Comparative effects of gallopamil and verapamil on the mechanical and electrophysiological parameters of isolated guinea-pig myocardium

Canadian Journal of Physiology and Pharmacology

Volumn 75, Issue 12, 1997, Pages 1316-1321

  Noguchi, Kazuo ^a   Masumiya, Haruko ^b   Takahashi, Kenzo ^a   Kaneko, Katsuyoshi ^a   Higuchi, Shohei ^a   Tanaka, Hikaru ^b   Shigenobu, Koki ^b  

^a TAISHO PHARMACEUTICAL CO LTD   (Japan)

^b TOHO UNIVERSITY   (Japan)

Author keywords

Ca2+ channel; Gallopamil; Guinea pig; Myocardium; Verapamil

Indexed keywords

CALCIUM CHANNEL; GALLOPAMIL; VERAPAMIL;

ACTION POTENTIAL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHRONOTROPISM; CONTROLLED STUDY; DOSE RESPONSE; ELECTROPHYSIOLOGY; GUINEA PIG; HEART MUSCLE; HEART MUSCLE CELL; IN VITRO STUDY; INOTROPISM; MALE; MUSCLE TONE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL;

EID: 0031406458     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y97-161     Document Type: Article

References (35)

1. Bean, B.P. 1985. Two kinds of calcium channels in canine atrial cells. Differences in kinetics, selectivity, and pharmacology. J. Gen. Physiol. 86: 1-30.
2. Cranefield, P.F., Aronson, R.S., and Wit, A.L. 1974. Effect of verapamil on the normal action potential and on a calcium-dependent slow response of canine cardiac Purkinje fibers. Circ. Res. 34: 204-213.
3. Eigenmann, R., Blaber, L., Nakamura, L., Thorens, S., and Haeusler, G. 1981. Tiapamil, a new calcium antagonist. 1. Demonstration of calcium antagonistic activity and related studies. Arzneimittelforsch. 31: 1393-1401.
4. Ellrodt, G., Chew, C.Y., and Singh, B.N. 1980. Therapeutic implications of slow channel blockade in cardiocirculatory disorders. Circulation, 62: 669-679.
5. Fleckenstein, A., Fleckenstein, B., Spah, F., and Byon, Y.K. 1984. Gallopamil (D600) - a calcium antagonist of high potency and specificity. Effects on the myocardium and pacemakers. In Gallopamil. Edited by M. Kaltenbach and R. Hopf. Springer-Verlag, Berlin, Heidelberg, New York, Tokyo. pp. 1-32.
6. 2+-dependent bioelectrical automaticity and electromechanical coupling of smooth muscle cells by gallopamil (D600). In Gallopamil. Edited by M. Kaltenbach and R. Hopf. Springer-Verlag, Berlin, Heidelberg, New York, Tokyo. pp. 33-48.
7. Henry, P.D. 1980. Comparative pharmacology of calcium antagonists: nifedipine, verapamil and diltiazem. Am. J. Cardiol. 46: 1047-1058.
8. Hess, P., Lansman, J.B., and Tsien, R.W. 1984. Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists. Nature (London), 311: 538-544.
9. Hofmann, H.P., Raschack, M., and Unger, L. 1989. (S)-Emopamil, a novel calcium and serotonin antagonist for the treatment of cerebrovascular disorders. Arzneimittelforsch. 39: 304-308.
10. Hopf, R., Drews, H., and Kaltenbach, M. 1984. Anti-anginal effects of gallopamil in comparison with another calcium antagonist and placebo. Z. Kardiol. 73: 578-585.
11. Imai, Y., Himori, N., and Taira, N. 1977. Cardiohemodynamic effects of SK&F24260, D600, diltiazem, dilazep, and trimetazidine in the dog. Jpn. Heart J. 18: 120-131.
12. Isenberg, G., and Klöckner, U. 1982. Calcium currents of isolated bovine ventricular myocytes are fast and of large amplitude. Pfluegers Arch. 395: 30-41.
13. Kato, Y., Masumiya, H., Agata, N., Tanaka, H., and Shigenobu, K. 1996. Developmental changes in action potential and membrane currents in fetal, neonatal and adult guinea-pig ventricular myocytes. J. Mol. Cell. Cardiol. 28: 1515-1522.
14. Laragh, S.H., Buhler, F.R., Chobanian, A., Hansson, L., and Zachariah, P.K. 1987. Calcium antagonists in hypertension: Update 1986. J. Cardiovasc. Pharmacol. 9(Suppl. 4): 1-3.
15. Lee, K.S., and Tsien, R.W. 1983. Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells. Nature (London), 302: 790-794.
16. Lehmann, H.-U., Taegener-Torge, C., Witt, E., Beck, O.A., and Hochrein, H. 1979. Comparison of antiarrhythmic effects of gallopamil (D600) and verapamil. Angiocardiology, 2: 103-111.
17. 2+ channel blocker in models of ventricular arrhythmia in dogs. Eur. J. Pharmacol. 231: 363-370.
18. Nakaya, H., Hattori, Y., Nakao, Y., and Kanno, M. 1988. Cardiac versus vascular effects of a new dihydropyridine derivative, CV-4093. In vitro comparison with other calcium antagonists. Eur. J. Pharmacol. 146: 35-43.
19. Nawrath, H., and Zong, X.A. 1984. Electrophysiological studies with gallopamil on the myocardium of the human ventricle. In Gallopamil. Edited by M. Kaltenbach and R. Hopf. Springer-Verlag, Berlin, Heidelberg, New York, Tokyo. pp. 66-71.
20. Nawrath, H., Eick, R.E., McDonald, T.F., and Trautwein, W. 1977. On the mechanism underlying the action of D-600 on slow inward current and tension in mammalian myocardium. Circ. Res. 40: 408-414.
21. Nelson, M.T., and Worley, J.F. 1989. Dihydropyridine inhibition of single calcium channels and contraction in rabbit mesenteric artery depends on voltage. J. Physiol. (London), 412: 65-91.
22. Noguchi, K., Masumiya, H., Sasaki, T., Takahashi, K., Araki, H., Higuchi, S., Tanaka, H., and Shigenobu, K. 1996. Relative selectivity for negative chronotropic and inotropic effects of a novel dihydropyridine derivative, CD-832. Eur. J. Pharmacol. 308: 53-59.
23. Parker, R.B., and Waud, D.R. 1971. Pharmacological estimation of drug-receptor dissociation constants. Statistical evalution. I. Agonist. J. Pharmacol. Exp. Ther. 177: 1-12.
24. Perez, J.E., Borda, L., Schuchleib, R., and Henry, P.D. 1982. Inotropic and chronotropic effects of vasodilators. J. Pharmacol. Exp. Ther. 221: 609-613.
25. Raschack, M., Gries, J., Buhler, V., and Maurer, R. 1984. Studies on the cardiovascular effect of gallopamil. In Gallopamil. Edited by M. Kaltenbach and R. Hopf. Springer-Verlag, Berlin, Heidelberg, New York, Tokyo, pp. 72-80.
26. Schwartz, A., and Triggle, D.J. 1984. Cellular action of calcium channel blocking drugs. Annu. Rev. Med. 35: 325-329.
27. Takahashi, K., Tsuchida, K., and Aihara, H. 1988. Cardioselective effects of gallopamil compared with verapamil in the dog hearts. Arch. Int. Pharmacodyn. Ther. 295: 157-173.
28. Takahashi, S., Kato, Y., Adachi, M., Agata, N., Tanaka, H., and Shigenobu, K. 1995. Effects of cyclopiazonic acid on rat myocardium: inhibition of calcium uptake into sarcoplasmic reticulum. J. Pharmacol. Exp. Ther. 272: 1095-1100.
29. Tanaka, H., Masumiya, H., Sekine, T., Sijuku, T., Sugahara, M., Taniguchi, H., Terada, M., Saito, W., and Shigenobu, K. 1996. Myocardial and vascular effects of efonidipine in vitro as compared with nifedipine, verapamil and diltiazem. Gen. Pharmacol. 27: 451-454.
30. 2+ channel antagonists. A 2-diazo-3,3,3-trifluoropropionamide derivative related to verapamil as a potential photoaffinity probe. J. Med. Chem. 33: 873-877.
31. 2-adrenoceptor stimulation. Naunyn-Schmiedebergs Arch. Pharmacol. 322: 34-37.
32. Wegener, J.W., and Nawrath, H. 1995. Extracellular site of action of phenylalkylamines on L-type calcium current in rat ventricular myocytes. Naunyn-Schmiedeberg's Arch. Pharmacol. 352: 322-330.
33. 2+ channel interaction. Trends Pharmacol. Sci. 11: 38-44.
34. Zucchi, R., Limbruno, U., Ronca-Testoni, S., Yu, G., Galbani, P., Ronca, G., and Mariani, M. 1992a. Effects of verapamil, gallopamil, diltiazem and nifedipine on sarcoplasmic reticulum function in rat heart. Cardioscience, 3: 167-172.
35. Zucchi, R., Ronca-Testoni, S., Limbruno, U., Yu, G., Galbani, P., Ronca, G., and Mariani, M. 1992b. Effects of gallopamil on cardiac sarcoplasmic reticulum. J. Cardiovasc. Pharmacol. 20(Suppl. 7): S11-S15.