Pharmacological actions of curcumin in liver diseases or damage

Liver International

Volumn 29, Issue 10, 2009, Pages 1457-1466

  Rivera Espinoza, Yadira ^a   Muriel, Pablo ^b  

^a Instituto Polité cnico Nacional   (Mexico)

^b DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

Anti oxidants; Cirrhosis; Curcuma longa; Curcumin; Cytokines; Fibrosis; Liver damage; NF B

Indexed keywords

ALANINE AMINOTRANSFERASE; ALCOHOL; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; CURCUMA LONGA EXTRACT; CURCUMIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IRON; LACTATE DEHYDROGENASE; LIPID PEROXIDE; THIOACETAMIDE; TRANSFORMING GROWTH FACTOR BETA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIARY CIRRHOSIS; BOTANY; CHOLESTASIS; CLINICAL TRIAL; DRUG PROTEIN BINDING; DRUG SAFETY; HEPATITIS; HUMAN; INFLAMMATION; LACTATE DEHYDROGENASE BLOOD LEVEL; LIPID PEROXIDATION; LIVER CIRRHOSIS; LIVER DISEASE; LIVER FIBROSIS; LIVER NECROSIS; LIVER PROTECTION; LIVER TOXICITY; NONHUMAN; OXIDATIVE STRESS; REVIEW;

EID: 73349116573     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2009.02086.x     Document Type: Review

References (96)

1. Strimpakos AS, Sharma R.A. Curcumin: preventive and therapeutic properties in laboratory studies and clinical trials. Antioxid Redox Signal 2008; 10: 511-45.
2. Goel A, Jhurani S, Aggarwal B.B. Multi-targeted therapy by curcumin: how spicy is it? Mol Nutr Food Res 2008; 52: 1010-3.
3. Goel A, Kunnumakkara AB, Aggarwal B.B. Curcumin as ''Curecumin'': from kitchen to clinic. Biochem Pharmacol 2008; 75: 787-809.
4. Sreejayan N, Rao M.N. Free radical scavenging activity of curcuminoids. Arzneimittelforschung 1996; 46: 169-71.
5. Ahsan H, Parveen N, Khan NU, Hadi S.M. Pro-oxidant, anti-oxidant and cleavage activities on DNA of curcumin and its derivative demethoxycurcumin and bisdemethoxycurcumin. Chem Biol Interact 1998; 121: 161-75.
6. Syu WJ, Shen CC, Don MJ, et al. Cytotoxicity of curcuminoids and some novel compounds from Curcuma zedoaria. J Nat Prod 1998; 61: 1531-4.
7. Aggarwal BB, Sundaram C, Malani M, Ichikawa H. Curcumin: the Indian solid gold. Adv Exp Med Biol 2007; 595: 1-75.
8. Sreejayan N, Rao M.N. Nitric oxide scavenging by curcuminoids. J Pharm Pharmacol 1997; 49: 105-7.
9. Huang MT, Lou YR, Xie JG, et al. Effect of dietary curcumin and dibenzoylmethane on formation of 7,12-dimethylbenz[a]anthracene-induced mammary tumors and lymphomas/leukemias in Sencar mice. Carcinogenesis 1998; 19: 1697-700.
10. Ploto A. Turmeric: Post-Production Management for Improved Market Access for Herbs and Spices - Turmeric. Rome: Food and Agriculture Organization of the United Nations (FAO), 2003.
11. NCI. Clinical development plan: curcumin. J Cell Biochem 1996; 26S: 72-85.
12. Shankar TN, Shantha NV, Ramesh HP, et al. Toxicity studies on turmeric (Curcuma longa): acute toxicity studies in rats, guinea pigs and monkeys. Indian J Exp Biol 1980; 18: 73-5.
13. Qureshi S, Shah AH, Ageel A.M. Toxicity studies on Alpinia galangal and Curcuma longa. Planta Med 1992; 58: 124-7.
14. Lao CD, Ruffin MT, Normolle D, et al. Dose escalation of a curcuminoid formulation. BMC Complement Altern Med 2006; 6: 10-3.
15. Romiti N, Tongiani R, Cervelli F, Chieli E. Effects of curcumin on P-glycoprotein in primary cultures of rat hepatocytes. Life Sci 1998; 62: 2349-58.
16. Anuchapreda S, Leechanachai P, Smith MM, et al. Modulation of P-glycoprotein expression and function by curcumin in multidrug-resistant human KB cells. Biochem Pharmacol 2002; 64: 573-82.
17. Wortelboer HM, Usta M, Van der Velde AE, et al. Interplay between MRP inhibition and metabolism of MRP inhibitors: the case of curcumin. Chem Res Toxicol 2003; 16: 1642-51.
18. Iersel ML, Ploemen JP, Struik I, et al. Inhibition of glutathione-S-transferase activity in human melanoma cells by alpha, beta-unsaturated carbonyl derivatives. Effects of acrolein, cinnamaldehyde, citral, crotonaldehyde, curcumin ethacrynic acid, and trans-2-hexenal. Chem Biol Interact 1996; 102: 117-32.
19. Logan-Smith MJ, Lockyer PJ, East JM, Lee A.G. Curcumin, a molecule that inhibits the Ca21-ATPase of sarcoplasmic reticulum but increases the rate of accumulation of Ca21. J Biol Chem 2001; 276: 46905-11.
20. Bilmen JG, Khan SZ, Javed M.H. Inhibition of the SERCA Ca21 pumps by curcumin. Curcumin putatively stabilizes the interaction between the nucleotide-binding and phosphorylation domains in the absence of A.T.P. Eur J Biochem 2001; 268: 6318-27.
21. Zsila F, Bikadi Z, Simonyi M. Induced circular dichroism spectra reveal binding of the antiinflammatory curcumin to human alpha1-acid glycoprotein. Bioorg Med Chem 2004; 12: 3239-45.
22. Yang F, Lim GP, Begum AN, et al. Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo. J Biol Chem 2005; 280: 5892-901.
23. Shim JS, Kim JH, Cho HY, et al. Irreversible inhibition of CD13/aminopeptidase N by the antiangiogenic agent curcumin. Chem Biol 2003; 10: 695-704.
24. Skrzypczak-Jankun E, Zhou K, McCabe NP, et al. Structure of curcumin in complex with lipoxygenase and its significance in cancer. Int J Mol Med 2003; 12: 17-24.
25. Began G, Sudharshan E, Appu Rao A.G. Inhibition of lipoxygenase 1 by phosphatidylcholine micelles-bound curcumin. Lipids 1998; 33: 1223-8.
26. Shishodia S, Singh T, Chaturvedi M.M. Modulation of transcription factors by curcumin. Adv Exp Med Biol 2007; 595: 127-48.
27. Bosetti C, Levi F, Lucchini F, et al. Worldwide mortality from cirrhosis: an update to 2002. J Hepatol 2007; 46: 827-39.
28. Briton RS, Bacon BR, Recknagel R.O. Lipid peroxidation and associated hepatic organelle dysfunction in iron overload. Chem Physiol Lipids 1987; 45: 207-39.
29. Weintraub LR, Gorel A, Grasso J, et al. Pathogenesis of hepatic fibrosis in experimental iron overload. Br J Haematol 1985; 59: 321-3.
30. Deugnier Y, Brissot P, Loréal O. Iron and the liver: update 2008. J Hepatol 2008; 48: S113-23.
31. Reddy ACP, Lokesh B.R. Alterations in lipid peroxides in rat liver by dietary n-3 fatty acids: modulation of antioxidant enzymes by curcumin, eugenol, and vitamin E. J Nutr Biochem 1994; 5: 181-8.
32. Reddy ACP, Lokesh B.R. Studies on the inhibitory effects of curcumin and eugenol on the formation of reactive oxygen species and the oxidation of ferrous iron. Mol Cell Biochem 1994; 137: 1-8.
33. Girotti AW, Thomas J.P. Damaging effects of oxygen radicals on resealed erythrocyte ghosts. J Biol Chem 1984; 259: 1744-52.
34. Reddy PACh, Lokesh B.R. Effect of curcumin and eugenol on iron-induced hepatic toxicity in rats. Toxicology 1996; 107: 39-45.
35. Singh S, Aggarwal B.B. Activation of transcription factor NF-kB is suppressed by curcumin (diferuloylmethane). J Biol Chem 1995; 270: 24995-5000.
36. Messner D, Sivam G, Kowdley K.V. Curcumin reduces the toxic effects of iron loading in rat liver epithelial cells. Liver Int 2009; 29: 63-73.
37. Rajakrishnan V, Viswanathan P, Rajashekaran KN, Menon V.P. Neuroprotective role of curcumin from Curcuma longa on ethanol-induced brain damage. Phytother Res 1999; 13: 571-4.
38. Clemens MR, Kessler W, Schied HW, et al. Plasma and red cell lipids in alcoholics with macrocytosis. Clin Chim Acta 1986; 156: 321-8.
39. Horrobin D.F. Essential fatty acids, prostaglandins and alcoholism: an overview. Alcoholism: Clin Exp Res 1987; 11: 2-9.
40. Morimoto M, Hagbjork AL, Wan YJY, et al. Modulation of experimental alcohol-induced liver disease by cytochrome P450E1 inhibitors. Hepatology 1995; 21: 1610-7.
41. Lambeau G, Gelb M.H. Biochemistry and physiology of mammalian secreted phospholipase A2. Ann Rev Biochem 2008; 77: 495-520.
42. Harizi H, Corcuff JB, Gualde N. Arachidonic-acid-derived eicosanoids: roles in biology and immunopathology. Trends Mol Med 2008; 14: 461-9.
43. Zheng Z, Barki AI, Hungund B.L. Effects of ethanol on the incorporation of free fatty acids into cerebral membrane phospholipids. Neurochem Int 1996; 28: 551-5.
44. Hugund BL, Zheng Z, Lin L, Barkai A.I. Ganglioside GMI reduces ethanol induced phospholipase A2 activity in synaptosomal preparations from mice. Neurochem Intern 1994; 25: 321-5.
45. Holtzmann M.J. Arachidonic acid metabolism. Am Rev Resp Dis 1991; 143: 188-203.
46. Rajakrishnan V, Jayadeep A, Arun OS, et al. Changes in the prostaglandin levels in alcohol toxicity: effect of curcumin and N-acetylcysteine. J Nutr Biochem 2000; 11: 509-14.
47. Aggarwal BB, Takada Y, Oommen O.V. From chemoprevention to chemotherapy: common targets and common goals. Exp Opin Investig Drugs 2004; 13: 1327-38.
48. Nanji AA, Zakim D, Rahematulla A, et al. Dietary saturated fatty acids down-regulate cycloxygenase-2 and tumor necrosis factor alpha and reverse fibrosis in alcoholinduced liver disease in the rat. Hepatology 1997; 26: 1538-45.
49. Rao CV, Simi B, Reddy B.S. Inhibition by dietary curcumin of azoxymethane-induced ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt foci formation in the rat colon. Carcinogenesis 1993; 14: 2219-25.
50. Huang MT, Lysz T, Ferraro T, et al. Inhibitory effects of curcumin on in vitro lipoxygenase and cycloxygenase activities in mouse epidermis. Cancer Res 1991; 51: 813-9.
51. Lee W.L. Drug-induced hepatotoxicity. N Engl J Med 2003; 349: 474-85.
52. O'Grady J, Schalman SW, Williams R. Acute liver failure: redefining the syndrome. Lancet 1993; 324: 273-5.
53. Bruck R, Aeed H, Avni Y, et al. Melatonin inhibits nuclear factor kappa B activation and oxidative stress and protects against thioacetamide induced liver damage in rats. J Hepatol 2004; 40: 86-93.
54. Abul H, Mathew TC, Dashti HM, Al-Bader A. Level of superoxide dismutase, glutathione peroxidase and uric acid in thioacetamide-induced cirrhotic rats. Anat Histol Embryol 2002; 31: 66-71.
55. Sun F, Hayami S, Origiri Y, et al. Evaluation of oxidative stress based on lipid hydroperoxide, vitamin C and vitamin E during apoptosis and necrosis caused by thioacetamide in rat liver. Biochim Biophys Acta 2000; 1500: 181-5.
56. Lu SC, Huang ZZ, Yang H, Tsukamoto H. Effect of thioacetamide on the hepatic expression of gamma-glutamylcysteine synthetase subunits in the rat. Toxicol Appl Pharmacol 1999; 159: 161-8.
57. Rahman TM, Hodgson H.J. The effect of early and late administration of inhibitors of inducible nitric oxide synthase in a thioacetamide-induced model of acute hepatic failure in the rat. J Hepatol 2003; 38: 583-90.
58. Miquel J, Bernd A, Sempere JM, et al. The curcuma antioxidants: pharmacological effects and prospects for future clinical use. A review. Arch Gerontol Geriatr 2002; 34: 37-46.
59. Das KC, Das C.K. Curcumin (diferuloylmethane), a singlet oxygen ((1)O(2)) quencher. Biochem Biophys Res Commun 2002; 295: 62-6.
60. Ak T, Gülçin I. Antioxidant and radical scavenging properties of curcumin. Chem Biol Interact 2008; 174: 27-37.
61. Brouet I, Ohshima H. Curcumin, an anti-tumor promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages. Biochem Biophys Res Comm 1995; 206: 533-40.
62. Kim JE, Kim AR, Chung HY, et al. In vitro peroxynitrite scavenging activity of diarylheptanoids from Curcuma longa. Phytother Res 2003; 17: 481-4.
63. Iqbal M, Sharma SD, Okazaki Y, et al. Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddY male mice: possible role in protection against chemical carcinogenesis and toxicity. Pharmacol Toxicol 2003; 92: 33-8.
64. Motterlini R, Foresti R, Bassi R, Green C.J. Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress. Free Rad Biol Med 2000; 28: 1303-12.
65. Nanji AA, Jokelainen K, Jokelainen K, et al. Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-kappa B-dependent genes. Am J Physiol Gastrointest Liver Physiol 2003; 284: G321-7.
66. Shapiro H, Ashkenazi M, Weizman N, et al. Curcumin ameliorates acute thioacetamide-induced hepatotoxicity. J Gastroenterol Hepatol 2006; 21: 358-66.
67. Chainani-Wu N. Safety and anti-inflammatory activity of curcumin: a component of turmeric (Curcuma longa). J Alter Comp Med 2003; 9: 161-8.
68. Bruck R, Ashkenazi M, Weiss S, et al. Prevention of liver cirrhosis in rats by curcumin. Liver Int 2007; 27: 373-8.
69. Hunter AL, Holscher MA, Neal R.A. Thioacetamide-induced hepatic necrosis. I. Involvement of the mixed-function oxidase enzyme system. J Pharmacol Exp Ther 1977; 200: 439-48.
70. Bruck R, Shirin H, Aeed H, et al. Prevention of hepatic cirrhosis in rats by hydroxyl radical scavengers. J Hepatol 2001; 35: 457-64.
71. Muriel P. NF-kappaB in liver diseases: a target for drug therapy. J Appl Toxicol 2009; 29: 91-100.
72. Bruck R, Aeed H, Schey R, et al. Pyrrolidine dithiocarbamate protects against thioacetamide-induced fulminant hepatic failure in rats. J Hepatol 2002; 36: 370-7.
73. Muriel P. Some experimental models of liver damage. In: Sahu SC, ed. Hepatotoxicity: From Genomics to In Vitro and In Vivo Models. Chichester: Wiley, 2007a; 119-37.
74. Muriel P. Cytokines in liver diseases. In: Sahu SC, ed. Hepatotoxicity: From Genomics to In Vitro and In Vivo Models. Chichester: Wiley, 2007b; 371-89.
75. Friedman S.L. Mechanisms of disease: mechanisms of hepatic fibrosis and therapeutic implications. Nat Clin Pract Gastroenterol Hepatol 2004; 1: 98-105.
76. Pinzani M, Marra F, Carloni V. Signal transduction in hepatic stellate cells. Liver 1998; 18: 2-13.
77. Gressner AM, Weiskirchen R. Modern pathogenic concepts of liver fibrosis suggest stellate cells and TGF-b as major players and therapeutic targets. J CellMolMed 2006; 10: 76-99.
78. Punithavathi D, Venkatesan N, Babu M. Protective effects of curcumin against amiodarone-induced pulmonary fibrosis in rats. Br J Pharmacol 2003; 139: 1342-50.
79. Gaedeke J, Noble AN, BorderWA. Curcumin blocks multiple sites of the TGF-b signaling cascade in renal cells. Kidney Int 2004; 66: 112-20.
80. Reyes-Gordillo K, Segovia J, Shibayama M, et al. Curcumin prevents and reverses cirrhosis induced by bile duct obstruction or CCl4 in rats: role of TGF-b modulation and oxidative stress. Fund Clin Pharmacol 2008; 22: 417-27.
81. Simpson KJ, Lukacs NW, Colleti L, et al. Cytokines and the liver. J Hepatol 1997; 27: 1120-32.
82. Weber LW, Boll M, Stampfl A. Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Crit Rev Toxicol 2003; 33: 105-36.
83. Maheswari RK, Singh AK, Gaddipati J, Srimal R.C. Multiple biological activities of curcumin: a short review. Life Sci 2006; 78: 2081-7.
84. Park EJ, Jeon CH, Ko G, et al. Protective effect of curcumin in rat liver injury induced by carbon tetrachloride. J Pharm Pharmacol 2000; 52: 437-40.
85. Reyes-Gordillo K, Segovia J, Shibayama M, et al. Curcumin protects against acute liver damage in the rat by inhibiting NF-kB, proinflammatory cytokines production and oxidative stress. Biochim Biophys Acta 2007; 1770: 989-96.
86. Abe Y, Hashimoto S, Horie T. Curcumin inhibition of inflammatory cytokine production by human peripherals blood monocytes and alveolar macrophages. Pharmacol Res 1999; 39: 41-7.
87. Chavez E., Alcantar LK, Moreno MG, Muriel P. Gadolinium chloride inhibits the spontaneous resolution of fibrosis in CCl4-induced cirrhosis. Toxicol Mech Meths 2006; 16: 507-13.
88. Muriel P, Moreno MG, Hernández MC, et al. Resolution of liver fibrosis in chronic CCl4 administration in the rat after discontinuation of treatment: effect of silymarin, silibinin, colchicine and trimethylcolchicinic acid. Basic Clin Pharmacol Toxicol 2005; 96: 375-80.
89. Kowluru AR, Kanwar M. Effects of curcumin on retinal oxidative stress and inflammation in diabetes. Nutr Metabolism 2007; 4: 1-8.
90. Muriel P. Peroxidation of lipids and liver damage. In: Baskin SI, Salem H, eds. Oxidants Antioxidants and Free Radicals. Washington, DC: Taylor and Francis, 1997; 237-57.
91. Pari L, Murugan P. Effect of tetrahydrocurcumin on blood glucose, plasma insulin and hepatic key enzymes in streptozotocin induced diabetic rats. J Basic Clin Physiol Pharmacol 2005; 16: 257-74.
92. Hironaka K, Sakaida I, Matsumura Y, et al. Enhanced interstitial collagenase (matrix metalloproteinase-13) production of Kupffer cells by gadolinium chloride prevents pig serum-induced rat liver fibrosis. Biochem Biophys Res Commun 2000; 267: 290-5.
93. Sakaida I, Hironaka K, Terai S, Okita K. Gadolinium chloride reverses dimethylnitrosamine (DMN)-induced rat liver fibrosis with increased matrix metalloproteinases (MMPs) of Kupffer cells. Life Sci 2003; 72: 943-59.
94. Swarnakar S, Ganguly K, Kundu P, et al. Curcumin regulates expression and activity of matrix metalloproteinases 9 and 2 during prevention and healing of indomethacin-induced gastric ulcer. J Biol Chem 2005; 280: 9409-15.
95. Hozumi A, Nishimura Y, Nishiuma T, et al. Induction of MMP-9 in normal human bronchial epithelial cells by TNF-alpha via NF-kappa B-mediated pathway. Am J Physiol Lung Cell Mol Physiol 2001; 281: 1444-52.
96. Kang HC, Nan JX, Park PH, et al. Curcumin inhibits collagen synthesis and hepatic stellate cell activation invivo and in-vitro. J Pharm Pharmacol 2002; 54: 119-26