Pharmacology and chemistry of a potent hepatoprotective compound Picroliv isolated from the roots and rhizomes of Picrorhiza kurroa Royle ex Benth. (Kutki)

Current Pharmaceutical Biotechnology

Volumn 10, Issue 6, 2009, Pages 641-649

  Verma, Praveen C ^a   Basu, Vaishali ^a   Gupta, Vijayta ^a   Saxena, Gauri ^b   Rahman, Laiq Ur ^c  

^a CSIR NATIONAL BOTANICAL RESEARCH INSTITUTE   (India)

^b UNIVERSITY OF LUCKNOW   (India)

^c CSIR CENTRAL INSTITUTE OF MEDICINAL AND AROMATIC PLANTS   (India)

Author keywords

Immunomodulator; Kutki; Kutkoside; Picroliv; Picrorhiza kurroa; Picroside I

Indexed keywords

APOCYANIN; KUTKIN; KUTKOSIDE; LIVER PROTECTIVE AGENT; PICROSIDE I; PICROSIDE II; SILYMARIN; UNCLASSIFIED DRUG;

ADJUVANT THERAPY; DOSE RESPONSE; DRUG ACTIVITY; DRUG DETERMINATION; DRUG ISOLATION; DRUG MECHANISM; DRUG MEGADOSE; DRUG STRUCTURE; DRUG SYNTHESIS; IMMUNOMODULATION; LEISHMANIASIS; LIVER DISEASE; LIVER INJURY; LIVER PROTECTION; NONHUMAN; PICRORHIZA KURROA; PLANT ROOT; QUANTITATIVE ANALYSIS; REVIEW; RHIZOME; STRUCTURE ACTIVITY RELATION; TESTIS INJURY; VIRUS HEPATITIS;

ANIMALS; CINNAMATES; GLYCOSIDES; HUMANS; LIVER; LIVER DISEASES; PICRORHIZA; PLANT EXTRACTS; PLANT ROOTS; VANILLIC ACID;

CAVIA; PICRORHIZA; PICRORHIZA KURROOA; RATTUS; RODENTIA;

EID: 71749116900     PISSN: 13892010     EISSN: 18734316     Source Type: Journal    
DOI: 10.2174/138920109789069314     Document Type: Review

References (97)

1. Khan, L.; Shafi, N.; Yunis, M. and Irfan, M. (1999) Hamd. Med., 42, 38.
2. Dhawan, BN. (1995) Picrorhiza kurroa, Med. Chem. Res., 5, 595.
3. Date, S.; Sakharkar, P. and Dhawan, B. (1999) Hamd. Med., 42, 22-25.
4. Handa, S.S.; Sharma, A. and Chakrabarti, K.K. (1986) Fitoterapia, 57, 307-351.
5. Gupta, P.P. (2001) Drugs Fut., 26, 25-31.
6. Satyavati, G.V.; Gupta, A.K. and Tandon, N. (1987) Med. Plants India (Indian Counc. Med. Res. New Delhi), 2, 423.
7. Subedi B.P. (2000) Himalayan Bioreso., 4, 14-15.
8. Dorsch, W.; Stuppner, H.; Wagner, H.; Gropp, M.; Demoulin, S. and Ring, J. (1991) Int. Arch. Allergy Appl. Immunol., 94, 262-265.
9. Anonymous (2001) Altern. Med. Rev., 6, 319-321.
10. Luper S. (1998) Altern. Med. Rev., 3, 410-421.
11. Girish, C. and Pradhan, S.C. (2008). Fund.Clin. Pharmacol., 22, 623-632.
12. Singh, B. and Rastogi, R.P. (1972) Ind. J. Chem., 10, 29-31.
13. Langer, J.G.; Gupta, O.P. and Atal, C.K. (1981) Ind. J. Pharmacol., 13, 98.
14. Ansari, R.A.; Aswal, B.S. and Chander, R. (1988) Ind. J. Med. Res., 87, 401-404.
15. Visen, P.K.S.; Shukla, B.; Patnaik, G.K. and Dhawan, B.N. (1993) Planta Med., 59, 37-41.
16. Singh, G.B.; Bani, S.; Singh, S.; Khjuria, A.; Sharma L,; Gupta, B.D. and Banerjee, S.K. (1993) Phytotherapy Res., 7, 402-407.
17. Vohora, S.B.; Kumar, I.; Naqvi, S.A.H. and Afaq, S.H. (1972) Ind. J. Pharmacol., 34, 17.
18. Atal, C.K.; Sharma, M.L.; Kaul, A. and Khajuria, A. (1986) J. Ethnopharmacol., 18, 133-141.
19. Sharma, M.L.; Rao, C.S. and Duda, P.I. (1994) J. Elhnopharmacol., 41, 185-192.
20. Puri, A.; Saxena, R.P.; Sumali Guru, P.Y.; Kulshreshtha, D.K.; Saxena, K.C. and Dhawan, B.N. (1992) Planta Med., 58, 528-532.
21. Khajuria, A.; Gupta, A.; Singh, S.; Malik, F.; Singh, J.; Suri, K.A.; Satti, N.K.; Qazi, G.N.; Srinivas, V.K.; Gopinathan and Ella K. (2007) Vaccine, 25, 2706-2715.
22. Gupta, A.; Khajuria, A.; Singh, J.; Bedi.; Satti, N.K.; Prabhu, D.; Suri, K.A.; Suri, O.P. and Qazi, G.N. (2006) Int. Immunopharmacol., 6, 1543-1549.
23. Yadav, N. and Khandelwal, S. (2008) Food Chem. Toxicol., 46, 494-501.
24. Khanna, A.K.; Chander, R.; Kapoor, N.K. and Dhar, B.N. (1994) Phytother. Res., 8, 403.
25. Tandon, S.; Rastogi, R.; Shukla, R.; Kapoor, N.K.; Srimal, R.C. and Dhawan, B.N. (1995) Med. Sci. Res., 23, 515.
26. Dorsch, W.; Stuppner, H. and Wagner, H. (1991) Int. Arch. Allergy Appl. Immunol., 95, 128-131.
27. Doshi, V.B.; Shetye, V.M. and Mahashur, A.A. (1983) J. Postgrad. Med., 29, 89-95.
28. Antarkar, D.S.; Vaidya, A.B.; Doshi, J.C.; Athavale, A.V.; Vinchoo, K.S.; Natekar, M.R.; Tathed, P.S.; Ramesh, V. and Kale, N. (1980) Indian J. Med. Res., 72, 588.
29. Yegnarayan, R.; Dange, S.V.; Vaidya, S.D. and Balwani, J.H. (1982) Bombay Hosp. J., 24, 81.
30. Gupta, P.P.; Srimal, R.C. and Tandon, J.S. (1993) Int. J. Pharmacogn., 31, 15-18.
31. Thomas, M.; Sheran, J.; Smith, N.; Fonseca, S. and Lee, A.J. (2007) BMC Pulmonary Med., 7, 4-14.
32. Baruah, C.C.; Gupta, P.P.; Nath, A.; Patnaik, G.K. and Dhawan, B.N. (1998) Pharmacol. Res., 38, 487-492.
33. Ram, V.J. (2001) Drugs News Perspect., 14, 353-356.
34. Dhuley, J.N. (2005-2006) Hindustan Antibiot. Bull, 13-19.
35. Sultana, S. and Rahman, S. (2007) J. Environ. Pathol. Toxicol. Oncol., 26, 195-205.
36. Dwivedi, Y.; Rastogi, R. and Chander, R. (1990) Ind. J. Med. Res., 92, 195-200.
37. Mogre, K.; Vara, K.K. and Seth, U.K. (1981) Ind. J. Pharmacal., 13, 253.
38. Chander, R.; Kapoor, N.K. and Dhawan, B.N. (1992) Ind. J. Exp. Biol., 30, 711-714.
39. Recknagel, R.O. (1983) Life Sci., 33, 401-408.
40. Wendel, A.; Feuersteins, S. and Konz, K.H. (1987) Biochem. Pharmacol., 28, 2051.
41. Vaidya, A.B. (1996) J. Pastgrad. Med., 42, 105-108.
42. Saraswat, B.; Visen, P.K.S.; Patnaik, G.K. and Dhawan, B.N. (1999) J. Ethnopharmacol., 66, 263-269.
43. Rauen, H.M. and Schriewer, H. (1971) Arzneim-Forsch Drug Res., 21, 1194-1201.
44. Shukla, B.; Visen, P.K.S.; Patnaik, G.K. and Dhawan, B.N. (1991) Planta Med., 57, 29-33.
45. Visen, P.K.S.; Shukla, B.; Patnaik, G.K.; Chandra, R.; Singh, V.; Kapoor, N.K. and Dhawan, B.N. (1991) Phytother. Res., 5, 224-227.
46. Visen, P.K.S.; Shuka, B.; Patnaik, G.K.; Kaul, S.; Kapoor, N.K. and Dhawan, B.N. (1991) Drug Dev. Res., 22, 209-211.
47. Saraswat, B.; Visen, P.K.S.; Patnaik, G.K. and Dhawan, B.N. (1997) Drug Dev. Res., 40, 299.
48. Visen, P.K.S.; Saraswat, B.; Patnaik, G.K.; Agarwal, D.P. and Dhawan, B.N. (1996) Ind. J. Pharmacol., 28, 98.
49. Saraswat, B.; Visen, P.K.S.; Patnaik, G.K. and Dhawan, B.N. (1999) J. Ethnopharmacol., 66, 263-269.
50. Lee, H.S.; Keum, K.Y. and Ku, S.K. (2007) J. Med. Food, 10, 110-117.
51. Saraswat, B.; Visen, P.K.S, Patnaik, G.K. and Dhawan B.N. (1997) Ind. J. Exp. Biol., 35, 1302-1305.
52. Gaddipati, J.P.; Madhavan, S.; Sidhu, G.S. (1999) Mol. Cell Biochem., 194, 271-281.
53. Singh, V.; Kapoor, N.K. and Dhawan, B.N. (1992) Ind. J. Exp. Biol., 30, 68-69.
54. Srivastava, S.; Srivastava, A.K.; Srivastava, S.; Patnaik, G.K. and Dhawan, B.N. (1994) Ind. J. Pharmacol., 26, 19-22.
55. Srivastava, S.; Srivastava, A.K.; Patnaik, G.K. and Dhawan, B.N. (1996) Fitoterapia, 67, 252-254.
56. Rastogi, R.; Saksena, S.; Garg, N.K. and Dhawan, B.N. (1995) Phytother. Res., 9, 364-366.
57. Saksena, S; Rastogi, R. Garg, N.K. and Dhawan, B.N. (1995) Phytother. Res., 9, 518-520.
58. Mehrotra, R.; Rawat, S.; Kulshrestha, D.K.; Patnaik, G.K. and Dhawan, B.N. (1990) Ind. J. Med. Res., 92, 133-138.
59. Mittal, N.; Gupta, N.; Saksena, S.; Goyal, N.; Roy, U. and Rastogi, A.K. (1998) Life Sci., 63, 1823-1834.
60. Kumar, R.N.V. and Kuttan, R. (2000) J. Pharmacol., 32, 135-137.
61. Alexander, G.; Singh, B.; Sahoo, A. and Bhat, T.K. (2008). Animal Feed Sci. Tech., 145, 229-244.
62. He, L.J.; Liang, M.; Hou, F.F.; Guo, Z.J.; Xie, D. and Zhang, X. (2008) J. Endocrinol.,. (In Press).
63. Dhar, M.L.; Dhar, M.M.; Dhawan, B.N.; Mehrotra, B.N.; Srimal, R.C. and Tondon, J.S. (1973) Ind. J. Exp. Biol., 11, 43-45.
64. Rani, P. and Khullar, N. (2004) Phytother. Res., 18, 670-673.
65. Singh, V.; Visen, P.K.S.; Palnaik, G.K.; Kapoor, N.K. and Dhawan, B.N. (1992) Ind. J. Biochem. Biophys., 29, 428-431.
66. Chander, R.; Kapoor, N.K. and Dhawan, B.N (1992) Biochem. Pharmacol., 44, 180-183.
67. Russo, A.; Izzo, A.; Cardile, V.; Borrelli, F. and Vanella, A. (2001) Phytomedicine, 8, 125-132.
68. Simons, J.M.; 't Hart, B.A. and Ip Vai Ching, T.R. (1990) Free Radic. Biol. Med., 8, 251-258.
69. Sethi, N.; Singh, R.K.; Sinha, N.; Bhatia, G.; Srivastava, S. and Roy, A.K. (1991) Biol. Memoirs., 17, 57.
70. Jain, A.K. and Sethi, N. (1992) Fitoterapia, 63, 255-257.
71. Dymock, W. and Hooper. (1890) Pharmacographia India, Kegan Paul, Trench, T'rubner and Co. Ltd. London. 3,12.
72. Chopra, R.N. and Ghosh, S. (1935) Ind. Med. Record, 55, 77.
73. Rastogi, R.P.; Sharma, V.N. and Siddiqui, S. (1949) J. Sci. Ind. Res., 8B, 173-178.
74. Rastogi, R.P.; Dhar, M.L. and Sen, A.B. (1955) J. Sci. Ind. Res., 14B, 512-519.
75. Rastogi, R.P. and Dhar M.L. (1959) J. Sci. Ind. Res., 18B, 219.
76. Kitagawa, I.; Hino, K.; Nishimura, T.; Mukai, E.; Yosioka, I. (1969) Tetrahedron Lett., 43, 3837-3840.
77. Kumar, V.; Mehrotra, N.; Lal, J. and Gupta, R.C. (2004) J. Chromato. A., 1045, 145-152.
78. Basu, K.; Dasgupta, B.; Bhattacharya, S.K. and Debnath, P.K. (1971) Curr. Sci., 40, 603-604.
79. Van den Worm, E.; Beukelman, C.J.; Van den Berg, A.J.J.; Kroes, B.H.; Labadie, R.P and Van Dijk, H. (2001) Eur. J. Pharmacol., 433, 225-230.
80. Kitagawa, I.; Hino, K.; Nishimura, T.; Mukai, E. and Yosioka, I. (1971) Chem. Pharm. Bull., 19, 2534-2544.
81. Weinges, K.; Kloss, P. and Herkets, WD. (1972) Liebigs Ann. Chem.,759, 173.
82. Laurie, W.A.; McHale, D. and Sheridan, JB. (1985) Phytochemistry, 24, 2659-2660.
83. Simons, J.M.; Hart, L.A.; van Dijk, H.; de Silva, K.T.D. and Labadie, R.P. (1989) Planta Med., 55, 113.
84. Stuppner, H. and Wagner, H. (1989) Planta Med., 55, 467-469.
85. Stuppner, H. and Wagner, H. (1989) Planta Med., 55, 559-563.
86. Stuppner, H.; Kahlig, H.; Seligmann, O. and Wagner, H. (1990) Phytochem., 29, 1633-1637.
87. Stuppner, H.; Muller, E.P. and Wagner, H. (1991) Phytochemistry, 30, 305-310.
88. Stuppner, H. and Muller, E.P. (1993) Phytochemistry, 33, 1139-1145.
89. Jia, Q.; Hong, M.F. and Minter, D. (1999) J. Nat. Prod., 62, 901-903.
90. Zhang, Y.; DeWitt, D.L; Murugesan, S. and Nair, M.G. (2005) Life Sci., 77, 3222-3230.
91. Dwivedi, A.K. Chaudhary, M. and Sarin, J.P.S. (1989) Ind. J. Pharma. Sci., 51, 23-24.
92. Dwivedi, A.K.; Chaudhary, M.; Seth, R.K. and Sarin, J.P.S. (1989) Ind. J. Pharma. Sci., 51, 274-275.
93. Dwivedi, A.K.; Jayanti, L.; Chaudhary, M. and Sarin, J.P.S, (1989) Ind. J. Pharma. Sci., 54, 189.
94. Narayanan, P. and Akamanchi, K.G. (2003) J. Asian Nat. Prod. Res., 5, 105-111.
95. Bhandari, P.; Kumar, N.; Singh, B and Kaul, V.K. (2008) J. Chromat. A., 1194, 257-261.
96. Singh, N.; Gupta, A.P.; Singh, B. and Kaul, V.K. (2005) J. Liq. Chromato. Related Technol., 28, 1679-1691.
97. Dhar, U. and Kachroo, P. (1983) An assessment of threatened plants of India, in Botanical survey of India, Howrah (edited by SK Jain and RR Rao), 18.