Effects of pressure overload-induced hypertrophy on TTX-sensitive inward currents in guinea pig left ventricle

Molecular and Cellular Biochemistry

Volumn 261, Issue 1, 2004, Pages 217-226

  Chorvatova, Alzbeta ^a   Snowdon, Richard ^a   Hart, George ^a   Hussain, Munir ^a  

^a Clinical Department   (United Kingdom)

Author keywords

Action potential clamp; Cardiac hypertrophy; ICa(TTX); Sodium and calcium current

Indexed keywords

CALCIUM CHANNEL; CALCIUM ION; SODIUM CHANNEL; SODIUM ION; TETRODOTOXIN; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL;

ABDOMINAL AORTA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; FEMALE; GUINEA PIG; HEART LEFT VENTRICLE HYPERTROPHY; HEART LEFT VENTRICLE OVERLOAD; HEART LEFT VENTRICLE PRESSURE; HEART MUSCLE CELL; HEART MUSCLE FIBER MEMBRANE POTENTIAL; NONHUMAN; PATCH CLAMP; PATHOPHYSIOLOGY; SODIUM CURRENT;

ACTION POTENTIALS; ANIMALS; CALCIUM CHANNELS; GUINEA PIGS; HEART VENTRICLES; HYPERTROPHY, LEFT VENTRICULAR; MYOCYTES, CARDIAC; SODIUM CHANNELS; TETRODOTOXIN;

CAVIA PORCELLUS; SUS SCROFA;

EID: 3442900813     PISSN: 03008177     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:MCBI.0000028759.22274.cf     Document Type: Article

References (30)

1. Boyden PA, Jeck CD: Ion channel function in disease. Cardiovasc Res 29: 312-3188, 1995
2. Hart G: Cellular electrophysiology in cardiac hypertrophy and failure. Cardiovasc Res 28: 933-946, 1994
3. Tomaselli GF, Marban E: Electrophysiological remodeling in hypertrophy and heart failure. Cardiovasc Res 42: 270-283, 1999
4. Noda M, Shimizu S, Tanabe T, Takai T, Kayano T, Ikeda T, Takahashi H, Nakayama H, Kanaoka Y, Minamino N: Primary structure of electrophorus electricus sodium channel deduced from cDNA sequence. Nature 312(5990): 121-127, 1984
5. 2+ cycling proteins underlie cardiac action potential prolongation in a pressure-overload guinea-pig model with cardiac hypertrophy and failure. Circ Res 86: 558-570, 2000
6. Gray RP, McIntyre H, Sheridan DS, Fry CH: Intracellular sodium and contractile function in hypertrophied human and guinea-pig myocardium. Pflügers Arch 442: 117-123, 2001
7. i in pressure-overloaded guinea pig heart. Am J Hypertension 8: 934-943, 1995
8. + concentration is elevated in heart failure but Na/K pump function is unchanged. Circulation 105: 2543-2548, 2002
9. i and contractility in non-failing and failing human myocardium. Circulation 106: 447-453, 2002
10. Kiyosue T, Arita M: Late sodium current and its contribution to action potential configuration in guinea pig ventricular myocytes. Circ Res 64: 389-397, 1989
11. Maltesev VA, Sabbah HN, Higgins RSD, Silverman N, Lesch M, Undrovinas AI: Novel, ultraslow inactivating sodium currents in human ventricular cardiomyocytes. Circulation 98: 2545-2552, 1998
12. Saint DA, Ju YK, Gage PW: A persistent sodium current in rat ventricular myocytes. J Physiol 453: 219-231, 1992
13. Sakmann BF, Spindler AJ, Bryant SM, Linz KW, Noble D: Distribution of a persistent sodium current across the ventricular wall in guinea-pigs. Circ Res 87: 910-914, 2000
14. Ju YK, Saint DA, Gage PA: Hypoxia increases persistent sodium current in rat ventricular myocytes. J Physiol 497(Pt 2): 337-347, 1996
15. Undrovinas AI, Maltsev VA, Sabbah HN: Repolarization abnormalities in cardiomyocytes of dogs with chronic heart failure: Role of sustained inward current. Cell Mol Life Sci 55: 494-505, 1999
16. Valdivia C, Nagatomo T, Makielski J: Late Na currents affected by alpha subunit isoform and beta1 subunit co-expression in HEK293 Cells. J Mol Cell Cardiol 34: 1029-1039, 2000
17. Antzelevitch C: Molecular biology and cellular mechanisms of Brugada and long QT syndromes in infants and young children. J Electrocardiol 34: S177-S181, 2001
18. + channel intermediate inactivation in Brugada syndrome. Circ Res 87: e37-e43, 2000
19. + channel. Circ Res 88: 740-745, 2000
20. + channel. Circ Res 86: E91-E97, 2000
21. Ryder KO, Bryant SM, Hart G: Membrane current changes in left ventricular myocytes from guinea pigs after abdominal aortic coarctation. Cardiovas Res 27: 1278-1287, 1993
22. 2+ transient in rat myocytes during β-adrenergic stimulation. J Physiol 505: 385-402, 1997
23. Bryant SM, Shipsey S, Hart G: Regional differences in electrical and mechanical properties of myocytes from guinea-pig hearts with mild left ventricular hypertrophy. Cardiovasc Res 35: 315-323, 1997
24. Aggarwal R, Shorofsky SR, Goldman L, Balke CW: Tetrodotoxin-blockable calcium currents in rat ventricular myocytes: A third type of cardiac sodium current. J Physiol 505.2: 353-369, 1997
25. + channels in guinea pig myocytes. Am J Physiol 273: H128-H137, 1997
26. + channels: Slip-mode conductance. Science 279: 1027-1033, 1998
27. + current. Biophysical J 81: 2647-2659, 2001
28. 2+ current. Am J Physiol 280: C1327-C1339, 2001
29. Ca(TTX) density in rat ventricular myocytes isolated from a mild hypertrophy model. J Physiol 533: 29P, 2001
30. 2+ channels in rabbit ventricular myocytes during action potential clamp: Influence of temperature. Circ Res 85: e7-e16, 1999