Effects of embelin on lipid peroxidation and free radical scavenging activity against liver damage in rats

Basic and Clinical Pharmacology and Toxicology

Volumn 105, Issue 4, 2009, Pages 243-248

  Singh, Dharmendra ^a   Singh, Ruchi ^a   Singh, Pahup ^a   Gupta, Radhey S ^a  

^a UNIVERSITY OF RAJASTHAN   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CARBON TETRACHLORIDE; CATALASE; EMBELIN; FREE RADICAL; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; LACTATE DEHYDROGENASE; SILYMARIN; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BILIRUBIN BLOOD LEVEL; BLOOD SAMPLING; CONTROLLED STUDY; DRUG INTOXICATION; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME ASSAY; LIPID PEROXIDATION; LIVER INJURY; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN CONTENT; RAT; TISSUE LEVEL; TISSUE SECTION;

ALANINE TRANSAMINASE; ALKALINE PHOSPHATASE; ANIMALS; BENZOQUINONES; CARBON TETRACHLORIDE; FREE RADICAL SCAVENGERS; GAMMA-GLUTAMYLTRANSFERASE; L-LACTATE DEHYDROGENASE; LIPID PEROXIDATION; LIVER; LIVER DISEASES; MALE; PLANT EXTRACTS; RATS; RATS, WISTAR; SEEDS; SILYMARIN;

EMBELIA RIBES; RATTUS; SILYBUM MARIANUM;

EID: 70349120250     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2009.00429.x     Document Type: Article

References (39)

1. Bast A. Diet and Free Radicals. In : Halliwell B, Aruoma OI (eds). Ellis Harwood, London, 1993 95 7.
2. Halliwell B. Free radical and food additives. In : Aruoma OI, Halliwell B (eds). Taylor and Francis, London, 1991 37 42.
3. Kamalakkannan N, Rukkumani R, Verma PS, Viswanathan P, Rajasekharan KN, Menon VP. Comparative effects of curcumin and an analogue of curcumin in carbon tetrachloride-induced hepatotoxicity in rats. Basic Clin Pharmcol Toxicol 2005 97 : 12 21.
4. 4-induced hepatotoxicity in rats. Indian J Exp Biol 2005 43 : 526 530.
5. Bhandari U, Kanojia R, Pillai KK. Effect of ethanolic extract of Embelia ribes on dyslipidemia in diabetic rats. Int J Exp Diabetes Res 2002 3 : 159 162.
6. Bhandari U, Jain N, Pillai KK. Further studies on antioxidant potential and protection of pancreatic beta-cells by Embelia ribes in experimental diabetes. Exp Diabetes Res 2007 15 : 1 6.
7. Kirtikar KR, Basu BD. Indian Medicinal Plants. In : Blatter E, Caius JF, Mhaskar KS (eds). Vol 6. Oriental Enterprises, Deheradun, 2001 2045 2048.
8. Chitra M, Sukumar E, Suja V, Devi CS. Antitumor, anti-inflammatory and analgesic property of emblin, a plant product. Chemotherapy 1994 40 : 109 113.
9. Xu M, Cui J, Fu H, Proksch P, Lin W, Li M. Embelin derivatives and their anticancer activity through microtubule disassembly. Planta Med 2005 71 : 944 948.
10. Sreepriya M, Bali G. Chemopreventive effects of embelin and curcumin against N-nitrosodiethylamine/phenobarbital-induced hepatocarcinogenesis in wistar rats. Fitoterapia 2005 76 : 549 555.
11. Joshi R, Kamat JP, Mukherjee T. Free radical scavenging reactions and antioxidant activity of embelin: Biochemical and radiolytic studies. Chem Biol Interact 2007 167 : 125 134.
12. Hao K, Ali M, Siddiqui AW. New compounds from the seeds of Embelia ribes Burm. Pharmazie 2005 60 : 69 71.
13. Marklund S, Marklund G. Involvement of superoxide anion radical in auto-oxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 1974 47 : 469 474.
14. Aebi H. Catalase in vitro. In : Colowick SP, Kaplan NO (eds). Methods in Enzymology. Vol 105. Academic Press. New York, 1984 121 126.
15. Moron MS, Depierre JW, Mannervick B. Levels of glutathione, glutathione reductase and glutathione-s-transferase activities in rat lung and liver. Biochem Biophys Acta 1979 582 : 67 78.
16. Paglia DE, Velentine WM. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967 70 : 158 169.
17. Habig WH, Pabst MJ, Jacoby WB. Glutathione-s-transferase-the first step in mercapturic acid formation. J Biol Chem 1974 249 : 7130 7139.
18. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxidation in animal tissue by thiobarbituric acid reaction. Anal Biochem 1979 95 : 351 353.
19. Schneider WC, Hogeboom GH. Intracellular distribution of enzymes. V. Further studies on the distribution of cytochrome c in rat liver homogenates. J Biol Chem 1950 183 : 123 128.
20. Omura T, Sato R. The carbon monoxide binding pigment of liver microsomes. J Biol Chem 1964 239 : 2370 2378.
21. Brent JA, Rumack BH. Role of free radicals in toxic hepatic injury II. Clin Toxicol 1993 31 : 173 196.
22. Weber LWD, Bull M, Stamsfl A. Hepatotoxicity and mechanism of action of haloalkans: carbon tetrachloride as a toxicological model. Crit Rev Toxicol 2003 33 : 105 136.
23. Gupta M, Mazumdar UK, Kumar RS, Sivakumar T, Gomathi P, Rajeshwar Y. Antioxidant defense system induced by a methanol extract of Caesalpinia bonducella in rat liver. Pharmaceuti Biol 2005 43 : 411 419.
24. Bassio E, Benelli C, Pirola O. Effect of the flavonolignans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes. Pharmacal Res 1992 25 : 147 154.
25. Mandal PK, Bishayee A, Chatterjee M. Stimulation of tissue repair by Mikania cordata root extract in carbon tetrachloride-induced liver injury in mice. Phytother Res 1993 7 : 103 105.
26. Allis JW, Brown BL, Simmons JE, Hatch GE, McDonald A, House DE. Methanol potentation of carbon tetrachloride hepatotoxicity: the central role of cytochrome P-450. Toxicology 1996 112 : 131 140.
27. Zanger RC, Benson JM, Burnett VL, Springer DL. Cytochrome P 450 2E1 is the primary enzyme responsible for low-dose carbon tetrachloride mechanism in human liver microsomes. Chemico-Biological Interaction 2000 125 : 233 243.
28. Brattin WJ, Glende EA Jr., Recknagel RO. Pathological mechanisms in carbon tetrachloride hepatotoxicity. Free Radic Biol Med 1985 1 : 27 38.
29. Raja S, Nazeer Ahamed KFH, Kumar V, Mukherjee K, Bandyopadhyay A, Mukherjee PK. Antioxidant effect of Cytisus scoparius against carbon tetrachloride treated liver injury in rats. J Ethnopharmacol 2007 109 : 41 7.
30. Aniya Y, Anders MW. Alternation in hepatic glutathione-s-transferase and release into serum after treatment with bromobenzene and carbon tetrachloride. Biochemical Pharmacol 1985 39 : 4239 4244.
31. Pari L, Kumar AN. Hepatoprotective activity of Moringa oleifera on antitubercular drug induced liver damage in rats. J Med Food 2002 5 : 171 177.
32. Recknagel RO, Glende EA Jr., Dolak JA, Waller RL. Mechanisms of carbon tetrachloride toxicity. Pharmacol Therap 1989 43 : 139 145.
33. Jain A, Soni M, Deb L, Jain A, Rout SP, Gupta VB et al. Antioxidant and hepatoprotective activity of ethanolic and aqueous extract of Momordica dioica Roxb. leaves. J Ethnopharmacol 2008 115 : 61 6.
34. Willianson EM, Okpako, DT, Evans FJ. Selection, Preparation and Pharmacological Evaluation of Plant Material. John Wiley, Chichester, UK, 1996.
35. Moss DW, Butterworth PJ. Enzymology and Medicine. Pitman Medical, London, 1974 139.
36. Venukumar MR, Latha MS. Effect of Coscinium fenestratum on hepatotoxicity in rats. Indian J Exp Biol 2004 42 : 792 797.
37. Manna S, Bhattacharyya D, Basak DK, Mandal TK. Single oral dose toxicity study of α-cypermethrin in rats. Indian J Pharmacal 2004 36 : 25 8.
38. Bishayee A, Sarkar A, Chatterjee M. Hepatoprotective activity of carrot (Daucus carota L.) against carbon tetrachloride intoxication in mouse liver. J Ethnopharmacol 1995 47 : 69 74.
39. Pessayre D, Larrey D, Brentano FC, Benhamon JP. Drug interaction and hepatitis produced by some macrolide antibiotics. J Antimicrob Chemother 1985 16 : 181 194.