Mechanism of the superoxide scavenging activity of neoandrographolide - A natural product from Andrographis paniculata nees

Journal of Agricultural and Food Chemistry

Volumn 50, Issue 16, 2002, Pages 4662-4665

  Kamdem, Ricky Emery ^a   Sang, Shengmin ^a   Ho, Chi Tang ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

Andrographis paniculata; Antiradical activity; Diterpene lactone; Neoandrographolide; Superoxide radical

Indexed keywords

DITERPENE; GLUCOSIDE; LACTONE; NATURAL PRODUCT; NEOANDROGRAPHOLIDE; SCAVENGER; SUPEROXIDE; TETRALIN DERIVATIVE;

ANALYTIC METHOD; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL REACTION; CHEMISTRY; FAST ATOM BOMBARDMENT MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIPID OXIDATION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTON TRANSPORT; REACTION ANALYSIS; STOICHIOMETRY; DRUG ANTAGONISM;

ANDROGRAPHIS; ANDROGRAPHIS PANICULATA;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FREE RADICAL SCAVENGERS; GLUCOSIDES; MAGNETIC RESONANCE SPECTROSCOPY; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT; SUPEROXIDES; TETRAHYDRONAPHTHALENES;

EID: 0037205641     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf025556f     Document Type: Article

References (18)

1. The structure and stereochemistry of neoandrographolide, a diterpene glucoside from Andrographis paniculata Nees
2. On the diterpenoids of Andrographis paniculata: X-ray crystallographic analysis of andrographolide and structure determination of new minor diterpenoids
3. Antidiarrhoeal activity of diterpenes of Andrographis paniculata (Kal-Megh) against Escherichia coli enterotoxin in in vivo models
4. Antihyperglycemic and antioxidant properties of Andrographis paniculata in normal and diabetic rats
5. Immunostimulant agents from Andrographis paniculata
6. Hepatoprotective activity of andrographolide from Andrographis paniculata against carbon tetrachloride
7. Antimalarial activity of Andrographis paniculata (kalmegh) against Plasmodium berghei NK 65 in Mastomys natalensis
8. Analgesic, antipyretic and antiulcerogenic effects of andrographolide
9. Antihepatotoxic effects of major diterpenoid constituents of Andrographis paniculata
10. Structure-activity relationships for the antioxidant activities of a series of flavonoids in liposomal system
11. Antioxidative polyphenols isolated from Theobroma cacao
12. A convenient preparation of solutions of superoxide anion and the reaction of superoxide anion with copper (II) complex
13. Reactivity of superoxide ion
14. Cell differentiation-inducing diterpenes from Andrographis paniculata Nees
15. -.) mediated oxidation of diarylamethanes
16. Mechanism of superoxide ion disproportionation in aprotic solvents
17. Modulatory influence of Andrographis paniculata on mouse hepatic and extrahepatic carcinogen metabolizing enzymes and antioxidant status
18. Antihepatotoxic activity of diterpenes of Andrographis paniculata (Kal-Megh) against Plasmodium berghei-induced hepatic damage in Matstomys natalensis