Endocardial versus epicardial differences in L-type calcium current in canine ventricular myocytes studied by action potential voltage clamp

Cardiovascular Research

Volumn 58, Issue 1, 2003, Pages 66-75

  Bányász, Tamás ^a   Fülöp, László ^a   Magyar, János ^a   Szentandrássy, Norbert ^a   Varró, András ^b   Nánási, Péter P ^a  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Ca channel; Ion channels; Membrane currents; Membrane potential; Myocytes

Indexed keywords

CALCIUM; NISOLDIPINE;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CALCIUM CURRENT; CELL ASSAY; CELLULAR PARAMETERS; CONTROLLED STUDY; DENSITY; DOG; DYNAMICS; ENDOCARDIUM; EPICARDIUM; FEMALE; HEART MUSCLE CELL; KINETICS; MALE; NONHUMAN; PRIORITY JOURNAL; TECHNIQUE; VOLTAGE CLAMP;

ACTION POTENTIALS; ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; DOGS; ENDOCARDIUM; FEMALE; MALE; MYOCYTES, CARDIAC; NISOLDIPINE; PATCH-CLAMP TECHNIQUES; PERICARDIUM;

EID: 17544396717     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(02)00853-2     Document Type: Article

References (29)

1. Litovsky S.H., Antzelevitch C. Transient outward current prominent in canine ventricular epicardium but not endocardium. Circ Res. 62:1988;116-126.
2. Stankovicova T., Szilard M., Scheerder I.D., Sipido K.R. M cells and transmural heterogeneity of action potential configuration in myocytes from the left ventricular wall of the pig heart. Cardiovasc Res. 45:2000;952-960.
3. Liu D.W., Gintant G.A., Antzelevitch C. Ionic bases for electrophysiological distinctions among epicardial, midmyocardial, and endocardial myocytes from the free wall of the canine left ventricle. Circ Res. 72:1993;671-687.
4. Ks contributes to the longer action potential of the M cell. Circ Res. 76:1995;351-365.
5. Furukawa T., Kimura S., Furukawa N., Bassett A.L., Myerburg R.J. Potassium rectifier currents differ in myocytes of endocardial and epicardial origin. Circ Res. 70:1992;91-103.
6. to) phenotypes and distribution of fast-inactivating potassium channel alpha subunit in ferret left ventricular myocytes. J Gen Physiol. 113:1999;581-600.
7. Wettwer E., Amos G.J., Posival H., Ravens U. Transient outward current in human ventricular myocytes of subepicardial and subendocardial origin. Circ Res. 75:1994;473-482.
8. Krishnan S.C., Antzelevitch C. Sodium channel block produces opposite electrophysiological effects in canine ventricular epicardium and endocardium. Circ Res. 69:1991;277-291.
9. Litovsky S.H., Antzelevitch C. Differences in the electrophysiological response of canine ventricular subendocardium and subepicardium to acetylcholine and isoproterenol. Circ Res. 67:1990;615-627.
10. 2+ in left ventricular myocyte sub-types from rabbits with heart failure. Cardiovasc Res. 45:2000;397-409.
11. DiFrancesco D., Noble D. A model of cardiac electrical activity incorporating ionic pumps and concentration changes. Phil Trans R Soc Lond B Biol Sci. 307:1985;353-398.
12. 2+ transients under action potential clamp in guinea pig ventricular myocytes. Am J Physiol. 261:1991;C393-C397.
13. Doerr T., Denger R., Doerr A., Trautwein W. Ionic currents contributing to the action potential in single ventricular myocytes of the guinea pig studied with action potential clamp. Pflügers Arch. 416:1990;230-237.
14. + current during the action potential of guinea pig ventricular myocytes. Biophys J. 60:1991;1534-1539.
15. Magyar J., Iost N., Körtvély Á, et al. Effects of endothelin-1 on calcium and potassium currents in undiseased human ventricular myocytes. Pflügers Arch. 441:2000;144-149.
16. Bányász T., Magyar J., Körtvély Á, et al. Different effects of endothelin-1 on calcium and potassium currents in canine ventricular cells. Naunyn Schmiedeberg's Arch Pharmacol. 363:2001;383-390.
17. Hamill O.P., Marty A., Neher E., Sakmann B., Sigworth F.J. Improved patch-clamp techniques for high resolution current recording from cells and cell-free membrane patches. Pflügers Arch. 391:1981;85-100.
18. + current during the ventricular action potential. Circ Res. 82:1998;947-956.
19. Rocchetti M., Besana A., Gurrola G.B., Possani L.D., Zaza A. Rate dependency of delayed rectifier currents during the guinea-pig ventricular action potential. J Physiol. 534:2001;721-732.
20. Luo C.H., Rudy L. A dynamic model of the cardiac ventricular action potential. Circ Res. 74:1994;1071-1096.
21. Kass R.S., Sanguinetti M.C. Inactivation of calcium channel current in the calf cardiac Purkinje fiber: evidence for voltage- and calcium-mediated mechanisms. J Gen Physiol. 84:1984;705-726.
22. Yuan W., Ginsburg K.S., Bers D.M. Comparison of sarcolemmal calcium channel current in rabbit and rat ventricular myocytes. J Physiol. 493:1996;733-746.
23. Linz K.W., Meyer R. Control of L-type calcium current during the action potential of guinea-pig ventricular myocytes. J Physiol. 513:1998;425-442.
24. Linz K.W., Meyer R. Profile and kinetics of the L-type calcium current during the cardiac ventricular action potential compared in guinea-pigs, rats and rabbits. Pflügers Arch. 439:2000;588-599.
25. Cl(Ca) during early repolarization of canine ventricle. Am J Physiol. 273:1997;H1096-H1106.
26. 2+ influx in rat cardiac myocytes of endo- and epicardial origin. J Physiol. 519:1999;841-850.
27. Wit A.L., Rosen M.R. Afterdepolarizations and triggered activity: distinction from automaticity as an arrhythmogen mechanism. Fozzard H.A., Haber E., Jennings R.B., Katz A.M., Morgan H.E. The heart and cardiovascular system. 1992;2148-2149 Raven Press, New York.
28. 2+-channel agonist Bay K 8644. Circ Res. 62:1988;563-571.
29. 2+ current. Circ Res. 64:1990;977-990.