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Volumn 11, Issue 7, 2010, Pages 865-874

Vascular endothelial growth factor receptor as target for advanced non-small cell lung cancer therapy

Author keywords

NSCLC; Sorafenib; Sunitinib; Tyrosine kinase inhibitors; Vandetanib; VEGF; VEGFR

Indexed keywords

1 [4 (3 AMINO 1H INDAZOL 4 YL)PHENYL] 3 (2 FLUORO 5 METHYLPHENYL)UREA; 6 [4 (4 ETHYL 1 PIPERAZINYLMETHYL)PHENYL] 4 (ALPHA METHYLBENZYLAMINO) 7H PYRROLO[2,3 D]PYRIMIDINE; ANTINEOPLASTIC AGENT; AXITINIB; BIBF 1120; BMS 690514; CARBOPLATIN; CEDIRANIB; CISPLATIN; DOCETAXEL; DOVITINIB; ERLOTINIB; GEFITINIB; GEMCITABINE; MOTESANIB; PACLITAXEL; PANITUMUMAB; PAZOPANIB; PEMETREXED; PROTEIN TYROSINE KINASE; SORAFENIB; SUNITINIB; UNCLASSIFIED DRUG; VANDETANIB; VASCULOTROPIN RECEPTOR; VATALANIB; XL 647; XL 880;

EID: 77953861145     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/138945010791320791     Document Type: Article
Times cited : (6)

References (69)
  • 1
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. Tumor angiogenesis: Therapeutic implications. N Engl J Med 1971; 285: 1182-6.
    • (1971) N Engl J Med , vol.285 , pp. 1182-1186
    • Folkman, J.1
  • 2
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D, Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996; 86: 353-64.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 3
    • 77954715923 scopus 로고    scopus 로고
    • Avastin Treatment Information for Healthcare Professionals -Avastin (bevacizumab). Available at, [accessed February 11, 2010]
    • Avastin Treatment Information for Healthcare Professionals -Avastin (bevacizumab). Available at: http://www.avastin.com/ avastin/hcp/index.m [accessed February 11, 2010].
  • 4
    • 66549109768 scopus 로고    scopus 로고
    • Non-small-cell lung cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up
    • D'Addario G, Felip E. Non-small-cell lung cancer: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol 2009; 20 (suppl. 4): iv68-iv70.
    • (2009) Ann Oncol , vol.20 , Issue.SUPPL. 4
    • D'Addario, G.1    Felip, E.2
  • 6
    • 0037967272 scopus 로고    scopus 로고
    • Tumorigenesis and the angiogenic switch
    • Bergers G, Benjamin LE. Tumorigenesis and the angiogenic switch. Nat Rev Cancer 2003; 3: 401-10.
    • (2003) Nat Rev Cancer , vol.3 , pp. 401-410
    • Bergers, G.1    Benjamin, L.E.2
  • 7
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 2005; 23: 1011-27.
    • (2005) J Clin Oncol , vol.23 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 8
    • 0033454716 scopus 로고    scopus 로고
    • Anticancer drug targets: Approaching angiogenesis
    • Keshet E, Ben-Sasson SA. Anticancer drug targets: approaching angiogenesis. J Clin Invest 1999; 104: 1497-501.
    • (1999) J Clin Invest , vol.104 , pp. 1497-1501
    • Keshet, E.1    Ben-Sasson, S.A.2
  • 9
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003; 9: 669-76.
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    Lecouter, J.3
  • 10
    • 0026395163 scopus 로고
    • The vascular endothelial growth factor family: Identification of a fourth molecular species and characterization of alternative splicing of RNA
    • Houck KA, Ferrara N, Winer J, Cachianes G, Li B, Leung DW. The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA. Mol Endocrinol 1991; 5: 1806-14.
    • (1991) Mol Endocrinol , vol.5 , pp. 1806-1814
    • Houck, K.A.1    Ferrara, N.2    Winer, J.3    Cachianes, G.4    Li, B.5    Leung, D.W.6
  • 11
    • 0025999033 scopus 로고
    • The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing
    • Tischer E, Mitchell R, Hartman T, et al. The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing. J Biol Chem 1991; 266: 11947-54.
    • (1991) J Biol Chem , vol.266 , pp. 11947-54
    • Tischer, E.1    Mitchell, R.2    Hartman, T.3
  • 12
    • 0035881307 scopus 로고    scopus 로고
    • Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo
    • Fukumura D, Xu L, Chen Y, Gohongi T, Seed B, Jain RK. Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo. Cancer Res 2001; 61: 6020-4.
    • (2001) Cancer Res , vol.61 , pp. 6020-6024
    • Fukumura, D.1    Xu, L.2    Chen, Y.3    Gohongi, T.4    Seed, B.5    Jain, R.K.6
  • 13
    • 0141838134 scopus 로고    scopus 로고
    • Flt-1-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoids
    • Bates RC, Goldsmith JD, Bachelder RE, et al. Flt-1-dependent survival characterizes the epithelial-mesenchymal transition of colonic organoids. Curr Biol 2003; 13: 1721-7.
    • (2003) Curr Biol , vol.13 , pp. 1721-1727
    • Bates, R.C.1    Goldsmith, J.D.2    Bachelder, R.E.3
  • 14
    • 29144510243 scopus 로고    scopus 로고
    • Vascular endothelial growth factors and receptors in colorectal cancer: Implications for anti-angiogenic therapy
    • Duff SE, Jeziorska M, Rosa DD, et al. Vascular endothelial growth factors and receptors in colorectal cancer: implications for anti-angiogenic therapy. Eur J Cancer 2006; 42: 112-7.
    • (2006) Eur J Cancer , vol.42 , pp. 112-117
    • Duff, S.E.1    Jeziorska, M.2    Rosa, D.D.3
  • 15
    • 20944441857 scopus 로고    scopus 로고
    • Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells
    • Fan F, Wey JS, McCarty MF, et al. Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells. Oncogene 2005; 24: 2647-53.
    • (2005) Oncogene , vol.24 , pp. 2647-2653
    • Fan, F.1    Wey, J.S.2    McCarty, M.F.3
  • 16
    • 31544463515 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-1 activation mediates epithelial to mesenchymal transition in human pancreatic carcinoma cells
    • Yang AD, Camp ER, Fan F, et al. Vascular endothelial growth factor receptor-1 activation mediates epithelial to mesenchymal transition in human pancreatic carcinoma cells. Cancer Res 2006; 66: 46-51.
    • (2006) Cancer Res , vol.66 , pp. 46-51
    • Yang, A.D.1    Camp, E.R.2    Fan, F.3
  • 18
    • 0027487087 scopus 로고
    • Vascular endothelial growth factor
    • Ferrara N. Vascular endothelial growth factor. Trends Cardiovasc Med 1993; 3: 244-50.
    • (1993) Trends Cardiovasc Med , vol.3 , pp. 244-250
    • Ferrara, N.1
  • 19
    • 0028938746 scopus 로고
    • Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development
    • Kaipainen A, Korhonen J, Mustonen T, et al. Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development. Proc Natl Acad Sci USA 1995; 92: 3566-70.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3566-3570
    • Kaipainen, A.1    Korhonen, J.2    Mustonen, T.3
  • 20
    • 0033846016 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-3 in lymphangio-genesis in wound healing
    • Paavonen K, Puolakkainen P, Jussila L, Jahkola T, Alitalo K. Vascular endothelial growth factor receptor-3 in lymphangio-genesis in wound healing. Am J Pathol 2000; 156; 1499-1504.
    • (2000) Am J Pathol , vol.156 , pp. 1499-1504
    • Paavonen, K.1    Puolakkainen, P.2    Jussila, L.3    Jahkola, T.4    Alitalo, K.5
  • 21
    • 0029021660 scopus 로고
    • Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    • Fong GH, Rossant J, Gertsenstein M, Breitman ML. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature 1995; 376: 66-70.
    • (1995) Nature , vol.376 , pp. 66-70
    • Fong, G.H.1    Rossant, J.2    Gertsenstein, M.3    Breitman, M.L.4
  • 22
    • 0032764427 scopus 로고    scopus 로고
    • Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice
    • Fong GH, Zhang L, Bryce DM, Peng J. Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice. Development 1999; 126: 3015-25.
    • (1999) Development , vol.126 , pp. 3015-3025
    • Fong, G.H.1    Zhang, L.2    Bryce, D.M.3    Peng, J.4
  • 23
    • 0034595635 scopus 로고    scopus 로고
    • Receptor chimeras indicate that the vascular endothelial growth factor receptor-1 (VEGFR-1) modulates mitogenic activity of VEGFR-2 in endothelial cells
    • Rahimi N, Dayanir V, Lashkari K. Receptor chimeras indicate that the vascular endothelial growth factor receptor-1 (VEGFR-1) modulates mitogenic activity of VEGFR-2 in endothelial cells. J Biol Chem 2000; 275: 16986-92.
    • (2000) J Biol Chem , vol.275 , pp. 16986-92
    • Rahimi, N.1    Dayanir, V.2    Lashkari, K.3
  • 24
    • 0032482978 scopus 로고    scopus 로고
    • Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice
    • Hiratsuka S, Minowa O, Kuno J, Noda T, Shibuya M. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. Proc Natl Acad Sci USA 1998; 95: 9349-54.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 9349-9354
    • Hiratsuka, S.1    Minowa, O.2    Kuno, J.3    Noda, T.4    Shibuya, M.5
  • 25
    • 0032713925 scopus 로고    scopus 로고
    • Vascular endothelial growth factor levels and induction of permeability in malignant pleural effusions
    • Zebrowski BK, Yano S, Liu W, et al. Vascular endothelial growth factor levels and induction of permeability in malignant pleural effusions. Clin Cancer Res 1999; 5: 3364-8.
    • (1999) Clin Cancer Res , vol.5 , pp. 3364-3368
    • Zebrowski, B.K.1    Yano, S.2    Liu, W.3
  • 27
    • 0037102369 scopus 로고    scopus 로고
    • ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
    • Wedge SR, Ogilvie DJ, Dukes M, et al. ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration. Cancer Res 2002; 62: 4645-55.
    • (2002) Cancer Res , vol.62 , pp. 4645-4655
    • Wedge, S.R.1    Ogilvie, D.J.2    Dukes, M.3
  • 28
    • 66349087009 scopus 로고    scopus 로고
    • Vandetanib versus gefitinib in patients with advanced non-small cell lung cancer: Results from a two-part, double-blind, randomized phase II trial
    • Natale RB, Bodkin D, Govindan R, et al. Vandetanib versus gefitinib in patients with advanced non-small cell lung cancer: results from a two-part, double-blind, randomized phase II trial. J Clin Oncol 2009; 27: 2523-9.
    • (2009) J Clin Oncol , vol.27 , pp. 2523-2529
    • Natale, R.B.1    Bodkin, D.2    Govindan, R.3
  • 29
    • 56749102822 scopus 로고    scopus 로고
    • Randomized phase II study of vandetanib alone or with paclitaxel and carboplatin as first-line treatment for advanced non-small-cell lung cancer
    • Heymach JV, Paz-Ares L, De Braud F, et al. Randomized phase II study of vandetanib alone or with paclitaxel and carboplatin as first-line treatment for advanced non-small-cell lung cancer. J Clin Oncol 2008; 26: 5407-15.
    • (2008) J Clin Oncol , vol.26 , pp. 5407-5415
    • Heymach, J.V.1    Paz-Ares, L.2    de Braud, F.3
  • 30
    • 34948838898 scopus 로고    scopus 로고
    • Randomized, placebo-controlled phase II study of vandetanib plus docetaxel in previously treated non small-cell lung cancer
    • Heymach JV, Johnson BE, Prager D, et al. Randomized, placebo-controlled phase II study of vandetanib plus docetaxel in previously treated non small-cell lung cancer. J Clin Oncol 2007; 25: 4270-7.
    • (2007) J Clin Oncol , vol.25 , pp. 4270-4277
    • Heymach, J.V.1    Johnson, B.E.2    Prager, D.3
  • 31
    • 69349097838 scopus 로고    scopus 로고
    • Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small cell lung cancer (NSCLC): A randomized, double-blind phase III trial (ZODIAC)
    • (abstr. CRA8003)
    • Herbst RS, Sun Y, Korfee S, et al. Vandetanib plus docetaxel versus docetaxel as second-line treatment for patients with advanced non-small cell lung cancer (NSCLC): A randomized, double-blind phase III trial (ZODIAC). J Clin Oncol 2009; 27(18S): 807s (abstr. CRA8003).
    • (2009) J Clin Oncol , vol.27 , Issue.18 S
    • Herbst, R.S.1    Sun, Y.2    Korfee, S.3
  • 32
    • 70349474058 scopus 로고    scopus 로고
    • Vandetanib plus pemetrexed versus pemetrexed as second-line therapy in patients with advanced non-small cell lung cancer (NSCLC): A randomized, double-blind phase III trial (ZEAL)
    • (abstr. 8010)
    • De Boer R, Arrieta O, Gottfried M, et al. Vandetanib plus pemetrexed versus pemetrexed as second-line therapy in patients with advanced non-small cell lung cancer (NSCLC): A randomized, double-blind phase III trial (ZEAL). J Clin Oncol 2009; 27(15S): 409s (abstr. 8010).
    • (2009) J Clin Oncol , vol.27 , Issue.15 S
    • de Boer, R.1    Arrieta, O.2    Gottfried, M.3
  • 33
    • 70349476412 scopus 로고    scopus 로고
    • Vandetanib versus erlotinib in patients with advanced non-small cell lung cancer (NSCLC) after failure of at least one prior cytotoxic chemotherapy: A randomized, double-blind phase III trial (ZEST)
    • (abstr. 8009)
    • Natale RB, Thongprasert S, Greco FA, et al. Vandetanib versus erlotinib in patients with advanced non-small cell lung cancer (NSCLC) after failure of at least one prior cytotoxic chemotherapy: A randomized, double-blind phase III trial (ZEST). J Clin Oncol 2009; 27(15S): 409s (abstr. 8009).
    • (2009) J Clin Oncol , vol.27 , Issue.15 S
    • Natale, R.B.1    Thongprasert, S.2    Greco, F.A.3
  • 34
    • 77954709140 scopus 로고    scopus 로고
    • ZEPHYR trial of zactima (vandetanib) vs. placebo -negative. Available at, [accessed February 11, 2010]
    • ZEPHYR trial of zactima (vandetanib) vs. placebo -negative. Available at: http://cancergrace.org/lung/2010/01/29/zephyr-trial-negative/ [accessed February 11, 2010].
  • 35
    • 4944249117 scopus 로고    scopus 로고
    • BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis
    • Wilhelm SM, Carter C, Tang L, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res 2004; 64: 7099-109.
    • (2004) Cancer Res , vol.64 , pp. 7099-7109
    • Wilhelm, S.M.1    Carter, C.2    Tang, L.3
  • 36
    • 44449142019 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of sorafenib, an oral multikinase inhibitor, in Japanese patients with advanced refractory solid tumors
    • Minami H, Kawada K, Ebi H, et al. Phase I and pharmacokinetic study of sorafenib, an oral multikinase inhibitor, in Japanese patients with advanced refractory solid tumors. Cancer Sci 2008; 99: 1492-8.
    • (2008) Cancer Sci , vol.99 , pp. 1492-1498
    • Minami, H.1    Kawada, K.2    Ebi, H.3
  • 37
    • 70349304196 scopus 로고    scopus 로고
    • Phase II, multicenter, uncontrolled trial of single-agent sorafenib in patients with relapsed or refractory, advanced non-small-cell lung cancer
    • Blumenschein GR Jr, Gatzemeier U, Fossella F, et al. Phase II, multicenter, uncontrolled trial of single-agent sorafenib in patients with relapsed or refractory, advanced non-small-cell lung cancer. J Clin Oncol 2009; 27: 4274-80.
    • (2009) J Clin Oncol , vol.27 , pp. 4274-4280
    • Blumenschein Jr., G.R.1    Gatzemeier, U.2    Fossella, F.3
  • 38
    • 77954357051 scopus 로고    scopus 로고
    • A randomized discontinuation phase II study of sorafenib versus placebo in patients with non-small cell lung cancer who have failed at least two prior chemotherapy regimens: E2501
    • (abstr. C1.6)
    • Schiller J, Lee JW, Hanna NH, Traynor AM, Wakelee H, Carbone DP. A randomized discontinuation phase II study of sorafenib versus placebo in patients with non-small cell lung cancer who have failed at least two prior chemotherapy regimens: E2501. J Thorac Oncol 2009; 4(suppl. 1): S355-6 (abstr. C1.6).
    • (2009) J Thorac Oncol , vol.4 , Issue.SUPPL. 1
    • Schiller, J.1    Lee, J.W.2    Hanna, N.H.3    Traynor, A.M.4    Wakelee, H.5    Carbone, D.P.6
  • 39
    • 63549123584 scopus 로고    scopus 로고
    • Carboplatin/ paclitaxel with/without sorafenib in chemonaive patients with stage IIIB-IV non-small cell lung cancer (NSCLC): Interim analysis (ia) results from a randomized phase III trial (escape)
    • (abstr. 13)
    • Hanna NH, von Pawel J, Reck M, Scagliotti G. Carboplatin/ paclitaxel with/without sorafenib in chemonaive patients with stage IIIB-IV non-small cell lung cancer (NSCLC): Interim analysis (ia) results from a randomized phase III trial (escape). J Thorac Oncol 2008; 3 (suppl.): S268 (abstr. 13).
    • (2008) J Thorac Oncol , vol.3 , Issue.SUPPL.
    • Hanna, N.H.1    von Pawel, J.2    Reck, M.3    Scagliotti, G.4
  • 40
    • 34548077118 scopus 로고    scopus 로고
    • Phase I targeted combination trial of sorafenib and erlotinib in patients with advanced solid tumors
    • Duran I, Hotté SJ, Hirte H, et al. Phase I targeted combination trial of sorafenib and erlotinib in patients with advanced solid tumors. Clin Cancer Res 2007; 13: 4849-57.
    • (2007) Clin Cancer Res , vol.13 , pp. 4849-4857
    • Duran, I.1    Hotté, S.J.2    Hirte, H.3
  • 41
    • 70450212475 scopus 로고    scopus 로고
    • A phase II study of erlotinib and sorafenib in chemotherapy-naïve patients with locally advanced/metastatic non-small cell lung cancer (NSCLC)
    • (abstr. 8018)
    • Lind JS, Dingemans AC, Groen HJ, Smit EF. A phase II study of erlotinib and sorafenib in chemotherapy-naïve patients with locally advanced/metastatic non-small cell lung cancer (NSCLC). J Clin Oncol 2009; 27(15S): 411s (abstr. 8018).
    • (2009) J Clin Oncol , vol.27 , Issue.15 S
    • Lind, J.S.1    Dingemans, A.C.2    Groen, H.J.3    Smit, E.F.4
  • 42
    • 42049098575 scopus 로고    scopus 로고
    • Phase II testing of sunitinib: The National Cancer Institute of Canada Clinical Trials Group IND Program Trials IND.182-185
    • Buckstein R, Meyer RM, Seymour L, et al. Phase II testing of sunitinib: the National Cancer Institute of Canada Clinical Trials Group IND Program Trials IND.182-185. Curr Oncol 2007; 14: 154-61.
    • (2007) Curr Oncol , vol.14 , pp. 154-161
    • Buckstein, R.1    Meyer, R.M.2    Seymour, L.3
  • 43
    • 37249072373 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic study of sunitinib administered daily for 2 weeks, followed by a 1-week off period
    • Britten CD, Kabbinavar F, Randolph Hecht JR, et al. A phase I and pharmacokinetic study of sunitinib administered daily for 2 weeks, followed by a 1-week off period. Cancer Chemother Pharmacol 2008; 61: 515-24.
    • (2008) Cancer Chemother Pharmacol , vol.61 , pp. 515-524
    • Britten, C.D.1    Kabbinavar, F.2    Randolph Hecht, J.R.3
  • 44
    • 33947416658 scopus 로고    scopus 로고
    • Sunitinib: A VEGF and PDGF receptor protein kinase and angiogenesis inhibitor
    • Roskoski R Jr. Sunitinib: a VEGF and PDGF receptor protein kinase and angiogenesis inhibitor. Biochem Biophys Res Commun 2007; 356: 323-8.
    • (2007) Biochem Biophys Res Commun , vol.356 , pp. 323-328
    • Roskoski Jr., R.1
  • 45
    • 39149120621 scopus 로고    scopus 로고
    • Multicenter, phase II trial of sunitinib in previously treated, advanced non-small-cell lung cancer
    • Socinski MA, Novello S, Brahmer JR, et al. Multicenter, phase II trial of sunitinib in previously treated, advanced non-small-cell lung cancer. J Clin Oncol 2008; 26: 650-6.
    • (2008) J Clin Oncol , vol.26 , pp. 650-656
    • Socinski, M.A.1    Novello, S.2    Brahmer, J.R.3
  • 46
    • 70350655546 scopus 로고    scopus 로고
    • Phase II study of continuous daily sunitinib dosing in patients with previously treated advanced non-small cell lung cancer
    • Novello S, Scagliotti GV, Rosell R, et al. Phase II study of continuous daily sunitinib dosing in patients with previously treated advanced non-small cell lung cancer. Br J Cancer 2009; 101: 1543-8.
    • (2009) Br J Cancer , vol.101 , pp. 1543-1548
    • Novello, S.1    Scagliotti, G.V.2    Rosell, R.3
  • 47
    • 70450207891 scopus 로고    scopus 로고
    • Erlotinib (E) with or without sunitinib (SU) in the treatment of metastatic non-small cell lung cancer (NSCLC): A phase II study
    • (abstr. 212P)
    • Blumenschein Jr GR, Robert F, Melnyk O, et al. Erlotinib (E) with or without sunitinib (SU) in the treatment of metastatic non-small cell lung cancer (NSCLC): A phase II study. J Thorac Oncol 2008; 3 (suppl. 1): S77-8 (abstr. 212P).
    • (2008) J Thorac Oncol , vol.3 , Issue.SUPPL. 1
    • Blumenschein Jr, G.R.1    Robert, F.2    Melnyk, O.3
  • 48
    • 70450199896 scopus 로고    scopus 로고
    • Sunitinib plus erlotinib, a novel VEGFR-EGFR co-inhibition treatment strategy in patients (pts) with metastatic non-small cell lung cancer (NSCLC)
    • (abstr. 216P)
    • Govindan R, Blumenschein G, Groen HJM, et al. Sunitinib plus erlotinib, a novel VEGFR-EGFR co-inhibition treatment strategy in patients (pts) with metastatic non-small cell lung cancer (NSCLC). J Thorac Oncol 2008; 3 (suppl. 1): S79 (abstr. 216P).
    • (2008) J Thorac Oncol , vol.3 , Issue.SUPPL. 1
    • Govindan, R.1    Blumenschein, G.2    Groen, H.J.M.3
  • 49
    • 55849108694 scopus 로고    scopus 로고
    • Safety and Phar-Macokinetics (PK) of AMG 706 In Combination With Panitumumab and Gemcitabine-cisplatin In Patients (pts) With Advanced Cancer
    • (abstr. 14057)
    • Crawford J, Burris H, Stephenson J, et al. Safety and phar-macokinetics (PK) of AMG 706 in combination with panitumumab and gemcitabine-cisplatin in patients (pts) with advanced cancer. J Clin Oncol 2007; 25(18S): 616s (abstr. 14057).
    • (2007) J Clin Oncol , Issue.18 S
    • Crawford, J.1    Burris, H.2    Stephenson, J.3
  • 50
    • 74949088883 scopus 로고    scopus 로고
    • Phase 1b study of motesanib, an oral angiogenesis inhibitor, in combination with carboplatin/paclitaxel and/or panitumumab for the treatment of advanced non-small cell lung cancer
    • Blumenschein GR Jr, Reckamp K, Stephenson GJ, et al. Phase 1b study of motesanib, an oral angiogenesis inhibitor, in combination with carboplatin/paclitaxel and/or panitumumab for the treatment of advanced non-small cell lung cancer. Clin Cancer Res 2010; 16: 279-90.
    • (2010) Clin Cancer Res , vol.16 , pp. 279-290
    • Blumenschein Jr., G.R.1    Reckamp, K.2    Stephenson, G.J.3
  • 51
    • 77954743884 scopus 로고    scopus 로고
    • Independent Data Monitoring Committee Recommends Resuming Enrollment of Non-Squamous NSCLC Patients in the Motesanib MONET1 Trial. Available at, [accessed February 11, 2010]
    • Independent Data Monitoring Committee Recommends Resuming Enrollment of Non-Squamous NSCLC Patients in the Motesanib MONET1 Trial. Available at: http://www.amgen.com/media/ media_pr_detail.jsp?releaseID=1255738 [accessed February 11, 2010].
  • 52
    • 49649123154 scopus 로고    scopus 로고
    • BIBF 1120: Triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy
    • Hilberg F, Roth GJ, Krssak M, et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res 2008; 68: 4774-82.
    • (2008) Cancer Res , vol.68 , pp. 4774-4782
    • Hilberg, F.1    Roth, G.J.2    Krssak, M.3
  • 53
    • 37549024347 scopus 로고    scopus 로고
    • A double blind phase II study of BIBF 1,120 in patients suffering from relapsed advanced non-small cell lung cancer (NSCLC)
    • (abstr. 7635)
    • von Pawel J, Kaiser R, Eschbach C, et al. A double blind phase II study of BIBF 1,120 in patients suffering from relapsed advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2007; 25(18S): 418s (abstr. 7635).
    • (2007) J Clin Oncol , vol.25 , Issue.18 S
    • von Pawel, J.1    Kaiser, R.2    Eschbach, C.3
  • 54
    • 69349105666 scopus 로고    scopus 로고
    • A phase I study of continuous oral treatment with the triple angiokinase inhibitor BIBF 1120 together with pemetrexed in previously treated patients with non-small cell lung cancer
    • (abstr. P3-091)
    • Hanna N, Ellis P, Stopfer P, Shapiro D, Gyorffy S. A phase I study of continuous oral treatment with the triple angiokinase inhibitor BIBF 1120 together with pemetrexed in previously treated patients with non-small cell lung cancer. J Thorac Oncol 2007; 2 (suppl. 4): S717-8 (abstr. P3-091).
    • (2007) J Thorac Oncol , vol.2 , Issue.SUPPL. 4
    • Hanna, N.1    Ellis, P.2    Stopfer, P.3    Shapiro, D.4    Gyorffy, S.5
  • 55
    • 75749109443 scopus 로고    scopus 로고
    • Pharmacokinetic (PK) analysis of a phase I study of continuous oral treatment with the angiokinase inhibitor BIBF 1120, in combination with carboplatin and paclitaxel in patients with advanced non-small cell lung cancer (NSCLC)
    • (abstr. 3567)
    • Camidge DR, Conkling P, Stephenson JJ, et al. Pharmacokinetic (PK) analysis of a phase I study of continuous oral treatment with the angiokinase inhibitor BIBF 1120, in combination with carboplatin and paclitaxel in patients with advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2008; 26(15S): 169s (abstr. 3567).
    • (2008) J Clin Oncol , vol.26 , Issue.15 S
    • Camidge, D.R.1    Conkling, P.2    Stephenson, J.J.3
  • 56
    • 77954711191 scopus 로고    scopus 로고
    • LUME-Lung 1: BIBF 1120 plus docetaxel as compared to placebo plus docetaxel in 2nd line non small cell lung cancer. Available at, [accessed February 11, 2010]
    • LUME-Lung 1: BIBF 1120 plus docetaxel as compared to placebo plus docetaxel in 2nd line non small cell lung cancer. Available at: http://www.cancer.gov/search/ViewClinicalTrials.aspx?cdrid=6302 97&version=HealthProfessional&protocolsearchid=7337960 [accessed February 11, 2010].
  • 57
    • 77954694125 scopus 로고    scopus 로고
    • LUME Lung 2: BIBF 1120 plus pemetrexed compared to placebo plus pemetrexed in 2nd line nonsquamous NSCLC. Available at, [accessed February 11, 2010]
    • LUME Lung 2: BIBF 1120 plus pemetrexed compared to placebo plus pemetrexed in 2nd line nonsquamous NSCLC. Available at: http://www.cancer.gov/search/ViewClinicalTrials.aspx?cdrid=6306 48&version=HealthProfessional&protocolsearchid=7337960 [accessed February 11, 2010].
  • 58
    • 20144370978 scopus 로고    scopus 로고
    • AZD2171: A highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer
    • Wedge SR, Kendrew J, Hennequin LF, et al. AZD2171: a highly potent, orally bioavailable, vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for the treatment of cancer. Cancer Res 2005; 65: 4389-400.
    • (2005) Cancer Res , vol.65 , pp. 4389-4400
    • Wedge, S.R.1    Kendrew, J.2    Hennequin, L.F.3
  • 59
    • 61349124193 scopus 로고    scopus 로고
    • A phase I and phar-macokinetic study of daily oral cediranib, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with cisplatin and gemcitabine in patients with advanced non-small cell lung cancer: A study of the National Cancer Institute of Canada Clinical Trials Group
    • Goss G, Shepherd FA, Laurie S, et al. A phase I and phar-macokinetic study of daily oral cediranib, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with cisplatin and gemcitabine in patients with advanced non-small cell lung cancer: a study of the National Cancer Institute of Canada Clinical Trials Group. Eur J Cancer 2009; 45: 782-8.
    • (2009) Eur J Cancer , vol.45 , pp. 782-788
    • Goss, G.1    Shepherd, F.A.2    Laurie, S.3
  • 60
    • 42949105645 scopus 로고    scopus 로고
    • Phase I and pharmaco-kinetic study of daily oral AZD2171, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer: The National Cancer Institute of Canada clinical trials group
    • Laurie SA, Gauthier I, Arnold A, et al. Phase I and pharmaco-kinetic study of daily oral AZD2171, an inhibitor of vascular endothelial growth factor tyrosine kinases, in combination with carboplatin and paclitaxel in patients with advanced non-small-cell lung cancer: the National Cancer Institute of Canada clinical trials group. J Clin Oncol 2008; 26: 1871-8.
    • (2008) J Clin Oncol , vol.26 , pp. 1871-1878
    • Laurie, S.A.1    Gauthier, I.2    Arnold, A.3
  • 61
    • 73949092851 scopus 로고    scopus 로고
    • Randomized, double-blind trial of carboplatin and paclitaxel with either daily oral cediranib or placebo in advanced non-small-cell lung cancer: NCIC clinical trials group BR24 study
    • Goss GD, Arnold A, Shepherd FA, et al. Randomized, double-blind trial of carboplatin and paclitaxel with either daily oral cediranib or placebo in advanced non-small-cell lung cancer: NCIC clinical trials group BR24 study. J Clin Oncol 2010; 28: 49-55.
    • (2010) J Clin Oncol , vol.28 , pp. 49-55
    • Goss, G.D.1    Arnold, A.2    Shepherd, F.A.3
  • 62
    • 59349096968 scopus 로고    scopus 로고
    • Phase I multicenter trial of BMS-690514: Safety, pharmacokinetic profile, biological effects, and early clinical evaluation in patients with advanced solid tumors and non-small cell lung cancer
    • (abstr. 2564)
    • Bahleda R, Felip E, Herbst RS, et al. Phase I multicenter trial of BMS-690514: Safety, pharmacokinetic profile, biological effects, and early clinical evaluation in patients with advanced solid tumors and non-small cell lung cancer. J Clin Oncol 2008; 26(15S): 128s (abstr. 2564).
    • (2008) J Clin Oncol , vol.26 , Issue.15 S
    • Bahleda, R.1    Felip, E.2    Herbst, R.S.3
  • 63
    • 75449088707 scopus 로고    scopus 로고
    • Tumor regression and pharmacodynamic (PD) biomarker validation in non-small cell lung cancer (NSCLC) patients treated with the ErbB/VEGFR inhibitor BMS-690514
    • (abstr. 8098)
    • Bahleda R, Soria J, Harbison C, et al. tumor regression and pharmacodynamic (PD) biomarker validation in non-small cell lung cancer (NSCLC) patients treated with the ErbB/VEGFR inhibitor BMS-690514. J Clin Oncol 2009; 27(15S): 431s (abstr. 8098).
    • (2009) J Clin Oncol , vol.27 , Issue.15 S
    • Bahleda, R.1    Soria, J.2    Harbison, C.3
  • 65
    • 4644271546 scopus 로고    scopus 로고
    • Increased plasma vascular endothelial growth factor (VEGF) as a surrogate marker for optimal therapeutic dosing of VEGF receptor-2 monoclonal antibodies
    • Bocci G, Man S, Green SK, et al. Increased plasma vascular endothelial growth factor (VEGF) as a surrogate marker for optimal therapeutic dosing of VEGF receptor-2 monoclonal antibodies. Cancer Res 2004; 64: 6616-25.
    • (2004) Cancer Res , vol.64 , pp. 6616-6625
    • Bocci, G.1    Man, S.2    Green, S.K.3
  • 66
    • 66149188254 scopus 로고    scopus 로고
    • Baseline vascular endothelial growth factor concentration as a potential predictive marker of benefit from vandetanib in non-small cell lung cancer
    • Hanrahan EO, Ryan AJ, Mann H, et al. Baseline vascular endothelial growth factor concentration as a potential predictive marker of benefit from vandetanib in non-small cell lung cancer. Clin Cancer Res 2009; 15: 3600-9.
    • (2009) Clin Cancer Res , vol.15 , pp. 3600-3609
    • Hanrahan, E.O.1    Ryan, A.J.2    Mann, H.3
  • 67
    • 74949090109 scopus 로고    scopus 로고
    • Distinct patterns of cytokine and angiogenic factor modulation and markers of benefit for vandetanib and/or chemotherapy in patients with non-small-cell lung cancer
    • Hanrahan EO, Lin HY, Kim ES, et al. Distinct patterns of cytokine and angiogenic factor modulation and markers of benefit for vandetanib and/or chemotherapy in patients with non-small-cell lung cancer. J Clin Oncol 2010; 28: 193-201.
    • (2010) J Clin Oncol , vol.28 , pp. 193-201
    • Hanrahan, E.O.1    Lin, H.Y.2    Kim, E.S.3
  • 68
    • 0034705367 scopus 로고    scopus 로고
    • Vascular endothelial growth factor(165) gene transfer augments circulating endothelial progenitor cells in human subjects
    • Kalka C, Masuda H, Takahashi T, et al. Vascular endothelial growth factor(165) gene transfer augments circulating endothelial progenitor cells in human subjects. Circ Res 2000; 86: 1198-202.
    • (2000) Circ Res , vol.86 , pp. 1198-1202
    • Kalka, C.1    Masuda, H.2    Takahashi, T.3
  • 69
    • 69949110600 scopus 로고    scopus 로고
    • Hypertension (HTN) in National Cancer Institute of Canada Clinical Trials Group study BR.24: A randomized, double-blind phase II trial of carboplatin (C) and paclitaxel (P) with either daily oral cediranib (CED), an inhibitor of vascular endothelial growth factor receptors, or placebo, in patients with advanced non-small cell lung cancer
    • (abstr. 3527)
    • Goodwin RA, Seymour L, Ding K, et al. Hypertension (HTN) in National Cancer Institute of Canada Clinical Trials Group study BR.24: A randomized, double-blind phase II trial of carboplatin (C) and paclitaxel (P) with either daily oral cediranib (CED), an inhibitor of vascular endothelial growth factor receptors, or placebo, in patients with advanced non-small cell lung cancer. J Clin Oncol 2009; 27(15S): 152s (abstr. 3527).
    • (2009) J Clin Oncol , vol.27 , Issue.15 S
    • Goodwin, R.A.1    Seymour, L.2    Ding, K.3


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