Inhibition of HERG K+ current and prolongation of the guinea-pig ventricular action potential by 4-aminopyridine

Journal of Physiology

Volumn 549, Issue 3, 2003, Pages 667-672

  Ridley, J M ^a   Milnes, J T ^a   Zhang, Y H ^a   Witchel, H J ^a   Hancox, Jules C ^a  

^a SCHOOL OF MEDICAL SCIENCES   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOPYRIDINE; CELL PROTEIN; POTASSIUM CHANNEL; POTASSIUM ION; FAMPRIDINE; POTASSIUM;

ALPHA CHAIN; ANIMAL CELL; ARTICLE; CALCULATION; CELL ISOLATION; CELL LINE; CHANNEL GATING; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DATA ANALYSIS; ELECTRIC POTENTIAL; GUINEA PIG; HEART MUSCLE CELL; HEART REPOLARIZATION; HEART VENTRICLE; HUMAN; HUMAN CELL; IC 50; MAMMAL CELL; MODULATION; MUSCLE ACTION POTENTIAL; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; VOLTAGE CLAMP; ACTION POTENTIAL; ADULT; ANIMAL EXPERIMENT; HEK293 CELL LINE; IC50; MALE; VOLTAGE CLAMP TECHNIQUE; WAVEFORM;

4-AMINOPYRIDINE; ACTION POTENTIALS; ANIMALS; CATION TRANSPORT PROTEINS; CELL LINE; CELL SEPARATION; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; ETHER-A-GO-GO POTASSIUM CHANNELS; GUINEA PIGS; HEART; HEART VENTRICLES; HUMANS; MEMBRANE POTENTIALS; MUSCLE CELLS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, VOLTAGE-GATED; TRANS-ACTIVATORS;

EID: 0037704565     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2003.043976     Document Type: Article

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