Characterization of nifedipine block of the human heart delayed rectifier, hKv1.5

Journal of Pharmacology and Experimental Therapeutics

Volumn 281, Issue 3, 1997, Pages 1247-1256

  Zhang, Xue ^a   Anderson, James W ^a   Fedida, David ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM CHANNEL; NIFEDIPINE;

ARTICLE; BINDING SITE; CHANNEL GATING; CONTROLLED STUDY; DOSE RESPONSE; HEART CONDUCTION; HEART DEPOLARIZATION; HEART MUSCLE POTENTIAL; HUMAN; HUMAN CELL; KINETICS; LIPID BILAYER; MEMBRANE CURRENT; PRIORITY JOURNAL;

CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HEART; HUMANS; NIFEDIPINE; POTASSIUM CHANNELS;

EID: 0030920265     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. + channel. Science 271: 653-656, 1996.
2. BEZANILLA, F., PEROZO, E., PAPMIAN, D. M. AND STEFANI, E.: Molecular basis of gating charge immobilization in Shaker potassium channels. Science 254: 679-683, 1991.
3. BOUCHARD, R. A. AND FEDIDA, D.: Closed and open state binding of 4-aminopyridine to the cloned human potassium channel Kv1.5. J. Pharmacol. Exp Ther. 275: 864-876, 1995.
4. CATTERALL, W. A.: Structure and function of voltage-sensitive ion channels. Science 242: 50-61, 1988.
5. CHARNET, P., OUADID, H., RICHARD, S. AND NARGEOT, J.: Electrophysiological analysis of the action of nifedipine and nicardipine on myocardial fibers. Fundament. Clin. Pharmacol. 1: 413-431, 1987.
6. CHOQUET, D. AND KORN, H.: Mechanism of 4-aminopyridine action on voltagegated potassium channels in lymphocytes. J. Gen. Physiol 99: 217-240, 1992.
7. + channel block by verapamil and related compounds in rat alveolar epithelial cells. J. Gen. Physiol. 106: 745-779, 1995.
8. + channel current. Circ. Res. 73: 210-216, 1993.
9. FEDIDA, D.: Gating charge and innic currents associated with quinidine block of hKv1.5. J. Physiol. 499.3: 661-675, 1997.
10. 2+ antagonists and agonists in rabbit cardiac myocytes. Am. J. Physiol. Heart Circ. Physiol. 260: H1737-H1742, 1991.
11. + channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines. Mol. Pharmacol. 45: 1227-1234, 1994.
12. HAMILL, O. P., MARTY, A., NEHER, E., SAKMANN, B. AND SIGWORTH, F. J.: Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch. 391: 85-100, 1981.
13. + channels. J. Pharmacol. Exp. Ther. 234: 134-140, 1985.
14. JACOBS, E. R. AND DECOURSEY, T. E.: Mechanisms of potassium channel block in rat alveolar epithelial cells. J. Pharmacol. Exp. Ther. 255: 459-472, 1990.
15. JAHNEL, U., KLEMM, P. AND NAWRATH, H.: Different mechanisms of the inhibition of the transient outward current in rat ventricular myocytes. Naunyn Schmiedeberg Arch. Pharmacol. 349: 87-94, 1994.
16. JAN, L. Y. AND JAN, Y.: Voltage-sensitive ion channels. Cell 56: 13-25, 1989.
17. + channels. Neuron 12: 301-315, 1994.
18. MECCA, T. E. AND LOVE, S. D.: Comparative cardiovascular actions of clentiazem, diltiazem, verapamil, nifedipine, and nimodipine in isolated rabbit tissues. J. Cardiovasc. Pharmacol. 20: 678-682, 1992.
19. 2+ channels by photoaffinity labelling with diazepine. Proc. Natl. Acad. Sci. USA 88: 9203-9207, 1991.
20. + channel cloned from human heart. Mol. Pharmacol. 44: 642-648, 1993.
21. SANGUINETTI, M. C. AND KASS, R. S.: Voltage-dependent block of calcium channel current in the calf cardiac Purkinje fiber by dihydropyridine calcium channel antagonists. Circ. Res. 55: 336-348, 1984.
22. SCHUSTER, A., LACINOVÁ, L., KLUGBAUER, N., ITO, H., BIRNBAUMER, L. AND HOFMANN, F.: The IVS6 segment of the L-type calcium channel is critical for the action of dihydropyridines and phenylalkylamines. EMBO J. 15: 2365-2370, 1996.
23. + channel blocking actions of flecainide compared with those of propafenone and quinidine in adult rat ventricular myocytes. J. Pharmacol. Exp. Ther. 269: 66-74, 1994.
24. SNYDES, D. J., KNOTH, K. M., ROBERDS, S. L. AND TAMKUN, M. M.: Time-, voltage-, and state-dependent block by quinidine of a cloned human cardiac potassium channel. Mol. Pharmacol. 41: 322-330, 1992.
25. SNYDERS, D. J. AND YEOLA, S. W.: Determinants of antiarrhythmic drug action - Electrostatic and hydrophobic components of block of the human cardiac hKv1.5 channel. Circ. Res. 77: 575-583, 1995.
26. +' channels: I. Ionic and gating currents. Biophys. J. 66: 996-1010, 1994.
27. STÜHMER, W., CONTI, F., STOCKER, M., PONGS, O. AND HEINEMANN, S. H.: Gating currents of inactivating and non-inactivating potassium channel expressed in Xenopus oocytes. Pflugers Arch. 410: 423-429, 1991.
28. + channel cDNAs from human ventricle. FASEB J. 5: 331-337, 1991.
29. UEHARA, A. AND HUME, J. R.: Interactions of organic calcium channel antagonists with calcium channels in single frog atrial cells. J. Gen. Physiol. 85: 621-647, 1985.
30. + currents in rat atrial myocytes. Am. J. Physiol. Heart Circ. Physiol. 271: H937-H946, 1996.