Competitive and cooperative effects of Bay K8644 on the L-type calcium channel current inhibition by calcium channel antagonists

Journal of Pharmacology and Experimental Therapeutics

Volumn 322, Issue 2, 2007, Pages 638-645

  Zahradníková, Alexandra ^a   Minarovič, Igor ^a   Zahradník, Ivan ^a  

^a INSTITUTE OF MOLECULAR PHYSIOLOGY AND GENETICS   (Slovakia)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; DILTIAZEM; FELODIPINE; VERAPAMIL;

ANALYTIC METHOD; ANIMAL CELL; ARTICLE; BINDING SITE; CELL ISOLATION; CONTROLLED STUDY; DRUG BINDING; MEMBRANE POTENTIAL; MUSCLE CELL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RAT; RECEPTOR OCCUPANCY;

3-PYRIDINECARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-(2-(TRIFLUOROMETHYL)PHENYL)-, METHYL ESTER; ALGORITHMS; ALLOSTERIC REGULATION; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; CALCIUM; CALCIUM CHANNEL AGONISTS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; CELLS, CULTURED; DILTIAZEM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FELODIPINE; ION CHANNEL GATING; MALE; MEMBRANE POTENTIALS; MODELS, BIOLOGICAL; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; PROTEIN BINDING; RATS; RATS, WISTAR; VERAPAMIL;

EID: 34547095497     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.107.122176     Document Type: Article

References (38)

1. Bean BP (1984) Nitrendipine block of cardiac calcium channels: high-affinity binding to the inactivated state. Proc Natl Acad Sci U S A 81:6388-6392.
2. 2+ channel subunits reveal structural determinants of a guarded and modulated benzothiazepine receptor. J Biol Chem 274:6154-6160.
3. Brauns T, Prinz H, Kimball SD, Haugland RP, Striessnig J, and Glossmann H (1997) L-type calcium channels: binding domains for dihydropyridines and benzothiazepines are located in close proximity to each other. Biochemistry 36:3625-3631.
4. Brown AM, Kunze DL, and Yatani A (1986) Dual effects of dihydropyridines on whole cell and unitary calcium currents in single ventricular cells of guinea-pig. J Physiol 379:495-514.
5. Glossmann H, Ferry DR, Goll A, Striessnig J, and Zernig G (1985) Calcium channels and calcium channel drugs: recent biochemical and biophysical findings. Arzneimittelforschung 35:1917-1935.
6. Hadley RW and Hume JR (1988) Calcium channel antagonist properties of Bay K 8644 in single guinea pig ventricular cells. Circ Res 62:97-104.
7. Hamill OP, Marty A, Neher E, Sakmann B, and Sigworth FJ (1981) Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflugers Arch 391:85-100.
8. Hering S, Aczel S, Grabner M, Doring F, Berjukow S, Mitterdorfer J, Sinnegger MJ, Striessnig J, Degtiar VE, Wang ZY, et al. (1996) Transfer of high sensitivity for benzothiazepines from L-type to class A (BI) calcium channels. J Biol Chem 271:24471-24475.
9. Hering S, Aczel S, Kraus RL, Berjukow S, Striessnig J, and Timin EN (1997) Molecular mechanism of use-dependent calcium channel block by phenylalkylamines: role of inactivation. Proc Natl Acad Sci U S A 94:13323-13328.
10. 2+ channel block and inactivation: common molecular determinants. Trends Pharmacol Sci 19:439-443.
11. Hess P, Lansman JB, and Tsien RW (1984) Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists. Nature 311:538-544.
12. Hockerman GH, Peterson BZ, Johnson BD, and Catterall WA (1997a) Molecular determinants of drug binding and action on L-type calcium channels. Annu Rev Pharmacol Toxicol 37:361-396.
13. 2+ channel. Proc Natl Acad Sci U S A 94:14906-14911.
14. Ito H, Klugbauer N, and Hofmann F (1997) Transfer of the high affinity dihydropyridine sensitivity from L-type to non-L-type calcium channel. Mol Pharmacol 52:735-740.
15. Kamp TJ, Sanguinetti MC, and Miller RJ (1989) Voltage- and use-dependent modulation of cardiac calcium channels by the dihydropyridine (+)-202-791. Circ Res 64:338-351.
16. 2+ channels. Eur J Pharmacol 358:277-287.
17. Kanda S, Kurokawa J, Adachi-Akahane S, and Nagao T (1997) Diltiazem derivatives modulate the dihydropyridine-binding to intact rat ventricular myocytes. Eur J Pharmacol 319:101-107.
18. Kokubun S and Reuter H (1984) Dihydropyridine derivatives prolong the open state of Ca channels in cultured cardiac cells. Proc Natl Acad Sci U S A 81:4824-4827.
19. 2+ channels. J Biol Chem 273:27205-27212.
20. Lee KS and Tsien RW (1983) Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells. Nature 302:790-794.
21. 2+ channel. Mol Pharmacol 63:499-511.
22. McDonald TF, Pelzer S, Trautwein W, and Pelzer DJ (1994) Regulation and modulation of calcium channels in cardiac, skeletal, and smooth muscle cells. Physiol Rev 74:365-507.
23. 2+ current responses to rapid applications and washouts of nifedipine in frog cardiac myocytes. J Physiol 494:105-120.
24. Minarovic I and Meszaros LG (1998) Fluorescent probing with felodipine of the dihydropyridine receptor and its interaction with the ryanodine receptor calcium release channel. Biochem Biophys Res Commun 244:519-524.
25. Mitterdorfer J, Wang Z, Sinnegger MJ, Hering S, Striessnig J, Grabner M, and Glossmann H (1996) Two amino acid residues in the IIIS5 segment of L-type calcium channels differentially contribute to 1,4-dihydropyridine sensitivity. J Biol Chem 271:30330-30335.
26. Motoike HK, Bodi I, Nakayama H, Schwartz A, and Varadi G (1999) A region in IVS5 of the human cardiac L-type calcium channel is required for the use-dependent block by phenylalkylamines and benzothiazepines. J Biol Chem 274:9409-9420.
27. Porzig H and Becker C (1988) Potential-dependent allosteric modulation of 1,4-dihydropyridine binding by d-(cis)-diltiazem and (+/-)-verapamil in living cardiac cells. Mol Pharmacol 34:172-179.
28. Proska J and Tucek S (1994) Mechanisms of steric and cooperative actions of alcuronium on cardiac muscarinic acetylcholine receptors. Mol Pharmacol 45:709-717.
29. Sanguinetti MC, Krafte DS, and Kass RS (1986) Voltage-dependent modulation of Ca channel current in heart cells by BAY K8644. J Gen Physiol 88:369-392.
30. Schuster A, Lacinova L, Klugbauer N, Ito H, Birnbaumer L, and Hofmann F (1996) The IVS6 segment of the L-type calcium channel is critical for the action of dihydropyridines and phenylalkylamines. EMBO J 15:2365-2370.
31. Striessnig J, Goll A, Moosburger K, and Glossmann H (1986) Purified calcium channels have three allosterically coupled drug receptors. FEBS Lett 197:204-210.
32. 2+ channels. Trends Pharmacol Sci 19:108-115.
33. Uehara A and Hume JR (1985) Interactions of organic calcium channel antagonists with calcium channels in single frog atrial cells. J Gen Physiol 85:621-647.
34. 2+ channel antagonists and activators in cultured neonatal rat ventricular myocytes. Mol Pharmacol 35:541-552.
35. 2+ channel agonists. Mol Pharmacol 64:235-248.
36. Zahradník I and Palade P (1993) Multiple effects of caffeine on calcium current in rat ventricular myocytes. Pflugers Arch 424:129-136.
37. Zahradniková A and Lacinova L (1998) Molecular determinants of the interaction of calcium channels with calcium channel drugs. Exp Clin Cardiol 3:121-127.
38. Zhorov BS, Folkman EV, and Ananthanarayanan VS (2001) Homology model of dihydropyridine receptor: implications for L-type Ca(2+) channel modulation by agonists and antagonists. Arch Biochem Biophys 393:22-41.