Mechanism underlying mitochondrial protection of asiatic acid against hepatotoxicity in mice

Journal of Pharmacy and Pharmacology

Volumn 58, Issue 2, 2006, Pages 227-233

  Gao, Jing ^a   Chen, Jin ^a   Tang, Xinhui ^b   Pan, Liya ^a   Fang, Feng ^a   Xu, Lizhi ^a   Zhao, Xiaoning ^a   Xu, Qiang ^a  

^a NANJING UNIVERSITY   (China)

^b YANCHENG TEACHERS UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANION CHANNEL; ASIATIC ACID; CALCIUM ION; CYTOCHROME C; GALACTOSAMINE; LIPID; LIPOPOLYSACCHARIDE; TRITERPENOID; UNCLASSIFIED DRUG; VOLTAGE DEPENDENT ANION CHANNEL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CALCIUM TRANSPORT; CELL CULTURE; CELL NUCLEUS; CELL PROTECTION; CELL ULTRASTRUCTURE; CONTROLLED STUDY; CULTURE MEDIUM; CYTOSOL; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; ELECTRON MICROSCOPY; LIPID STORAGE; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; MALE; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL PERMEABILITY; MITOCHONDRION; MOUSE; NONHUMAN; PROTEIN TRANSPORT; RNA TRANSCRIPTION; RNA TRANSLATION; RUGBY; TERMINALIA; TERMINALIA CATAPPA;

ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; CALCIUM; CYTOCHROMES C; GALACTOSAMINE; HEPATITIS, TOXIC; ION CHANNELS; LIPOPOLYSACCHARIDES; LIVER; MALE; MEMBRANE POTENTIALS; MICE; MICE, INBRED ICR; MITOCHONDRIA, LIVER; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL SWELLING; RNA, MESSENGER; TRITERPENES; VOLTAGE-DEPENDENT ANION CHANNELS;

EID: 31544436930     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1211/jpp.58.2.0010     Document Type: Article

References (40)

1. Aprille, J. R., Hom, J. A., Rulfs, J. (1977) Liver and skeletal muscle mitochondrial function following bum injury. J. Trauma 17:279-287
2. Bohlinger, I., Leist, M., Gantner, F., Angermuller, S., Tiegs, G., Wendel, A. (1996) DNA fragmentation in mouse organs during endotoxic shock. Am. J. Pathol. 1149: 1381-1393
3. Bradford, M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72: 248-254
4. Elimadi, A., Sapena, R., Settaf, A., Louet, H. L., Tillement, J. P., Morin, D. (2001) Attenuation of liver normothermic ischemia-reperfusion injury by preservation of mitochondrial functions with S-15176, a potent trimetazidine derivative. Biochem. Pharmacol. 62: 509-516
5. Elimadi, A., Jullien, V., Tillement, J. P., Morin, D. (2003) S-15176 inhibits mitochondrial permeability transition via a mechanism independent of its antioxidant properties. Eur. J. Pharmacol. 468: 93-101
6. Emaus, R. K., Grunwald, R., Lemaster, J. J. (1986) Rhodamine 123 as a probe of transmembrane potential in isolated rat liver mitochondria. Biochim. Biophys. Acta 850: 436-448
7. Gao, J., Tang, X., Dou, H., Fan, Y., Zhao, X., Xu, Q. (2004) Hepatoprotective activity of Terminalia catappa L. leaves and its two triterpenoids. J. Pharm. Pharmacol. 56: 1449-1455
8. Godbole, A., Varghese, J., Sarin, A., Mathew, M. K. (2003) VDAC is a conserved element of death pathways in plant and animal systems. Biochim. Biophys. Acta 1624: 87-96
9. Green, D. R., Kroemer, G. (2004) The pathophysiology of mitochondrial cell death. Science 305: 626-629
10. Hsu, Y. L., Kuo, P. L., Lin, L. T, Lin, C. C. (2005) Asiatic acid, a triterpene, induces apoptosis and cell cycle arrest through activation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways in human breast cancer cells. J. Pharmacol. Exp. Ther. 313: 333-344
11. Itokazu, Y., Segawa, Y., Omata, T., Inoue, N., Tsuzuike, N., Nagasawa, M., Nishioka, H., Kobayashi, T., Nakano, Y., Kanda, T. (2000) Effects of ZNC-2381, a new oral compound, on several hepatic injury models and on hepatocellular apoptosis in mice and rats. J. Pharm. Pharmacol. 52: 531-538
12. Jaeschke, H., Gujral, J. S., Bajt, M. L. (2004) Apoptosis and necrosis in liver disease. Liver Int. 24: 85-89
13. Jambrina, E., Alonso, R., Alcalde, M., del Carmen Rodriguez, M., Serrano, A., Martinez, A. C., Garcia-Sancho, J., Izquierdo, M. (2003) Calcium influx through receptor-operated channel induces mitochondria-triggered paraptotic cell death. J. Biol. Chem. 278: 14134-14145
14. Kim, J. S., Na, C. S., Pak, S. C., Kim, Y. G. (2000) Effects of yukmi, an herbal formula, on the liver of senescence accelerated mice (SAM) exposed to oxidative stress. Am. J. Chin. Med. 28: 343-350
15. Kim, J. S., He, L., Qian, T., Lemasters, J. J. (2003) Role of the mitochondrial permeability transition in apoptotic and necrotic death after ischemia/reperfusion injury to hepatocytes. Curr. Mol. Med. 3: 527-535
16. Kobayashi, T., Kuroda, S., Tada, M., Houkin, K., Iwasaki, Y., Abe, H. (2003) Calcium-induced mitochondrial swelling and cytochrome c release in the brain: its biochemical characteristics and implication in ischemic neuronal injury. Brain Res. 960: 62-70
17. Kokoszka, J. E., Waymire, K. G., Levy, S. E., Sligh, J. E., Cai, J., Jones, D. P., MacGregor, G. R., Wallace, D. C. (2004) The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore. Nature 427: 461-465
18. Lee, M. K., Kim, S. R., Sung, S. H., Lim, D., Kim, H., Choi, H., Park, H. K., Je, S., Ki, Y. C. (2000) Asiatic acid derivatives protect cultured cortical neurons from glutamate-induced excitotoxicity. Res. Commun. Mol. Pathol. Pharmacol. 108: 75-86
19. + on membrane permeability in brain mitochondria and cell viability in PC12 cells. Neurochem. Int. 40: 361-369
20. 2+ release and enhanced expression of p53 in HepG2 human hepatoma cells. Cancer Lett. 186:83-91
21. Lemasters, J. J., Nieminen, A. L., Qian, T., Trost, L. C., Herman, B. (1997) The mitochondrial permeability transition in toxic, hypoxic and reperfusion injury. Mol. Cell Biochem. 174: 159-165
22. Marzo, I., Brenner, C., Zamzami, N., Susin, S. A., Beutner, G., Brdiczka, D., Remy, R., Xie, Z. H., Reed, J. C., Kroemer, G. (1998) The permeability transition pore complex: a target for apoptosis regulation by caspases and bcl-2-related proteins. J. Exp. Med. 187: 1261-1271
23. Nowak, M., Gaines, G. C., Rosenberg, J., Minier, R., Bahjat, F. R., Rectenwald, J., MacKay, S. L., Edwards, C. K., Moldawer, L. L. (2000) LPS-induced liver injury in D-galactosamine-sensitized mice requires secreted TNF-α and the TNF-p55 receptor. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 278: R1202-R1209
24. Morin, D., Papadopoulos, V., Tillement, J. P. (2002) Prevention of cell damage in ischemia: novel molecular targets in mitochondria. Expert Opin. Ther. Targets 6: 315-334
25. Neuman, M. G. (2001) Apoptosis in diseases of the liver. Crit. Rev. Clin. Lab. Sci. 38: 109-166
26. Newmeyer, D. D., Ferguson-Miller, S. (2003) Mitochondria: releasing power for life and unleashing the machineries of death. Cell 112: 481-490
27. Orrenius, S. (2004) Mitochondrial regulation of apoptotic cell death. Toxicol. Lett. 149: 19-23
28. Park, B. C., Bosire, K. O., Lee, E. S., Lee, Y. S., Kim, J. A. (2005) Asiatic acid induces apoptosis in SK-MEL-2 human melanoma cells. Cancer Lett. 218: 81-90
29. Saito, M., Korsmeyer, S. J., Schlesinger, P. H. (2000) Bax-dependent transport of cytochrome c reconstituted in pure liposomes. Nat. Cell Biol. 2: 553-555
30. Salvi, M., Fiore, C., Armanini, D., Toninello, A. (2003) Glycyrrhetinic acid-induced permeability transition in rat liver mitochondria. Biochem. Pharmacol. 66: 2375-2379
31. 2+ thresholds determine cytochrome c release or permeability transition pore opening in brain mitochondria. FASEB J. 15:565-567
32. Schumann, J., Tiegs, G. (1999) Pathophysiological mechanisms of TNF during intoxication with natural or man-made toxins (review). Toxicology 138: 103-126
33. Shimizu, S., Narita, M., Tsujimoto, Y. (1999) Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC. Nature 399: 483-487
34. Shimizu, S., Matsuoka, Y., Shinohara, Y., Yoneda, Y., Tsujimoto, Y. (2001) Essential role of voltage-dependent anion channel in various forms of apoptosis in mammalian cells. J. Cell Biol. 152: 237-250
35. Tafani, M., Schneider, T. G., Pastorino, L. G., Farber, J. L. (2000) Cytochrome c-dependent activation of caspase-3 by tumor necrosis factor requires induction of the mitochondrial permeability transition. Am. J. Pathol. 156: 2111-2121
36. L regulates the membrane potential and volume homeostasis of mitochondria. Cell 91: 627-637
37. Varbiro, G., Veres, B., Gallyas, F. J., Sumegi, B. (2001) Direct effect of Taxol on free radical formation and mitochondrial permeability transition. Free Radic. Biol. Med. 31: 548-558
38. Wang, X. (2001) The expanding role of mitochondria in apoptosis. Genes Dev. 15: 2922-2933
39. Zheng, Y., Shi, Y., Tian, C., Jiang, C., Jin, H., Chen, J., Almasan, A., Tang, H., Chen, Q. (2004) Essential role of the voltage-dependent anion channel (VDAC) in mitochondrial permeability transition pore opening and cytochrome c release induced by arsenic trioxide. Oncogene 23: 1239-1247
40. Zou, H., Li, Y., Liu, X., Wang, X. (1999) An APAF-1·Cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J. Biol. Chem. 274: 11549-11556