Paradoxical effect of dofetilide on action potential duration and calcium transient amplitude in newborn rabbit ventricular myocytes

Journal of Cardiovascular Pharmacology

Volumn 45, Issue 2, 2005, Pages 165-174

  Srivastava, Shekhar ^a   Collis, Leon ^a   Go, Anita ^a   Mancarella, Salvatore ^a   Coetzee, William A ^a   Artman, Michael ^a,b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Action potential; Calcium transients; Dofetilide; Indo 1; Neonate; Voltage clamp

Indexed keywords

CALCIUM CHANNEL L TYPE; DOFETILIDE; INDO 1; SODIUM CALCIUM EXCHANGE PROTEIN;

ACTION POTENTIAL; ACTION POTENTIAL DURATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CELL MATURATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; HEART MUSCLE CELL; MALE; MEMBRANE DEPOLARIZATION; NONHUMAN; PRIORITY JOURNAL; RABBIT; VOLTAGE CLAMP;

ACTION POTENTIALS; ANIMALS; ANIMALS, NEWBORN; ANTI-ARRHYTHMIA AGENTS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; CARDIOTONIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HEART VENTRICLES; MALE; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; PHENETHYLAMINES; RABBITS; SODIUM-CALCIUM EXCHANGER; SULFONAMIDES;

EID: 12844250623     PISSN: 01602446     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.fjc.0000151896.57637.66     Document Type: Article

References (42)

1. Wahler GM, Dollinger SJ, Smith JM, et al. Time course of postnatal changes in rat heart action potential and in transient outward current is different. Am J Physiol. 1994;267:H1157-H1166.
2. Conforti L, Tohse N, Sperelakis N. Tetrodotoxin-sensitive sodium current in rat fetal ventricular myocytcs-contribution to the plateau phase of action potential. J Mol Cell Cardiol. 1993;25:159-173.
3. Kato Y, Masumiya H, Agata N, et al. Developmental changes in action potential and membrane currents in fetal, neonatal and adult guinea-pig ventricular myocytes. J Mol Cell Cardiol. 1996;28:1515-1522.
4. Agata N, Tanaka H, Shigenobu K. Effects of tetrodotoxin and low-sodium on action potential plateau of ventricular myocardium from neonatal and adult guinea-pigs. Comp Biochem Physiol Comp Physiol. 1994;107:459-461.
5. Armoundas AA, Hobai IA, Tomaselli GF, et al. Role of sodium-calcium exchanger in modulating the action potential of ventricular myocytes from normal and failing hearts. Circ Res. 2003;93:46-53.
6. Follmer CH, Cullinan CA, Colatsky TJ. Differential block of cardiac delayed rectifier current by class 1c antiarrhythmic drugs: evidence for open channel block and unblock. Cardiovasc Res. 1992;26:1121-1130.
7. K, contribute to age-related expression of dofetilide effects on repolarization and proarrhythmia. Cardiovasc Res. 2003; 59:339-350.
8. Paul AA, Leishman DJ, Witchel HJ, et al. Effects of the class 111 antiarrhythmic agent dofetilide (UK-68,798) on L-type calcium current from rabbit ventricular myocytes. J Pharm Pharmacol. 2001;53:1671-1678.
9. Moak JP. Developmental cellular electrophysiologic effects of d-sotalol on canine cardiac Purkinje fibers. Pediatr Res. 1991;29:104-109.
10. Pickoff AS, Singh S, Flinn CJ, et al. Dose-dependent electrophysiologic effects of amiodarone in the immature canine heart. Am J Cardiol. 1983; 52:621-625.
11. Dise T, Stolfi A, Yamasaki S, et al. Electropharmacodynamics of N-acetylprocainamide in the immature mammalian heart-evidence for a prominent class III effect in the newborn. J Cardiovasc Pharmacol. 1991;17:96-101.
12. 2+ exchange protein in developing rabbit myocytes. Am J Physiol. 1995; 268:C1126-C1132.
13. 2+] gradients during excitation-contraction coupling in newborn rabbit ventricular myocytes. Circ Res. 1999;85:415-427.
14. 2+-exchanger and SERCA2 in rat heart. J Mol Cell Cardiol. 1995;27:1689-1701.
15. 2+ exchanger expression during postnatal maturation and in adult rabbit ventricular myocardium. Cardiovasc Res. 1996;31[Spec No]:E145-E152.
16. --free conditions in developing rabbit hearts. Am J Physiol. 1997;273:H837-H846.
17. 2+ exchange current density in cardiac myocytes from rabbits and guinea pigs during postnatal development. Am J Physiol. 1995;268:H1714-H1722.
18. 2+ exchange in rabbit ventricular myocytes. Pflugers Arch. 1998;435:789-795.
19. Bers DM. Cardiac excitation-contraction coupling. Natue. 2002;415: 198-205.
20. 2+ transient of failing human ventricular myocytes. Circ Res. 1999;84:435-444.
21. NCX is favored in failing human ventricular myocytes. Ann N Y Acad Sci. 2002;976:478-479.
22. Balaguru D, Haddock PS, Puglisi JL, et al. Role of the sarcoplasmic reticulum in contraction and relaxation of immature rabbit ventricular myocytes. J Mol Cell Cardiol. 1997;29:2747-2757.
23. 2+ in left ventricular myocyte sub-types from rabbits with heart failure. Cardiovasc Res. 2000;45:397-409.
24. Horn R, Marty A. Muscarinic activation of ionic currents measured by a new whole-cell recording method. J Gen Physiol. 1988;92:145-159.
25. Rae J, Cooper K, Gates P, et al. Low access resistance perforated patch recordings using amphotericin B. J Neurosci Methods. 1991;37:15-26.
26. i during caffeine contractures in rabbit cardiac myocytes. J Physiol. 1992;453:591-608.
27. 2+ exchange current from rabbit isolated atrioventricular nodal and ventricular myocytes compared using action potential and ramp waveforms. Acta Physiol Scand. 2000;168:393-401.
28. Yuan W, Ginsburg KS, Bers DM. Comparison of sarcolemmal calcium channel current in rabbit and rat ventricular myocytes. J Physiol. 1996;493:733-746.
29. + current in rabbit ventricular myocytes. Cardiovasc Drugs Ther. 1993;7(Suppl 3):599-604.
30. Kiehn J, Lacerda AE, Wible B, et al. Molecular physiology and pharmacology of HERG. Single-channel currents and block by dofetilide. Circulation. 1996;94:2572-2579.
31. 2+ exchange and cell contraction in isolated neonatal and adult rabbit cardiac myocytes. Am J Physiol. 1995;268:H1723-H1733.
32. 2+ exchange activity and exchanger immunoreactivity in developing rabbit hearts. Am J Physiol. 1992;263: H1506-H1513.
33. Artman M, Henry G, Coetzec WA. Cellular basis for age-related differences in cardiac excitation-contraction coupling. Prog Pediatr Cardiol 2000;11:185-194.
34. Artman M. Developmental changes in myocardial contractile responses to inotropic agents. Cardiovasc Res. 1992;26:3-13.
35. 2+ regulation. J Mol Cell Cardiol 2002;34: 641-648.
36. Chin TK, Christiansen GA, Caldwell JG, et al. Contribution of the sodium-calcium exchanger to contractions in immature rabbit ventricular myocytes. Pediatr Res. 1997;41:480-485.
37. + current by dofetilide. Circ Res. 1993;72:75-83.
38. Mounsey JP, DiMarco JP. Cardiovascular drugs. Dofetilide. Circulation. 2000;102:2665-2670.
39. Tham TC, MacLennan BA, Burke MT, et al. Pharmacodynamics and pharmacokinetics of the class III antiarrhythmic agent dofetilide (UK-68.798) in humans. J Cardiovasc Pharmacol. 1993;21:507-512.
40. Smith DA, Rasmussen HS, Stopher DA, et al. Pharmacokinetics and metabolism of dofetilide in mouse, rat, dog and man. Xenobiotica. 1992;22:709-719.
41. Osaka T, Joyner RW. Developmental changes in calcium currents of rabbit ventricular cells. Circ Res. 1991;68:788-796.
42. Wetzel GT, Chen F, Klitzner TS. L- and T-type calcium channels in acutely isolated neonatal and adult cardiac myocytes. Pediatr Res. 1991;30: 89-94.