Dofetilide enhances the contractility of rat ventricular myocytes via augmentation of Na+-Ca2+ exchange

Cardiovascular Drugs and Therapy

Volumn 23, Issue 3, 2009, Pages 207-214

  Zhang, Xuan Ping ^a   Wu, Bo Wei ^a   Yang, Cai Hong ^a   Wang, Jie ^a   Niu, Shuan Cheng ^a   Zhang, Ming Sheng ^a  

^a SHANXI MEDICAL UNIVERSITY   (China)

Author keywords

Calcium transient; Cell shortening; Contractility; Dofetilide; Isolated rat ventricular myocytes; Na+ Ca2+ exchange; Whole cell patch clamping

Indexed keywords

2 [2 [4 (4 NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA METHANESULFONATE; DOFETILIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CELL ISOLATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ELECTROSTIMULATION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CELL; HEART STIMULATION; HEART VENTRICLE; IMAGING SYSTEM; INOTROPISM; ISOLATED HEART; MALE; MUSCLE FIBER CONTRACTION; NONHUMAN; PRIORITY JOURNAL; RAT; SODIUM CALCIUM EXCHANGE; VOLTAGE CLAMP;

ACTION POTENTIALS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; CALCIUM SIGNALING; HEART VENTRICLES; MALE; MEMBRANE POTENTIALS; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; PHENETHYLAMINES; RATS; RATS, WISTAR; SODIUM-CALCIUM EXCHANGER; SULFONAMIDES; THIOUREA; VENTRICULAR FUNCTION, LEFT;

EID: 67649101331     PISSN: 09203206     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10557-009-6163-x     Document Type: Article

References (38)

1. S Litwin O Kohmoto AJ Levi KW Spitzer JH Bridge 1996 Evidence that reverse Na-Ca exchange can trigger SR calcium release Ann N Y Acad Sci 779 451 463 (Pubitemid 26194679)
2. 2+ exchanger is essential for the action of cardiac glycosides Circ Res 90 305 308 (Pubitemid 34633932)
3. 2+ exchange in the regulation of cardiac excitation-contraction coupling Cardiovasc Res 67 198 207 (Pubitemid 40943612)
4. 2+ exchanger expression and function in an arrhythmogenic rabbit model of heart failure Circ Res 85 1009 1019
5. 2+ exchange: molecular and pharmacological aspects Circ Res 88 864 876 (Pubitemid 32441464)
6. MP Blaustein WJ Lederer 1999 Sodium/calcium exchange: its physiological implications Physiol Rev 79 763 854 (Pubitemid 29330173)
7. 2+ release in cardiomyocytes Biophys J 91 779 792 (Pubitemid 44161910)
8. G Hasenfuss 1998 Animal models of human cardiovascular disease, heart failure and hypertrophy Cardiovasc Res 39 60 76 (Pubitemid 28322380)
9. B O'Rourke DA Kass GF Tomaselli S Kääb R Tunin E Marba'n 1999 Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart, I: experimental studies Circ Res 84 562 570 (Pubitemid 29138593)
10. RL Winslow J Rice S Jafri E Marbán B O'Rourke 1999 Mechanisms of altered excitation-contraction coupling in canine tachycardia-induced heart failure, II: model studies Circ Res 84 571 586 (Pubitemid 29138594)
11. 2+ transient of failing human ventricular myocytes Circ Res 84 435 444 (Pubitemid 29120009)
12. F del Monte RJ Hajjar 2003 Targeting calcium cycling proteins in heart failure through gene transfer J Physiol 546 49 61
13. V Piacentino 3rd CR Weber JP Gaughan KB Margulies DM Bers SR Houser 2002 Modulation of contractility in failing human myocytes by reverse-mode Na/Ca exchange Ann N Y Acad Sci 976 466 471 (Pubitemid 36126931)
14. J Weisser-Thomas V Piacentino 3rd JP Gaughan K Margulies SR Houser 2003 Calcium entry via Na/Ca exchange during the action potential directly contributes to contraction of failing human ventricular myocytes Cardiovasc Res 57 974 985 (Pubitemid 36324602)
15. 2+ flux Circ Res 97 1288 1295 (Pubitemid 43755186)
16. MR Lauer 2001 Dofetilide: is the treatment worse than the disease? J Am Coll Cardiol 37 1106 1110 (Pubitemid 32217614)
17. M Gwilt JE Arrowsmith KJ Blackburn RA Burges PE Cross HW Dalrymple 1991 UK-68,798: a novel, potent and highly selective class III antiarrhythmic agent which blocks potassium channels in cardiac cells J Pharmacol Exp Ther 256 318 324
18. JP Mounsey JP DiMarco 2000 Cardiovascular drugs. Dofetilide Circulation 102 2665 2670
19. N Abi-Gerges BG Small CL Lawrence TG Hammond JP Valentin CE Pollard 2004 Evidence for gender differences in electrophysiological properties of canine Purkinje fibres Br J Pharmacol 142 1255 1264 (Pubitemid 39178879)
20. E Mortensen T Yang H Refsum 1992 Class III antiarrhythmic action and inotropy: effects of dofetilide in acute ischemic heart failure in dogs J Cardiovasc Pharmacol 19 216 221
21. B Brendorp H Elming L Jun L Køber M Malik GB Jensen 2001 QTc interval as a guide to select those patients with congestive heart failure and reduced left ventricular systolic function who will benefit from antiarrhythmic treatment with dofetilide Circulation 103 1422 427
22. k blocking drug, UK-68,798: potent in guinea pig but no effect in rat myocardium J Cardiovasc Pharmacol 16 401 410 (Pubitemid 20254979)
23. K blocking drugs, UK-68798 (dofetilide) and E-4031 Cardiovasc Res 27 861 867 (Pubitemid 23162686)
24. AO Peralta RM John WH Gaasch PI Taggart DT Martin FJ Venditti 2000 The Class III antiarrhythmic effect of sotalol exerts a reverse use-dependent positive inotropic effect in the intact canine heart J Am Coll Cardiol 36 1404 1410 (Pubitemid 30760613)
25. 2+ exchange in ventricular myocytes of adult guinea pigs Chin Pharmacol Bull 20 1366 1369
26. S Yamashiro K Noguchi T Matsuzaki K Miyagi J Nakasone M Sakanashi 2002 Beneficial effect of tetrahydrobiopterin on ischemia-reperfusion injury in isolated perfused rat hearts J Thorac Cardiovasc Surg 124 775 784 (Pubitemid 36025356)
27. A Nygren C Kondo RB Clark WR Giles 2003 Voltage-sensitive dye mapping in Langendorff-perfused rat hearts Am J Physiol Heart Circ Physiol 284 H892 H902
28. 2+ exchange inhibitor CGP-37157 in rat atrial myocytes Eur J Pharmacol 552 15 19 (Pubitemid 44648082)
29. 2+ exchange inhibitor in guinea pig cardiac ventricular myocytes Eur J Pharmacol 573 161 169 (Pubitemid 47464203)
30. 2+ exchange in normal and hypertrophic rats Acta Pharmacol Sin 23 797 802
31. 2+ transients in guinea pig ventricular myocytes J Pharmacol Exp Ther 284 66 74 (Pubitemid 28109530)
32. S Srivastava L Collis A Go S Mancarella WA Coetzee M Artman 2005 Paradoxical effect of dofetilide on action potential duration and calcium transient amplitude in newborn rabbit ventricular myocytes J Cardiovasc Pharmacol 45 165 174 (Pubitemid 40170680)
33. T Namiki RW Joyner MB Wagner 2007 Developmental changes in time course of recovery from inactivation in l-type calcium currents of rabbit ventricular myocytes Am J Physiol Heart Circ Physiol 292 H295 H303
34. 2+ exchange currents in isolated guinea pig ventricular myocytes Chin J Pharmacol Toxico 13 161 164
35. 2+ exchange current by KB-R7943 in guinea-pig cardiac myocytes Br J Pharmacol 128 969 974 (Pubitemid 29512029)
36. 2+ exchange as a drug target-insights from molecular pharmacology and genetic engineering Ann N Y Acad Sci 1099 516 528 (Pubitemid 47092602)
37. AA Paul DJ Leishman HJ Witchel JC Hancox 2001 Effects of the class III antiarrhythmic agent dofetilide (UK-68,798) on l-type calcium current from rabbit ventricular myocytes J Pharm Pharmacol 53 1671 1678 (Pubitemid 34044255)
38. 2+ exchanger function J Physiol 575 845 854 (Pubitemid 44348510)