Comparative effects of the short QT N588K mutation at 37°C on herg K+ channel current during ventricular, Purkinje fibre and atrial action potentials: An action potential clamp study

Journal of Physiology and Pharmacology

Volumn 60, Issue 1, 2009, Pages 23-41

  Mcpate, M J ^a   Zhang, H ^b   Adeniran, I ^b   Cordeiro, J M ^c   Witchel, H J ^a,d   Hancox, Jules C ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c MASONIC MEDICAL RESEARCH LABORATORY   (United States)

^d BRIGHTON AND SUSSEX MEDICAL SCHOOL   (United Kingdom)

Author keywords

Arrhythmia; hERG; Human ether a go go related gene; Ikr; KCNH2; QT interval; Rapid delayed rectifier; Repolarisation disorder; Short QT syndrome

Indexed keywords

POTASSIUM CHANNEL HERG;

ANIMAL CELL; ARTICLE; CHO CELL; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; GENE MUTATION; HEART ATRIUM; HEART MUSCLE POTENTIAL; HEART VENTRICLE; MEMBRANE CURRENT; NONHUMAN; PURKINJE FIBER; REPOLARIZATION; SHORT QT SYNDROME; SIMULATION; TEMPERATURE; VOLTAGE CLAMP; WILD TYPE;

ACTION POTENTIALS; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DELAYED RECTIFIER POTASSIUM CHANNELS; ELECTROCARDIOGRAPHY; ELECTROPHYSIOLOGY; ETHER-A-GO-GO POTASSIUM CHANNELS; HEART ATRIA; HEART VENTRICLES; HUMANS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PATCH-CLAMP TECHNIQUES; PURKINJE FIBERS;

EID: 65949120706     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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