Effects of ropinirole on action potential characteristics and the underlying ion currents in canine ventricular myocytes

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 382, Issue 3, 2010, Pages 213-220

  Simkó, József ^a   Szentandrássy, Norbert ^b   Harmati, Gábor ^b   Bárándi, László ^b   Horváth, Balázs ^b   Magyar, János ^b   Bányász, Tamás ^b   Lőrincz, István ^c   Nánási, Péter P ^b  

^a Semmelweis Health Care Center   (Hungary)

^b UNIVERSITY OF DEBRECEN   (Hungary)

^c UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

Action potential duration; Dog cardiomyocytes; Dopamine receptor agonists; HERG channel; Ion currents; Ropinirole

Indexed keywords

DELAYED RECTIFIER POTASSIUM CHANNEL; DOPAMINE RECEPTOR STIMULATING AGENT; POTASSIUM CHANNEL HERG; ROPINIROLE;

ACTION POTENTIAL; ANIMAL CELL; ARTICLE; CARDIOVASCULAR RISK; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLARIZATION; DOG; DRUG EFFECT; FEMALE; HEART VENTRICLE; IC 50; ION CURRENT; LONG QT SYNDROME; MALE; MUSCLE CELL; NONHUMAN; PATCH CLAMP; REPOLARIZATION; VOLTAGE CLAMP;

EID: 77957580210     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-010-0538-1     Document Type: Article

References (20)

1. T Bányász L Fülöp J Magyar N Szentandrássy A Varró PP Nánási 2003 Endocardial versus epicardial differences in L-type calcium current in canine ventricular myocytes studied by action potential voltage clamp Cardiovasc Res 58 66 75 10.1016/S0008-6363(02) 00853-2 12667947 (Pubitemid 36351623)
2. + currents in canine cardiomyocytes: their role in ventricular repolarization Acta Physiol 190 189 198 10.1111/j.1748-1716. 2007.01674.x (Pubitemid 46934656)
3. RB Dewy SC Reimold PE O'Suilleabhain 2007 Cardiac valve regurgitation with pergolide compared with nonergot agonists in Parkinson's disease Arch Neurol 64 377 380 10.1001/archneur.64.3.377 (Pubitemid 46425692)
4. R Fischmeister LJ DeFelice RK Ayer R Levi RL DeHaan 1984 Channel currents during spontaneous action potentials in embryonic chick heart sells. The action potential patch clamp Biophys J 46 267 271 10.1016/S0006-3495(84)84020-5 1:STN:280:DyaL2M%2FgtVOltw%3D%3D 6089925
5. OP Hamill A Marty E Neher B Sakmann FJ Sigworth 1981 Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches Pflügers Arch 391 85 100 10.1007/BF00656997 1:STN:280:DyaL38%2FjslWrug%3D%3D 6270629 (Pubitemid 11012976)
6. LM Hondeghem BG Katzung 1977 Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels Biochim Biophys Acta 472 373 398 1:CAS:528:DyaE1cXjtFOisQ%3D%3D 334262
7. Ks to ventricular repolarization in canine myocytes Pflügers Arch 452 698 706 10.1007/s00424-006-0077-2 16586092 (Pubitemid 44337905)
8. SJ Humphrey CN Turman JT Curry GJ Wheeler 2006 Cardiovascular and electrocardiographic effects of the dopamine receptor agonists ropinirole, apomorphine, and PNU-142774E in conscious beagle dogs J Cardiovasc Pharmacol 47 337 347 1:CAS:528:DC%2BD28Xjs1Krs7o%3D 16633074
9. RS Hurst NR Higdon JA Lawson MA Clark KL Rutherford-Root WG McDonald JV Haas JP McGrath MD Meglasson 2003 Dopamine receptor agonists differ in their actions on cardiac ion channels Eur J Pharmacol 482 31 37 10.1016/j.ejphar.2003. 09.054 1:CAS:528:DC%2BD3sXps1OktLc%3D 14660002 (Pubitemid 37505924)
10. CM Kaye B Nicholls 2000 Clinical pharmacokinetics of ropinirole Clin Pharmacokinet 39 243 254 10.2165/00003088-200039040-00001 1:CAS:528: DC%2BD3cXotV2js7s%3D 11069211
11. RB Rothman MH Baumann 2009 Serotonergic drugs and valvular heart disease Expert Opin Drug Safety 8 317 329 10.1517/14740330902931524 1:CAS:528: DC%2BD1MXlslaiu74%3D
12. 2B receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications Circulation 102 2836 2841 1:CAS:528:DC%2BD3cXptVSjtrs%3D 11104741
13. AE Schrag DJ Brooks E Brunt D Fuell A Korczyn W Poewe NP Quinn O Rascol F Stocchi 1998 The safety of ropinirole, a selective nonergoline dopamine agonist, in patients with Parkinson's disease Clin Neuropharmacol 21 169 175 1:CAS:528:DyaK1cXjvVejs7w%3D 9617508
14. Na in nerve and cardiac membranes Biophys J 23 153 156 10.1016/S0006-3495(78)85440-X 1:CAS:528:DyaE1cXltVCqs78%3D 667304
15. JE Swagzdis RW Wittendorf RM DeMarinis BA Mico 1986 Pharmacokinetics of dopamine-2 agonists in rats and dogs J Pharm Sci 75 925 928 10.1002/jps. 2600751002 1:CAS:528:DyaL2sXnvVWqsQ%3D%3D 3795020 (Pubitemid 17182362)
16. G Szabó N Szentandrássy T Bíró IB Tóth G Czifra J Magyar T Bányász A Varró L Kovács PP Nánási 2005 Asymmetrical distribution of ion channels in canine and human left ventricular wall: epicardium versus midmyocardium Pflügers Arch 450 307 316 10.1007/s00424-005-1445-z 15952036 (Pubitemid 41204177)
17. N Szentandrássy T Bányász T Bíró G Szabó IB Tóth J Magyar J Lázár A Varró L Kovács PP Nánási 2005 Apico-basal inhomogeneity in distribution of ion channels in canine and human ventricular myocardium Cardiovasc Res 65 851 860 10.1016/j.cardiores.2004.11.022 (Pubitemid 40249729)
18. C Szymanski S Boey JS Hermida 2008 Ropinirole-induced symptomatic sinus node dysfunction PACE 31 1078 1081
19. DJ Thompson D Vearer 2007 Steady-state pharmacokinetic properties of a 24-hour prolonged-release formulation of ropinirole: results of two randomized studies in patients with Parkinson's disease Clin Ther 29 2654 2666 10.1016/j.clinthera.2007.12.010
20. Kr : model systems and relevance to human arrhythmias J Cardiovasc Pharmacol 38 737 744 10.1097/00005344-200111000-00010 1:CAS:528:DC%2BD3MXnvFSgs7Y%3D 11602820 (Pubitemid 32983280)