricular myocytes. Eur. J. Pharmacol. 2000, 391(3), 217-223. (Pubitemid 30154087)
176. 2+ ions. Arch. Biochem. Biophys. 1997, 341(2), 238-244. (Pubitemid 27203027)
177. Grove, A.; Tomich, JM.; Iwamoto, T.; Montal, M. Design of a functional calcium channel protein: inferences about an ion channel-forming motif derived from the primary structure of voltage-gated calcium channels. Protein Sci. 1993, 2(11), 1918-1930. (Pubitemid 23328546)
178. 2+ ions and dihydropyridine ligand. Biophys. J. 1996, 70(1), 22-37.
179. Zhorov, BS.; Govryin, VA. Chelate conformation of calcium antagonist, in Physico-chemical Properties of Biopolymers in Solution and Cells. A. P. Sarvazyan, editor. Institute of Biophysics of the USSR Academy of Sciences/Pushchino, Moscow Region. 1985 p160-162.
180. Goldmann, S.; Stoltefuss, J. 1,4 Dihydropyridines effects of chirality and conformation on the calcium channel antagonist and calcium agonist activity, Angew. Chemistry International Edition England, 1991, 30, 1559-1578.
181. Masuda, Y.; Miyajima, M.; Shudo, C.; Tanaka, S.; Shigenobu, K.; Kasuya, Y. Cardiovascular selectivity of 1,4-dihydropyridine derivatives, efonidipine (NZ-105), nicardipine and structure related compounds in isolated guinea-pig tissues. Gen. Pharmacol. 1995, 26(2), 339-345.
182. Triggle, DJ. 1,4-Dihydropyridines as calcium channel ligands and privileged structures. Cell. Mol. Neurobiol. 2003, 23(3), 293-303. (Pubitemid 36676276)
183. Simkó, J.; Szentandrássy, N.; Harmati, G.; Bárándi, L.; Horváth, B.; Magyar, J.; Bányá sz, T.; Lorincz, I.; Nánási, PP. Effects of ropinirole on action potential characteristics and the underlying ion currents in canine ventricular myocytes. Naunyn Schmiedebergs Arch. Pharmacol. 2010, 382(3), 213-220.
184. Szabó, A.; Szentandrássy, N.; Birinyi, P.; Horváth, B.; Szabó, G.; Bányász, T.; Márton, I.; Magyar, J.; Nánási, P P. Effects of ropivacaine on action potential configuration and ion currents in isolated canine ventricular cardiomyocytes. Anesthesiology. 2008, 108(4), 693-702. (Pubitemid 351440591)