Effects of four Indian medicinal herbs on Isoniazid-, Rifampicin- and Pyrazinamide-induced hepatic injury and immunosuppression in guinea pigs

World Journal of Gastroenterology

Volumn 13, Issue 23, 2007, Pages 3199-3205

  Adhvaryu, Meghna R ^a   Reddy, Narsimha ^a   Parabia, Minoo H ^a  

^a VEER NARMAD SOUTH GUJARAT UNIVERSITY   (India)

Author keywords

Curcuma longa; Hepatoprotective; Hepatotoxicity; Immunomodulatory; Isoniazid; Ocimum sanctum; Pyrazinamide; Rifampicin; Tinospora cordifolia; Zizyphus mauritiana

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CURCUMA LONGA EXTRACT; ISONIAZID; OCIMUM SANCTUM EXTRACT; PLANT EXTRACT; PYRAZINAMIDE; RIFAMPICIN; TINOSPORA CORDIFOLIA EXTRACT; UNCLASSIFIED DRUG; ZIZYPHUS MAURITIANA EXTRACT;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CHEMOTAXIS; CONTROLLED STUDY; FATTY LIVER; GUINEA PIG; HEPATITIS; HISTOPATHOLOGY; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOSTIMULATION; IMMUNOSUPPRESSIVE TREATMENT; INDIA; JUJUBE; LEUKOCYTE FUNCTION; LIVER HISTOLOGY; LIVER INJURY; LIVER NECROSIS; LIVER PROTECTION; LIVER TOXICITY; MACROPHAGE FUNCTION; NEUTROPHIL; NONHUMAN; PHAGOCYTOSIS; TRADITIONAL MEDICINE; ZIZYPHUS MAURITIANA;

EID: 34447539752     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v13.i23.3199     Document Type: Article

References (55)

1. Raviglione MC, Snider DE Jr, Kochi A. Global epidemiology of tuberculosis. Morbidity and mortality of a worldwide epidemic. JAMA 1995; 273: 220-226
2. WHO Report. Global tuberculosis control, surveillance, planning, financing. Geneva: World Health Organization. WHO document WHO/CDS/TB/ 2002, 295
3. Chan ED, Iseman MD. Current medical treatment for tuberculosis. BMJ 2002; 325: 1282-1286
4. Mahashur AA, Prabhudesai PP. Hepatitis and antitubercular therapy. J Assoc Physicians India 1991; 39: 595-596
5. Steele MA, Burk RF, DesPrez RM. Toxic hepatitis with isoniazid and rifampin. A meta-analysis. Chest 1991; 99: 465-471
6. Teleman MD, Chee CB, Earnest A, Wang YT. Hepatotoxicity of tuberculosis chemotherapy under general programme conditions in Singapore. Int J Tuberc Lung Dis 2002; 6: 699-705
7. Wada M. The adverse reactions of anti-tuberculosis drugs and its management. Nippon Rinsho 1998; 56: 3091-3095
8. McNeill L, Allen M, Estrada C, Cook P. Pyrazinamide and rifampin vs isoniazid for the treatment of latent tuberculosis: improved completion rates but more hepatotoxicity. Chest 2003; 123: 102-106
9. van Hest R, Baars H, Kik S, van Gerven P, Trompenaars MC, Kalisvaart N, Keizer S, Borgdorff M, Mensen M, Cobelens F. Hepatotoxicity of rifampin-pyrazinamide and isoniazid preventive therapy and tuberculosis treatment. Clin Infect Dis 2004; 39: 488-496
10. Younossian AB, Rochat T, Ketterer JP, Wacker J, Janssens JP. High hepatotoxicity of pyrazinamide and ethambutol for treatment of latent tuberculosis. Eur Respir J 2005; 26: 462-464
11. Tasduq SA, Singh K, Satti NK, Gupta DK, Suri KA, Johri RK. Terminalia chebula (fruit) prevents liver toxicity caused by sub-chronic administration of rifampicin, isoniazid and pyrazinamide in combination. Hum Exp Toxicol 2006; 25: 111-118
12. Tasduq SA, Kaisar P, Gupta DK, Kapahi BK, Maheshwari HS, Jyotsna S, Johri RK. Protective effect of a 50% hydroalcoholic fruit extract of Emblica officinalis against anti-tuberculosis drugs induced liver toxicity. Phytother Res 2005; 19: 193-197
13. Pal R, Vaiphei K, Sikander A, Singh K, Rana SV. Effect of garlic on isortiazid and rifampicin-induced hepatic injury in rats. World J Gastroenterol 2006; 12: 636-639
14. Ron Banks. The guinea pig biology, care, identification, nomenclature, breeding and genetics. USA MRIID Seminar Series; 1989 17-Feb
15. Kohli K, Ali J, Ansari MJ, Raheman Z. Curcumin: A natural anti-inflammatory agent. Indian J Pharmacol 2004; 37: 141-147
16. Rege NN, Thatte UM, Dahanukar SA. Adaptogenic properties of six rasayana herbs used in Ayurvedic medicine. Phytother Res 1999; 13: 275-291
17. Archana R, Namasivayam A. Effect of Ocimum sanctum on noise induced changes in neutrophil functions. J Ethnopharmacol 2000; 73: 81-85
18. Bhargava KP, Singh N. Anti-stress activity of Ocimum sanctum Linn. Indian J Med Res 1981; 73: 443-451
19. Godhwani S, Godhwani JL, Vyas DS. Ocimum sanctum: an experimental study evaluating its anti-inflammatory, analgesic and antipyretic activity in animals. J Ethnopharmacol 1987; 21: 153-163
20. Samson J, Sheela Devi R, Ravindran R, Senthilvelan M. Biogenic amine changes in brain regions and attenuating action of Ocimum sanctum in noise exposure. Pharmacol Biochem Behav 2006; 83: 67-75
21. Kapil A, Sharma S. Immunopotentiating compounds from Tinospora cordifolia. J Ethnopharmacol 1997; 58: 89-95
22. Lee SM, Park JG, Lee YH, Lee CG, Min BS, Kim JH, Lee HK. Anti-complementary activity of triterpenoides from fruits of Zizyphus jujuba. Biol Pharm Bull 2004; 27: 1883-1886
23. Dahiru D, William ET, Nadro MS. Protective effect of Zizyphus mauritiana leaf extract on carbon tetrachloride induced liver injury. African J Biotech 2005; 4: 1177-1179
24. Fernandez-Villar A, Sopena B, Fernandez-Villar J, Vazquez- Gallardo R, Ulloa F, Leiro V, Mosteiro M, Pineiro L. The influence of risk factors on the severity of anti-tuberculosis drug-induced hepatotoxicity. Int J Tuberc Lung Dis 2004; 8: 1499-1505
25. Harris I. Euthanasia of animals used for scientific purposes. 2nd ed. Reilly JS, editor. ANZCCART Adelaide (SA): Section 4 Guinea pigs, 2001: 37-40
26. Jendrassik L, Grof P. Vereinfachte photometrische methode zur bestimmung des blutbilurubins. Biochem Z 1938; 297: 81-89
27. Moss DW, Henderson AK. Clinical Enzymology. In: Burtis CA, Ashwood ER. Tietz textbook of clinical chemistry. Philadelphia: W.B.Saunders, 1994: 617-721
28. Boyum A. Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand J Clin Lab Invest Suppl 1968; 97: 77-89
29. Lehrer RI, Cline MJ. Interaction of Candida albicans with human leukocytes and serum. J Bacteriol 1969; 98: 996-1004
30. Chenoweth DE, Rowe JG, Hugli TE. A modified method for chemotaxis under agarose. J Immunol Methods 1979; 25: 337-353
31. Rej R. Aminotransferases in disease. Clin Lab Med 1989; 9: 667-687
32. Edward J C. Comparative biology of test species. Environ Heal perspecti 1988; 77: 55-62
33. Attri S, Rana SV, Vaiphei K, Sodhi CP, Katyal R, Goel RC, Nain CK, Singh K. Isoniazid- and rifampicin-induced oxidative hepatic injury-protection by N-acetylcysteine. Hum Exp Toxicol 2000; 19: 517-522
34. Richards VE, Chau B, White MR, McQueen CA. Hepatic gene expression and lipid homeostasis in C57BL/6 mice exposed to hydrazine or acetylhydrazine. Toxicol Sci 2004; 82: 318-332
35. Karthikeyan S. Isoniazid and rifampicin treatment on phospholipids and their subfractions in liver tissue of rabbits. Drug Chem Toxicol 2005; 28: 273-280
36. Chowdhury A, Santra A, Bhattacharjee K, Ghatak S, Saha DR, Dhali GK. Mitochondrial oxidative stress and permeability transition in isoniazid and rifampicin induced liver injury in mice. J Hepatol 2006; 45: 117-126
37. Yue J, Peng RX, Yang J, Kong R, Liu J. CYP2E1 mediated isoniazid-induced hepatotoxicity in rats. Acta Pharmacol Sin 2004; 25: 699-704
38. Okuyan B, Izzettin FV, Sancar M, Ertas O, Cevikbas A, Gurer US. Effect of antituberculous drugs on human polymorphonuclear leukocyte functions in vitro. Int Immunopharmacol 2005; 5: 1337-1342
39. Hoger PH, Vosbeck K, Seger R, Hitzig WH. Uptake, intracellular activity, and influence of rifampin on normal function of polymorphonuclear leukocytes. Antimicrob Agents Chemother 1985; 28: 667-674
40. van Zyl JM, Basson K, Uebel RA, van der Walt BJ. Isoniazid-mediated irreversible inhibition of the myeloperoxidase antimicrobial system of the human neutrophil and the effect of thyronines. Biochem Pharmacol 1989; 38: 2363-2373
41. Dhuley JN. Hepatoprotective effect of rhinax on antitubercular drug-induced hepato-toxicity in rats. Hindustan Antibiot Bull 2002; 44: 53-59
42. Vijaya P, Suja V, Shyamladevi C S, Prema. Hepatoprotective effect of liv-52 on antitubercular drug induced hepatotoxicity in rats. Fitoterapia 1998; 6: 520
43. Skakun NP, Slivka IuI. The correction of the hepatotoxicity of antitubercular preparations with tocopherol acetate and riboxin. Eksp Klin Farmakol 1992; 55: 52-54
44. Wallach J B. Interpretation of diagnostic tests. 6th ed. Boston: Little, Brown and Company, 1996: 55
45. Srivastava R. Inhibition of neutrophil response by curcumin. Agents Actions 1989; 28: 298-303
46. Song EK, Cho H, Kim JS, Kim NY, An NH, Kim JA, Lee SH, Kim YC. Diarylheptanoids with free radical scavenging and hepatoprotective activity in vitro from Curcuma longa. Planta Med 2001; 67: 876-877
47. Lukita-Atmadja W, Ito Y, Baker GL, McCuskey RS. Effect of curcuminoids as anti-inflammatory agents on the hepatic microvascular response to endotoxin. Shock 2002; 17: 399-403
48. Reddy AC, Lokesh BR. Studies on spice principles as antioxidants in the inhibition of lipid peroxidation of rat liver microsomes. Mol Cell Biochem 1992; 111: 117-124
49. Panda S, Kar A. Ocimum sanctum leaf extract in the regulation of thyroid function in the male mouse. Pharmacol Res 1998; 38: 107-110
50. Mizutani T, Satoh K, Nomura H. Hepatotoxicity of eugenol and related compounds in mice depleted of glutathione: structural requirements for toxic potency. Res Commun Chem Pathol Pharmacol 1991; 73: 87-95
51. Jadhav H R, Singh A, Bhutani K K. Rationale for immunomodulatory and antiinflammatory effects of Ocimum sanctum: Radical scavenging potential and effect on nitric oxide production. In: Franz C, Mathe A, Craker LE, Gardened ZE, editors. III WOCMAP Congress on medicinal and aromatic plants-Volume 4: Targeted screening of medicinal and aromatic plants, economics and law 2005. Thailand: ISHS Acta Horticulturae 2005; 678: 159-162
52. Singh RP, Banerjee S, Kumar PV, Raveesha KA, Rao AR. Tinospora cordifolia induces enzymes of carcinogen/drug metabolism and antioxidant system, and inhibits lipid peroxidation in mice. Phytomedicine 2006; 13: 74-84
53. Desai VR, Kamat J P, Sainis K B. An immunomodulator from Tinospora cordifolia with antioxidant activity in cell free systems. Proc Indian Acad Sci (chem Sci) 2002; 114: 713-719
54. Oka H, Yamamoto S, Kuroki T, Harihara S, Marumo T, Kim SR, Monna T, Kobayashi K, Tango T. Prospective study of chemoprevention of hepatocellular carcinoma with Sho-saikoto (TJ-9). Cancer 1995; 76: 743-749
55. Richards VE, Chau B, White MR, McQueen CA. Hepatic gene expression and lipid homeostasis in C57BL/6 mice exposed to hydrazine or acetylhydrazine. Toxicol Sci 2004; 82: 318-322