Effects of administration of Embelin and Curcumin on lipid peroxidation, hepatic glutathione antioxidant defense and hematopoietic system during N-nitrosodiethylamine/Phenobarbital-induced hepatocarcinogenesis in Wistar rats

Molecular and Cellular Biochemistry

Volumn 284, Issue 1-2, 2006, Pages 49-55

  Sreepriya, Meenakshisundaram ^a   Bali, Geetha ^a  

^a BANGALORE UNIVERSITY   (India)

Author keywords

Antioxidants; DENA; Hematopoieticcells; Hepatocarcinogenesis; Phenobarbital

Indexed keywords

CURCUMIN; DIPHENYLNITROSAMINE; EMBELIN; GLUTATHIONE; PHENOBARBITAL; ANTINEOPLASTIC AGENT; ANTIOXIDANT; BENZOQUINONE DERIVATIVE; CARCINOGEN; DIETHYLNITROSAMINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CHROMATIN; CONTROLLED STUDY; CYTOTOXICITY; DEFENSE MECHANISM; HEMATOPOIETIC CELL; HISTOPATHOLOGY; LIPID PEROXIDATION; LIVER CANCER; LIVER CARCINOGENESIS; LIVER INJURY; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; RAT STRAIN; STATISTICAL SIGNIFICANCE; ANIMAL; BLOOD; BLOOD CELL COUNT; DRUG EFFECT; DRUG POTENTIATION; HEMATOPOIESIS; LIVER; LIVER TUMOR; METABOLISM; PATHOLOGY; WISTAR RAT;

RATTUS NORVEGICUS;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIOXIDANTS; BENZOQUINONES; BLOOD CELL COUNT; CARCINOGENS; CURCUMIN; DIETHYLNITROSAMINE; DRUG SYNERGISM; GLUTATHIONE; HEMATOPOIESIS; LIPID PEROXIDATION; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; MALE; OXIDATIVE STRESS; PHENOBARBITAL; RATS; RATS, WISTAR;

EID: 33745907263     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-005-9012-7     Document Type: Article

References (29)

1. Guner G, Islekel H, Oto O, Hazan E, Acikel V: Evaluation of some antioxidant enzymes in lung carcinoma tissues. Cancer Letters 103(2): 233-239, 1996
2. Halliwell B: Free radicals, antioxidants and human disease. Lancet 344(8924): 721-724, 1994
3. Mukhopadhyay S, Mandal A, Poddar KM: Chronic administration of caffeine: Effect on the activities of hepatic antioxidant enzymes of Ehrlich ascites tumor bearing mice.Indian J Exp Biol 41: 283-289, 2003
4. Park TJ, Kim HS, Byun KH, Jang JJ, Lee YS, Kim IK: Sequential changes in hepatocarcinogenesis induced by diethylnitrosamine plus thioacetamide in Fischer 344 rats: Induction of gankyrin expression in liver fibrosis, pRB degradation in cirrhosis and methylation of p16(1NK4A) exon in hepatocellular carcinoma. Mol Carcinog 30(3): 138-150, 2001
5. Loppen S, Schneider D, Gaunitz F, Liebhardt R, Kurek R, Buchmann A, Schwarz M: Cancer Res 62: 5685-5688, 2002
6. Indap MA, Barkume MS: Efficacies of plant phenolics on sodium butyrate induced anti-tumor activity. Indian J Exp Biol 41: 861-864, 2003
7. Yoshiji H, Nakae D, Kinugasa T, Matsuzaki M, Denda A, Tsujii T, Konishi Y: Inhibitory effect of dietary iron deficiency on the induction of putative preneoplastic foci in rat liver initiated with diethylnitrosamine and promoted by Phenobarbital. Br J Cancer 64: 839-842, 1991.
8. Raghuramulu N, Nair KM, Kalyanasundaram S: A Manual of Laboratory Techniques. In: Raghuramulu N, Nair KM (eds) NIN, ICMR, Hyderabad pp. 254-255
9. Huxtable KJ: Activation and pulmonary toxicity of pyrrolizadine alkaloids. Pharmacol Ther 47: 371-390, 1990
10. Dacie JV, Lewis SM: Practical Hematology. In: S.M. Lewis, B.J. Bain and I. Bates (eds). 8th edition, Edinburgh, Scotland, Churchill livingstone, 1995
11. Drabkin DL, Austin JH: Spectrophotometric studies, spectophotometric constants for common haemoglobin derivatives in human, dog, and rabbit blood. J Biol Chem 98: 719-733, 1932
12. Yagi K: Simple fluorimetric assay for lipid peroxides in blood plasma. Biochem Med 15: 212-215, 1976
13. Ohkawa H, Ohishi N, Yagi K: Assay of lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biocem 95: 351-358, 1979
14. Moron MS, Depierre JN, Mannervik B: Levels of glutathione, glutathione reductase, and glutathione-S-transferase activities in rat lung and liver. Biochim Biophys Acta 582(1): 67-78, 1979
15. Rotruck JT, Pop AL, Ganther HP, Swanson AB, Hafeman BG, Hoeksira WG: Selenium: Biochemical role as a component of glutathione peroxidase. Science 179: 588-590, 1973
16. Habig WH, Pabst MJ, Jakoby WB: Glutathione-S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem 249: 7130-7139, 1974
17. Wiseman H, Halliwell B: Damage to DNA by reactive oxygen and nitrogen species: Role in inflammatory disease and progression to cancer. Biochem J 313: 17-29, 1996
18. Bansal AK, Trivedi R, Soni GL, Bhatnagar D: Hepatic and renal oxidative stress in acute toxicity of N-nitrosodiethylamine in rats. Indian J Exp Biol 38(9): 916-920, 2000
19. Sreepriya M, Porckodi M, Devaki T, Nayeem M: Antioxidant effects of L- arginine against isoproterenol-induced myocardial stress in rats. Medical Science Research 26: 587-593, 1998
20. Karthikeyan J, Rani P: Enzymatic and non enzymatic antioxidants in selected piper species. Indian J Exp Biol 41: 135-140, 2003
21. Banakar MC, Paramasivam SK, Chattopadhyay MB, Datta S, Chakraborty P, Chatterjee M, Kannan K, Thyagarajan E: 1 alpha 25-dihydroxy vitamin D3 prevents DNA damage and restores antioxidant enzymes in rat hepatocarcinogenesis induced by diethylnitrosamine and promoted by Phenobarbital. World J Gastroenterol 10(9): 1268-1275, 2004
22. Rajeshkumar NV, Kuttan R: Inhibition of N-nitrosodiethylamine-induced hepatocarcinogenesis by Picroliv. I Exp Clin Cancer Res 19(4): 459-465, 2000
23. Razo H, Ahmed I, John A, Sharma AK: Modulation of xenebiotic metabolism and oxidative stress in chronic streptozotocin induced diabetic rats fed with Momondica Charantia fruit extract. J Biochem Mol Toxicol 3: 131-139, 2000
24. Miquel J, Bernd A, Sempere JM, Diaz-Alperi J, Ramirez A: The curcuma antioxidants: Pharmacological effects and prospects for future clinical use. A review.Arch Gerontol Geriatr 34(1): 37-46, 2002
25. Ammon AP, Wahl MA: Pharmacology of Curcuma longa. Planta Med 57: 1-7, 1991
26. Johri RK, Dhar SK, Pahwa GS, Sharma SC, Kaul JL, Zutshi V: Toxicity studies with potassium embelate, a new analgesic compound. Indian J Exp Biol 28(3): 213-217, 1990
27. Choudhuri T, Pal S, Agarwal ML, Das T, Sa G: Curcumin induces apoptosis in human breast cancer cells through p 53-dependent Bax induction. FEBS Lett 512: 334-340, 2002
28. Hofer-Warbinek R, Schmid JA, Stehlik C, Binder BR, Lipp J, deMartin R: Activation of NF kappa B by XIAP, the X-chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1. J Biol Chem 275: 22064-22068, 2000
29. Coleska N, Xu L, Hu Z, Tomita Y, Li P, Roller PP, Wang R, Fang X, Guo R, Zhang M, Lippman ME, Yang D, Wang S: Discovery of embelin as a cell permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database. J Med Chem 47(10): 2430-2440, 2004