Inactivation of cytochrome P450 (P450) 3A4 but not P450 3A5 by OSI-930, a thiophene-containing anticancer drug

Drug Metabolism and Disposition

Volumn 39, Issue 2, 2011, Pages 345-350

  Lin, Hsia Lien ^a   Zhang, Haoming ^a   Medower, Christine ^b   Hollenberg, Paul F ^a   Johnson, William W ^b  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b OSI PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 BENZYLOXY 4 (TRIFLUOROMETHYL)COUMARIN; ANTINEOPLASTIC AGENT; CATALASE; COUMARIN DERIVATIVE; CYTOCHROME P450 2B6; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; HEME; OSI 930; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SULFOXIDE; SULFUR; THIOPHENE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BINDING SITE; ENZYME INACTIVATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MAXIMUM TOLERATED DOSE; OXIDATION; PRIORITY JOURNAL; PROTEIN MODIFICATION;

ANTINEOPLASTIC AGENTS; BINDING SITES; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 CYP3A; CYTOCHROMES B5; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; HUMANS; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; PROTEIN BINDING; QUINOLINES; THIOPHENES;

EID: 79251470430     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.110.034074     Document Type: Article

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