메뉴 건너뛰기




Volumn 11, Issue 5, 2011, Pages 624-653

VEGF/VEGFR pathway inhibitors as anti-angiogenic agents: Present and future

Author keywords

Angiogenesis; Bevacizumab; flk 1; KDR; Sorafenib; Suntinib; Tyrosine kinase; VEGFR

Indexed keywords

2 AMINOBENZAMIDE; 5 [(5 FLUORO 1,2 DIHYDRO 2 OXO 3H INDOL 3 YLIDENE)METHYL] N (2 HYDROXY 3 MORPHOLINOPROPYL) 2,4 DIMETHYL 1H PYRROLE 3 CARBOXAMIDE; AAL993; ANGIOGENESIS INHIBITOR; AXITINIB; BENZIMIDAZOLE; BRIVANIB; BRIVANIB ALANINATE; CARBAZOLE DERIVATIVE; CEDIRANIB; INDAZOLE DERIVATIVE; INDIRUBIN; INTEDANIB; LINIFANIB; MOTESANIB; N (4 BROMO 2 FLUOROPHENYL) 6 METHOXY 7 [2 (1H 1,2,3 TRIAZOL 1 YL)ETHOXY] 4 QUINAZOLINAMINE; ORANTINIB; OXINDOLE; PAZOPANIB; PYRIDINE; PYRIMIDINE; QUINAZOLINE; SEMAXANIB; SORAFENIB; SU010382; SUNITINIB; TIVOZANIB; TOCERANIB; TRIAZINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANDETANIB; VASCULOTROPIN INHIBITOR; VATALANIB;

EID: 79958121732     PISSN: 15680096     EISSN: 18735576     Source Type: Journal    
DOI: 10.2174/156800911795655985     Document Type: Review
Times cited : (90)

References (203)
  • 1
    • 33947370773 scopus 로고    scopus 로고
    • Vascular endothelial growth factor (VEGF) signaling in tumor progression
    • Roskoski, R. Jr. Vascular endothelial growth factor (VEGF) signaling in tumor progression. Crit. Rev. Oncol. Hematol. 2007, 62(3), 179-213.
    • (2007) Crit. Rev. Oncol. Hematol , vol.62 , Issue.3 , pp. 179-213
    • Roskoski Jr., R.1
  • 2
    • 0027241752 scopus 로고
    • Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis
    • Shweiki, D.; Itin, A.; Neufeld, G.; Gitay-Goren, H.; Keshet, E. Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally regulated angiogenesis. J. Clin. Invest. 1993, 91(5), 2235-2243.
    • (1993) J. Clin. Invest , vol.91 , Issue.5 , pp. 2235-2243
    • Shweiki, D.1    Itin, A.2    Neufeld, G.3    Gitay-Goren, H.4    Keshet, E.5
  • 3
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan, D.; Folkman, J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996, 86 (3), 353-364.
    • (1996) Cell , vol.86 , Issue.3 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 4
    • 0014304893 scopus 로고
    • Tumor angiogenesis: Transfilter diffusion studies in the hamster by the transparent chamber technique
    • Greenblatt, M.; Shubi, P. Tumor angiogenesis: transfilter diffusion studies in the hamster by the transparent chamber technique. J. Natl. Cancer Inst. 1968, 41(1), 111-124.
    • (1968) J. Natl. Cancer Inst , vol.41 , Issue.1 , pp. 111-124
    • Greenblatt, M.1    Shubi, P.2
  • 5
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman, J. Tumor angiogenesis: therapeutic implications. N. Engl. J. Med. 1971, 285(21), 1182-1186.
    • (1971) N. Engl. J. Med , vol.285 , Issue.21 , pp. 1182-1186
    • Folkman, J.1
  • 6
    • 0018364326 scopus 로고
    • Evaluation of tumor angiogenesis factor with the rabbit cornea model
    • Ryu, S.; Albert, D. M. Evaluation of tumor angiogenesis factor with the rabbit cornea model. Invest. Ophthalmol. Vis. Sci. 1979, 18(8), 831-841.
    • (1979) Invest. Ophthalmol. Vis. Sci , vol.18 , Issue.8 , pp. 831-841
    • Ryu, S.1    Albert, D.M.2
  • 7
    • 0036984640 scopus 로고    scopus 로고
    • Role of angiogenesis in tumor growth and metastasis
    • Folkman, J. Role of angiogenesis in tumor growth and metastasis. Semin. Oncol. 2002, 29(6), 15-18.
    • (2002) Semin. Oncol , vol.29 , Issue.6 , pp. 15-18
    • Folkman, J.1
  • 8
    • 64549150071 scopus 로고    scopus 로고
    • Receptor tyrosine kinase inhibitors as potent weapons in war against cancers
    • Sharma, P. S.; Sharma, R.; Tyagi, T. Receptor tyrosine kinase inhibitors as potent weapons in war against cancers. Curr. Pharm. Des. 2009, 15(7), 758-776.
    • (2009) Curr. Pharm. Des. , vol.15 , Issue.7 , pp. 758-776
    • Sharma, P.S.1    Sharma, R.2    Tyagi, T.3
  • 9
    • 39049126024 scopus 로고    scopus 로고
    • Inhibitors of cyclin dependent kinases: Useful targets for cancer treatment
    • Sharma, P. S.; Sharma, R.; Tyagi, R. Inhibitors of cyclin dependent kinases: useful targets for cancer treatment. Curr. Cancer Drug Targets 2008, 8(1), 53-75.
    • (2008) Curr. Cancer Drug Targets , vol.8 , Issue.1 , pp. 53-75
    • Sharma, P.S.1    Sharma, R.2    Tyagi, R.3
  • 10
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • Bergers, G.; Benjamin, L. E. Tumorigenesis and the angiogenic switch. Nat. Rev. Cancer 2003, 3(6), 401-410.
    • (2003) Nat. Rev. Cancer , vol.3 , Issue.6 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 11
    • 0031053759 scopus 로고    scopus 로고
    • Biological roles of fibroblast growth factor-2
    • Bikfalvi, A.; Klein, S.; Pintucci, G.; Rifkin, D.B. Biological roles of fibroblast growth factor-2. Endocr. Rev. 1997, 18(1), 26-45.
    • (1997) Endocr. Rev. , vol.18 , Issue.1 , pp. 26-45
    • Bikfalvi, A.1    Klein, S.2    Pintucci, G.3    Rifkin, D.B.4
  • 13
    • 33646569993 scopus 로고    scopus 로고
    • Biology of vascular endothelial growth factors
    • Roy, H.; Bhardwaj, S.; Ylä-Herttuala, S. Biology of vascular endothelial growth factors. FEBS Lett. 2006, 580(12), 2879-2887.
    • (2006) FEBS Lett. , vol.580 , Issue.12 , pp. 2879-2887
    • Roy, H.1    Bhardwaj, S.2    Ylä-Herttuala, S.3
  • 14
    • 1642280409 scopus 로고    scopus 로고
    • Differentiated human podocytes endogenously express an inhibitory isoform of vascular endothelial growth factor (VEGF165b) mRNA and protein
    • Cui, T. G.; Foster, R. R.; Saleem, M.; Mathieson, P. W.; Gillatt, D. A.; Bates, D. O.; Harper, S. J. Differentiated human podocytes endogenously express an inhibitory isoform of vascular endothelial growth factor (VEGF165b) mRNA and protein. Am. J. Physiol. Renal Physiol. 2004, 286(4), F767-73.
    • (2004) Am. J. Physiol. Renal Physiol , vol.286 , Issue.4
    • Cui, T.G.1    Foster, R.R.2    Saleem, M.3    Mathieson, P.W.4    Gillatt, D.A.5    Bates, D.O.6    Harper, S.J.7
  • 15
    • 50849120002 scopus 로고    scopus 로고
    • VEGF receptor protein-tyrosine kinases: Structure and regulation
    • Roskoski, R. Jr. VEGF receptor protein-tyrosine kinases: structure and regulation. Biochem. Biophys. Res. Commun. 2008, 375(3), 287-291.
    • (2008) Biochem. Biophys. Res. Commun , vol.375 , Issue.3 , pp. 287-291
    • Roskoski Jr., R.1
  • 16
    • 0026572345 scopus 로고
    • The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor
    • deVries, C.; Escobedo, J. A.; Ueno, H.; Houck, K.; Ferrara, N.; Williams, L. T. The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor. Science 1992, 255(5047), 989-991.
    • (1992) Science , vol.255 , Issue.5047 , pp. 989-991
    • deVries, C.1    Escobedo, J.A.2    Ueno, H.3    Houck, K.4    Ferrara, N.5    Williams, L.T.6
  • 18
    • 0027997863 scopus 로고
    • Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor
    • Waltenberger, J.; Claesson-Welsh, L.; Siegbahn, A.; Shibuya, M.; Heldin, C. H. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J. Biol. Chem. 1994, 269(43), 26988-26995.
    • (1994) J. Biol. Chem , vol.269 , Issue.43 , pp. 26988-26995
    • Waltenberger, J.1    Claesson-Welsh, L.2    Siegbahn, A.3    Shibuya, M.4    Heldin, C.H.5
  • 20
    • 34047141776 scopus 로고    scopus 로고
    • Vascular endothelial growth factor family of ligand and receptors
    • Otrock, Z. K.; Makarem, J. A.; Shamseddine, A. I. Vascular endothelial growth factor family of ligand and receptors. Blood Cells Mol. Dis. 2007, 38, 258-268.
    • (2007) Blood Cells Mol. Dis. , vol.38 , pp. 258-268
    • Otrock, Z.K.1    Makarem, J.A.2    Shamseddine, A.I.3
  • 22
    • 33745063095 scopus 로고    scopus 로고
    • The role of neuropilins in cancer
    • Ellis, L. M. The role of neuropilins in cancer. Mol. Cancer Ther. 2006, 5(5), 1099-1107.
    • (2006) Mol. Cancer Ther , vol.5 , Issue.5 , pp. 1099-1107
    • Ellis, L.M.1
  • 25
    • 11244335640 scopus 로고    scopus 로고
    • Strategies for multiple signaling inhibition
    • Tortora, G.; Bianco, R.; Daniele, G. Strategies for multiple signaling inhibition. J. Chemother. 2004, 16, 41-43.
    • (2004) J. Chemother. , vol.16 , pp. 41-43
    • Tortora, G.1    Bianco, R.2    Daniele, G.3
  • 26
    • 0034090097 scopus 로고    scopus 로고
    • Angiogenesis: Potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation
    • Griffioen, A. W.; Molema, G. Angiogenesis: potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation. Pharmacol. Rev. 2000, 52(2), 237-268.
    • (2000) Pharmacol. Rev. , vol.52 , Issue.2 , pp. 237-268
    • Griffioen, A.W.1    Molema, G.2
  • 27
    • 54949156454 scopus 로고    scopus 로고
    • Inhibitors of vascular endothelial growth factor in cancer
    • Pourgholami, M. H.; Morris, D. L. Inhibitors of vascular endothelial growth factor in cancer. Cardiovasc. Hematol. Agent Med. Chem. 2008, 6(4), 343-347.
    • (2008) Cardiovasc. Hematol. Agent Med. Chem , vol.6 , Issue.4 , pp. 343-347
    • Pourgholami, M.H.1    Morris, D.L.2
  • 28
    • 49149124199 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Karamysheva, A. F. Mechanisms of angiogenesis. Biochemistry (Mosc). 2008, 73(7), 751-762.
    • (2008) Biochemistry (Mosc) , vol.73 , Issue.7 , pp. 751-762
    • Karamysheva, A.F.1
  • 29
    • 0038544202 scopus 로고    scopus 로고
    • Platelet-derived growth factor signaling and human cancer
    • Yu, J.; Ustach, C.; Kim, H. R. Platelet-derived growth factor signaling and human cancer. J. Biochem. Mol. Biol. 2003, 36(1), 49-59.
    • (2003) J. Biochem. Mol. Biol , vol.36 , Issue.1 , pp. 49-59
    • Yu, J.1    Ustach, C.2    Kim, H.R.3
  • 30
    • 0242489030 scopus 로고    scopus 로고
    • EphB receptors and ephrinB ligands: Regulators of vascular assembly and homeostasis
    • Augustin, H. G.; Reiss, Y. EphB receptors and ephrinB ligands: regulators of vascular assembly and homeostasis. Cell Tissue Res. 2003, 314(1), 25-31.
    • (2003) Cell Tissue Res , vol.314 , Issue.1 , pp. 25-31
    • Augustin, H.G.1    Reiss, Y.2
  • 31
    • 61449240141 scopus 로고    scopus 로고
    • Paths of FGFRdriven tumorigenesis
    • Acevedo, V. D.; Ittmann, M.; Spencer, D. M. Paths of FGFRdriven tumorigenesis. Cell Cycle 2009, 8(4), 580-588.
    • (2009) Cell Cycle , vol.8 , Issue.4 , pp. 580-588
    • Acevedo, V.D.1    Ittmann, M.2    Spencer, D.M.3
  • 32
    • 11844254414 scopus 로고    scopus 로고
    • Normalization of tumor vasculature: An emerging concept in antiangiogenic therapy
    • Jain, R. K. Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science 2005, 307(5706), 58-62.
    • (2005) Science , vol.307 , Issue.5706 , pp. 58-62
    • Jain, R.K.1
  • 33
    • 47949121903 scopus 로고    scopus 로고
    • Vessel normalization by VEGF inhibition. A complex story
    • Claes, A.; Leenders, W. Vessel normalization by VEGF inhibition. A complex story. Cancer Biol. Ther. 2008, 7(7), 1014-1016.
    • (2008) Cancer Biol. Ther. , vol.7 , Issue.7 , pp. 1014-1016
    • Claes, A.1    Leenders, W.2
  • 34
    • 34147190880 scopus 로고    scopus 로고
    • FDA drug approval summary: Bevacizumab plus FOLFOX4 as second-line treatment of colorectal cancer
    • Cohen, M. H.; Gootenberg, J.; Keegan, P.; Pazdur, R. FDA drug approval summary: Bevacizumab plus FOLFOX4 as second-line treatment of colorectal cancer. The Oncologist 2007, 12(3), 356-361.
    • (2007) The Oncologist , vol.12 , Issue.3 , pp. 356-361
    • Cohen, M.H.1    Gootenberg, J.2    Keegan, P.3    Pazdur, R.4
  • 35
    • 34248136112 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and vascular endothelial growth factor receptor inhibitors as anti-angiogenic agents in cancer therapy
    • Veeravagu, A.; Hsu, A. R.; Cai, W.; Hou, L.C.; Tse, V. C.; Chen, X. Vascular endothelial growth factor and vascular endothelial growth factor receptor inhibitors as anti-angiogenic agents in cancer therapy. Recent Pat. Anticancer Drug Discov. 2007, 2(1), 59-71.
    • (2007) Recent Pat. Anticancer Drug Discov , vol.2 , Issue.1 , pp. 59-71
    • Veeravagu, A.1    Hsu, A.R.2    Cai, W.3    Hou, L.C.4    Tse, V.C.5    Chen, X.6
  • 36
    • 77953861145 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor as target for advanced non-small cell lung cancer therapy
    • Rossi, A.; Maione, P.; Sacco, P. C.; Falanga, M.; Gridelli, C. Vascular endothelial growth factor receptor as target for advanced non-small cell lung cancer therapy. Curr. Drug Targets 2010, 11(7), 865-874.
    • (2010) Curr. Drug Targets , vol.11 , Issue.7 , pp. 865-874
    • Rossi, A.1    Maione, P.2    Sacco, P.C.3    Falanga, M.4    Gridelli, C.5
  • 39
    • 52149099655 scopus 로고    scopus 로고
    • Antiangiogenic cancer therapy using tumor vasculature-targeted liposomes encapsulating 3-(3,5-dimethyl-1Hpyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one, SU5416
    • Katanasaka, Y.; Ida, T.; Asai, T.; Shimizu, K.; Koizumi, F.; Maeda, N.; Baba, K.; Oku, N. Antiangiogenic cancer therapy using tumor vasculature-targeted liposomes encapsulating 3-(3,5-dimethyl-1Hpyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one, SU5416. Cancer Lett. 2008, 270(2), 260-268.
    • (2008) Cancer Lett , vol.270 , Issue.2 , pp. 260-268
    • Katanasaka, Y.1    Ida, T.2    Asai, T.3    Shimizu, K.4    Koizumi, F.5    Maeda, N.6    Baba, K.7    Oku, N.8
  • 40
    • 50949120901 scopus 로고    scopus 로고
    • Development of an intravenous formulation of SU010382 (prodrug of SU5416, an antiangiogenesis agent)
    • Sistla, A.; Kertelj, A.; Shenoy, N. Development of an intravenous formulation of SU010382 (prodrug of SU5416, an antiangiogenesis agent). PDA J. Pharm. Sci. Technol. 2008, 62(3), 200-210.
    • (2008) PDA J. Pharm. Sci. Technol , vol.62 , Issue.3 , pp. 200-210
    • Sistla, A.1    Kertelj, A.2    Shenoy, N.3
  • 45
    • 16344369880 scopus 로고    scopus 로고
    • Tyrosine kinase inhibitor SU6668 inhibits peritoneal dissemination of gastric cancer via suppression of tumor angiogenesis
    • Tokuyama, J.; Kubota, T.; Saikawa, Y.; Yoshida, M.; Furukawa, T.; Otani, Y.; Kumai, K.; Kitajima, M. Tyrosine kinase inhibitor SU6668 inhibits peritoneal dissemination of gastric cancer via suppression of tumor angiogenesis. Anticancer Res. 2005, 25(1A), 17-22.
    • (2005) Anticancer Res , vol.25 , Issue.1 A , pp. 17-22
    • Tokuyama, J.1    Kubota, T.2    Saikawa, Y.3    Yoshida, M.4    Furukawa, T.5    Otani, Y.6    Kumai, K.7    Kitajima, M.8
  • 47
    • 33645657886 scopus 로고    scopus 로고
    • The vascular targeting property of paclitaxel is enhanced by SU6668, a receptor tyrosine kinase inhibitor, causing apoptosis of endothelial cells and inhibition of angiogenesis
    • Naumova, E.; Ubezio, P.; Garofalo, A.; Borsotti, P.; Cassis, L.; Riccardi, E.; Scanziani, E.; Eccles, S. A.; Bani, M. R.; Giavazzi, R. The vascular targeting property of paclitaxel is enhanced by SU6668, a receptor tyrosine kinase inhibitor, causing apoptosis of endothelial cells and inhibition of angiogenesis. Clin. Cancer Res. 2006, 12(6), 1839-1849.
    • (2006) Clin. Cancer Res , vol.12 , Issue.6 , pp. 1839-1849
    • Naumova, E.1    Ubezio, P.2    Garofalo, A.3    Borsotti, P.4    Cassis, L.5    Riccardi, E.6    Scanziani, E.7    Eccles, S.A.8    Bani, M.R.9    Giavazzi, R.10
  • 49
    • 78650874372 scopus 로고    scopus 로고
    • SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer
    • Abrams, T. J.; Lee, J. B.; Murray, L. J.; Pyer, N. K.; Cherrington, J. M. SU11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer. Mol. Cancer Ther. 2003, 2(5), 471-478.
    • (2003) Mol. Cancer Ther , vol.2 , Issue.5 , pp. 471-478
    • Abrams, T.J.1    Lee, J.B.2    Murray, L.J.3    Pyer, N.K.4    Cherrington, J.M.5
  • 53
    • 42949148257 scopus 로고    scopus 로고
    • Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane
    • Burstein, H. J.; Elias, A. D.; Rugo, H. S.; Cobleigh, M. A.; Wolff, A. C.; Eisenberg, P. D.; Lehman, M.; Adams, B. J.; Bello, C. L.; DePrimo, S. E.; Baum, C. M.; Miller, K. D. Phase II study of sunitinib malate, an oral multitargeted tyrosine kinase inhibitor, in patients with metastatic breast cancer previously treated with an anthracycline and a taxane. J. Clin. Oncol. 2008, 26(11), 1810-1816.
    • (2008) J. Clin. Oncol , vol.26 , Issue.11 , pp. 1810-1816
    • Burstein, H.J.1    Elias, A.D.2    Rugo, H.S.3    Cobleigh, M.A.4    Wolff, A.C.5    Eisenberg, P.D.6    Lehman, M.7    Adams, B.J.8    Bello, C.L.9    DePrimo, S.E.10    Baum, C.M.11    Miller, K.D.12
  • 54
    • 67649354223 scopus 로고    scopus 로고
    • Sunitinib malate is active against human urothelial carcinoma and enhances the activity of cisplatin in a preclinical model
    • Sonpavde, G.; Jian, W.; Liu, H.; Wu, M. F.; Shen, S. S.; Lerner, S. P. Sunitinib malate is active against human urothelial carcinoma and enhances the activity of cisplatin in a preclinical model. Urol. Oncol. 2009, 27(4), 391-399.
    • (2009) Urol. Oncol , vol.27 , Issue.4 , pp. 391-399
    • Sonpavde, G.1    Jian, W.2    Liu, H.3    Wu, M.F.4    Shen, S.S.5    Lerner, S.P.6
  • 55
    • 68249152630 scopus 로고    scopus 로고
    • Antiangiogenic versus cytotoxic therapeutic approaches in a mouse model of pancreatic cancer: An experimental study with a multitarget tyrosine kinase inhibitor (sunitinib), gemcitabine and radiotherapy
    • Casneuf, V. F.; Demetter, P.; Boterberg, T.; Delrue, L.; Peeters, M.; Van Damme, N. Antiangiogenic versus cytotoxic therapeutic approaches in a mouse model of pancreatic cancer: an experimental study with a multitarget tyrosine kinase inhibitor (sunitinib), gemcitabine and radiotherapy. Oncol. Rep. 2009, 22(1), 105-113.
    • (2009) Oncol. Rep , vol.22 , Issue.1 , pp. 105-113
    • Casneuf, V.F.1    Demetter, P.2    Boterberg, T.3    Delrue, L.4    Peeters, M.5    van Damme, N.6
  • 56
    • 33947504730 scopus 로고    scopus 로고
    • Sunitinib: From rational design to clinical efficacy
    • Chow, L. Q.; Eckhardt, S. G. Sunitinib: from rational design to clinical efficacy. J. Clin. Oncol. 2007, 25(7), 884-896.
    • (2007) J. Clin. Oncol , vol.25 , Issue.7 , pp. 884-896
    • Chow, L.Q.1    Eckhardt, S.G.2
  • 59
    • 0037100281 scopus 로고    scopus 로고
    • Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors
    • Liao, A. T.; Chien, M. B.; Shenoy, N.; Mendel, D. B.; McMahon, G.; Cherrington, J. M.; London, C. A. Inhibition of constitutively active forms of mutant kit by multitargeted indolinone tyrosine kinase inhibitors. Blood 2002, 100(2), 585-593.
    • (2002) Blood , vol.100 , Issue.2 , pp. 585-593
    • Liao, A.T.1    Chien, M.B.2    Shenoy, N.3    Mendel, D.B.4    McMahon, G.5    Cherrington, J.M.6    London, C.A.7
  • 60
    • 77949411632 scopus 로고    scopus 로고
    • Pharmacokinetic properties of toceranib phosphate (Palladia, SU11654), a novel tyrosine kinase inhibitor, in laboratory dogs and dogs with mast cell tumors
    • Yancey, M. F.; Merritt, D. A.; Lesman, S. P.; Boucher, J. F.; Michels, G. M. Pharmacokinetic properties of toceranib phosphate (Palladia, SU11654), a novel tyrosine kinase inhibitor, in laboratory dogs and dogs with mast cell tumors. J. Vet. Pharmacol. Ther. 2010, 33(2), 162-171.
    • (2010) J. Vet. Pharmacol. Ther. , vol.33 , Issue.2 , pp. 162-171
    • Yancey, M.F.1    Merritt, D.A.2    Lesman, S.P.3    Boucher, J.F.4    Michels, G.M.5
  • 62
    • 18344391889 scopus 로고    scopus 로고
    • SU11248: Genesis of a New Cancer Drug
    • Schlessinger, J. SU11248: Genesis of a New Cancer Drug. The Scientist 2005, 19(7), 17.
    • (2005) The Scientist , vol.19 , Issue.7 , pp. 17
    • Schlessinger, J.1
  • 64
    • 67650714103 scopus 로고    scopus 로고
    • Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120)
    • Roth, G. J.; Heckel, A.; Colbatzky, F.; Handschuh, S.; Kley, J.; Lehmann-Lintz, T.; Lotz, R.; Tontsch-Grunt, U.; Walter, R.; Hilberg, F. Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120). J. Med. Chem. 2009, 52(14), 4466-4480.
    • (2009) J. Med. Chem , vol.52 , Issue.14 , pp. 4466-4480
    • Roth, G.J.1    Heckel, A.2    Colbatzky, F.3    Handschuh, S.4    Kley, J.5    Lehmann-Lintz, T.6    Lotz, R.7    Tontsch-Grunt, U.8    Walter, R.9    Hilberg, F.10
  • 66
    • 33645077600 scopus 로고    scopus 로고
    • YM-359445, an orally bioavailable vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor, has highly potent antitumor activity against established tumors
    • Amino, N.; Ideyama, Y.; Yamano, M.; Kuromitsu, S.; Tajinda, K.; Samizu, K.; Hisamichi, H.; Matsuhisa, A.; Shirasuna, K.; Kudoh, M.; Shibasaki, M. YM-359445, an orally bioavailable vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor, has highly potent antitumor activity against established tumors. Clin. Cancer Res. 2006, 12(5), 1630-1638.
    • (2006) Clin. Cancer Res , vol.12 , Issue.5 , pp. 1630-1638
    • Amino, N.1    Ideyama, Y.2    Yamano, M.3    Kuromitsu, S.4    Tajinda, K.5    Samizu, K.6    Hisamichi, H.7    Matsuhisa, A.8    Shirasuna, K.9    Kudoh, M.10    Shibasaki, M.11
  • 70
    • 79952543555 scopus 로고    scopus 로고
    • Pazopanib: The newest tyrosine kinase inhibitor for the treatment of advanced or metastatic renal cell carcinoma
    • Keisner, S. V.; Shah, S. R. Pazopanib: the newest tyrosine kinase inhibitor for the treatment of advanced or metastatic renal cell carcinoma. Drugs 2011, 71(4), 443-454.
    • (2011) Drugs , vol.71 , Issue.4 , pp. 443-454
    • Keisner, S.V.1    Shah, S.R.2
  • 72
    • 78751501299 scopus 로고    scopus 로고
    • Pazopanib reveals a role for tumor cell B-Raf in the prevention of HER2+ breast cancer brain metastasis
    • Gril, B.; Palmieri, D.; Qian, Y.; Smart, D.; Ileva, L.; Liewehr, D. J.; Steinberg, S. M.; Steeg, P. S. Pazopanib reveals a role for tumor cell B-Raf in the prevention of HER2+ breast cancer brain metastasis. Clin. Cancer Res. 2011, 17(1), 142-153.
    • (2011) Clin. Cancer Res. , vol.17 , Issue.1 , pp. 142-153
    • Gril, B.1    Palmieri, D.2    Qian, Y.3    Smart, D.4    Ileva, L.5    Liewehr, D.J.6    Steinberg, S.M.7    Steeg, P.S.8
  • 75
    • 38849202509 scopus 로고    scopus 로고
    • Scalable synthesis of the VEGF-R2 kinase inhibitor JNJ-17029259 using ultrasoundmediated addition of MeLi-CeCl3 to a nitrile
    • Reuman, M.; Beish, S.; Davis, J.; Batchelor, M. J.; Hutchings, M. C.; Moffat, D. F.; Connolly, P. J.; Russell, R. K. Scalable synthesis of the VEGF-R2 kinase inhibitor JNJ-17029259 using ultrasoundmediated addition of MeLi-CeCl3 to a nitrile. J. Org. Chem. 2008, 73(3), 1121-1123.
    • (2008) J. Org. Chem , vol.73 , Issue.3 , pp. 1121-1123
    • Reuman, M.1    Beish, S.2    Davis, J.3    Batchelor, M.J.4    Hutchings, M.C.5    Moffat, D.F.6    Connolly, P.J.7    Russell, R.K.8
  • 84
    • 27744518445 scopus 로고    scopus 로고
    • In vitro pharmacological characterization of TKI-28, a broad-spectrum tyrosine kinase inhibitor with anti-tumor and anti-angiogenic effects
    • Guo, X. N.; Zhong, L.; Tan, J. Z.; Li, J.; Luo, X. M.; Jiang, H. L.; Nan, F. J.; Lin, L. P.; Zhang, X. W.; Ding, J. In vitro pharmacological characterization of TKI-28, a broad-spectrum tyrosine kinase inhibitor with anti-tumor and anti-angiogenic effects. Cancer Biol. Ther. 2005, 4(10), 1125-1132.
    • (2005) Cancer Biol. Ther , vol.4 , Issue.10 , pp. 1125-1132
    • Guo, X.N.1    Zhong, L.2    Tan, J.Z.3    Li, J.4    Luo, X.M.5    Jiang, H.L.6    Nan, F.J.7    Lin, L.P.8    Zhang, X.W.9    Ding, J.10
  • 86
    • 33751032849 scopus 로고    scopus 로고
    • Synthesis and biological study of 4-aminopyrimidine-5-carboxaldehyde oximes as antiproliferative VEGFR-2 inhibitors
    • Huang, S.; Li, R.; Connolly, P. J.; Xu, G.; Gaul, M. D.; Emanuel, S. L.; Lamontagne, K. R.; Greenberger, L M. Synthesis and biological study of 4-aminopyrimidine-5-carboxaldehyde oximes as antiproliferative VEGFR-2 inhibitors. Bioorg. Med. Chem. Lett. 2006, 16(23), 6063-6066.
    • (2006) Bioorg. Med. Chem. Lett , vol.16 , Issue.23 , pp. 6063-6066
    • Huang, S.1    Li, R.2    Connolly, P.J.3    Xu, G.4    Gaul, M.D.5    Emanuel, S.L.6    Lamontagne, K.R.7    Greenberger, L.M.8
  • 87
  • 88
    • 42949157650 scopus 로고    scopus 로고
    • Macrocyclic aminopyrimidines as multitarget CDK and VEGF-R inhibitors with potent antiproliferative activities
    • Lücking, U.; Siemeister, G.; Schäfer, M.; Briem, H.; Krüger, M.; Lienau, P.; Jautelat, R. Macrocyclic aminopyrimidines as multitarget CDK and VEGF-R inhibitors with potent antiproliferative activities. Chem. Med. Chem. 2007, 2(1), 63-77.
    • (2007) Chem. Med. Chem , vol.2 , Issue.1 , pp. 63-77
    • Lücking, U.1    Siemeister, G.2    Schäfer, M.3    Briem, H.4    Krüger, M.5    Lienau, P.6    Jautelat, R.7
  • 89
    • 40849098809 scopus 로고    scopus 로고
    • Molecular modeling study and synthesis of novel pyrrolo[2,3-d]pyrimidines and pyrrolotriazolopyrimidines of expected antitumor and radioprotective activities
    • Abou El Ella, D. A.; Ghorab, M. M.; Noaman, E.; Heiba, H. I.; Khalil, A. I. Molecular modeling study and synthesis of novel pyrrolo[2,3-d]pyrimidines and pyrrolotriazolopyrimidines of expected antitumor and radioprotective activities. Bioorg. Med. Chem. 2008, 16(5), 2391-2402.
    • (2008) Bioorg. Med. Chem , vol.16 , Issue.5 , pp. 2391-2402
    • Abou El Ella, D.A.1    Ghorab, M.M.2    Noaman, E.3    Heiba, H.I.4    Khalil, A.I.5
  • 98
  • 99
    • 33846186883 scopus 로고    scopus 로고
    • Upregulation of Flk-1 by bFGF via the ERK pathway is essential for VEGFmediated promotion of neural stem cell proliferation
    • Xiao, Z.; Kong, Y.; Yang, S.; Li, M.; Wen, J.; Li, L. Upregulation of Flk-1 by bFGF via the ERK pathway is essential for VEGFmediated promotion of neural stem cell proliferation. Cell Res. 2007, 17(1), 73-79.
    • (2007) Cell Res , vol.17 , Issue.1 , pp. 73-79
    • Xiao, Z.1    Kong, Y.2    Yang, S.3    Li, M.4    Wen, J.5    Li, L.6
  • 101
    • 33748336510 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor (VEGF)-165 and semaphorin 3A-mediated cellular invasion and tumor growth by the VEGF signaling inhibitor ZD4190 in human colon cancer cells and xenografts
    • Nguyen, Q. D.; Rodrigues, S.; Rodrigue, C. M.; Rivat, C.; Grijelmo, C.; Bruyneel, E.; Emami, S.; Attoub, S.; Gespach, C. Inhibition of vascular endothelial growth factor (VEGF)-165 and semaphorin 3A-mediated cellular invasion and tumor growth by the VEGF signaling inhibitor ZD4190 in human colon cancer cells and xenografts. Mol. Cancer Ther. 2006, 5(8), 2070-2077.
    • (2006) Mol. Cancer Ther , vol.5 , Issue.8 , pp. 2070-2077
    • Nguyen, Q.D.1    Rodrigues, S.2    Rodrigue, C.M.3    Rivat, C.4    Grijelmo, C.5    Bruyneel, E.6    Emami, S.7    Attoub, S.8    Gespach, C.9
  • 102
    • 68149137730 scopus 로고    scopus 로고
    • The antiangiogenic agent ZD4190 prevents tumor outgrowth in a model of minimal residual carcinoma in deep tissues
    • Gaballah, K.; Oakley, R.; Hills, A.; Ryan, A.; Partridge, M. The antiangiogenic agent ZD4190 prevents tumor outgrowth in a model of minimal residual carcinoma in deep tissues. Br. J. Cancer. 2009, 101(3), 418-423.
    • (2009) Br. J. Cancer , vol.101 , Issue.3 , pp. 418-423
    • Gaballah, K.1    Oakley, R.2    Hills, A.3    Ryan, A.4    Partridge, M.5
  • 103
    • 0037075812 scopus 로고    scopus 로고
    • Novel 4-anilinoquinazolines with C-7 basic side chains: Design and structure activity relationship of a series of potent, orally active, VEGF receptor tyrosine kinase inhibitors
    • Hennequin, L. F.; Stokes, E. S.; Thomas, A. P.; Johnstone, C.; Plé, P. A.; Ogilvie, D. J.; Dukes, M.; Wedge, S. R.; Kendrew, J.; Curwen, J. O. Novel 4-anilinoquinazolines with C-7 basic side chains: design and structure activity relationship of a series of potent, orally active, VEGF receptor tyrosine kinase inhibitors. J. Med. Chem. 2002, 45(6), 1300-1312.
    • (2002) J. Med. Chem. , vol.45 , Issue.6 , pp. 1300-1312
    • Hennequin, L.F.1    Stokes, E.S.2    Thomas, A.P.3    Johnstone, C.4    Plé, P.A.5    Ogilvie, D.J.6    Dukes, M.7    Wedge, S.R.8    Kendrew, J.9    Curwen, J.O.10
  • 104
    • 77950852399 scopus 로고    scopus 로고
    • ZD6474, a multitargeted inhibitor for receptor tyrosine kinases, suppresses growth of gliomas expressing an epidermal growth factor receptor mutant, EGFRvIII, in the brain
    • Yiin, J. J.; Hu, B.; Schornack, P. A.; Sengar, R. S.; Liu, K. W.; Feng, H.; Lieberman, F. S.; Chiou, S. H.; Sarkaria, J. N.; Wiener, E. C.; Ma, H. I.; Cheng, S. Y. ZD6474, a multitargeted inhibitor for receptor tyrosine kinases, suppresses growth of gliomas expressing an epidermal growth factor receptor mutant, EGFRvIII, in the brain. Mol. Cancer Ther. 2010, 9(4), 929-941.
    • (2010) Mol. Cancer Ther. , vol.9 , Issue.4 , pp. 929-941
    • Yiin, J.J.1    Hu, B.2    Schornack, P.A.3    Sengar, R.S.4    Liu, K.W.5    Feng, H.6    Lieberman, F.S.7    Chiou, S.H.8    Sarkaria, J.N.9    Wiener, E.C.10    Ma, H.I.11    Cheng, S.Y.12
  • 105
    • 66249118670 scopus 로고    scopus 로고
    • Vandetanib (ZD6474), a dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinases: Current status and future directions
    • Morabito, A.; Piccirillo, M. C.; Falasconi, F.; DeFeo, G.; DelGiudice, A.; Bryce, J.; DiMaio. M.; DeMaio. E.; Normanno, N.; Perrone, F. Vandetanib (ZD6474), a dual inhibitor of vascular endothelial growth factor receptor (VEGFR) and epidermal growth factor receptor (EGFR) tyrosine kinases: current status and future directions. Oncologist 2009, 14(4), 378-390.
    • (2009) Oncologist , vol.14 , Issue.4 , pp. 378-390
    • Morabito, A.1    Piccirillo, M.C.2    Falasconi, F.3    DeFeo, G.4    DelGiudice, A.5    Bryce, J.6    DiMaio, M.7    DeMaio, E.8    Normanno, N.9    Perrone, F.10
  • 110
    • 12344263868 scopus 로고    scopus 로고
    • KRN633: A selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase that suppresses tumor angiogenesis and growth
    • Nakamura, K.; Yamamoto, A.; Kamishohara, M.; Takahashi, K.; Taguchi, E.; Miura, T.; Kubo, K.; Shibuya, M.; Isoe, T. KRN633: A selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase that suppresses tumor angiogenesis and growth. Mol. Cancer Ther. 2004, 3(12), 1639-1649.
    • (2004) Mol. Cancer Ther , vol.3 , Issue.12 , pp. 1639-1649
    • Nakamura, K.1    Yamamoto, A.2    Kamishohara, M.3    Takahashi, K.4    Taguchi, E.5    Miura, T.6    Kubo, K.7    Shibuya, M.8    Isoe, T.9
  • 111
    • 33644851073 scopus 로고    scopus 로고
    • Improvement by solid dispersion of the bioavailability of KRN633, a selective inhibitor of VEGF receptor-2 tyrosine kinase, and identification of its potential therapeutic window
    • Matsunaga, N.; Nakamura, K.; Yamamoto, A.; Taguchi, E.; Tsunoda, H.; Takahashi, K. Improvement by solid dispersion of the bioavailability of KRN633, a selective inhibitor of VEGF receptor-2 tyrosine kinase, and identification of its potential therapeutic window. Mol. Cancer Ther. 2006, 5(1), 80-88.
    • (2006) Mol. Cancer Ther. , vol.5 , Issue.1 , pp. 80-88
    • Matsunaga, N.1    Nakamura, K.2    Yamamoto, A.3    Taguchi, E.4    Tsunoda, H.5    Takahashi, K.6
  • 112
    • 34247393271 scopus 로고    scopus 로고
    • Dual irreversible kinase inhibitors: Quinazoline-based inhibitors incorporating two independent reactive centers with each targeting different cysteine residues in the kinase domains of EGFR and VEGFR-2
    • Wissner, A.; Fraser, H. L.; Ingalls, C. L.; Dushin, R. G.; Floyd, M. B.; Cheung, K.; Nittoli, T.; Ravi, M. R.; Tan, X.; Loganzo, F. Dual irreversible kinase inhibitors: quinazoline-based inhibitors incorporating two independent reactive centers with each targeting different cysteine residues in the kinase domains of EGFR and VEGFR-2. Bioorg. Med. Chem. 2007, 15(11), 3635-3648.
    • (2007) Bioorg. Med. Chem , vol.15 , Issue.11 , pp. 3635-3648
    • Wissner, A.1    Fraser, H.L.2    Ingalls, C.L.3    Dushin, R.G.4    Floyd, M.B.5    Cheung, K.6    Nittoli, T.7    Ravi, M.R.8    Tan, X.9    Loganzo, F.10
  • 114
    • 20144375600 scopus 로고    scopus 로고
    • Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: Synthesis, structure-activity relationships, and antitumor activities of Nphenyl-N'-{4-(4-quinolyloxy)phenyl}ureas
    • Kubo, K.; Shimizu, T.; Ohyama, S.; Murooka, H.; Iwai, A.; Nakamura, K.; Hasegawa, K.; Kobayashi, Y.; Takahashi, N.; Takahashi, K.; Kato, S.; Izawa, T.; Isoe, T. Novel potent orally active selective VEGFR-2 tyrosine kinase inhibitors: synthesis, structure-activity relationships, and antitumor activities of Nphenyl-N'-{4-(4-quinolyloxy)phenyl}ureas. J. Med. Chem. 2005, 48(5), 1359-1366.
    • (2005) J. Med. Chem. , vol.48 , Issue.5 , pp. 1359-1366
    • Kubo, K.1    Shimizu, T.2    Ohyama, S.3    Murooka, H.4    Iwai, A.5    Nakamura, K.6    Hasegawa, K.7    Kobayashi, Y.8    Takahashi, N.9    Takahashi, K.10    Kato, S.11    Izawa, T.12    Isoe, T.13
  • 115
    • 40949085595 scopus 로고    scopus 로고
    • A quantitative structure-activity relationship study of novel, potent, orally active, selective VEGFR-2 and PDGFRalpha tyrosine kinase inhibitors: Derivatives of N-phenyl-N'-{4-(4-quinolyloxy) phenyl} urea as antitumor agents
    • Sharma, B. K.; Sharma, S. K.; Singh, P.; Sharma, S. A quantitative structure-activity relationship study of novel, potent, orally active, selective VEGFR-2 and PDGFRalpha tyrosine kinase inhibitors: derivatives of N-phenyl-N'-{4-(4-quinolyloxy) phenyl} urea as antitumor agents. J. Enzyme Inhib. Med. Chem. 2008, 23(2), 168-173.
    • (2008) J. Enzyme Inhib. Med. Chem , vol.23 , Issue.2 , pp. 168-173
    • Sharma, B.K.1    Sharma, S.K.2    Singh, P.3    Sharma, S.4
  • 117
    • 77956216884 scopus 로고    scopus 로고
    • Tivozanib, a pan-VEGFR tyrosine kinase inhibitor for the potential treatment of solid tumors
    • De Luca, A.; Normanno, N. Tivozanib, a pan-VEGFR tyrosine kinase inhibitor for the potential treatment of solid tumors. IDrugs 2010, 13(9), 636-645.
    • (2010) IDrugs , vol.13 , Issue.9 , pp. 636-645
    • de Luca, A.1    Normanno, N.2
  • 119
    • 33846212284 scopus 로고    scopus 로고
    • Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5
    • Liu, L.; Cao, Y.; Chen, C.; Zhang, X.; McNabola, A.; Wilkie, D.; Wilhelm, S.; Lynch, M.; Carter, C. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. Cancer Res. 2006, 66(24), 11851-11858.
    • (2006) Cancer Res , vol.66 , Issue.24 , pp. 11851-11858
    • Liu, L.1    Cao, Y.2    Chen, C.3    Zhang, X.4    McNabola, A.5    Wilkie, D.6    Wilhelm, S.7    Lynch, M.8    Carter, C.9
  • 120
    • 69249132057 scopus 로고    scopus 로고
    • Sorafenib inhibits non-small cell lung cancer cell growth by targeting B-RAF in KRAS wild-type cells and C-RAF in KRAS mutant cells
    • Takezawa, K.; Okamoto, I.; Yonesaka, K.; Hatashita, E.; Yamada, Y.; Fukuoka, M.; Nakagawa, K. Sorafenib inhibits non-small cell lung cancer cell growth by targeting B-RAF in KRAS wild-type cells and C-RAF in KRAS mutant cells. Cancer Res. 2009, 69(16), 6515-6521.
    • (2009) Cancer Res , vol.69 , Issue.16 , pp. 6515-6521
    • Takezawa, K.1    Okamoto, I.2    Yonesaka, K.3    Hatashita, E.4    Yamada, Y.5    Fukuoka, M.6    Nakagawa, K.7
  • 124
    • 65549163439 scopus 로고    scopus 로고
    • Motesanib diphosphate (AMG 706), an oral angiogenesis inhibitor, demonstrates clinical efficacy in advanced thymoma
    • Azad, A.; Herbertson, R. A.; Pook, D.; White, S.; Mitchell, P. L.; Tebbutt, N. C. Motesanib diphosphate (AMG 706), an oral angiogenesis inhibitor, demonstrates clinical efficacy in advanced thymoma. Acta Oncol. 2009, 48(4), 619-621.
    • (2009) Acta Oncol. , vol.48 , Issue.4 , pp. 619-621
    • Azad, A.1    Herbertson, R.A.2    Pook, D.3    White, S.4    Mitchell, P.L.5    Tebbutt, N.C.6
  • 128
    • 33144483524 scopus 로고    scopus 로고
    • Inhibitors of VEGF receptors-1 and-2 based on the 2-((pyridin-4-yl)ethyl)pyridine template
    • Kiselyov, A. S.; Semenova, M.; Semenov, V. V.; Milligan, D. inhibitors of VEGF receptors-1 and-2 based on the 2-((pyridin-4-yl)ethyl)pyridine template. Bioorg. Med. Chem. Lett. 2006, 16(7), 1913-1919.
    • (2006) Bioorg. Med. Chem. Lett. , vol.16 , Issue.7 , pp. 1913-1919
    • Kiselyov, A.S.1    Semenova, M.2    Semenov, V.V.3    Milligan, D.4
  • 131
    • 37849009384 scopus 로고    scopus 로고
    • Phase II, open-label study of PTK787/ZK222584 for the treatment of metastatic gastrointestinal stromal tumors resistant to imatinib mesylate
    • Joensuu, H.; DeBraud, F.; Coco, P.; DePas, T.; Putzu, C.; Spreafico, C.; Bono, P.; Bosselli, S.; Jalava, T.; Lauret, D.; Casali, P. G. Phase II, open-label study of PTK787/ZK222584 for the treatment of metastatic gastrointestinal stromal tumors resistant to imatinib mesylate. Ann. Oncol. 2008, 19(1), 173-177.
    • (2008) Ann. Oncol , vol.19 , Issue.1 , pp. 173-177
    • Joensuu, H.1    DeBraud, F.2    Coco, P.3    DePas, T.4    Putzu, C.5    Spreafico, C.6    Bono, P.7    Bosselli, S.8    Jalava, T.9    Lauret, D.10    Casali, P.G.11
  • 132
    • 33947182049 scopus 로고    scopus 로고
    • Vatalanib: The clinical development of a tyrosine kinase inhibitor of angiogenesis in solid tumors
    • Scott, E. N.; Meinhardt, G.; Jacques, C.; Laurent, D.; Thomas, A. L. Vatalanib: the clinical development of a tyrosine kinase inhibitor of angiogenesis in solid tumors. Expert Opin. Investig. Drugs 2007, 16(3), 367-379.
    • (2007) Expert Opin. Investig. Drugs , vol.16 , Issue.3 , pp. 367-379
    • Scott, E.N.1    Meinhardt, G.2    Jacques, C.3    Laurent, D.4    Thomas, A.L.5
  • 133
    • 77955748591 scopus 로고    scopus 로고
    • Biological evidence for dual antiangiogenic-antiaromatase activity of the VEGFR inhibitor PTK787/ZK222584 in vivo
    • Banerjee, S.; A'Hern, R.; Detre, S.; Littlewood-Evans, A. J.; Evans, D. B.; Dowsett, M.; Martin, L. A.; Biological evidence for dual antiangiogenic-antiaromatase activity of the VEGFR inhibitor PTK787/ZK222584 in vivo. Clin. Cancer Res. 2010, 16(16), 4178-4187.
    • (2010) Clin. Cancer Res. , vol.16 , Issue.16 , pp. 4178-4187
    • Banerjee, S.1    A'Hern, R.2    Detre, S.3    Littlewood-Evans, A.J.4    Evans, D.B.5    Dowsett, M.6    Martin, L.A.7
  • 135
    • 33845562814 scopus 로고    scopus 로고
    • 4-(Azolylphenyl)-phthalazin-1-amines: Novel inhibitors of VEGF receptors I and II
    • Kiselyov, A. S.; Semenov, V. V.; Milligan, D. 4-(Azolylphenyl)-phthalazin-1-amines: Novel inhibitors of VEGF receptors I and II. Chem. Biol. Drug Des. 2006, 68(6), 308-313.
    • (2006) Chem. Biol. Drug Des , vol.68 , Issue.6 , pp. 308-313
    • Kiselyov, A.S.1    Semenov, V.V.2    Milligan, D.3
  • 136
    • 33845516261 scopus 로고    scopus 로고
    • 1-(Azolyl)-4-(aryl)-phthalazines: Novel potent inhibitors of VEGF receptors I and II
    • Kiselyov, A. S.; Semenova, M.; Semenov, V. V.; Piatnitski, E. L. 1-(Azolyl)-4-(aryl)-phthalazines: novel potent inhibitors of VEGF receptors I and II. Chem. Biol. Drug Des. 2006, 68(5), 250-255.
    • (2006) Chem. Biol. Drug Des , vol.68 , Issue.5 , pp. 250-255
    • Kiselyov, A.S.1    Semenova, M.2    Semenov, V.V.3    Piatnitski, E.L.4
  • 137
    • 34247097979 scopus 로고    scopus 로고
    • Receptor tyrosine kinase inhibitors AG013764 and AG013711 reduce choroidal neovascularization in rat eye
    • Wang, F. E.; Shi, G.; Niesman, M. R.; Rewolinski, D. A.; Miller, S. S. Receptor tyrosine kinase inhibitors AG013764 and AG013711 reduce choroidal neovascularization in rat eye. Exp. Eye Res. 2007, 84(5), 922-933.
    • (2007) Exp. Eye Res , vol.84 , Issue.5 , pp. 922-933
    • Wang, F.E.1    Shi, G.2    Niesman, M.R.3    Rewolinski, D.A.4    Miller, S.S.5
  • 138
    • 69249142285 scopus 로고    scopus 로고
    • ABT-869, a promising multi-targeted tyrosine kinase inhibitor: From bench to bedside
    • Zhou, J.; Goh, B. C.; Albert, D. H.; Chen, C. S. ABT-869, a promising multi-targeted tyrosine kinase inhibitor: from bench to bedside. J. Hematol. Oncol. 2009, 2, 33.
    • (2009) J. Hematol. Oncol. , vol.2 , pp. 33
    • Zhou, J.1    Goh, B.C.2    Albert, D.H.3    Chen, C.S.4
  • 141
    • 77951907727 scopus 로고    scopus 로고
    • A phase I study of axitinib (AG-013736) in combination with bevacizumab plus chemotherapy or chemotherapy alone in patients with metastatic colorectal cancer and other solid tumors
    • Sharma, S.; Abhyankar, V.; Burgess, R. E.; Infante, J.; Trowbridge, R. C.; Tarazi, J.; Kim, S.; Tortorici, M.; Chen, Y.; Robles, R. L. A phase I study of axitinib (AG-013736) in combination with bevacizumab plus chemotherapy or chemotherapy alone in patients with metastatic colorectal cancer and other solid tumors. Ann. Oncol. 2010, 21(2), 297-304.
    • (2010) Ann. Oncol. , vol.21 , Issue.2 , pp. 297-304
    • Sharma, S.1    Abhyankar, V.2    Burgess, R.E.3    Infante, J.4    Trowbridge, R.C.5    Tarazi, J.6    Kim, S.7    Tortorici, M.8    Chen, Y.9    Robles, R.L.10
  • 145
    • 10744227153 scopus 로고    scopus 로고
    • A new class of potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: Structure-activity relationships for a series of 9-alkoxymethyl-12-(3-hydroxypropyl)indeno[2,1-a]pyrrolo[3,4-c]carbazole-5-ones and the identification of CEP-5214 and its dimethylglycine ester prodrug clinical candidate CEP-7055
    • Gingrich, D. E.; Reddy, D. R.; Iqbal, M. A.; Singh, J.; Aimone, L. D.; Angeles, T. S.; Albom, M.; Yang, S.; Ator, M. A.; Meyer, S. L.; Robinson, C.; Ruggeri, B. A.; Dionne, C. A.; Vaught, J. L; Mallamo, J. P.; Hudkins, R. L. A new class of potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: structure-activity relationships for a series of 9-alkoxymethyl-12-(3-hydroxypropyl)indeno[2,1-a]pyrrolo[3,4-c]carbazole-5-ones and the identification of CEP-5214 and its dimethylglycine ester prodrug clinical candidate CEP-7055. J. Med. Chem. 2003, 46(25), 5375-5388.
    • (2003) J. Med. Chem , vol.46 , Issue.25 , pp. 5375-5388
    • Gingrich, D.E.1    Reddy, D.R.2    Iqbal, M.A.3    Singh, J.4    Aimone, L.D.5    Angeles, T.S.6    Albom, M.7    Yang, S.8    Ator, M.A.9    Meyer, S.L.10    Robinson, C.11    Ruggeri, B.A.12    Dionne, C.A.13    Vaught, J.L.14    Mallamo, J.P.15    Hudkins, R.L.16
  • 147
    • 33748304477 scopus 로고    scopus 로고
    • The effects of the oral, pan-VEGF-R kinase inhibitor CEP-7055 and chemotherapy in orthotopic models of glioblastoma and colon carcinoma in mice
    • Jones-Bolin, S.; Zhao, H.; Hunter, K.; Klein-Szanto, A.; Ruggeri, B. The effects of the oral, pan-VEGF-R kinase inhibitor CEP-7055 and chemotherapy in orthotopic models of glioblastoma and colon carcinoma in mice. Mol. Cancer Ther. 2006, 5(7), 1744-1753.
    • (2006) Mol. Cancer Ther. , vol.5 , Issue.7 , pp. 1744-1753
    • Jones-Bolin, S.1    Zhao, H.2    Hunter, K.3    Klein-Szanto, A.4    Ruggeri, B.5
  • 148
    • 33748313108 scopus 로고    scopus 로고
    • Novel C-3 N-urea, amide, and carbamate dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole analogs as potent TIE-2 and VEGFR-2 dual inhibitors
    • Becknell, N. C.; Zulli, A. L.; Angeles, T. S.; Yang, S.; Albom, M. S.; Aimone, L. D.; Robinson, C.; Chang, H.; Hudkins, R. L. Novel C-3 N-urea, amide, and carbamate dihydroindazolo[5,4-a]pyrrolo[3,4-c]carbazole analogs as potent TIE-2 and VEGFR-2 dual inhibitors. Bioorg. Med. Chem. Lett. 2006, 16(20), 5368-5372.
    • (2006) Bioorg. Med. Chem. Lett , vol.16 , Issue.20 , pp. 5368-5372
    • Becknell, N.C.1    Zulli, A.L.2    Angeles, T.S.3    Yang, S.4    Albom, M.S.5    Aimone, L.D.6    Robinson, C.7    Chang, H.8    Hudkins, R.L.9
  • 150
  • 155
    • 34247326880 scopus 로고    scopus 로고
    • A phase I/randomized phase II, noncomparative, multicenter, open label trial of CP-547,632 in combination with paclitaxel and carboplatin or paclitaxel and carboplatin alone as first-line treatment for advanced non-small cell lung cancer (NSCLC)
    • Cohen, R. B.; Langer, C. J.; Simon, G. R.; Eisenberg, P. D.; Hainsworth, J. D.; Madajewicz, S.; Cosgriff, T. M.; Pierce, K.; Xu, H.; Liau, K.; Healey, D. A phase I/randomized phase II, noncomparative, multicenter, open label trial of CP-547,632 in combination with paclitaxel and carboplatin or paclitaxel and carboplatin alone as first-line treatment for advanced non-small cell lung cancer (NSCLC). Cancer Chemother. Pharmacol. 2007, 60(1), 81-89.
    • (2007) Cancer Chemother. Pharmacol. , vol.60 , Issue.1 , pp. 81-89
    • Cohen, R.B.1    Langer, C.J.2    Simon, G.R.3    Eisenberg, P.D.4    Hainsworth, J.D.5    Madajewicz, S.6    Cosgriff, T.M.7    Pierce, K.8    Xu, H.9    Liau, K.10    Healey, D.11
  • 156
    • 59649112339 scopus 로고    scopus 로고
    • 3,4-Disubstituted isothiazoles: Novel potent inhibitors of VEGF receptors 1 and 2
    • Kiselyov, A. S.; Semenova, M.; Semenov, V.V. 3,4-Disubstituted isothiazoles: novel potent inhibitors of VEGF receptors 1 and 2. Bioorg. Med. Chem. Lett. 2009, 19(4), 1195-1198.
    • (2009) Bioorg. Med. Chem. Lett , vol.19 , Issue.4 , pp. 1195-1198
    • Kiselyov, A.S.1    Semenova, M.2    Semenov, V.V.3
  • 158
    • 34249311318 scopus 로고    scopus 로고
    • 1H-1,2,4-triazol-3-yl-anilines: Novel potent inhibitors of vascular endothelial growth factor receptors 1 and 2
    • Kiselyov, A. S.; Piatnitski, E.; Milligan, D.; Ouyang, X. 1H-1,2,4-triazol-3-yl-anilines: novel potent inhibitors of vascular endothelial growth factor receptors 1 and 2. Chem. Biol. Drug Des. 2007, 69(5), 331-337.
    • (2007) Chem. Biol. Drug Des , vol.69 , Issue.5 , pp. 331-337
    • Kiselyov, A.S.1    Piatnitski, E.2    Milligan, D.3    Ouyang, X.4
  • 163
    • 79251470430 scopus 로고    scopus 로고
    • Inactivation of cytochrome P450 (P450) 3A4 but not P450 3A5 by OSI-930, a thiophene-containing anticancer drug
    • Lin H. L.; Zhang, H.; Medower, C.; Hollenberg, P. F.; Johnson, W. W. Inactivation of cytochrome P450 (P450) 3A4 but not P450 3A5 by OSI-930, a thiophene-containing anticancer drug. Drug. Metab. Dispos. 2011, 39(2), 345-350.
    • (2011) Drug. Metab. Dispos. , vol.39 , Issue.2 , pp. 345-350
    • Lin, H.L.1    Zhang, H.2    Medower, C.3    Hollenberg, P.F.4    Johnson, W.W.5
  • 164
    • 37349105704 scopus 로고    scopus 로고
    • E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition
    • Matsui, J.; Yamamoto, Y.; Funahashi, Y.; Tsuruoka, A.; Watanabe, T.; Wakabayashi, T.; Uenaka, T.; Asada, M. E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition. Int. J. Cancer 2008, 122(3), 664-671.
    • (2008) Int. J. Cancer , vol.122 , Issue.3 , pp. 664-671
    • Matsui, J.1    Yamamoto, Y.2    Funahashi, Y.3    Tsuruoka, A.4    Watanabe, T.5    Wakabayashi, T.6    Uenaka, T.7    Asada, M.8
  • 165
    • 53049085556 scopus 로고    scopus 로고
    • Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R) 2 and VEGF-R3 kinase
    • Matsui, J.; Funahashi, Y.; Uenaka, T.; Watanabe, T.; Tsuruoka, A.; Asada, M. Multi-kinase inhibitor E7080 suppresses lymph node and lung metastases of human mammary breast tumor MDA-MB-231 via inhibition of vascular endothelial growth factor-receptor (VEGF-R) 2 and VEGF-R3 kinase. Clin. Cancer Res. 2008, 14(17), 5459-5465.
    • (2008) Clin. Cancer Res , vol.14 , Issue.17 , pp. 5459-5465
    • Matsui, J.1    Funahashi, Y.2    Uenaka, T.3    Watanabe, T.4    Tsuruoka, A.5    Asada, M.6
  • 168
    • 75949107937 scopus 로고    scopus 로고
    • VEGF Inhibitors and Prostate Cancer Therapy
    • Aragon-Ching, J. B.; Dahut, W. L. VEGF Inhibitors and Prostate Cancer Therapy. Curr. Mol. Pharmacol. 2009, 2(2), 161-168.
    • (2009) Curr. Mol. Pharmacol. , vol.2 , Issue.2 , pp. 161-168
    • Aragon-Ching, J.B.1    Dahut, W.L.2
  • 170
    • 72549112083 scopus 로고    scopus 로고
    • Discovery of novel taspine derivatives as antiangiogenic agent
    • Zhang, J.; Zhang, Y.; Zhang, S.; Wang, S.; He, L. Discovery of novel taspine derivatives as antiangiogenic agent. Bioorg. Med. Chem. Lett. 2010, 20(2), 718-721.
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , Issue.2 , pp. 718-721
    • Zhang, J.1    Zhang, Y.2    Zhang, S.3    Wang, S.4    He, L.5
  • 173
    • 44649193281 scopus 로고    scopus 로고
    • Inflammatory corneal (lymph)angiogenesis is blocked by VEGFR-tyrosine kinase inhibitor ZK 261991, resulting in improved graft survival after corneal transplantation
    • Hos, D.; Bock, F.; Dietrich, T.; Onderka, J.; Kruse, F. E.; Thierauch, K. H.; Cursiefen, C. Inflammatory corneal (lymph)angiogenesis is blocked by VEGFR-tyrosine kinase inhibitor ZK 261991, resulting in improved graft survival after corneal transplantation. Invest. Ophthalmol. Vis. Sci. 2008, 49(5), 1836-1842.
    • (2008) Invest. Ophthalmol. Vis. Sci , vol.49 , Issue.5 , pp. 1836-1842
    • Hos, D.1    Bock, F.2    Dietrich, T.3    Onderka, J.4    Kruse, F.E.5    Thierauch, K.H.6    Cursiefen, C.7
  • 178
    • 22244491050 scopus 로고    scopus 로고
    • Synthesis and structure-activity relationships of soluble 7-substituted 3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-2-amines and related ureas as dual inhibitors of the fibroblast growth factor receptor-1 and vascular endothelial growth factor receptor-2 tyrosine kinases
    • Thompson, A. M.; Delaney, A. M.; Hamby, J. M.; Schroeder, M. C.; Spoon, T. A.; Crean, S. M.; Showalter, H. D.; Denny, W. A. Synthesis and structure-activity relationships of soluble 7-substituted 3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-2-amines and related ureas as dual inhibitors of the fibroblast growth factor receptor-1 and vascular endothelial growth factor receptor-2 tyrosine kinases. J. Med. Chem. 2005, 48(14), 4628-4653.
    • (2005) J. Med. Chem , vol.48 , Issue.14 , pp. 4628-4653
    • Thompson, A.M.1    Delaney, A.M.2    Hamby, J.M.3    Schroeder, M.C.4    Spoon, T.A.5    Crean, S.M.6    Showalter, H.D.7    Denny, W.A.8
  • 179
    • 46249099175 scopus 로고    scopus 로고
    • De novo design and synthesis of N-benzylanilines as new candidates for VEGFR tyrosine kinase inhibitors
    • Uno, M.; Ban, H. S.; Nabeyama, W.; Nakamura, H. de novo design and synthesis of N-benzylanilines as new candidates for VEGFR tyrosine kinase inhibitors. Org. Biomol. Chem. 2008, 6(6), 979-981.
    • (2008) Org. Biomol. Chem , vol.6 , Issue.6 , pp. 979-981
    • Uno, M.1    Ban, H.S.2    Nabeyama, W.3    Nakamura, H.4
  • 184
    • 34250162117 scopus 로고    scopus 로고
    • Novel inhibitors of VEGF receptors-1 and-2 based on azole-5-carboxamide templates
    • Kiselyov, A. S.; Milligan, D.; Ouyang, X. Novel inhibitors of VEGF receptors-1 and-2 based on azole-5-carboxamide templates. Bioorg. Med. Chem. Lett. 2007, 17(13), 3550-3557.
    • (2007) Bioorg. Med. Chem. Lett , vol.17 , Issue.13 , pp. 3550-3557
    • Kiselyov, A.S.1    Milligan, D.2    Ouyang, X.3
  • 185
    • 29544444969 scopus 로고    scopus 로고
    • N-(Aryl)-4-(azolylethyl) thiazole-5-carboxamides: Novel potent inhibitors of VEGF receptors I and II
    • Kiselyov, A. S.; Piatnitski, E.; Semenova M.; Semenov, V. V. N-(Aryl)-4-(azolylethyl) thiazole-5-carboxamides: novel potent inhibitors of VEGF receptors I and II. Bioorg. Med. Chem. Lett. 2006, 16(3), 602-606.
    • (2006) Bioorg. Med. Chem. Lett , vol.16 , Issue.3 , pp. 602-606
    • Kiselyov, A.S.1    Piatnitski, E.2    Semenova, M.3    Semenov, V.V.4
  • 187
    • 29544435867 scopus 로고    scopus 로고
    • Naphthofuroquinone derivatives: Inhibition of receptor tyrosine kinases. Naphthofuroquinone derivatives: Inhibition of receptor tyrosine kinases
    • Lee, K. I.; Park, Y.; Park, S. J.; Hwang, J. H.; Lee, S. J.; Kim, G. D.; Park, W. K.; Lee, S.; Jeong, D.; Kong, J. Y.; Kang, H. K.; Cho, H. Naphthofuroquinone derivatives: inhibition of receptor tyrosine kinases. Naphthofuroquinone derivatives: inhibition of receptor tyrosine kinases. Bioorg. Med. Chem. Lett. 2006, 16(3), 737-742.
    • (2006) Bioorg. Med. Chem. Lett , vol.16 , Issue.3 , pp. 737-742
    • Lee, K.I.1    Park, Y.2    Park, S.J.3    Hwang, J.H.4    Lee, S.J.5    Kim, G.D.6    Park, W.K.7    Lee, S.8    Jeong, D.9    Kong, J.Y.10    Kang, H.K.11    Cho, H.12
  • 188
    • 34247273996 scopus 로고    scopus 로고
    • The discovery of novel vascular endothelial growth factor receptor tyrosine kinases inhibitors: Pharmacophore modeling, virtual screening and docking studies
    • Yu, H.; Wang, Z.; Zhang, L.; Zhang, J.; Huang, Q. The discovery of novel vascular endothelial growth factor receptor tyrosine kinases inhibitors: pharmacophore modeling, virtual screening and docking studies. Chem. Biol. Drug Des. 2007, 69(3), 204-211.
    • (2007) Chem. Biol. Drug Des , vol.69 , Issue.3 , pp. 204-211
    • Yu, H.1    Wang, Z.2    Zhang, L.3    Zhang, J.4    Huang, Q.5
  • 190
    • 35548940240 scopus 로고    scopus 로고
    • Neovastat (AE-941) inhibits the airway inflammation via VEGF and HIF-2 alpha suppression
    • Lee, S. Y.; Chung, S. M. Neovastat (AE-941) inhibits the airway inflammation via VEGF and HIF-2 alpha suppression. Vascul. Pharmacol. 2007, 47(5-6), 313-318.
    • (2007) Vascul. Pharmacol , vol.47 , Issue.5-6 , pp. 313-318
    • Lee, S.Y.1    Chung, S.M.2
  • 191
    • 67650473470 scopus 로고    scopus 로고
    • Recent advances of novel targeted therapy in non-small cell lung cancer
    • Katzel, J. A.; Fanucchi, M. P.; Li, Z. Recent advances of novel targeted therapy in non-small cell lung cancer. J. Hematol. Oncol. 2009, 2, 2.
    • (2009) J. Hematol. Oncol. , vol.2 , pp. 2
    • Katzel, J.A.1    Fanucchi, M.P.2    Li, Z.3
  • 192
    • 65349189877 scopus 로고    scopus 로고
    • Angiogenesis in the treatment of nonsmall cell lung cancer
    • Horn, L.; Sandler, A. B. Angiogenesis in the treatment of nonsmall cell lung cancer. Proc. Am. Thorac. Soc. 2009, 6(2), 206-217.
    • (2009) Proc. Am. Thorac. Soc. , vol.6 , Issue.2 , pp. 206-217
    • Horn, L.1    Sandler, A.B.2
  • 193
    • 70349492706 scopus 로고    scopus 로고
    • A highly selective, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor has potent activity in vitro and in vivo
    • LaMontagne, K. R.; Butler, J.; Borowski, V. B.; Fuentes-Pesquera, A. R.; Blevitt, J. M.; Huang, S.; Li, R.; Connolly, P. J.; Greenberger, L. M. A highly selective, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor has potent activity in vitro and in vivo. Angiogenesis 2009, 12(3), 287-296.
    • (2009) Angiogenesis , vol.12 , Issue.3 , pp. 287-296
    • LaMontagne, K.R.1    Butler, J.2    Borowski, V.B.3    Fuentes-Pesquera, A.R.4    Blevitt, J.M.5    Huang, S.6    Li, R.7    Connolly, P.J.8    Greenberger, L.M.9
  • 195
    • 73349126704 scopus 로고    scopus 로고
    • What is new in kidney cancer?
    • Kirkali, Z. What is new in kidney cancer? Expert. Rev. Anticancer Ther. 2009, 9(12), 1753-1755.
    • (2009) Expert. Rev. Anticancer Ther. , vol.9 , Issue.12 , pp. 1753-1755
    • Kirkali, Z.1
  • 196
    • 0030856731 scopus 로고    scopus 로고
    • Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders
    • Presta, L. G.; Chen, H.; O'Connor, S. J.; Chisholm, V.; Meng, Y. G.; Krummen, L.; Winkler, M.; Ferrara, N. Humanization of an anti-vascular endothelial growth factor monoclonal antibody for the therapy of solid tumors and other disorders. Cancer Res. 1997, 57(20), 4593-4599.
    • (1997) Cancer Res , vol.57 , Issue.20 , pp. 4593-4599
    • Presta, L.G.1    Chen, H.2    O'Connor, S.J.3    Chisholm, V.4    Meng, Y.G.5    Krummen, L.6    Winkler, M.7    Ferrara, N.8
  • 197
  • 198
    • 65349189877 scopus 로고    scopus 로고
    • Angiogenesis in the treatment of nonsmall cell lung cancer. Proc
    • Horn, L.; Sandler, A. B. Angiogenesis in the treatment of nonsmall cell lung cancer. Proc. Am. Thorac. Soc. 2009, 6(2), 206-217.
    • (2009) Am. Thorac. Soc. , vol.6 , Issue.2 , pp. 206-217
    • Horn, L.1    Sandler, A.B.2
  • 199
    • 79851507124 scopus 로고    scopus 로고
    • Ranibizumab for age-related macular degeneration
    • Cheng, J. W.; Wei, R. L. Ranibizumab for age-related macular degeneration. N. Engl. J. Med. 2011, 364(6), 582.
    • (2011) N. Engl. J. Med. , vol.364 , Issue.6 , pp. 582
    • Cheng, J.W.1    Wei, R.L.2
  • 201
    • 0037386937 scopus 로고    scopus 로고
    • A phase I study of anti-kinase insert domain-containing receptor antibody, IMC-1C11, in patients with liver metastases from colorectal carcinoma
    • Posey, J. A.; Ng, T. C.; Yang, B.; Khazaeli, M. B.; Carpenter, M. D.; Fox, F.; Needle, M.; Waksal, H.; LoBuglio, A. F. A phase I study of anti-kinase insert domain-containing receptor antibody, IMC-1C11, in patients with liver metastases from colorectal carcinoma. Clin. Cancer Res. 2003, 9(4), 1323-1332.
    • (2003) Clin. Cancer Res , vol.9 , Issue.4 , pp. 1323-1332
    • Posey, J.A.1    Ng, T.C.2    Yang, B.3    Khazaeli, M.B.4    Carpenter, M.D.5    Fox, F.6    Needle, M.7    Waksal, H.8    LoBuglio, A.F.9
  • 202
    • 79955798791 scopus 로고    scopus 로고
    • Ramucirumab (IMC-1121B): Monoclonal antibody inhibition of vascular endothelial growth factor receptor-2
    • Spratlin, J. Ramucirumab (IMC-1121B): monoclonal antibody inhibition of vascular endothelial growth factor receptor-2. Curr. Oncol. Rep. 2011, 13(2), 97-102.
    • (2011) Curr. Oncol. Rep. , vol.13 , Issue.2 , pp. 97-102
    • Spratlin, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.