Molecular modeling study and synthesis of novel pyrrolo[2,3-d]pyrimidines and pyrrolotriazolopyrimidines of expected antitumor and radioprotective activities

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 5, 2008, Pages 2391-2402

  Abou El Ella, Dalal A ^a   Ghorab, Mostafa M ^b   Noaman, Eman ^b   Heiba, Helmy I ^b   Khalil, Amira I ^b  

^a Ain Shams University   (Egypt)

^b NATIONAL CENTER FOR RADIATION RESEARCH AND TECHNOLOGY   (Egypt)

Author keywords

3 d pyrimidine; Antitumor and radioprotective activities; Molecular modeling studies; Novel pyrrolo 2; Tyrosine kinase inhibitors

Indexed keywords

3 (4 CHLOROBENZOYLAMINO) 4 (4 CHLOROBENZOYLAMINO) 5 PHENYL 7 (4 SULFAMOYLPHENYL) 3,4 DIHYDROPYRROLO[2,3 D]PYRIMIDIN; 4 (2 CYANOMETHYL 9 PHENYL 7H PYRROLO[3,2 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDIN 7 YL)BENZENESULFONAMIDE; 4 (2 MERCAPTO 9 PHENYL 7H PYRROLO[3,2 E][1,2,4]TRIAZOLO[1,5 C]PYRIDIN 7 YL)BENZENESULFONAMIDE; 4 (2 METHYL 9 PHENYL 7H PYRROLO[3,2 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDIN 7 YL)BENZENESULFONAMIDE; 4 (2 OXO 10 PHENYL 3,4 DIHYDROPYRROLO[2,3 D]PYRIMIDIN[3,4 E][1,2,4]TRIAZINE 8 YL)BENZENESULFONAMIDE; 4 (2 OXO 9 PHENYL 7H PYRROLO[3,2 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDIN 7 YL)BENZENESULFONAMIDE; 4 (2,9 DIPHENYL 7H PYRROLO[3,2 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDIN 7 YL)BENZENESULFONAMIDE; 4 (3 2 HYDROXYETHYL 4 IMINO 5 PHENYL 3,4 DIHYDROPYRROLO[2,3 D]PYRIMIDIN 7 YL)BENZENESULFONAMIDE; 4 (3 3 HYDROXYPROPYL 4 IMINO 5 PHENYL 3,4 DIHYDROPYRROLO[2,3 D]PYRIMIDIN 7 YL]BENZENESULFONAMIDE; 4 (3 AMINO 4 IMINO 5 PHENYL 3,4 DIHYDROPYRROLO[2,3 D]PYRIMIDIN 7 YL)BENZENESULFONAMIDE; 4 (3 BENZYL 4 IMINO 5 PHENYL 3,4 DIHYDROPYRROLO[2,3 D]PYRIMIDIN 7 YL)BENZENESULFONAMIDE; 4 (3 ETHYL 4 IMINO 5 PHENYL 3,4 DIHYDROPYRROLO[2,3 D]PYRIMIDIN 7 YL)BENZENESULFONAMIDE; 4 (8 AMINO 9 CYANO 1 PHENYL 3H PYRAZOLO[1,5 C]PYRROLO[3,2 E]PYRIMIDIN 3 YL)BENZENESULFONAMIDE; 4 (9 PHENYL 7H PYRROLO[3,2 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDIN 7 YL)BENZENESULFONAMIDE; 4 [3 (3 ETHYLTHIOUREIDO) 4 IMINO 5 PHENYL 3,4 DIHYDROPYRROLO[2,3 D]PYRIMIDIN 7 YL)BENZENESULFONAMIDE; 4 [3 (3 PHENYLTHIOUREIDO) 4 AIMINO 5 PHENYL 3,4 DIHYDROPYRROLO[2,3 D]PYRIMIDIN 7 YL)BENZENESULFONAMIDE; ANTINEOPLASTIC AGENT; DOXORUBICIN; PYRIMIDINE DERIVATIVE; PYRROLOTRIAZOLOPYRIMIDINE DERIVATIVE; RADIOPROTECTIVE AGENT; UNCLASSIFIED DRUG; VATALANIB;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; FEMALE; HYDROGEN BOND; IC 50; INFRARED SPECTROSCOPY; LIPID PEROXIDATION; MICROANALYSIS; MOLECULAR MODEL; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RADIATION INJURY; RADIATION PROTECTION;

ANIMALS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; AZO COMPOUNDS; CELL LINE, TUMOR; CELL SURVIVAL; FEMALE; GLUTATHIONE; LIPID PEROXIDATION; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; PYRIMIDINES; PYRROLES; RADIATION-PROTECTIVE AGENTS; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; SOFTWARE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 40849098809     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.11.072     Document Type: Article

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