The blocking effects of six antiarrhythmic drugs on transient outward current in rat ventricular myocytes

Yaoxue Xuebao

Volumn 32, Issue 3, 1997, Pages 183-187

  Liu, Q Y ^a   Wang, X L ^a  

^a PEKING UNION MEDICAL COLLEGE   (China)

Author keywords

Antiarrhythmic drug; Patchchamp whole cell recording techniques; Transient outward current; Ventricular myocytes

Indexed keywords

ANTIARRHYTHMIC AGENT; IMIPRAMINE; NIFEDIPINE; POTASSIUM CHANNEL; QUINIDINE;

ANIMAL; ARTICLE; CYTOLOGY; DRUG EFFECT; HEART MUSCLE; HEART VENTRICLE; MALE; PATCH CLAMP; PHYSIOLOGY; RAT; WISTAR RAT;

ANIMALS; ANTI-ARRHYTHMIA AGENTS; HEART VENTRICLES; IMIPRAMINE; MALE; MYOCARDIUM; NIFEDIPINE; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; QUINIDINE; RATS; RATS, WISTAR;

EID: 0031290976     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Wettwer E, Amos G, Gath J, et al. Transient outward current in human and rat ventricular myocytes. Cardiovasc Res, 1993, 27:1662
2. Escande D, Coulomber A, Faivre JF, et al. Two types of transient outward currents in adult human atrial cells. Am J Physiol, 1987, 252:H142
3. Shibata EF, Drury T, Refsum H, et al. Contributions of a transient outward current to repolarization in human atrium. Am J Physiol, 1989, 257:H1773
4. + Channel blocking actions of flecainide compared with those of propafenone and quinidine in adult rat ventricular myocytes. J Pharmacol Exp Ther, 1993, 269:66
5. Wang Z, Fermini B, Nattel S. Effects of flecainide, quinidine, and 4-aminopyridine on transient outward and ultrarapid delayed rectifier currents in human atrial myocytes. J Pharmacol Exp Ther, 1995, 272:184
6. + channel cDNAs from human ventricle. FASEB J, 1991, 5:331
7. Gettes LS, Foster JR, Simpson RJ. Clinical use of antiarrhythmic drugs. In: Rosen MR, Hoffman RF eds. Cardiac Therapy. New york: Martinus Nijhoff Publishers, 1983, 235-298
8. Chandy KG, Gutman GA, Grissmer S. Physiological role, molecular structure and evolutionary relationships of voltage-gated potassium channels in T lymphocytes. Semin Neurosci, 1992, 5:125
9. + channels, types Kv 1. 1, 1. 2, 1. 3, 1. 5, and 3. 1, stably expressed in mammalian cell lines. Mol Pharmacol, 1994, 45:1227
10. Delpon E, Valenzuela C, Tamargo J. Tonic and frequency-dependent Vmax block induced by imipramine in guinea-pig ventricular muscle fibres. J Cardiovasc Pharmacol, 1990, 15:414
11. Ogata N, Narahashi T. Block of sodium channels by psychotropic drugs in single guinea-pig cardiac myocytes. Br J Pharmacol, 1989, 97:905
12. Delpon N, Tamargo J, Sanchez-Chapula J. Further characterization of the effects of imipramine on plateau membrane currents in guinea-pig ventricular myocytes. Naunyn Schmiedebergs Arch Pharmacol, 1991, 344:645
13. Marshell JB, Forker AD. Cardiovascular effects of tricyclic antidepressant drugs: therapeutic usage, overdose and management of complications. Am Heart J, 1982, 103:401
14. Coraboeuf E, Deroubaix E, Escande D, et al. Comparative effects of class I antiarrhythmic drugs on plateau and pacemaker currents of sheep cardiac Pukinje fibres. Cardiovas Res, 1988, 22:375
15. Imaizumi Y, Giles WR. Quinidine-induced inhibition of transient outward current in cardiac muscle. Am J Physiol, 1987, 253: H704